Journal
NEUROREPORT
Volume 21, Issue 5, Pages 324-327Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328335b518
Keywords
cochlear nucleus; cochleotomy; matrix metalloprotease-2; rat; regeneration; synaptogenesis
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Lesion-induced neuroplasticity, including fiber degeneration, axonal growth, and synaptogenesis, involves dynamical changes of the extracellular matrix. We discovered that the matrix metalloprotease-2 (MMP-2), a major actor in extracellular matrix recomposition, is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. There was a remarkable coincidence of MMP-2 accumulation and GAP-43 expression in time and space. We obtained evidence indicating that MMP-2 is delivered to regions of emerging GAP-43 positive synaptic endings by postsynaptic neurons as well as by adjoining astrocytes. These results indicate a major role of MMP-2 in lesion-induced remodeling of central auditory networks and suggest a cooperativity with GAP-43-directed axonal outgrowth and synaptogenesis. NeuroReport 21:324-327 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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