Journal
NEUROREPORT
Volume 22, Issue 2, Pages 68-72Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32834272eb
Keywords
experimental autoimmune encephalomyelitis; inflammation; neural precursor cells; transplantation
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Funding
- Greek Secretary of Research and Technology
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Recent studies on neural precursor cell (NPC) transplantation in multiple sclerosis animal models reveal that these cells exert their therapeutic effect mainly because of immunomodulation rather than cell replacement. In this study intraventricularly transplanted NPCs in mice, induced experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis, improved the clinical symptoms and suppressed inflammation in the brain by enhancing the apoptosis of inflammatory cells. However, the same treatment failed to reduce significantly the inflammatory cells in the spinal cord, the pathology of which predominantly determines the clinical manifestation of experimental autoimmune encephalomyelitis. Our findings suggest that immunosuppression is rather a local phenomenon and thus, bystander neuroprotective mechanisms triggered by NPC intraventricular transplantation should be accountable for their therapeutic effect. NeuroReport 22: 68-72 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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