Article
Radiology, Nuclear Medicine & Medical Imaging
Miao Zhang, Hui Huang, Wei Liu, Lihong Tang, Qikang Li, Jia Wang, Xinyun Huang, Xiaozhu Lin, Hongping Meng, Jin Wang, Shikun Zhan, Biao Li, Jie Luo
Summary: The combination of quantitative T2 mapping and [F-18]FDG PET can enhance lateralization accuracy for temporal lobe epilepsy, especially beneficial for MR-negative patients.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongxiang Tang, Ling Xiao, Chijun Deng, Haoyue Zhu, Xiaomei Gao, Jian Li, Zhiquan Yang, Dingyang Liu, Li Feng, Shuo Hu
Summary: This study investigated the patterns of metabolic abnormalities using [F-18]FDG PET in MTLE patients with different pathologic types. It was found that MTLE patients with isolated gliosis had the worst prognosis and exhibited significant hypometabolism in the insula. Therefore, hypometabolic regions should be prioritized for presurgical evaluation of MTLE patients rather than focusing solely on metabolic uptake values.
EUROPEAN RADIOLOGY
(2023)
Editorial Material
Clinical Neurology
Cleiton Formentin, Dayvid Leonardo de Castro Oliveira, Leo Gordiano Matias, Andrei Fernandes Joaquim, Helder Tedeschi, Enrico Ghizoni
Summary: Mesial temporal lobe epilepsy is the most common type of focal epilepsy in young adults and has high success rates with surgical resection. Although postoperative MRI scans showed temporal pole atrophy and potential gliosis, temporopolar amygdalohippocampectomy demonstrated good outcomes in terms of temporal stem preservation, visual outcomes, and memory results.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Review
Biochemistry & Molecular Biology
Alexey M. Yakimov, Elena E. Timechko, Irina G. Areshkina, Anna A. Usoltseva, Kristina D. Yakovleva, Elena A. Kantimirova, Nikita Utyashev, Nikita Ivin, Diana V. Dmitrenko
Summary: Mesial temporal lobe epilepsy is the most common type of epilepsy and surgery is often the only treatment option. This study focuses on miR-654-3p as a potential biomarker for surgical outcome, while also considering other miRNAs as indicators of relapse. The research on miRNAs as predictive biomarkers of surgical outcome is urgent, but several factors need to be taken into account.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Giorgi Kuchukhidze, Iris Unterberger, Elisabeth Schmid, Laura Zamarian, Christian Michael Siedentopf, Florian Koppelstaetter, Elke Gizewski, Martin Kronbichler, Gerhard Luef, Hennric Jokeit, Eugen Trinka
Summary: In this study, we found that unilateral mesial TLE and ipsilateral AE could lead to dysfunction in emotion recognition. Patients with right-side mTLE had more impaired perception and recognition of emotions compared to those with left-side mTLE. Patients also showed deficits in emotion recognition compared to healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Maria Luiza Benevides, Jean Costa Nunes, Ricardo Guarnieri, Hiago Melo, Mariana Lunardi, Marcelo Neves Linhares, Emil Kupek, Peter Wolf, Katia Lin, Roger Walz
Summary: Anxiety and depressive symptoms significantly improved in patients with MTLE-HS after ATL. Pre-surgical levels of anxiety and depression were positively associated with post-surgical levels, and longer follow-up was associated with anxiety, while worse seizure control was linked to depressive symptoms after ATL.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Joao P. S. A. S. de Souza, Luciana R. Pimentel-Silva, Gabriel Ayub, Mateus H. Nogueira, Tamires Zanao, Clarissa L. Yasuda, Brunno M. Campos, Fabio Rogerio, Helder Tedeschi, Fernando Cendes, Enrico Ghizoni
Summary: The study findings suggest that the TP-AH surgical approach provides better short-term seizure control compared to TU-AH, a lower rate of visual field defects compared to TI-AH, and improved visual memory and IQ. This indicates that TP-AH may be a more effective surgical approach for temporal lobe epilepsy with HS.
