Epigenetics in the Human Brain

DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex

(2012) Shusuke Numata et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cortical basket cell dysfunction in schizophrenia

(2012) Allison A. Curley et al.   JOURNAL OF PHYSIOLOGY-LONDON

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function

(2012) B. H. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics

(2011) Malik Mumtaz Taqi et al.   ADDICTION BIOLOGY

MYT1L is a candidate gene for intellectual disability in patients with 2p25.3 (2pter) deletions

(2011) Servi J.C. Stevens et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Alterations in GABAergic Biomarkers in the Autism Brain: Research Findings and Clinical Implications

(2011) Gene J. Blatt et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Epigenetic Signatures of Autism

(2011) Hennady P. Shulha   ARCHIVES OF GENERAL PSYCHIATRY

The human histone H3 complement anno 2011

(2011) Thomas H.A. Ederveen et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells

(2011) Bryce W. Carey et al.   Cell Stem Cell

Chromatin higher-order structures and gene regulation

(2011) Guohong Li et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Advances in Whole Genome Sequencing Technology

(2011) Jianhua Zhao et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines

(2011) Hiroko Sugawara et al.   Epigenetics

Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons

(2011) K. Iwamoto et al.   GENOME RESEARCH

Distinct DNA methylation changes highly correlated with chronological age in the human brain

(2011) Dena G. Hernandez et al.   HUMAN MOLECULAR GENETICS

Tissue-specific Distribution and Dynamic Changes of 5-Hydroxymethylcytosine in Mammalian Genomes

(2011) Shannon Morey Kinney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of Parvalbumin at Cortical GABA Synapses Reduces Network Gamma Oscillatory Activity

(2011) V. Volman et al.   JOURNAL OF NEUROSCIENCE

A novel, rapid, cell-counting method for unfixed frozen brains comprehensively quantifies at least four neural cell populations

(2011) Y Hayashi et al.   MOLECULAR PSYCHIATRY

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

(2011) Carlo Colantuoni et al.   NATURE

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

(2011) Yuki Ohi et al.   NATURE CELL BIOLOGY

Exome sequencing supports a de novo mutational paradigm for schizophrenia

(2011) Bin Xu et al.   NATURE GENETICS

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

(2011) Brian J O'Roak et al.   NATURE GENETICS

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory

(2011) Hongda Li et al.   NATURE NEUROSCIENCE

Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq

(2011) Mazhar Adli et al.   Nature Protocols

Impact of chromatin structure on sequence variability in the human genome

(2011) Michael Y Tolstorukov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The elongation rate of RNA polymerase determines the fate of transcribed nucleosomes

(2011) Lacramioara Bintu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease

(2011) David P. Gavin et al.   NEUROBIOLOGY OF DISEASE

Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function

(2011) Sonia Cohen et al.   NEURON

Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis

(2011) David P Gavin et al.   NEUROPSYCHOPHARMACOLOGY

MethylomeDB: a database of DNA methylation profiles of the brain

(2011) Yurong Xin et al.   NUCLEIC ACIDS RESEARCH

Genomic mapping of 5-hydroxymethylcytosine in the human brain

(2011) Seung-Gi Jin et al.   NUCLEIC ACIDS RESEARCH

RNA-Seq of Human Neurons Derived from iPS Cells Reveals Candidate Long Non-Coding RNAs Involved in Neurogenesis and Neuropsychiatric Disorders

(2011) Mingyan Lin et al.   PLoS One

DNA Methylation Dynamics in Human Induced Pluripotent Stem Cells over Time

(2011) Koichiro Nishino et al.   PLoS Genetics

Analysis of DNA Methylation in a Three-Generation Family Reveals Widespread Genetic Influence on Epigenetic Regulation

(2011) Jason Gertz et al.   PLoS Genetics

Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders

(2011) B Tang et al.   Translational Psychiatry

Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain

(2010) Dandan Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phospho-acetylation of histone H3 in the amygdala after acute lithium chloride

(2010) Bumsup Kwon et al.   BRAIN RESEARCH

White matter neuron alterations in schizophrenia and related disorders

(2010) Caroline M. Connor et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B

(2010) Y. Jiang et al.   JOURNAL OF NEUROSCIENCE

Maternal Care and DNA Methylation of a Glutamic Acid Decarboxylase 1 Promoter in Rat Hippocampus

