Article
Biochemistry & Molecular Biology
Larissa Erben, Jacqueline P. Welday, Ricardo Murphy, Andres Buonanno
Summary: Microinjection of AAV_Cre in the ventral tegmental area can have neurotoxic effects on dopaminergic neurons and elicit behavioral abnormalities, which are independent of ErbB4 Cyt-1 recombination and also observed in wild-type controls. These non-specific effects can be prevented by reducing viral titers while maintaining sufficient recombination activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lucie Valek, Irmgard Tegeder
Summary: Rodent models of Parkinson's disease are created using transgenic methods like mutant synuclein expression, PD gene deletions, MPTP or rotenone injections, or seeding with synuclein fibrils. These models exhibit histopathologic features of PD, such as Lewi bodies, but do not completely mimic the predominant loss of dopaminergic neurons. A study introducing transgenic diphtheria toxin receptor to mice showed partial ablation of neurons without PD-like behavioral correlates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mariah Mesquita de Figueiredo Cerqueira, Micaele Maria Lopes Castro, Amanda Almeida Vieira, Juliana Ayumi Azevedo Kurosawa, Fabio Leite do Amaral Junior, Fabiola de Carvalho Chaves de Siqueira Mendes, Marcia Consentino Kronka Sosthenes
Summary: Anxiety is increasingly being diagnosed in the elderly, and it is associated with cognitive decline, morbidity, and even mortality. The environment and age have an impact on anxiety-like behavior in mice, as assessed by the Elevated Plus Maze (EPM) and Open Field (OF) tests. The results from these tests suggest the need for a better evaluation of the parameters analyzed in each test.
Article
Neurosciences
Anna M. Lavezzi, Riffat Mehboob
Summary: This study focused on investigating the involvement of the periaqueductal gray (PAG) in Sudden Infant Death Syndrome (SIDS), revealing hypoplasia of the PAG subnucleus medialis in 65% of SIDS cases but not in controls, and significantly higher expression of tyrosine hydroxylase in controls than in SIDS. The findings also showed a significant correlation between PAG and substantia nigra abnormalities, suggesting a common involvement in the sleep-arousal phase failure leading to SIDS.
Article
Geriatrics & Gerontology
Alvaro C. Lima, Ywlliane S. R. Meurer, Vinicius S. Bioni, Debora M. G. Cunha, Narriman Goncalves, Leonardo B. Lopes-Silva, Marcela Becegato, Manuela B. L. Soares, Gabriela F. Marinho, Jose R. Santos, Regina H. Silva
Summary: Parkinson's disease is the second most common neurodegenerative disease, with a higher prevalence in men. Female rats showed a protective effect against the effects of low-dose reserpine treatment, exhibiting reduced or absent motor and cognitive deficits, as well as maintained levels of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Maryam Bigham, Abbas Mohammadipour, Mahmoud Hosseini, Amir Mohammad Malvandi, Alireza Ebrahimzadeh-Bideskan
Summary: Parkinson's disease is a common and severe neurodegenerative disorder that involves a selective loss of dopaminergic neurons. Studies have shown that garlic extract can protect cells from oxidative stress and inflammation, and improve movement disorders and behavioral deficits in animal models of PD.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Lijun Zhang, Jeoung Yun Park, Dong Zhao, Hak Cheol Kwon, Hyun Ok Yang
Summary: A study found that the active compound AKNS-2 isolated from Aster koraiensis Nakai can exert neuroprotective effects on Parkinson's disease models by regulating the autophagy pathway, leading to enhanced autophagy process, improved cell viability, increased dopamine synthesis, and modulation of protein expressions.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Neurosciences
Jyotshna Kanungo, Nathan C. Twaddle, Camila Silva, Bonnie Robinson, Mesay Wolle, Sean Conklin, Shaun MacMahon, Qiang Gu, Ian Edhlund, Linda Benjamin, Frederick A. Beland, Suzanne C. Fitzpatrick
Summary: This study evaluated the effects of inorganic arsenic on specific neuron types in zebrafish larvae. It found that inorganic arsenic alters the development of dopaminergic and motor neurons through the Sonic hedgehog (Shh) pathway. These results provide insights into the neurological effects of arsenic exposure.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Yi Li, Xin Wang, Xiaoqian Xie, Qingsong Liu, Haonan Dong, Yong Hou, Qingyou Xia, Ping Zhao
Summary: Animal behavior regulation is a complex process influenced by various factors, with the nervous system being a key factor. Pathogens can alter host behavior by affecting the host's nervous system. In this study, the researchers analyzed the transcriptome of silkworm brains infected with the nucleopolyhedrosis virus and found that genes related to behavior regulation changed after infection. The tyrosine hydroxylase gene was identified as a potential candidate gene, and its inhibition successfully blocked the enhanced locomotor behavior caused by the virus.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Anatomy & Morphology
Janina Borgonovo, Patricio Ahumada-Galleguillos, Alejandro Onate-Ponce, Camilo Allende-Castro, Pablo Henny, Miguel L. Concha
Summary: This study analyzed the neuroanatomical distribution of catecholaminergic neurons in the brain of adult Nothobranchius furzeri, revealing particular features in this species compared to other teleosts. The research provides a detailed neuroanatomical map of the catecholaminergic system in N. furzeri, contributing to phylogenetic understanding of this ancient neurochemical system.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Multidisciplinary Sciences
Shoko Fujino, Sayuri Hamano, Atsushi Tomokiyo, Risa Sugiura, Daiki Yamashita, Daigaku Hasegawa, Hideki Sugii, Shinsuke Fujii, Tomohiro Itoyama, Hirofumi Miyaji, Hidefumi Maeda
Summary: Conventional direct pulp-capping materials induce odontoblastic differentiation of dental pulp stem cells and promote reparative dentin formation, but sometimes result in dentin with poor sealing properties. This study explored the role of dopamine (DA) in odontoblastic differentiation and reparative dentin formation. The results showed that DA, produced by tyrosine hydroxylase (TH), plays a role in odontoblastic differentiation and induces the formation of tubular reparative dentin. These findings could contribute to the development of therapies for preserving vital pulp tissues.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Steven Miletic, Pierre-Louis Bazin, Scott J. S. Isherwood, Max C. Keuken, Anneke Alkemade, Birte U. Forstmann
Summary: The study provides a detailed account of 17 subcortical structures and ventricles in the human brain, including their iron and myelin contents, morphometry, and age-related changes. The results reveal the heterogeneity and intricate age-related alterations of these structures, as well as the shifting locations across the lifespan, which is relevant for the use of standard magnetic resonance imaging atlases. This study enhances our understanding of subcortical morphometry, neuroimaging properties, and normal aging processes, contributing to the improvement of our understanding of neurodegeneration.