Article
Biology
Iman Beheshti, Daichi Sone, Norihide Maikusa, Yukio Kimura, Yoko Shigemoto, Noriko Sato, Hiroshi Matsuda
Summary: This study demonstrates that combining DIR data with machine-learning algorithms can effectively distinguish normal individuals from epileptic subjects and accurately identify the laterality of the focus side in MRI-negative TLE patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Behavioral Sciences
Bulent Guven, Asli Ece Cilliler
Summary: Approximately half of patients with HS-MTLE had headaches, with about one third reporting migraine type headaches. This highlights the potential pathogenetic role of HS in the development of headaches, especially migraines, in patients with epilepsy. Further studies are necessary to determine if accompanying headaches, particularly migraine attacks, could be determining factors for HS-MTLE, and if they have a lateralizing value for HS.
EPILEPSY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Shameer Aslam, Ramiah Rajeshkannan, C. J. Sandya, Manjit Sarma, Siby Gopinath, Ashok Pillai
Summary: This study aimed to analyze statistically derived threshold values of volumetric MRI and FDG PET asymmetry for non-invasive detection/exclusion of temporal lobe epilepsy (TLE).
EPILEPSY & BEHAVIOR
(2022)
Article
Behavioral Sciences
Niyatee Samudra, Eric Armour, Hernan Gonzalez, Danielle Mattingly, Kevin Haas, Pradumna Singh, Hasan Sonmezturk, Martin Gallagher, Angela Crudele, William Nobis, Shilpa Reddy, Monica Jacobs, Joseph M. Aulino, Sarah Bick, Victoria Morgan, Dario Englot, Bassel Abou-Khalil
Summary: By comparing the clinical and neuropsychological characteristics of patients with ATE and MTS, this study identified ATE as a potential etiology of refractory TLE in adults. Female gender, delayed onset of epilepsy, and absence of febrile seizures were frequently observed in ATE patients. Initial imaging often failed to detect ATE, but targeted encephalocele resections resulted in good treatment outcomes.
EPILEPSY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Karoline Leiberg, Jane de Tisi, John S. Duncan, Bethany Little, Peter N. Taylor, Sjoerd B. Vos, Gavin P. Winston, Bruno Mota, Yujiang Wang
Summary: Neuroimaging captures brain restructuring after anterior temporal lobe resection (ATLR), a surgical procedure for drug-resistant temporal lobe epilepsy (TLE). This study examines the effects of ATLR on brain morphology, showing significant changes mainly in regions near the resection and structurally connected to the anterior temporal lobe.
Article
Clinical Neurology
Leonardo Favi Bocca, Thiago Pereira Rodrigues, Thiago Bortholin, Elza Marcia Targas Yacubian, Henrique Carrete Jr, Mirian Guaranha, Ricardo Silva Centeno
Summary: Sotos syndrome is a genetic disorder caused by NSD1 gene haploinsufficiency, with some patients experiencing epilepsy, including drug-resistant seizures. A 47-year-old female patient with Sotos syndrome had focal-onset seizures in the left temporal lobe, left-side hippocampal atrophy, and cognitive impairment. After undergoing left-side temporal lobe resection, the patient achieved complete awake seizure control and significant improvement in quality-of-life during the 3-year follow-up. Resective surgeries may be beneficial for improving seizure control and quality of life in selected patients with Sotos syndrome.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Mengyi Guo, Jing Wang, Zhonghua Xiong, Xiongfei Wang, Yujiao Yang, Yifan Zhang, Chongyang Tang, Jing Zhang, Yuguang Guan, Fan Chen, Kun Yao, Pengfei Teng, Jian Zhou, Feng Zhai, Detlev Boison, Guoming Luan, Tianfu Li
Summary: Mesial temporal lobe epilepsy without hippocampal sclerosis (no-HS MTLE) patients have resistance to antiepileptic drugs, difficulties in precise seizure location, and poor surgical outcomes. This study found maladaptive changes in adenosine metabolism and neuronal pathology in no-HS MTLE patients, suggesting potential new therapeutic targets.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Richard L. Wahl, Panithaya Chareonthaitawee, Bonnie Clarke, Alexander Drzezga, Liza Lindenberg, Arman Rahmim, James Thackeray, Gary A. Ulaner, Wolfgang Weber, Katherine Zukotynski, John Sunderland
Summary: The Society of Nuclear Medicine and Molecular Imaging's Value Initiative focuses on demonstrating the value of molecular imaging and molecularly targeted radiopharmaceutical therapy, with the research and discovery domain being crucial for advancing diagnostic and therapeutic nuclear medicine. Leaders have identified 5 broad areas of opportunity for future growth and clinical impact in this field.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Arda Konik, Joseph A. O'Donoghue, Richard L. Wahl, Michael M. Graham, Annick D. Van den Abbeele
Summary: Theranostics is a precision medicine discipline that integrates diagnostic nuclear medicine imaging with radionuclide therapy to provide personalized treatment for cancer patients. By using quantitative nuclear medicine imaging, accurate therapeutic plans can be developed based on the in-vivo distribution of radioactivity concentration within tumors and normal organs/tissues.
