Article
Immunology
Hiroki Shiwaku, Shingo Katayama, Mengxuan Gao, Kanoh Kondo, Yuri Nakano, Yukiko Motokawa, Saori Toyoda, Fuyuko Yoshida, Hiroaki Hori, Tetsuo Kubota, Kinya Ishikawa, Hiroshi Kunugi, Yuji Ikegaya, Hitoshi Okazawa, Hidehiko Takahashi
Summary: This study identified a novel autoantibody against NRXN1 alpha in patients with schizophrenia and demonstrated that these antibodies can cause schizophrenia-related pathology in mice. Removal of these antibodies may be a therapeutic target for some patients carrying these antibodies.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Cell Biology
Farbod Bahreini, Elham Rayzan, Nima Rezaei
Summary: Breast cancer, a multifactorial disease, may have an increased risk due to alterations in microRNA sequences. miR-SNPs are potential biomarkers for early detection of breast cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Genetics & Heredity
Regina F. Nasyrova, Elena E. Vaiman, Vera V. Repkina, Aiperi K. Khasanova, Azat R. Asadullin, German A. Shipulin, Kuanysh S. Altynbekov, Mustafa Al-Zamil, Marina M. Petrova, Natalia A. Shnayder
Summary: Antipsychotic-induced akathisia (AIA) is a movement disorder characterized by inner restlessness and repetitive movements, which can occur in patients taking antipsychotics. This study reviewed genetic studies on AIA and found several genetic markers associated with the condition. Understanding the genetic predictors of AIA could help in developing personalized prevention and treatment strategies for this adverse drug reaction in patients with schizophrenia.
Article
Chemistry, Analytical
Salvatore Petralia, Antonella Vigilanza, Emanuele Sciuto, Michele Maffia, Antonella Romanini, Sabrina Conoci
Summary: The study investigated single nucleotide polymorphisms in the MC1R gene using a miniaturized silicon-based microarray-chip, showing good sensitivity and high confidence level, paving the way for future development of portable genetic assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Medicine, General & Internal
Yujun Long, Qiongqiong Wu, Ye Yang, Jingda Cai, Jingmei Xiao, Zhaoqian Liu, Yifeng Xu, Ying Chen, Manli Huang, Ruiguo Zhang, Xijia Xu, Jian Hu, Zhifen Liu, Fang Liu, Yingjun Zheng, Huaqing Meng, Zhimin Wang, Yanqing Tang, Xueqin Song, Yunchun Chen, Xueyi Wang, Tiebang Liu, Xiaoli Wu, Maosheng Fang, Chunling Wan, Jingping Zhao, Renrong Wu
Summary: The study aimed to determine the optimal predictive cut-off value for early non-response in patients with schizophrenia. The reduction in PANSS total scores at week 2 can effectively predict later non-response to antipsychotics.
Article
Psychiatry
Lihong Pan, Zhonghai Cao, Lianghu Chen, Min Qian, Yuzhong Yan
Summary: This study found that SNPs of BDNF and MMP-9 are related to the clinical features of schizophrenia and could serve as useful biomarkers for changes, remission, or deterioration of the clinical status of schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Genetics & Heredity
Lulin Ma, Yan Huang, Shiqian Huang, Feng Xu, Yafeng Wang, Shuai Zhao, Daling Deng, Yuanyuan Ding, Tianhao Zhang, Wenjing Zhao, Xiangdong Chen
Summary: This study aimed to explore the molecular mechanisms of individual differences in etomidate anesthesia and identified several single nucleotide polymorphisms (SNPs) associated with the effectiveness of etomidate anesthesia. This provides theoretical evidence for future use of etomidate anesthesia.
