Journal
NEUROREPORT
Volume 19, Issue 16, Pages 1605-1609Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32831313ef
Keywords
axonal regeneration; ErbB receptors; median nerve; peripheral nerve reconstruction; rat
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Funding
- Ministero Italiano dell'istruzione, dell'Universita e delta Ricerca (MIUR)
- Regione Piemonte (Bando Ricerca Sanitaria Finalizzata)
- Compagnia di San Paolo
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ErbBs are a family of receptors involved in the trophic maintenance of Schwann cells. Little is known about their expression changes during peripheral nerve regeneration. The aim of this study was thus to investigate variations in ErbBs after end-to-end and end-to-side nerve regeneration in the rat median nerve model. Expression of ErbBs was assessed at 7, 14, and 28 days postoperatively by real-time PCR. Results showed that expression of ErbB1 and ErbB4 mRNAs was downregulated, whereas ErbB3 mRNA was upregulated. No significant changes in ErbB2 mRNA were detected. Our results suggest that ErbBs changes are involved in the molecular response to peripheral nerve injuries. NeuroReport 19:1605-1609 (C) 2008 Wolters Kluwer Health I Lippincott Williams & Wilkins.
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