Journal
NEUROREPORT
Volume 21, Issue 12, Pages 841-845Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32833d40e2
Keywords
axons; misdirection; N-CAM; nerve regeneration; nerve repair; neurofilaments; non-myelinating; Schwann cells
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Funding
- Swedish Research Council (Medicine and Science)
- Konsul Thure Carlsson Fund for Medical Research, Region Skane
- University Hospital Malmo, Sweden
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N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and sensory axons after nerve repair. NeuroReport 21:841-845 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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