FRONTIERS IN GENETICS
(2022)
Article
Behavioral Sciences
Mary Seeman
Summary: The review examines the potential role of intestinal organisms in response/non-response to antipsychotics, highlighting that current research in this area is mostly theoretical but showing increasing evidence from animal experiments and clinical trials on the impact of gut bacteria on drug response.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychology, Clinical
Lieuwe de Haan, Mirjam van Tricht, Floor van Dijk, Celso Arango, Covadonga M. Diaz-Caneja, Julio Bobes, Leticia Garcia-Alvarez, Stefan Leucht
Summary: This study evaluated the variation in subjective response (SR) to a single antipsychotic medication in patients with a first episode of schizophrenia spectrum disorder. It found that there is substantial variation in individual proneness for an unfavorable SR, and the relationship between SR and symptomatic response is only modest. Factors such as baseline affective symptoms and lower start dosage of the medication were associated with subjective remission.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Elias D. Mouchlianitis, Lucy D. Vanes, Derek K. Tracy, Anne-Katherin Fett, Daniel Joyce, Sukhi S. Shergill
Summary: Glutamatergic dysfunction is associated with treatment resistance in individuals with schizophrenia. This study used neurochemical and functional brain imaging methods to investigate glutamatergic dysfunction and reward processing in treatment-resistant and treatment-responsive schizophrenia. The results suggest that glutamatergic differences can differentiate treatment-resistant and treatment-responsive schizophrenia, which has potential diagnostic value.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Xihua Liu, Min Luo, Xiaofei Chen, Changjun Ding
Summary: This study analyzed partial sequences of six genes involved in nitrogen use efficiency in 32 different bamboo species, revealing relatively conserved nucleotide sequences with high haplotype diversity. The results of evolutionary neutrality tests indicated that the genes conform to neutral evolution, with some sequences potentially experiencing negative selection. Estimation and analysis of linkage disequilibrium and population genetic structure classified the 32 bamboo species into five categories, showing multivariate characteristics and heterogeneity within the overall population.
PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Nutrition & Dietetics
Susana Rojo-Tolosa, Laura Elena Pineda-Lancheros, Jose Maria Galvez-Navas, Jose Antonio Sanchez-Martinez, Maria Victoria Gonzalez-Gutierrez, Andrea Fernandez-Alonso, Concepcion Morales-Garcia, Alberto Jimenez-Morales, Cristina Perez-Ramirez
Summary: Asthma is a chronic non-communicable disease with a wide age range of affected individuals. The study aimed to evaluate the impact of various single nucleotide polymorphisms (SNPs) related to vitamin D metabolism on asthma susceptibility. The results showed that the Cdx2 polymorphism was significantly associated with an increased risk of asthma, potentially serving as a predictive biomarker for the disease. However, the other SNPs analyzed did not show any effect on asthma risk.
Article
Biotechnology & Applied Microbiology
Mimi Wang, Jingyun Wu, Shufeng Lei, Xingbo Mo
Summary: This study identified RNAm-SNPs related to rheumatoid arthritis (RA) and suggested that they may affect the expression levels of corresponding genes and proteins.
Article
Genetics & Heredity
Abudureyimu Shajidan, Abulaiti Palida, Hui Li, Zhi Xing, Shasha Liu, Wen Li, Ying Gao
Summary: The study evaluated the roles of endothelial lipase gene (LIPG) related SNPs in patients with coronary artery disease (CAD), finding that the CC + AC genotype in rs3813082 was protective for CAD, while rs3744843, rs3744841, and rs2000813 variants were associated with lipid parameters and vascular stenosis in CAD patients. The results provide a promising reference for preventing CAD.
