Article
Clinical Neurology
Sara Pietracupa, Daniele Belvisi, Claudia Piervincenzi, Silvia Tommasin, Gabriele Pasqua, Nikolaos Petsas, Maria Ilenia De Bartolo, Andrea Fabbrini, Matteo Costanzo, Nicoletta Manzo, Alfredo Berardelli, Patrizia Pantano
Summary: This study aimed to identify white matter (WM) and gray matter (GM) abnormalities in early PD patients and their correlations with motor and non-motor symptom severity. Results showed that PD patients exhibited lower WM fractional anisotropy and higher mean, axial, and radial diffusivity. There were also correlations between cognitive performance and WM fractional anisotropy values. Smaller cerebellar volumes in early PD patients were also found. No GM changes were observed in subcortical or cortical regions.
JOURNAL OF NEUROLOGY
(2023)
Review
Neurosciences
Jin-huan Yue, Qin-hong Zhang, Xu Yang, Peng Wang, Xu-Chen Sun, Shi-Yan Yan, Ang Li, Wei-Wei Zhao, Dan-Na Cao, Yang Wang, Ze-Yi Wei, Xiao-Ling Li, Lu-Wen Zhu, Guanhu Yang, Jeffrey Zhongxue Mah
Summary: This study used bibliometric analysis to provide an overview of publications on magnetic resonance imaging (MRI) of white matter in Alzheimer's disease (AD). The results showed an exponential growth in the number of published articles from 1990 to 2022, with the United States and the University of California Davis being the most active country and institution, respectively. Neurology was the most productive journal, and the research frontier trends included the association between small vessel disease and AD, clinical application and exploration of diffusion MRI, and related markers.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Yilei Zhao, Jingfeng Xu, Zhan Feng, Jincheng Wang
Summary: This meta-analysis suggests that lower levels of serum 25-hydroxy vitamin D are not associated with white matter hyperintensity (WMH), but a decrease in these levels may be linked to WMH. Further prospective trials are needed to confirm these findings and explore the association between vitamin D levels and WMH.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Francisca A. de Leeuw, Hata Karamujic-Comic, Betty M. Tijms, Carel F. W. Peeters, Maartje I. Kester, Philip Scheltens, Shahzad Ahmad, Dina Vojinovic, Hieab H. H. Adams, Thomas Hankemeier, Daniel Bos, Aad van der Lugt, Meike W. Vernooij, M. Arfan Ikram, Najaf Amin, Frederik Barkhof, Charlotte E. Teunissen, Cornelia M. van Duijn, Wiesje M. van der Flier
Summary: The study found that high glucose levels were associated with brain atrophy and WMH, while levels of small HDL particles were linked to brain atrophy. The research suggests that circulating metabolites may help in the development of future intervention trials.
ALZHEIMERS & DEMENTIA
(2021)
Article
Anatomy & Morphology
Tory O. Frizzell, Elisha Phull, Mishaa Khan, Xiaowei Song, Lukas A. Grajauskas, Jodie Gawryluk, Ryan C. N. D'Arcy
Summary: This study evaluated white matter neuroplasticity in healthy adults pre-post motor training, specifically focusing on motor learning in the non-dominant hand. Changes in neuroplasticity were observed in the internal capsule and corpus callosum, with significant amplitude reductions in low-frequency oscillations implicating optimized transmission through altered myelination. The findings open new avenues for white matter investigations and advance MRI clinical applications.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Clinical Neurology
Daniel J. Tozer, Robin B. Brown, Jessica Walsh, Young T. Hong, Guy B. Williams, John T. O'Brien, Franklin I. Aigbirhio, Tim D. Fryer, Hugh S. Markus
Summary: Recent studies have found evidence of increased microglial activation, indicating inflammation, in cerebral small vessel disease. However, it is unclear whether these areas of neuroinflammation progress to tissue damage. This study showed that white matter destined to become white matter hyperintensities already exhibited signs of altered inflammation at baseline.
