Article
Neurosciences
Lianwei Mu, Xiaojie Liu, Hao Yu, Mengming Hu, Vladislav Friedman, Thomas J. Kelly, Li Zhao, Qing-song Liu
Summary: Ibudilast effectively reduces the reinforcing effects of cocaine and relapse to cocaine seeking behavior. This may be achieved by restoring the balance between excitation and inhibition in VTA dopamine neurons.
Article
Behavioral Sciences
Macarena Gonzalez-Portilla, Susana Mellado, Sandra Montagud-Romero, Fernando Rodriguez de Fonseca, Maria Pascual, Marta Rodriguez-Arias
Summary: This study evaluated the effects of oleoylethanolamide (OEA) on the rewarding properties of cocaine and relapse-related gene expression in the striatum and hippocampus. The results showed that OEA did not affect cocaine-induced conditioned place preference acquisition, but it blocked drug-induced reinstatement and inhibited the expression of dopamine receptor gene D1, dopamine receptor gene D2, and cannabinoid receptor 1 in the striatum and hippocampus. These findings suggest that OEA may be a promising pharmacological agent in the treatment of cocaine use disorder.
BEHAVIORAL AND BRAIN FUNCTIONS
(2023)
Article
Substance Abuse
Robert W. Seaman, Kenner C. Rice, Gregory T. Collins
Summary: Recent evidence suggests that polysubstance use is common, emphasizing the need for a better understanding of interactions between commonly co-abused drugs. The study found that synthetic cathinones and cocaine can act as economic substitutes, and that the reinforcing effects determined under a progressive ratio schedule of reinforcement can predict drug choice.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Review
Biochemistry & Molecular Biology
Jyoti C. Patel, Kenneth D. Carr, Margaret E. Rice
Summary: Insulin can enter the brain from the periphery by crossing the blood-brain barrier, and it has established actions in the hypothalamus and the midbrain's mesolimbic dopamine neurons. Insulin receptors (InsRs) are abundantly expressed in the striatum, found on interneurons, striatal projection neurons, glial cells, and dopamine axons. Insulin elevation in the striatum promotes an increase in stimulated dopamine release through InsRs on cholinergic interneurons, but it also increases dopamine uptake through InsRs on dopamine axons. This striatal insulin signaling is crucial for flavor-nutrient learning and can influence dopaminergic transmission and striatal function.
Article
Biochemistry & Molecular Biology
Rocio Guerrero-Bautista, Aurelio Franco-Garcia, Juana M. Hidalgo, Francisco Jose Fernandez-Gomez, Bruno Ribeiro Do Couto, M. Victoria Milanes, Cristina Nunez
Summary: Preventing relapse in cocaine addiction is a major challenge in treatment. Cocaine relapse activates memory-related nuclei, affecting emotional and episodic memories. D3 receptor antagonists are emerging as potential treatments for preventing drug relapse.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Rebecca S. Hofford, Tanner J. Euston, Rashaun S. Wilson, Katherine R. Meckel, Emily G. Peck, Arthur Godino, Joseph A. Landry, Erin S. Calipari, TuKiet T. Lam, Drew D. Kiraly
Summary: The research shows that G-CSF can accelerate cocaine extinction and reduce cue-induced cocaine seeking during abstinence by regulating proteins related to synapse and glutamate signaling in the mPFC. These findings suggest that G-CSF may serve as a research target to reduce drug craving or seeking behaviors, and its FDA-approved status could facilitate clinical translation swiftly.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Miquel Martin, Miriam Gutierrez-Martos, Roberto Cabrera, Klaus Langohr, Rafael Maldonado, Magi Farre, Rafael de la Torre
Summary: Chronic treatment with daidzein or genistein decreased operant responding to obtain cocaine intravenous infusions. On the other hand, daidzein and daidzin, but not genistein, were effective in decreasing cue-induced cocaine reinstatement. Complementary studies revealed that daidzein effects on cocaine reinforcement were mediated through a mechanism that involved dopamine type-2/3 receptors (DA-D2/3) activities.
PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Dakota B. Zinani, Hanna N. Wetzel, Andrew B. Norman
Summary: This study revealed significant differences in the intake rate, satiety threshold, and half-life of different DAT inhibitors in rats. The duration of lever-pressing following termination of drug access was correlated with the t(1/2) estimates, suggesting a relationship between the time needed for animals to stop lever pressing and the PK properties of the agonist.