(2010) T.-Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

(2010) Peter J. Skene et al.   MOLECULAR CELL

A three-dimensional model of the yeast genome

(2010) Zhijun Duan et al.   NATURE

L1 retrotransposition in neurons is modulated by MeCP2

(2010) Alysson R. Muotri et al.   NATURE

Conserved role of intragenic DNA methylation in regulating alternative promoters

(2010) Alika K. Maunakea et al.   NATURE

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Cortical DNA methylation maintains remote memory

(2010) Courtney A Miller et al.   NATURE NEUROSCIENCE

DNA methylation and memory formation

(2010) Jeremy J Day et al.   NATURE NEUROSCIENCE

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

(2010) Quincey LaPlant et al.   NATURE NEUROSCIENCE

Condensin and cohesin complexity: the expanding repertoire of functions

(2010) Andrew J. Wood et al.   NATURE REVIEWS GENETICS

Charting histone modifications and the functional organization of mammalian genomes

(2010) Vicky W. Zhou et al.   NATURE REVIEWS GENETICS

Analysis of the GAD1 promoter: Trans-acting factors and DNA methylation converge on the 5′ untranslated region

(2010) Ying Chen et al.   NEUROPHARMACOLOGY

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

(2010) I. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

(2010) Christoph Loenarz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular Determinants of Dysregulated GABAergic Gene Expression in the Prefrontal Cortex of Subjects with Schizophrenia

(2009) Nikolaos Mellios et al.   BIOLOGICAL PSYCHIATRY

Chromosome Conformation Capture of All 13 Genomic Loci in the Transcriptional Regulation of the Multisubunit Bigenomic CytochromecOxidase in Neurons

(2009) Shilpa S. Dhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population

(2009) David P. Gavin et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Dynamic Histone Variant Exchange Accompanies Gene Induction in T Cells

(2009) E. L. Sutcliffe et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA methylation profiles in monozygotic and dizygotic twins

(2009) Zachary A Kaminsky et al.   NATURE GENETICS

Sense from sequence reads: methods for alignment and assembly

(2009) Paul Flicek et al.   NATURE METHODS

Computation for ChIP-seq and RNA-seq studies

(2009) Shirley Pepke et al.   NATURE METHODS

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

(2009) Patrick O McGowan et al.   NATURE NEUROSCIENCE

ChIP–seq: advantages and challenges of a maturing technology

(2009) Peter J. Park   NATURE REVIEWS GENETICS

Induced pluripotent stem (iPS) cells and their future in psychiatry

(2009) Kwang-Soo Kim   NEUROPSYCHOPHARMACOLOGY

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis

(2008) Jonathan Mill et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Isolation of neuronal chromatin from brain tissue

(2008) Yan Jiang et al.   BMC NEUROSCIENCE

The Colorful History of Active DNA Demethylation

(2008) Steen K.T. Ooi et al.   CELL

Activity-Dependent Suppression of Miniature Neurotransmission through the Regulation of DNA Methylation

(2008) E. D. Nelson et al.   JOURNAL OF NEUROSCIENCE

The effects of pH on DNA methylation state: In vitro and post-mortem brain studies

(2008) Carl Ernst et al.   JOURNAL OF NEUROSCIENCE METHODS

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation

(2008) In Tag Yu et al.   NEUROPHARMACOLOGY

Drug-Induced Activation of Dopamine D1 Receptor Signaling and Inhibition of Class I/II Histone Deacetylase Induce Chromatin Remodeling in Reward Circuitry and Modulate Cocaine-Related Behaviors

(2008) Frederick A Schroeder et al.   NEUROPSYCHOPHARMACOLOGY

Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain

(2008) Patrick O. McGowan et al.   PLoS One

Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation

(2008) E. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons

(2008) R. Satta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

(2008) M. Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects

(2008) David P. Gavin et al.   SCHIZOPHRENIA RESEARCH

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling

(2008) Alessandro Guidotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Methylation Status of the Reelin Promoter Region in the Brain of Schizophrenic Patients

(2007) Mamoru Tochigi et al.   BIOLOGICAL PSYCHIATRY

Genetic and Epigenetic Mechanisms in Metal Carcinogenesis and Cocarcinogenesis: Nickel, Arsenic, and Chromium

(2007) Konstantin Salnikow et al.   CHEMICAL RESEARCH IN TOXICOLOGY