Review
Behavioral Sciences
Aviv M. Weinstein
Summary: In the past 20 years, there has been an increasing number of brain imaging studies on the mechanisms underlying reward motivation in humans. This review describes studies on the neural mechanisms associated with reward motivation and their relationships with cognitive function in healthy human participants. The brain's reward circuitry controls reward-motivated behavior, and different regions such as the pre-frontal cortex, thalamus, and insula play specific roles in motivation, cognitive control, and incentive processing. The relationship between reward motivation and other cognitive processes such as learning, memory, and attention is reciprocal. There are also genetic and sex differences in reward motivation, and these studies have implications for understanding addiction, depression, and ADHD.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Review
Behavioral Sciences
Bowen J. Fung, Elissa Sutlief, Marshall G. Hussain Shuler
Summary: Time perception and reward processing interact through a common dopaminergic mechanism, as supported by both neurobiological and behavioral studies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Kurt M. Fraser, Heather J. Pribut, Patricia H. Janak, Ronald Keiflin
Summary: Reward seeking requires coordination of motor programs. Midbrain dopamine neurons are critical for reinforcement and learning. Ventral tegmental area (VTA) dopamine neurons imbue actions and cues with motivational value, allowing flexible pursuit, whereas substantia nigra (SNc) dopamine neurons support precise, action-specific learning. This heterogeneous dopamine system supports unique forms of instrumental learning and reward-seeking strategies.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Computer Science, Artificial Intelligence
Shivam Kalhan, Marta I. Garrido, Robert Hester, A. David Redish
Summary: Dysfunction in learning and motivational systems is believed to contribute to addictive behaviors. Previous models have limitations in explaining the key features of addictive behaviors, but this study proposes a novel mathematical model that combines dopamine's role in learning and motivation to simulate addictive behaviors accurately. The model also explains some key characteristics of addictive behaviors.
Review
Neurosciences
Johannes W. de Jong, Kurt M. Fraser, Stephan Lammel
Summary: Ventral tegmental area dopamine neurons encode reward prediction errors, but their release in the nucleus accumbens is involved in reinforcement learning, motivation, aversion, and incentive salience. The contrast between the homogeneous role of dopamine neuron activity and the heterogeneous functions of dopamine release raises questions about how VTA dopamine activity translates into NAc dopamine release.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Review
Psychiatry
Hironobu Fujiwara, Kosuke Tsurumi, Mami Shibata, Kei Kobayashi, Takashi Miyagi, Tsukasa Ueno, Naoya Oishi, Toshiya Murai
Summary: This review examines the mechanisms and risks of habitual behaviors such as internet use and media multitasking in relation to the reward/motivation system. The study suggests that routines that are beneficial when performed moderately can become excessive and have negative impacts, as demonstrated by the inverted U-curve model. Understanding the underlying mechanisms of behavioral addiction and finding optimal levels of habitual behaviors for mental health benefits can help in the management and prevention of addiction. The insights from this study are valuable for future research and the development of effective strategies to prevent and manage addiction.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Ping Ren, Gangqiang Hou, Manxiu Ma, Yuchuan Zhuang, Jiayin Huang, Meiling Tan, Donghui Wu, Guozhi Luo, Zhiguo Zhang, Han Rong
Summary: This study investigates the neural substrates of age-related altered financial risk-taking behavior, focusing on the putamen network. The results show that older adults exhibit different risk-taking behaviors compared to young adults, with subgroups showing young-like and over-conservative risk behaviors. The putamen functional connectivity plays a critical role in mediating the effects of age on risk behaviors and is associated with the putamen gray matter volume in over-conservative older adults.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Adam Gordon-Fennell, Garret D. Stuber
Summary: Studies have revealed generalizable findings across molecularly defined cell types in areas of the basal forebrain and anterior hypothalamus. Optogenetic stimulation of GABAergic neurons in these brain regions drives reward, while optogenetic stimulation of glutamatergic neurons in these regions drives aversion.