Article
Oncology
Zheng Lv, Changgui Kou, Naifei Chen, Lin Jia, Xu Sun, Yangyang Gao, Rilan Bai, Ming Yang, Jiuwei Cui
Summary: This study indicates that HOTAIR SNPs (rs920778 and rs4759314) are significantly associated with BC susceptibility and prognosis in the northeastern Chinese population, highlighting their importance in the occurrence and development of BC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ming Ren, Zhonghua Hu, Qiang Chen, Andrew Jaffe, Yingbo Li, Vijay Sadashivaiah, Shujuan Zhu, Nina Rajpurohit, Joo Heon Shin, Wei Xia, Yankai Jia, Jingxian Wu, Sunny Lang Qin, Xinjian Li, Jian Zhu, Qingjun Tian, Daniel Paredes, Fengyu Zhang, Kuan Hong Wang, Venkata S. Mattay, Joseph H. Callicott, Karen F. Berman, Daniel R. Weinberger, Feng Yang
MOLECULAR PSYCHIATRY
(2020)
Article
Pediatrics
Yidong Shen, Yamin Li, Lijuan Shi, Mengmeng Liu, Renrong Wu, Kun Xia, Fengyu Zhang, Jianjun Ou, Jingping Zhao
Summary: This study discovered that interferon-alpha (IFN-alpha), interleukin-7 (IL-7), IL-8, IFN-gamma-inducible protein-10, and macrophage inflammatory protein-1 beta are associated with ASD, with IL-8 being the only cytokine related to parental cytokine levels and social impairment in children with ASD. The log-transformed IL-8 level showed good discrimination between children with autism and controls, indicating its potential as a biomarker for ASD and involvement in its pathogenesis.
PEDIATRIC RESEARCH
(2021)
Review
Oncology
Yehong Tian, Xiaowei Qiu, Chengxiang Wang, Jianxin Zhao, Xin Jiang, Wenquan Niu, Jinchang Huang, Fengyu Zhang
Summary: The study found that cancer patients may have a higher likelihood of contracting COVID-19, with a pooled prevalence of 2.3% overall and 3.2% in Hubei province. Cancer comorbidity is significantly associated with severe events and death in COVID-19 patients, highlighting the need for special measures for individuals with cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Neurosciences
Robert Freedman, Sharon K. Hunter, Kathleen Noonan, Anna Wyrwa, Uwe Christians, Amanda J. Law, M. Camille Hoffman
Summary: The study reveals sex-specific associations of C-reactive protein and cortisol levels with prenatal depression in women, showing greater impact on neural development in male infants with maternal depression and cortisol levels. Male fetuses seem to metabolize cortisol more effectively to cortisone, which may have protective benefits in the face of adversity.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2021)
Article
Biochemistry & Molecular Biology
Sara Palumbo, Clare Paterson, Feng Yang, Veronica L. Hood, Amanda J. Law
Summary: The serine/threonine protein kinase v-AKT homologs (AKTs) play important roles in neurodevelopment, with Akt2 specifically involved in axonal development, dendritic patterning, and neural circuit physiology. Akt2 loss-of-function leads to impairments in anxiety, fear conditioned learning, social behaviors, and memory, as well as dysregulated mTOR and GSK3 beta signaling in the brain. Pharmacological enhancement of PI3K/AKT signaling and PIK3CD inhibition can rescue cognitive impairments associated with Akt2 deficiency.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychology, Clinical
Sharon K. Hunter, M. Camille Hoffman, Angelo D'Alessandro, Anna Wyrwa, Kathleen Noonan, Steven H. Zeisel, Amanda J. Law, Robert Freedman
Summary: The study aimed to investigate the impact of high maternal plasma choline concentrations on early childhood behaviors, with results showing that higher choline levels were associated with children's attention problems and social issues.