SEMINARS IN RADIATION ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David H. Ballard, Udayabhanu Jammalamadaka, Kathleen W. Meacham, Mark J. Hoegger, Broc A. Burke, Jason A. Morris, Alexander R. Scott, Zachary O'Connor, Connie Gan, Jesse Hu, Karthik Tappa, Richard L. Wahl, Pamela K. Woodard
Summary: The study aimed to design a 3D-printed alternative N95 respirator that passed OSHA-certified quantitative fit testing. Two out of ten prototypes designed with flexible materials passed fit testing, showing potential for use after comprehensive evaluation.
ACADEMIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Diane S. Abou, Amanda Fears, Lucy Summer, Mark Longtine, Nadia Benabdallah, Ryan C. Riddle, David Ulmert, Jeff M. Michalski, Richard L. Wahl, Denise Chesner, Michele Doucet, Nicholas C. Zachos, Brian W. Simons, Daniel L. J. Thorek
Summary: The study investigates the role of enteric ion channels in improving the uptake of Ra-223 and reducing toxicity. In vivo experiments showed that amiloride can enhance bone uptake and inhibit tumor growth when combined with other agents. This combination therapy has the potential to improve outcomes for bone-metastatic cancer patients while maintaining tolerability.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Richard L. Wahl, Vasken Dilsizian, Christopher J. Palestro
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin A. Lodge, Lilja B. Solnes, Muhammad A. Chaudhry, Richard L. Wahl
Summary: A study found that pre-dosing with unlabeled octreotide can decrease radiotracer uptake in normal liver and spleen, but has minimal impact on uptake in tumor and other organs. This suggests that discontinuing somatostatin analog therapy before PET/CT with Ga-68-DOTATOC may not be necessary, potentially simplifying patient protocols. Further research is needed to explore the implications of this approach in different clinical settings.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark J. Hoegger, Mark S. Longtine, Kyuhwan Shim, Richard L. Wahl
Summary: This study compared survival and optical imaging characteristics of mice strains with varied coat colors harboring luciferase-expressing disseminated lymphoma, finding that mouse pelt color and imaging aspect are critical considerations for quantifying bioluminescent tumor signal. The R2G2 mouse strain may be useful for preclinical targeted therapy studies.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ashwin Singh Parihar, Lisa R. Schmidt, Farrokh Dehdashti, Richard L. Wahl
Summary: The aim of this study was to evaluate the detection rate of incidental second primary neoplasms in patients with prostate cancer on F-18-fluciclovine PET/CT. The results showed that 9.1% of patients had findings suggestive of a second neoplasm, with renal cell carcinoma being the most common (45.5%).
