‘Second-Generation’ Mephedrone Analogs, 4-MEC and 4-MePPP, Differentially Affect Monoamine Transporter Function

Cathinones derivatives-related deaths as exemplified by two fatal cases involving methcathinone with 4-methylmethcathinone and 4-methylethcathinone

(2014) Sebastian Rojek et al.   Drug Testing and Analysis

Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)

(2014) Julie A. Marusich et al.   NEUROPHARMACOLOGY

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Hybrid Dopamine Uptake Blocker–Serotonin Releaser Ligands: A New Twist on Transporter-Focused Therapeutics

(2014) Bruce E. Blough et al.   ACS Medicinal Chemistry Letters

“Deconstruction” of the Abused Synthetic Cathinone Methylenedioxypyrovalerone (MDPV) and an Examination of Effects at the Human Dopamine Transporter

(2013) Renata Kolanos et al.   ACS Chemical Neuroscience

Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats

(2013) Shawn M. Aarde et al.   ADDICTION BIOLOGY

Locomotor stimulant and discriminative stimulus effects of ‘bath salt’ cathinones

(2013) Michael B. Gatch et al.   BEHAVIOURAL PHARMACOLOGY

Substituted methcathinones differ in transporter and receptor interactions

(2013) Amy J. Eshleman et al.   BIOCHEMICAL PHARMACOLOGY

Analysis of 4-MEC in biological and non-biological material—Three case reports

(2013) Dominika Gil et al.   FORENSIC SCIENCE INTERNATIONAL

The analytical investigation of synthetic street drugs containing cathinone analogs

(2013) Amanda M. Leffler et al.   FORENSIC SCIENCE INTERNATIONAL

Analysis of Synthetic Cathinones Commonly Found in Bath Salts in Human Performance and Postmortem Toxicology: Method Development, Drug Distribution and Interpretation of Results

(2013) L. J. Marinetti et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Emergence and properties of spice and bath salts: A medicinal chemistry perspective

(2013) Anita H. Lewin et al.   LIFE SCIENCES

Synthetic cathinones: Chemical phylogeny, physiology, and neuropharmacology

(2013) Louis J. De Felice et al.   LIFE SCIENCES

Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling

(2013) Amir Seddik et al.   Molecular Informatics

Structural basis for action by diverse antidepressants on biogenic amine transporters

(2013) Hui Wang et al.   NATURE

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters

(2013) Tina Hofmaier et al.   NEUROCHEMISTRY INTERNATIONAL

The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: Self-administration and locomotor activity in rats

(2013) S.M. Aarde et al.   NEUROPHARMACOLOGY

Monoamine transporter and receptor interaction profiles of a new series of designer cathinones

(2013) L.D. Simmler et al.   NEUROPHARMACOLOGY

Evidence for a Role of Transporter-Mediated Currents in the Depletion of Brain Serotonin Induced by Serotonin Transporter Substrates

(2013) Michael H Baumann et al.   NEUROPSYCHOPHARMACOLOGY

Abuse-related and abuse-limiting effects of methcathinone and the synthetic “bath salts” cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats

(2013) J. S. Bonano et al.   PSYCHOPHARMACOLOGY

Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV)

(2012) Lucas R. Watterson et al.   ADDICTION BIOLOGY

Pharmacological characterization of designer cathinonesin vitro

(2012) LD Simmler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone

(2012) Raul López-Arnau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bath saltscomponents mephedrone and methylenedioxypyrovalerone (MDPV) act synergistically at the human dopamine transporter

(2012) Krasnodara N Cameron et al.   BRITISH JOURNAL OF PHARMACOLOGY

Psychoactive “bath salts”: Not so soothing

(2012) Michael H. Baumann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vivo Effects of Abused ‘Bath Salt’ Constituent 3,4-methylenedioxypyrovalerone (MDPV) in Mice: Drug Discrimination, Thermoregulation and Locomotor Activity

(2012) William E Fantegrossi et al.   NEUROPSYCHOPHARMACOLOGY

Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products

(2012) Michael H Baumann et al.   NEUROPSYCHOPHARMACOLOGY

Effects of synthetic cathinones contained in “bath salts” on motor behavior and a functional observational battery in mice

(2012) Julie A. Marusich et al.   NEUROTOXICOLOGY

Effect of Ambient Temperature on the Thermoregulatory and Locomotor Stimulant Effects of 4-Methylmethcathinone in Wistar and Sprague-Dawley Rats

(2012) M. Jerry Wright et al.   PLoS One

A chemical analysis examining the pharmacology of novel psychoactive substances freely available over the internet and their impact on public (ill)health. Legal highs or illegal highs?

(2012) Tammy C Ayres et al.   BMJ Open

The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ‘Ecstasy’), methamphetamine and d-amphetamine

(2011) Thomas Steinkellner et al.   BIOLOGICAL CHEMISTRY

Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats

(2011) J Kehr et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clinical experience with and analytical confirmation of “bath salts” and “legal highs” (synthetic cathinones) in the United States

(2011) Henry A. Spiller et al.   CLINICAL TOXICOLOGY

The pharmacology and toxicology of the synthetic cathinone mephedrone (4-methylmethcathinone)

(2011) Paul I. Dargan et al.   Drug Testing and Analysis

In Vivo Effects of Amphetamine Analogs Reveal Evidence for Serotonergic Inhibition of Mesolimbic Dopamine Transmission in the Rat

(2011) M. H. Baumann et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Designer Methcathinone Analogs, Mephedrone and Methylone, are Substrates for Monoamine Transporters in Brain Tissue

(2011) Michael H Baumann et al.   NEUROPSYCHOPHARMACOLOGY

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

(2011) A. S. Kristensen et al.   PHARMACOLOGICAL REVIEWS

Analysis of NRG ‘legal highs’ in the UK: identification and formation of novel cathinones

(2010) Simon D. Brandt et al.   Drug Testing and Analysis

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

A randomized double-blind placebo-controlled study of the long-term efficacy and safety of diethylpropion in the treatment of obese subjects

(2009) C Cercato et al.   INTERNATIONAL JOURNAL OF OBESITY

Mutational Mapping and Modeling of the Binding Site for (S)-Citalopram in the Human Serotonin Transporter

(2009) Jacob Andersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The reverse operation of Na+/Cl−-coupled neurotransmitter transporters – why amphetamines take two to tango

(2009) Harald H. Sitte et al.   JOURNAL OF NEUROCHEMISTRY

Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil

(2009) D. Zolkowska et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents

(2008) Marco Gobbi et al.   JOURNAL OF NEUROCHEMISTRY