Article
Neurosciences
Rany Abend, Sonia G. Ruiz, Mira A. Bajaj, Anita Harrewijn, Julia O. Linke, Lauren Y. Atlas, Anderson M. Winkler, Daniel S. Pine
Summary: This study explores the pathological mechanisms of anxiety disorders and finds that patients with anxiety disorders exhibit excessive physiological responses to threats, which are related to intrinsic connectivity within specific brain circuits.
NEUROBIOLOGY OF STRESS
(2022)
Article
Neurosciences
Stephanie N. DeCross, Kelly A. Sambrook, Margaret A. Sheridan, Nim Tottenham, Katie A. McLaughlin
Summary: This study examines the neural activation and functional connectivity patterns during aversive learning in children with and without childhood trauma (CT) involving interpersonal violence. The findings suggest that CT is associated with poor threat-safety discrimination and altered functional coupling between salience and default mode network regions, which may mediate the association between CT and different forms of psychopathology.
BIOLOGICAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Goran Simic, Mladenka Tkalcic, Vana Vukic, Damir Mulc, Ena Spanic, Marina Sagud, Francisco E. Olucha-Bordonau, Mario Vuksic, Patrick R. Hof
Summary: Emotions are generated by activations of specific neuronal populations in the cerebral cortex, while feelings are conscious emotional experiences of these activations that contribute to enhancing neuronal networks mediating thoughts, language, and behavior. Contemporary theories of emotion highlight the central role of the amygdala as a subcortical emotional brain structure.
Article
Biochemistry & Molecular Biology
Barchiesi Riccardo, Chanthongdee Kanat, Petrella Michele, Xu Li, Soderholm Simon, Domi Esi, Augier Gaelle, Coppola Andrea, Joost Wiskerke, Ilona Szczot, Domi Ana, Adermark Louise, Augier Eric, Cantu Claudio, Heilig Markus, Barbier Estelle
Summary: Excessive fear is associated with anxiety disorders and is a significant global burden. This study reveals that downregulation of the histone methyltransferase PRDM2 in the dorsomedial prefrontal cortex enhances fear expression by modulating fear memory consolidation. The study also demonstrates that PRDM2 knock-down in the dmPFC-BLA circuit promotes increased fear expression and the expression of genes involved in synaptogenesis. Moreover, PRDM2 knock-down increases glutamatergic release probability in the amygdala and enhances the activity of amygdala neurons in response to fear-associated cues.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Jun Liu, Longnian Lin, Dong Wang
Summary: Specific BLA neurons exhibit increased firing rates, accompanied by increased heart rate and freezing, in response to height threats. These neurons are only activated under height threats, not other conditions, and develop conditioned responses to the context after fear conditioning, indicating a convergence in processing of dangerous/risky contextual information.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Andreas J. Forstner, Swapnil Awasthi, Christiane Wolf, Eduard Maron, Angelika Erhardt, Darina Czamara, Elias Eriksson, Catharina Lavebratt, Christer Allgulander, Nina Friedrich, Jessica Becker, Julian Hecker, Stefanie Rambau, Rupert Conrad, Franziska Geiser, Francis J. McMahon, Susanne Moebus, Timo Hess, Benedikt C. Buerfent, Per Hoffmann, Stefan Herms, Stefanie Heilmann-Heimbach, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Heike Weber, Georg W. Alpers, Volker Arolt, Lydia Fehm, Thomas Fydrich, Alexander L. Gerlach, Alfons Hamm, Tilo Kircher, Christiane A. Pane-Farre, Paul Pauli, Winfried Rief, Andreas Strohle, Jens Plag, Thomas Lang, Hans-Ulrich Wittchen, Manuel Mattheisen, Sandra Meier, Andres Metspalu, Katharina Domschke, Andreas Reif, Iiris Hovatta, Nils Lindefors, Evelyn Andersson, Martin Schalling, Hamdi Mbarek, Yuri Milaneschi, Eco J. C. de Geus, Dorret Boomsma, Brenda W. J. H. Penninx, Thorgeir E. Thorgeirsson, Stacy Steinberg, Kari Stefansson, Hreinn Stefansson, Bertram Muller-Myhsok, Thomas Folkmann Hansen, Anders D. Borglum, Thomas Werge, Preben Bo Mortensen, Merete Nordentoft, David M. Hougaard, Christina M. Hultman, Patrick F. Sullivan, Markus M. Nothen, David P. D. Woldbye, Ole Mors, Elisabeth B. Binder, Christian Rueck, Stephan Ripke, Juergen Deckert, Johannes Schumacher
Summary: The study describes the largest genome-wide association study of PD to date, identifying no significant loci but significant genetic correlations between PD and major depressive disorder, depressive symptoms, and neuroticism. The findings represent a major step towards elucidating the genetic susceptibility to PD.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Mohammad M. Herzallah, Alon Amir, Denis Pare
Summary: Foraging behavior involves a complex balance between multiple brain regions and their functions. The central medial thalamic nucleus (CMT) has been identified as an important regulator of foraging behavior. Inactivation and unit recording experiments revealed the contributions of CMT in foraging behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychiatry
Shangfeng Han, Jie Gao, Jie Hu, Yanghua Ye, Huiya Huang, Jing Liu, Mingfang Liu, Hui Ai, Jianyin Qiu, Yuejia Luo, Pengfei Xu
Summary: This study investigates the anticipatory processing of conflicts in individuals with anxiety disorder under uncertain conditions. Results suggest that anxious individuals show deficient top-down anticipatory control of upcoming conflicts, which may be related to dysfunctional brain networks and uncertainty in anticipation of conflict control.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Shangfeng Han, Jie Hu, Jie Gao, Jiayu Fan, Xinyun Xu, Pengfei Xu, Yue-Jia Luo
Summary: This study found that anxious individuals exhibit hyperactive anticipatory processing of goal-relevant information for upcoming conflicts, indicating altered anticipatory cognitive control in anxiety.