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Richard L. Wahl, Eric C. Frey, Heather A. Jacene, Brad S. Kahl, Steven Piantadosi, Jesus A. Bianco, Richard J. Hammes, Miah Jung, Wayne Kasecamp, Bin He, George Sgouros, Ian W. Flinn, Lode J. Swinnen
Summary: The study evaluates the feasibility of SPECT-CT/planar organ dosimetry-based radiation dose escalation radioimmunotherapy in patients with recurrent non-Hodgkin's lymphoma. The approach was patient-specific and showed efficient tumor response rates, variability in liver dosimetry, and feasibility of exceeding FDA-approved activity. The study supports the feasibility of patient-specific dose escalation in the treatment of NHL with stem cell transplant.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark J. Hoegger, Anup S. Shetty, Darcy R. Denner, Jennifer E. Gould, Richard L. Wahl, Constantine A. Raptis, David H. Ballard
Summary: The COVID-19 pandemic had a broad impact on radiology trainees and their training programs, affecting aspects such as resident wellness, imaging opinions, and opinions regarding exam delays. Most institutions reported positive cases of COVID-19, with residents generally favoring laboratory testing over imaging and some using COVID-19 terminology when encountering chest CT findings suggestive of viral pneumonia in symptomatic patients.
CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anne M. Smith, Nancy A. Obuchowski, Norman L. Foster, Gregory Klein, P. David Mozley, Adriaan A. Lammertsma, Richard L. Wahl, John J. Sunderland, Jean-Luc Vanderheyden, Tammie L. S. Benzinger, Paul E. Kinahan, Dean F. Wong, Eric S. Perlman, Satoshi Minoshima, Dawn Matthews
Summary: Standardized approach in acquiring amyloid PET images increases their value as disease and drug response biomarkers. The Quantitative Imaging Biomarkers Alliance amyloid PET biomarker committee developed and validated a profile to characterize and reduce the variability of SUVRs, increasing statistical power for these assessments.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Prabhakar Shantha Rajiah, Maria Jose Sarda, Ravi Ashwath, Harold Goerne
Review
Radiology, Nuclear Medicine & Medical Imaging
Donna M. Peehl, Cristian T. Badea, Thomas L. Chenevert, Heike E. Daldrup-Link, Li Ding, Lacey E. Dobrolecki, A. McGarry Houghton, Paul E. Kinahan, John Kurhanewicz, Michael T. Lewis, Shunqiang Li, Gary D. Luker, Cynthia X. Ma, H. Charles Manning, Yvonne M. Mowery, Peter J. O'Dwyer, Robia G. Pautler, Mark A. Rosen, Raheleh Roudi, Brian D. Ross, Kooresh I. Shoghi, Renuka Sriram, Moshe Talpaz, Richard L. Wahl, Rong Zhou
Summary: The availability of high-fidelity animal models has increased, allowing for preclinical studies relevant to cancer research. Co-clinical trials conducted on animal models that mirror patients' tumors have seen increased opportunities. However, quantitative imaging in co-clinical trials still needs optimization.
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura C. Bell, Natenael Semmineh, Hongyu An, Cihat Eldeniz, Richard Wahl, Kathleen M. Schmainda, Melissa A. Prah, Bradley J. Erickson, Panagiotis Korfiatis, Chengyue Wu, Anna G. Sorace, Thomas E. Yankeelov, Neal Rutledge, Thomas L. Chenevert, Dariya Malyarenko, Yichu Liu, Andrew Brenner, Leland S. Hu, Yuxiang Zhou, Jerrold L. Boxerman, Yi-Fen Yen, Jayashree Kalpathy-Cramer, Andrew L. Beers, Mark Muzi, Ananth J. Madhuranthakam, Marco Pinho, Brian Johnson, C. Chad Quarles
Review
Radiology, Nuclear Medicine & Medical Imaging
Ella F. Jones, John M. Buatti, Hui-Kuo Shu, Richard L. Wahl, Brenda F. Kurland, Hannah M. Linden, David A. Mankoff, Daniel L. Rubin, Darrell Tata, Robert J. Nordstrom, Lubomir Hadjiyski, Matthias Holdhoff, Lawrence H. Schwartz