Journal
NEUROREPORT
Volume 19, Issue 3, Pages 299-303Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3282f4cb96
Keywords
calcium spike; cerebellum; climbing fiber; complex spike; Purkinje cell; T-type and R-type calcium channels
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In Purkinje cells from cerebellar slice cultures, low-threshold Ca2+ spike (LTS) gives rise to complex bursts in the soma that resemble the complex spike induced by climbing fibers stimulation.We show that LTS is reduced by T-type and R-type Ca2+ channel blockers (SNX-482, nickel, or mibefradil).We propose that LTS is generated by openings of T-type Ca2+ channels (alpha-IG and/or alpha-II subunits) and R-type Ca2+ channels (alpha-IE subunit isoforms with a weak sensitivity to SNX-482 and to nickel). Using mibefradil we show that climbing fiber stimulation activates LTS, which contributes to the shape of the response. This Ca2+ entry may be involved in Ca2+ -dependent synaptic plasticity of the parallel fiber input induced by climbing fiber activation.
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