Article
Multidisciplinary Sciences
Fiorella Del Popolo Cristaldi, Giovanni Mento, Michela Sarlo, Giulia Buodo
Summary: Intolerance of uncertainty (IU) may influence emotional predictions in the implementation stage, affecting internal model updating and attention deployment. However, no significant impact of IU was found in the generation stage of emotional predictions.
Article
Multidisciplinary Sciences
Qinyuan Chen, Yangfeng Xu, Emma Christiaen, Guo-Rong Wu, Sara De Witte, Christian Vanhove, Jimmy Saunders, Kathelijne Peremans, Chris Baeken
Summary: Anxiety and fear are dysfunctional behaviors commonly observed in domesticated dogs. This study used diffusion tensor imaging (DTI) and graph theory to investigate how dysfunctional fear behaviors are represented in brain networks of anxious dogs. Anxious dogs showed decreased clustering coefficient, decreased global efficiency, and increased small-worldness compared to healthy dogs. The nodes that differed between anxious and healthy dogs were mainly located in the posterior part of the brain, including the occipital lobe, posterior cingulate gyrus, hippocampus, mesencephalon, and cerebellum. The left cerebellum's nodal degree was negatively correlated with excitability in anxious dogs. These findings contribute to understanding the disrupted brain structural connectome underlying anxiety-related disorders in dogs.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Brandee Feola, Maureen McHugo, Kristan Armstrong, Madison P. Noall, Elizabeth A. Flook, Neil D. Woodward, Stephan Heckers, Jennifer Urbano Blackford
Summary: The study examined the function and connectivity of the bed nucleus of the stria terminalis (BNST) in individuals with schizophrenia, especially those with comorbid anxiety disorders. Compared to controls, individuals with schizophrenia showed stronger connectivity in specific brain regions during anticipation of unpredictable and predictable threats, with broader patterns of altered connectivity observed in schizophrenia patients with comorbid anxiety disorders.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Stephanie M. Gorka, Milena Radoman, Jagan Jimmy, Kayla A. Kreutzer, Charles Manzler, Stacey Culp
Summary: Previous studies have shown that individuals with alcohol use disorder have exaggerated behavioral and brain reactivity to uncertain threats (U-threat). This study aimed to test this theory using a longitudinal within-subjects design. The results showed that greater baseline startle reactivity, bilateral anterior insula (AIC) reactivity, and dorsal anterior cingulate cortex (dACC) reactivity to U-threat were associated with increased probability of binge drinking.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fanny Demars, Ralitsa Todorova, Gabriel Makdah, Antonin Forestier, Marie-Odile Krebs, Bill P. Godsil, Therese M. Jay, Sidney I. Wiener, Marco N. Pompili
Summary: Current treatments for trauma-related disorders are ineffective for many patients. This study modeled individual differences in post-therapy fear relapse using an ethologically relevant trauma recovery paradigm. The results suggest that post-trauma behavioral phenotypes and gene expression patterns are associated with fear relapse susceptibility, which may be important for future treatment development.