Article
Biochemical Research Methods
Tian Cai, Kyra Alyssa Abbu, Yang Liu, Lei Xie
Summary: In this study, an end-to-end deep learning framework called DeepREAL was developed to address the correlation between drug-target interactions and clinical outcomes. The framework utilizes self-supervised learning and pre-trained methods to overcome the challenges of data scarcity and data distribution shift. Experimental results show that DeepREAL achieves state-of-the-art performance in simulating real-world scenarios.
Article
Biology
Xiaojie Liu, Casey R. Vickstrom, Hao Yu, Shuai Liu, Shana Terai Snarrenberg, Vladislav Friedman, Lianwei Mu, Bixuan Chen, Thomas J. Kelly, David A. Baker, Qing-song Liu
Summary: This study demonstrates that Epac2 in the mesolimbic dopamine system promotes cocaine reinforcement by enhancing dopamine release. Conditional knockout or inhibition of Epac2 reduces cocaine self-administration in mice, while Epac2 agonism increases dopamine release. This mechanism plays a crucial role in the reinforcing effects of cocaine.
Article
Biology
Suchan Chang, Yeonhee Ryu, Se Kyun Bang, Han Byeol Jang, DanBi Ahn, Hyung Kyu Kim, Hubert Lee, Sang Chan Kim, Bong Hyo Lee, Hee Young Kim
Summary: Drug addiction is a global problem, with most studies focusing on the central nervous system. However, this research reveals that cocaine injection increases peripheral body temperature, and that this increase is associated with the activation of dopamine D2 receptors.
Review
Behavioral Sciences
E. Theresa Bjorness, W. Robert Greene
Summary: Dopamine, orexin, and adenosine systems play dual roles in reward and sleep/arousal. Drug abuse may influence both reward and sleep/arousal mechanisms. Cocaine can cause acute sleep loss and abnormal recovery patterns under chronic exposure conditions. Experimentally induced sleep disturbance may increase cocaine seeking behavior.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Review
Behavioral Sciences
Davin R. Peart, Allyson K. Andrade, Carly N. Logan, Lori A. Knackstedt, Jennifer E. Murray
Summary: Women are more sensitive to cocaine craving triggered by relapse-related stimuli, and ovarian hormones modulate cocaine craving, potentially serving as risk factors or therapeutic agents for cocaine use disorder. The neuropharmacological effects of steroid hormones 17β-estradiol, progesterone, and allopregnanolone on cocaine-induced behaviors differ between female and male rats, with estradiol potentially being a risk factor and progesterone/allopregnanolone serving as potential treatment options for various components of cocaine use disorder in women.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Miguel A. Lujan, Laia Alegre-Zurano, Ana Martin-Sanchez, Lidia Cantacorps, Olga Valverde
Summary: The study found that cannabidiol has complex effects on the behavioral performance of rodent models of cocaine addiction, including no effect on extinction learning, increase in CB1 receptor protein levels, reduction in FosB accumulation, increase in GluR2 AMPA receptor subunits, attenuation of cue-induced reinstatement of drug seeking, but facilitation of stress-induced restoration of drug seeking. These findings suggest that cannabidiol induces a variety of CB1-related changes that have varying impacts on cocaine-seeking behavior, potentially limiting its therapeutic applications.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Xiang-Hu He, Ewa Galaj, Guo-Hua Bi, Yi He, Briana Hempel, Yan-Lin Wang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Recent research indicates that BCP, through its action on CB2 receptors and other mechanisms, can effectively reduce METH reward and intake, as well as motivation to seek and take METH. Additionally, BCP also inhibits METH-enhanced electrical BSR, and blocks METH-primed and cue-induced reinstatement of drug-seeking behavior.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Neurosciences
J. M. Wenzel, J. F. Cheer