PSYCHOLOGICAL MEDICINE
(2022)
Letter
Psychiatry
Sharon K. Hunter, M. Camille Hoffman, Lizbeth McCarthy, Angelo D'Alessandro, Anna Wyrwa, Kathleen Noonan, Uwe Christians, Etheldreda Nakimuli-Mpungu, Steven H. Zeisel, Amanda J. Law, Robert Freedman
Summary: Using prenatal vitamins and choline supplements may reduce the risk factor of preterm birth disproportionately affecting Black families. The dissemination of this research aligns with the principle of Justice in the Belmont Report, ensuring that participants from various racial, ethnic, and socioeconomic groups benefit from research addressing their specific issues.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychiatry
Robert Freedman, Sharon K. Hunter, Amanda J. Law, Alena M. Clark, Aquila Roberts, M. Camille Hoffman
Summary: Choline, folic acid, and Vitamin D are essential for fetal brain development. Micronutrient deficiencies are associated with changes in brain development and increased incidence of psychiatric disorders. Micronutrient supplements can prevent deficiency and positively affect brain development, potentially decreasing the risk of future psychotic disorders.
SCHIZOPHRENIA RESEARCH
(2022)
Editorial Material
Psychiatry
Robert Freedman, Sharon K. Hunter, Amanda J. Law, M. Camille Hoffman
Editorial Material
Psychiatry
Roberto Esposito, Fengyu Zhang, Maorong Hu, Ping Li, Wenbin Guo
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Sharon K. Hunter, M. Camille Hoffman, Angelo D'Alessandro, Victoria K. Walker, Madeline Balser, Kathleen Noonan, Amanda J. Law, Robert Freedman
Summary: Maternal inflammation during pregnancy negatively impacts offspring cognitive development, but higher maternal choline levels may have a positive association with offspring cognition, specifically processing speed. Lower choline levels in mothers are associated with more depression and stress, while higher choline levels are linked to larger head circumference in newborns. Higher maternal choline is also related to higher processing speed in offspring and may counteract the negative effects of maternal inflammation on cognitive and behavioral outcomes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Sharon K. Hunter, Robert Freedman, Amanda J. Law, Uwe Christians, Jacob B. W. Holzman, Zachary Johnson, M. Camille Hoffman
Summary: Maternal depression during gestation is associated with decreased fetal heart rate variability, especially for male fetuses. The lower cortisol to total corticosteroids ratios associated with maternal depression suggests its influence. Decreased FHRV is related to increased newborn sensory gating deficits, indicating impaired development of cerebral inhibition. Higher FHRV is associated with increased infant self-regulatory behaviors.
Review
Nutrition & Dietetics
M. Camille Hoffman, Robert Freedman, Amanda J. Law, Alena M. Clark, Sharon K. Hunter
Summary: Choline, folic acid, Vitamin D, and n-3 polyunsaturated fatty acids have been studied as potential mitigating factors for the effects of maternal infection and inflammation on fetal development. Higher maternal choline levels in early pregnancy have positive effects on infant brain development in the context of viral infections.
CLINICAL NUTRITION ESPEN
(2021)
Article
Obstetrics & Gynecology
Maria C. Hoffman, Sharon J. Hunter, Angelo D'Alessandro, Uwe Christians, Amanda J. Law, Robert Freedman
Summary: This study investigated the relationship between maternal choline concentration during pregnancy and small for gestational age (SGA) infants. The study found that maternal plasma choline concentrations were lower in mothers of SGA infants, with the 28-week concentration significantly lower compared with other participants. Maternal choline concentrations below 7 μM at 28 weeks' gestation were associated with a higher risk for SGA.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Psychiatry
Sharon K. Hunter, M. Camille Hoffman, Lizbeth McCarthy, Angelo D'Alessandro, Anna Wyrwa, Kathleen Noonan, Uwe Christians, Etheldreda Nakimuli-Mpungu, Steven H. Zeisel, Amanda J. Law, Robert Freedman
Summary: Black American pregnant women have lower levels of plasma choline, which may be associated with increased stress and developmental issues in offspring. Lower prenatal choline levels in Black Americans are linked to higher hair cortisol levels and impaired inhibitory neuron development, suggesting potential predisposition to mental illnesses later in life. Supplementation of phosphatidylcholine during pregnancy has shown to improve gestational age and inhibit behavioral issues in offspring of Black American women.
SCHIZOPHRENIA BULLETIN
(2021)