Article
Clinical Neurology
Anna Dewenter, Mina A. Jacob, Mengfei Cai, Benno Gesierich, Paul Hager, Anna Kopczak, Davina Biel, Michael Ewers, Anil M. Tuladhar, Frank-Erik De Leeuw, Martin Dichgans, Nicolai Franzmeier, Marco Duering
Summary: Fixel-based analysis of diffusion MRI can identify changes in white matter integrity. Neurodegeneration in Alzheimer's disease affects white matter macrostructure, while cerebral small vessel disease affects white matter microstructure. Fiber density reflects the impact of cerebral small vessel disease, while fiber-bundle cross-section is primarily determined by neurodegeneration.
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Mark R. Etherton, Ona Wu, Anne-Katrin Giese, Natalia S. Rost
Summary: In this study of 319 patients with acute ischemic stroke, it was found that normal-appearing white matter axial diffusivity increases with age and independently predicts white matter hyperintensity volume. Increasing age and admission diastolic blood pressure were also identified as independent predictors of normal-appearing white matter axial diffusivity.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Neurosciences
Ami Tsuchida, Philippe Boutinaud, Violaine Verrecchia, Christophe Tzourio, Stephanie Debette, Marc Joliot
Summary: White matter hyperintensities (WMHs) are markers of cerebral small vessel disease, associated with increased risk of stroke, dementia, and mortality. This study presents an automatic WMH segmentation tool based on deep learning, which can efficiently detect WMH with high accuracy.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Saima Hilal, Siwei Liu, Tien Yin Wong, Henri Vrooman, Ching-Yu Cheng, Narayanaswamy Venketasubramanian, Christopher L. H. Chen, Juan Helen Zhou
Summary: The study found that lacunar counts, WMH volume, and ICS were associated with worse performance in executive function, attention, language, verbal and visual memory, and these three markers were also related to white matter microstructural damage.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Loredana Storelli, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Massimo Filippi, Maria A. Rocca
Summary: The study suggests that advanced diffusion-weighted imaging techniques can accurately detect white matter atrophy in patients with multiple sclerosis, providing more specific information than traditional methods that only measure volume and diffusion. Additionally, measures such as voxel-wise fiber-bundle cross-section and intra-cellular volume obtained at baseline are better predictors of clinical disability and cognitive impairment.
JOURNAL OF NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Adam de Havenon, Nethra R. R. Parasuram, Anna L. L. Crawford, Mercy H. H. Mazurek, Isha R. R. Chavva, Vineetha Yadlapalli, Juan E. E. Iglesias, Matthew S. S. Rosen, Guido J. J. Falcone, Seyedmehdi Payabvash, Gordon Sze, Richa Sharma, Steven J. J. Schiff, Basmah Safdar, Charles Wira, William T. T. Kimberly, Kevin N. N. Sheth
Summary: This study found that portable magnetic resonance imaging (pMRI) could successfully identify white matter hyperintensity (WMH) in the brain and be used in unconventional settings. The results suggest that pMRI may have a potential role in reducing disparities in neuroimaging.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Boyu Zhang, Yingzhe Wang, Bei Wang, Ying-Hua Chu, Yanfeng Jiang, Mei Cui, He Wang, Xingdong Chen
Summary: The study found that high blood pressure may cause structural changes in cerebral vessels, which can in turn impact the occurrence of WMH. This suggests that elevated blood pressure might be one of the pathophysiological mechanisms involved in the co-occurrence of neurological disorders and cerebral small vessel disease.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Neurosciences
Rujing Sun, Shi-Yu Zhang, Xu Cheng, Sangma Xie, Peng-Gang Qiao, Gong-Jie Li
Summary: The study investigated structural and network topological changes in MMD patients with limb paresthesia using diffusion kurtosis imaging (DKI). Results showed significant reductions in FA and MK in extensive WM regions, decreased global network efficiency, increased characteristic path length, and increased sigma in patient groups compared to healthy controls. The study suggests that FA is more sensitive in detecting WM injury and identifies key nodes related to the development of acroparesthesia.
FRONTIERS IN NEUROSCIENCE
(2022)