Review
Behavioral Sciences
Gabriela Rodriguez-Manzo, Ana Canseco-Alba
Summary: The endocannabinoid system (ECS) plays a crucial role in regulating sexual behavior and sexual motivation. Sexual activity activates the mesolimbic dopaminergic system (MSL), and sustained sexual activity leads to sexual satiety. The cannabinoid receptor 1 (CB1R) is found to be involved in the induction of sexual inhibitory state during sexual satiety.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Psychology, Biological
Caroline E. Geisler, Matthew R. Hayes
Summary: Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by compulsive over-consumption of rewarding substances such as substance abuse, binge eating disorder, and obesity. Understanding how hormonal regulation of VTA dopaminergic output alters motivated behaviors is essential to leveraging therapeutics that target these hormone systems to treat addiction and disordered eating.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Neurosciences
Blake L. Elliott, Kimberlee D'Ardenne, Vishnu P. Murty, Gene A. Brewer, Samuel M. McClure
Summary: Motivation is a powerful driver of learning and memory, and the interactions among the dopaminergic midbrain substantia nigra/ventral tegmental area (SN/VTA), hippocampus, and nucleus accumbens (NAc) are critical for motivated memory encoding. This study found that individual differences in the structure of this circuit are associated with motivated memory encoding.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Ana Canseco-Alba, Ulises Coffeen, Orlando Jaimes, Francisco Pellicer, Gabriela Rodriguez-Manzo
Summary: This study investigates the changes in nucleus accumbens dopamine (DA) levels during sexual satiety. The results show that NAcc DA levels remain elevated during copulation to satiety, but significantly decrease 24 hours after. Additionally, anandamide injection can reverse the sexual inhibition state.
PSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xin-Yue Wang, Wen-Bin Jia, Xiang Xu, Rui Chen, Liang-Biao Wang, Xiao-Jing Su, Peng-Fei Xu, Xiao-Qing Liu, Jie Wen, Xiao-Yuan Song, Yuan-Yuan Liu, Zhi Zhang, Xin-Feng Liu, Yan Zhang
Summary: This study reveals a pathway involving vesicular glutamate transporter 3 neurons and dopamine neurons that plays a crucial role in chronic pain and comorbid anhedonia-like behavior. Chronic neuropathic pain dampens the transmission of glutamate and the neural excitability in this pathway. Activation of this pathway can alleviate pain and comorbid anhedonia-like behavior, while inhibition of this pathway leads to pain-like reflexive hypersensitivity and anhedonia-like behavior.
NATURE COMMUNICATIONS
(2023)
Review
Behavioral Sciences
Jiri Dvoracek, Dalibor Kodrik
Summary: The fruit fly Drosophila melanogaster brain is extensively studied as a model for insect reward system, capable of associative learning. While neurochemical systems mediating the 'wanting' component of reward are well documented, systems mediating the pleasure component are unlikely to be present in insects, such as endogenous opioid and endocannabinoid systems.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Yusuke Nakashima, So Kanazawa, Masami K. Yamaguchi
Summary: According to the study, infants under 7 months of age are immune to visual backward masking and have immature recurrent processing. Therefore, they are able to perceive objects even without recurrent processing.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
A. M. van Opstal, A. Hafkemeijer, A. A. van den Berg-Huysmans, M. Hoeksma, C. Blonk, H. Pijl, S. A. R. B. Rombouts, J. van der Grond
NUTRITIONAL NEUROSCIENCE
(2020)
Article
Nutrition & Dietetics