Article
Clinical Neurology
D. Fiedler, H. C. Pape, M. D. Lange
Summary: The study found that acute stress exposure can lead to long-term fear memory, extinction failure, and increased activity in the posterior paraventricular nucleus of the thalamus, which may have significant implications for the pathophysiology of stress-sensitive anxiety-related psychiatric disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Editorial Material
Psychology, Clinical
Matthew J. Hirshberg, Simon B. Goldberg, Melissa Rosenkranz, Richard J. Davidson
PSYCHOLOGICAL MEDICINE
(2023)
Article
Education & Educational Research
Karen Kurotsuchi Inkelas, Blake A. Colaianne, Matthew J. Hirshberg, Mark T. Greenberg, Richard J. Davidson, John D. Dunne, David Germano, Robert W. Roeser
Summary: This study investigates whether variability in the implementation of an undergraduate course on human flourishing is differentially associated with student outcomes. The findings suggest that despite differences in teaching methods and student engagement, the outcomes of the students are similar. Institutions interested in offering this course can make limited adaptations without concerns of altering its impact on students.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)
Article
Behavioral Sciences
Ashley N. Clausen, Kelene A. Fercho, Molly Monsour, Seth Disner, Lauren Salminen, Courtney C. Haswell, Emily Clarke Rubright, Amanda A. Watts, M. Nicole Buckley, Adi Maron-Katz, Anika Sierk, Antje Manthey, Benjamin Suarez-Jimenez, Bunmi O. Olatunji, Christopher L. Averill, David Hofmann, Dick J. Veltman, Elizabeth A. Olson, Gen Li, Gina L. Forster, Henrik Walter, Jacklynn Fitzgerald, Jean Theberge, Jeffrey S. Simons, Jessica A. Bomyea, Jessie L. Frijling, John H. Krystal, Justin T. Baker, K. Luan Phan, Kerry Ressler, Laura K. M. Han, Laura Nawijn, Lauren A. M. Lebois, Lianne Schmaall, Maria Densmore, Martha E. Shenton, Mirjam van Zuiden, Murray Stein, Negar Fani, Raluca M. Simons, Richard W. J. Neufeld, Ruth Lanius, Sanne van Rooij, Saskia B. J. Koch, Serena Bonomo, Tanja Jovanovic, Terri DeRoon-Cassini, Timothy D. Ely, Vincent A. Magnotta, Xiaofu He, Chadi G. Abdallah, Amit Etkin, Christian Schmahl, Christine Larson, Isabelle M. Rosso, Jennifer Urbano Blackford, Jennifer S. Stevens, Judith K. Daniels, Julia Herzog, Milissa L. Kaufman, Miranda Olff, Richard J. Davidson, Scott R. Sponheim, Sven C. Mueller, Thomas Straube, Xi Zhu, Yuval Neria, Lee A. Baugh, James H. Cole, Paul M. Thompson, Rajendra A. Morey
Summary: PTSD is associated with accelerated aging markers. Young males with PTSD showed higher brain age difference compared to male controls, while old males with PTSD exhibited lower brain age difference compared to male controls of all ages.
BRAIN AND BEHAVIOR
(2022)
Article
Psychology, Developmental
Elizabeth M. Planalp, Kristin N. Dowe, Andrew L. Alexander, H. Hill Goldsmith, Richard J. Davidson, Douglas C. Dean III
Summary: This study examines the neural correlates of negative emotions in infants and found that the microstructure of white matter tracts at 1 month of age is associated with the expression of fear later in infancy. Specifically, the left stria terminalis, a tract connecting frontal and tempo-parietal regions, showed differential associations with the level and change in infant fear. These findings suggest the unique neurobehavioral characteristics of fear as early as 1 month of age and contribute to our understanding of affective development.
DEVELOPMENTAL SCIENCE
(2023)
Article
Education & Educational Research
Matthew J. J. Hirshberg, Richard J. J. Davidson, Simon B. B. Goldberg
Summary: Educator mental health is connected to several urgent educational issues. A study found that during the COVID-19 pandemic, a majority of school system employees experienced clinically significant anxiety and depressive symptoms. Lower family income was associated with higher stress levels, more severe depressive symptoms, and decreased intentions to stay in the same job, contributing to the current staffing shortages in schools. Supporting the mental health of educators should be prioritized as a policy.
EDUCATIONAL RESEARCHER
(2023)
Article
Psychology, Clinical
Sin U. Lam, Kevin M. Riordan, Otto Simonsson, Richard J. J. Davidson, Simon B. B. Goldberg
Summary: Despite the well-documented psychological benefits of meditation practice, limited research has examined factors associated with meditation practice persistence. This study explored rates and correlates of meditation persistence using a population-based sample in the USA. The findings provide insights into factors that may promote persistence with meditation, which can guide the delivery of meditation training.