Article
Biochemistry & Molecular Biology
Matheus C. Bianchini, Luiz F. W. Soares, Joao M. F. M. Sousa, Bruna P. Ramborger, Mateus C. Gayer, Jessika C. Bridi, Rafael Roehrs, Simone Pinton, Michael Aschner, Daiana S. Avila, Robson L. Puntel
Summary: This study found that exposure to methylmercury in fruit flies led to reduced survival rate, decreased levels of dopamine and octopamine, and changes in behavior. These effects were associated with inhibition of acetylcholinesterase and tyrosine hydroxylase, increased oxidative stress, and altered glutathione-S-transferase activity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Nanoscience & Nanotechnology
Qi Shang, Ling Zhang, Chan Chen, Weikang Tang, Mengqi Han, Qinfei Chen, Wenbin Liu
Summary: This study developed a nanozyme based on ethylenediaminetetraacetic acid (EDTA)-Fe2+ complex decorated Fe3O4 magnetic nanoparticles for biomimetic synthesis of L-DOPA. The nanozyme exhibited high catalytic performance, good reusability, and potential applications in the low-cost and high-efficiency production of L-DOPA.
ACS APPLIED NANO MATERIALS
(2022)
Article
Neurosciences
Eunchong Hong, Hyun Kyu Min, Heena Lim, Sun Mi Gu, Abdulaziz Jabborov, Taddesse Yayeh, Mijin Kim, Woo-Kyu Park, Jae-Chul Jung, Jaesuk Yun, Seikwan Oh
Summary: Stress is a major problem causing neuronal damage and mental health issues, such as anxiety and depression. A compound called 3, 4, 5-trimethoxycinnamic acid (TMCA) has shown anti-stress effects, but the effects of its derivatives on anxiety were unknown. In this study, derivatives of TMCA were found to alleviate anxiety in rats and mice. Certain derivatives also restored the levels of dopamine and expression of tyrosine hydroxylase (TH) protein in stressed rats. These findings suggest that these derivatives could be promising agents for preventing neuronal damage associated with stress.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
G. R. Morel, T. Andersen, J. Pardo, G. O. Zuccolilli, V. L. Cambiaggi, C. B. Herenu, R. G. Goya
Article
Endocrinology & Metabolism
Paula C. Reggiani, Claudio G. Barbeito, Gustavo O. Zuccolilli, Gloria M. Console, Alicia M. Flamini, Mireille Dardenne, Rodolfo G. Goya
Article
Anatomy & Morphology
H. L. Sanchez, L. B. Silva, M. E. Rafasquino, A. G. Mateo, G. O. Zuccolilli, E. L. Portiansky, C. R. Alonso
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2013)
Article
Veterinary Sciences
Santiago Martinez Zuviria, Malgorzata Ciurkiewicz, Peter Wohlsein, Gonzalo Madariaga, Gustavo Zuccolilli
Summary: Cystic hygroma was identified as a cause of early pregnancy loss in equines in this study, and this is the first description of the condition in equine fetuses. Diagnosis of cystic hygroma can be made through ultrasound examination and histopathological analysis performed between day 52 and 75 of pregnancy.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2022)
Article
Neurosciences
Enrique Leo Portiansky, Claudio Gustavo Barbeito, Eduardo Juan Gimeno, Gustavo Oscar Zuccolilli, Rodolfo Gustavo Goya
EXPERIMENTAL NEUROLOGY
(2006)
Article
Neurosciences
Gustavo R. Morel, Oscar A. Brown, Paula C. Reggiani, Claudia B. Herenu, Enrique L. Portiansky, Gustavo O. Zuccolilli, Jean A. Pleau, Mireille Dardenne, Rodolfo G. Goya
BRAIN RESEARCH BULLETIN
(2006)
Article
Biochemical Research Methods
EL Portiansky, CG Barbeito, RG Goya, EJ Gimeno, GO Zuccolilli
JOURNAL OF NEUROSCIENCE METHODS
(2004)
Article
Neurosciences
HL Sánchez, LB Silva, EL Portiansky, RG Goya, GO Zuccolilli
JOURNAL OF COMPARATIVE NEUROLOGY
(2003)
Article
Anatomy & Morphology
HL Sánchez, LB Silva, WG Acosta, EL Portiansky, GO Zuccolilli
ANATOMIA HISTOLOGIA EMBRYOLOGIA-JOURNAL OF VETERINARY MEDICINE SERIES C
(2000)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.