A. M. van Opstal, I Kaal, A. A. van den Berg-Huysmans, M. Hoeksma, C. Blonk, H. Pijl, S. A. R. B. Rombouts, J. van der Grond
Article
Geriatrics & Gerontology
Jessica L. Panman, Lize C. Jiskoot, Mark J. R. J. Bouts, Lieke H. H. Meeter, Emma L. van der Ende, Jackie M. Poos, Rogier A. Feis, Anneke J. A. Kievit, Rick van Minkelen, Elise G. P. Dopper, Serge A. R. B. Rombouts, John C. van Swieten, Janne M. Papma
NEUROBIOLOGY OF AGING
(2019)
Article
Neurosciences
Hazel Zonneveld, Raimon H. R. Pruim, Daniel Bos, Henri A. Vrooman, Ryan L. Muetzel, Albert Hofman, Serge A. R. B. Rombouts, Aad van der Lugt, Wiro J. Niessen, M. Arfan Ikram, Meike W. Vernooij
Article
Neurosciences
Raymond P. Viviano, Jessica M. Hayes, Patrick J. Pruitt, Zachary J. Fernandez, Sanneke van Rooden, Jeroen van der Grond, Serge A. R. B. Rombouts, Jessica S. Damoiseaux
Article
Behavioral Sciences
M. M. E. Riem, M. J. van Hoof, A. S. Garrett, S. A. R. B. Rombouts, N. J. A. van der Wee, M. H. van Uzendoorn, R. R. J. M. Verrneiren
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Psychology, Clinical
Charlotte C. van Schie, Chui-De Chiu, Serge A. R. B. Rombouts, Willem J. Heiser, Bernet M. Elzinga
PSYCHOLOGICAL MEDICINE
(2020)
Article
Neurosciences
Bernadet L. Klaassens, Joop M. A. van Gerven, Erica S. Klaassen, Jeroen van der Grond, Serge A. R. B. Rombouts
Article
Clinical Neurology
Rogier A. Feis, Mark J. R. J. Bouts, Frank de Vos, Tijn M. Schouten, Jessica L. Panman, Lize C. Jiskoot, Elise G. P. Dopper, Jeroen van der Grond, John C. van Swieten, Serge A. R. B. Rombouts
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2019)
Article
Neurosciences
Anna M. Van Opstal, Anne Hafkemeijer, Annette A. van den Berg-Huysmans, Marco Hoeksma, Theo P. J. Mulder, Hanno Pijl, Serge A. R. B. Rombouts, Jeroen van der Grond
Summary: The study found that glucose and fructose led to decreased BOLD signal in specific areas of the brain, while sucralose and allulose had no effect on BOLD signal or network connectivity. However, sucralose did increase eigen vector centrality values in certain brain regions. This suggests that the type of sweetener used can impact brain responses and potentially affect feeding behavior and reward responses.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Rogier A. Feis, Mark J. R. J. Bouts, Elise G. P. Dopper, Nicola Filippini, Verena Heise, Aaron J. Trachtenberg, John C. van Swieten, Mark A. van Buchem, Jeroen van Der Grond, Clare E. Mackay, Serge A. R. B. Rombouts
Article
Multidisciplinary Sciences
Mirjam A. Rinne-Albers, Charlotte P. Boateng, Steven J. van der Werff, Francien Lamers-Winkelman, Serge A. Rombouts, Robert R. Vermeiren, Nic J. van der Wee
SCIENTIFIC REPORTS
(2020)
Article
Neuroimaging
Frank de Vos, Tijn M. Schouten, Marisa Koini, Mark J. R. J. Bouts, Rogier A. Feis, Anita Lechner, Reinhold Schmidt, Mark A. van Buchem, Frans R. J. Verhey, Marcel G. M. Olde Rikkert, Philip Scheltens, Mark de Rooij, Jeroen van der Grond, Serge A. R. B. Rombouts
NEUROIMAGE-CLINICAL
(2020)
Correction
Neuroimaging
Rogier A. Feis, Mark J. R. J. Bouts, Jessica L. Panman, Lize C. Jiskoot, Elise G. P. Dopper, Tijn M. Schouten, Frank de Vos, Jeroen van der Grond, John C. van Swieten, Serge A. R. B. Rombouts
NEUROIMAGE-CLINICAL
(2019)
Article
Neuroimaging
Nadieh Drenth, Jeroen van der Grond, Serge A. R. B. Rombouts, Mark A. van Buchem, Gisela M. Terwindt, Marieke J. H. Wermer, Jasmeer P. Chhatwal, M. Edip Gurol, Steven M. Greenberg, Sanneke van Rooden
Summary: The study found that patients with Dutch type hereditary CAA show diminished global brain functioning, particularly in symptomatic individuals. This suggests that the decreased brain connectivity may be considered a late consequence of the disease.
NEUROIMAGE-CLINICAL
(2021)