Article
Clinical Neurology
P. A. Rowley, M. J. Paukner, L. B. Eisenmenger, A. S. Field, R. J. Davidson, S. C. Johnson, S. Asthana, N. A. Chin, V. Prabhakaran, B. B. Bendlin, B. R. Postle, H. H. Goldsmith, C. M. Carlsson, M. A. Brooks, N. H. Kalin, L. E. Williams, H. A. Rowley
Summary: This study investigated 16,400 brain MRIs and found that incidental findings are common, ranging from trivial to life-threatening. Formal neuroradiologist interpretation yielded more reliable results compared to spontaneous detection by nonradiology scanning staff.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Wendy C. Crone, Pelin Kesebir, Beverly Hays, Shilagh A. Mirgain, Richard J. Davidson, Susan C. Hagness
Summary: The mental health crisis in graduate education highlights the importance of engineering graduate programs providing effective methods to promote well-being. Mindfulness-based training has been found to improve emotional well-being and research capacity. A study conducted on engineering graduate students showed significant improvements in emotional health, neuroticism, positive affect, negative affect, and mindfulness after participating in a mindfulness training program.
Article
Psychology, Social
Qinggang Yu, Stacey M. Schaefer, Richard J. Davidson, Shinobu Kitayama
Summary: The study examined the moderating role of behavioral adjustment on the relationship between neuroticism and brain structure. Findings indicated that behavioral adjustment significantly moderated the effect of neuroticism on total brain volume (TBV), with a negative association between neuroticism and TBV only observed when behavioral adjustment was low.
JOURNAL OF PERSONALITY
(2023)
Article
Education & Educational Research
Matthew J. Hirshberg, Blake Colaianne, Karen Kurotsuchi Inkelas, Godwill Oke, Natalia Van Doren, Richard J. Davidson, Robert W. Roeser
Summary: The objective of this study was to evaluate the impact of the COVID-19 pandemic on college student mental health. The study found that anxiety, depression, and well-being of college students did not significantly worsen during the pandemic compared to before. Additionally, more frequent in-person social interactions were associated with lower anxiety and depressive symptoms, higher well-being, but also less compliance with handwashing and face mask-wearing.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)
Editorial Material
Psychology, Biological
Laura D. Kubzansky, Elissa S. Epel, Richard J. Davidson
Summary: Hopelessness and despair have negative impacts on health and longevity, thus strategies to improve population health are urgently needed. Prosociality plays a significant role in promoting better mental and physical health for individuals and communities, making it a priority for public health.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Psychology, Clinical
Simon B. B. Goldberg, Zishan Jiwani, Daniel M. M. Bolt, Kevin M. M. Riordan, Richard J. J. Davidson, Matthew J. J. Hirshberg
Summary: Bidirectional associations between alliance and distress were found in a 4-week smartphone-based meditation intervention, similar to results from in-person psychotherapy. Alliance may play an important role in promoting engagement and effectiveness within unguided mobile-health interventions. Measuring alliance in unguided mHealth tools may improve their acceptability and effectiveness.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Psychology, Clinical
Christian A. Webb, Matthew J. Hirshberg, Oscar Gonzalez, Richard J. Davidson, Simon B. Goldberg
Summary: There is limited understanding of the mechanisms underlying the beneficial effects of psychosocial interventions. This study demonstrates the importance of considering individual differences and subgroup-specific mediators in understanding the mechanisms of change. By identifying baseline characteristics that predict differential response, we can gain insights into why certain interventions work for specific subgroups and inform personalized interventions.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2023)
Review
Psychology
Laura D. Kubzansky, Eric S. Kim, Julia K. Boehm, Richard J. Davidson, Jeffrey C. Huffman, Eric B. Loucks, Sonja Lyubomirsky, Rosalind W. Picard, Stephen M. Schueller, Claudia Trudel-Fitzgerald, Tyler J. VanderWeele, Katey Warran, David S. Yeager, Charlotte S. Yeh, Judith T. Moskowitz
Summary: Psychological well-being is associated with better physical health and can be improved through interventions. To improve population health, interventions need to be adapted and durable, and a shift to a public-health model is required. Interventions should be accessible and effective for diverse populations.
Article
Behavioral Sciences
Heather C. Abercrombie, Alexandra L. Barnes, Elizabeth C. Nord, Anna J. Finley, Estelle T. Higgins, Daniel W. Grupe, Melissa A. Rosenkranz, Richard J. Davidson, Stacey M. Schaefer
Summary: A greater cortisol response to acute stress is associated with smaller increases in negative affect, suggesting mood-protective effects of cortisol elevations.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)