Journal
NEUROREPORT
Volume 21, Issue 3, Pages 210-215Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328335c311
Keywords
anisomycin; hippocampal slice; isolated dendrites; long-term potentiation; synaptic capture; synaptic tag
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Funding
- Queen Elisabeth Fund for Medical Research
- Belgian Fund for Scientific Research
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In the CA1 region of mouse hippocampal slices, a strong tetanic stimulation triggers a long-lasting long-term potentiation (L-LTP), which requires transcription for the development of its late phase. Nevertheless, we were able to elicit such an L-LTP in CA1 dendrites separated from their somas provided that we restricted our investigations to isolated dendrites where a very robust early LTP was triggered. This particular type of L-LTP, which relied on translation of preexisting messenger RNAs - as it was blocked by anisomycin - could not be captured by another pathway activated only by a weak tetanic stimulation. This suggests that the plasticity-related proteins resulting from translation of messenger RNAs in dendrites cannot pass from the synaptic site where they were synthesized to another one. NeuroReport 21:210-215 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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