Journal
NEUROREPORT
Volume 22, Issue 8, Pages 402-406Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328346e154
Keywords
MK-801; N-methyl-D-aspartate receptor; prepulse inhibition; rat; working memory
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Funding
- Natural Science Foundation of China [30770775, 30800361]
- Youth Foundation of Peking University Sixth Hospital [IMHYG2008-01]
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The N-methyl-D-aspartate receptor plays a crucial role in developmental plasticity. Evidence shows that neonatal exposure to N-methyl-D-aspartate receptor antagonists impairs cognition in adult rats. This study investigated whether neonatal MK-801 treatment would produce long-term and age-specific effects on working memory and sensorimotor gating in adolescent and adult female rats. After treatment with MK-801 at postnatal days (PND) 5-14, female rats exhibited slightly impaired working memory during adolescence (PND: 35-42). In contrast, working memory was remarkably disrupted in adult (PND: 63-70) female rats. However, prepulse inhibition and startle amplitudes were not significantly affected at both ages. These findings indicate that neonatal MK-801 elicits working memory deficits, especially in the postpuberty female rats. NeuroReport 22:402-406 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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