Journal
NEUROREPORT
Volume 21, Issue 8, Pages 559-563Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32833980b2
Keywords
ATF3; infraorbital nerve injury; macrophage invasion; neuropathic pain; P2X(4) receptor; serotonin selective reuptake inhibitor
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [18791332]
- Grants-in-Aid for Scientific Research [18791332] Funding Source: KAKEN
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We investigated the P2X(4) receptor (P2X(4)R) expression in the cervical spinal cord, trigeminal ganglion, and infraorbital nerve (ION), after a chronic constriction injury of unilateral ION and a treatment with selective serotonin reuptake inhibitor (SSRI). A recent study has showed that SSRI inhibits P2X(4)R expression. Injured rats had significantly lower pain thresholds. In injured and slightly injured ION, the P2X(4)R expression was significantly higher than in the naive-rat ION. Injured animals with SSRI showed significantly higher pain thresholds than injured animals without the drug. Nonetheless, P2X(4)R expression in the ipsilateral ION remained high. Immunostaining showed that macrophages are the source of P2X(4)R. Our results suggest that the expression of P2X(4)R in our model is modulated not by neuropathic pain, but by slight nerve injury. NeuroReport 21:559-563 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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