TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects

Preclinical to Human Translational Pharmacology of the Novel M1Positive Allosteric Modulator MK-7622

(2018) Jason M. Uslaner et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Bitopic Binding Mode of an M1Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

(2018) Sophie J. Bradley et al.   MOLECULAR PHARMACOLOGY

Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity

(2017) Jennifer E. Davoren et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Approach to Discovering Novel Muscarinic M1Receptor Positive Allosteric Modulators with Potent Cognitive Improvement and Minimized Gastrointestinal Dysfunction

(2017) Emi Kurimoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales

(2017) Leonor M. Teles-Grilo Ruivo et al.   Cell Reports

Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

(2015) R. W. Gould et al.   ACS Chemical Neuroscience

The Use of Cholinesterase Inhibitors Across All Stages of Alzheimer’s Disease

(2015) William James Deardorff et al.   DRUGS & AGING

Mechanistic Insights into Allosteric Structure-Function Relationships at the M1Muscarinic Acetylcholine Receptor

(2014) Alaa Abdul-Ridha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction

(2012) Pradeep J. Nathan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Investigation into the efficacy of the acetylcholinesterase inhibitor, donepezil, and novel procognitive agents to induce gamma oscillations in rat hippocampal slices

(2010) J.P. Spencer et al.   NEUROPHARMACOLOGY

M1 Receptors Mediate Cholinergic Modulation of Excitability in Neocortical Pyramidal Neurons

(2009) A. T. Gulledge et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia

(2009) Jim van Os et al.   LANCET

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

(2009) P. Jeffrey Conn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia

(2008) Anantha Shekhar et al.   AMERICAN JOURNAL OF PSYCHIATRY

Role of the Central Cholinergic System in the Therapeutics of Schizophrenia

(2008) Alvin Terry et al.   Current Neuropharmacology

Muscarinic receptors: do they have a role in the pathology and treatment of schizophrenia?

(2008) Elizabeth Scarr et al.   JOURNAL OF NEUROCHEMISTRY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Muscarinic acetylcholine receptors as CNS drug targets

(2007) Christopher J. Langmead et al.   PHARMACOLOGY & THERAPEUTICS