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Jennifer M. Wenzel, Erik B. Oleson, Willard N. Gove, Anthony B. Cole, Utsav Gyawali, Hannah M. Dantrassy, Rebecca J. Bluett, Dilyan I. Dryanovski, Garret D. Stuber, Karl Deisseroth, Brian N. Mathur, Sachin Patel, Carl R. Lupica, Joseph F. Cheer
Article
Neurosciences
Matthew R. Bailey, Olivia Goldman, Estefania P. Bello, Muhammad O. Chohan, Nuri Jeong, Vanessa Winiger, Eileen Chun, Elke Schipani, Abigail Kalmbach, Joseph F. Cheer, Peter D. Balsam, Eleanor H. Simpson
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Dan P. Covey, Hannah M. Dantrassy, Samantha E. Yohn, Alberto Castro, P. Jeffrey Conn, Yolanda Mateo, Joseph F. Cheer
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Anna K. Radke, Adrina Kocharian, Dan P. Covey, David M. Lovinger, Joseph F. Cheer, Yolanda Mateo, Andrew Holmes
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Samantha E. Yohn, Daniel J. Foster, Dan P. Covey, Mark S. Moehle, Jordan Galbraith, Pedro M. Garcia-Barrantes, Hyekyung P. Cho, Michael Bubser, Anna L. Blobaum, Max E. Joffe, Joseph F. Cheer, Carrie K. Jones, Craig W. Lindsley, P. Jeffrey Conn
MOLECULAR PSYCHIATRY
(2020)
Article
Neurosciences
Sam Z. Bacharach, Helen M. Nasser, Natalie E. Zlebnik, Hannah M. Dantrassy, Daniel E. Kochli, Utsav Gyawali, Joseph F. Cheer, Donna J. Calu
PSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Hyungwoo Nam, Ramesh Chandra, T. Chase Francis, Caroline Dias, Joseph F. Cheer, Mary Kay Lobo
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Kasey S. Girven, Sonia Aroni, Jovana Navarrete, Rosa A. M. Marino, Paige N. McKeon, Joseph F. Cheer, Dennis R. Sparta
Summary: The insular cortex (IC) sends glutamatergic projections to vBNST-VTA neurons, activating IC-vBNST terminals may strengthen behavior in a dopamine-dependent manner, while silencing the IC-vBNST projection may lead to anxiety-like behavior, providing a potential mechanism for how the IC processes external triggers predictive of rewards.
Article
Neurosciences
Devan M. Gomez, Thomas J. Everett, Lindsey R. Hamilton, Ajit Ranganath, Joseph F. Cheer, Erik B. Oleson
Summary: Synthetic cannabinoids, a commonly abused drug in the US, may lead to blunted dopamine response and cross-tolerance to heroin. Chronic exposure to synthetic cannabinoids in rats resulted in reduced dopamine releasing effects of both cannabinoids and heroin.
Article
Neurosciences
Sonia Aroni, Rosa A. M. Marino, Kasey S. Girven, James M. Irving, Joseph F. Cheer, Dennis R. Sparta
Summary: Binge ethanol drinking is a major financial burden in the United States and leads to significant neuroplasticity changes in the brain. Corticotropin releasing factor (CRF) neurons in the central amygdala are believed to play a key role in modulating binge drinking. Research shows that these neurons exhibit diverse responses and enhanced electrical activity during binge drinking sessions.
Article
Neurosciences
Sheila A. Engi, Erin J. Beebe, Victoria M. Ayvazian, Fabio C. Cruz, Joseph F. Cheer, Jennifer M. Wenzel, Natalie E. Zlebnik
Summary: Mesolimbic dopamine plays a crucial role in motivated behavior, with CB1 receptor signaling in the VTA being implicated in the phasic activation of dopamine. Cocaine-induced increases in motivation appear to require 2-AG signaling at CB1 receptors in the VTA, suggesting potential cannabinoid-based pharmacotherapeutic targets for substance abuse treatment.
Review
Neurosciences
David M. Lovinger, Yolanda Mateo, Kari A. Johnson, Sheila A. Engi, Mario Antonazzo, Joseph F. Cheer
Summary: This Review discusses the communication between central nervous system neurons mediated by ligand-gated ion channel receptors and G protein-coupled receptors, and explores the mechanisms and future directions of presynaptic receptor actions.
NATURE REVIEWS NEUROSCIENCE
(2022)
Meeting Abstract
Neurosciences
Kate Peters, Erik Oleson, Daniel Covey, Yolanda Mateo, Raffaella Tonini, Joseph Cheer
BIOLOGICAL PSYCHIATRY
(2021)
Proceedings Paper
Acoustics
Yuri Levin-Schwartz, Dennis R. Sparta, Joseph F. Cheer, Tulay Adali
2017 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH AND SIGNAL PROCESSING (ICASSP)
(2017)