Article
Neurosciences
Tsuyoshi Yamaguchi, Shukuko Minami, Shuichi Ueda
Summary: The study found that offspring of dams administered MAM intraperitoneally exhibited micrencephaly and anxiety-related behavior, with a significant decrease in PV-positive neurons in the BLA. However, there were no significant changes in the number of Nissl- and Calb-positive neurons. These results suggest that histochemical alterations in the BLA of MAM-induced model rats may be attributed to an aberrant GABAergic inhibitory system.
Article
Neurosciences
Muhammad Asim, Huajie Wang, Xi Chen, Jufang He
Summary: This study investigates the role of basolateral amygdala (BLA) neurons in mediating the behavior associated with depression. The results suggest that increased activity of excitatory BLA neurons can lead to depressive-like behavior, while inhibition of these neurons can alleviate such behavior. Additionally, inhibiting GABAergic neurons in the BLA can increase the firing frequency of excitatory neurons and mediate depressive-like phenotypes. Furthermore, activating inhibitory neurons can inhibit the activity of excitatory neurons and alleviate depressive-like behavior.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Nowrin Ahmed, Denis Pare
Summary: This study aimed to determine the neurotransmitter used by MD-projecting BLA cells in male and female rats. The results indicate that the BLA sends a mixed, glutamatergic-GABAergic projection to MD, which likely influences coordination of activity between BLA, MD, and medial prefrontal cortex.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychiatry
Jonas Englund, Joni Haikonen, Vasilii Shteinikov, Shyrley Paola Amarilla, Tsvetomira Atanasova, Alexandra Shintyapina, Maria Ryazantseva, Juha Partanen, Vootele Voikar, Sari E. Lauri
Summary: Early life stress can alter the function of kainate receptors in the amygdala, leading to changes in GABAergic microcircuits and potentially contributing to anxio-genesis. These changes showed gender specificity and affected behavioral phenotypes in male rodents.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Kirstie A. Cummings, Sabina Bayshtok, Tri N. Dong, Paul J. Kenny, Roger L. Clem
Summary: This study shows that fear conditioning activates a heterogeneous population of SST-INs in the medial prefrontal cortex, which play an important role in memory expression. In contrast, a different population of SST-INs activated by morphine exerts opposing control over fear and supports reward-like effects.
Article
Cell Biology
Andrew Lutas, Kayla Fernando, Stephen X. Zhang, Abhijeet Sambangi, Mark L. Andermann
Summary: Dopaminergic inputs to basal amygdala play a crucial role in the learning process, which is regulated by intracellular plasticity signals like cAMP. The dynamics of dopamine and cAMP may regulate the learning of temporally clustered, salient stimuli.
Article
Multidisciplinary Sciences
Yan-Fen Chen, Qi Song, Paola Colucci, Federica Maltese, Cristina Siller-Perez, Karina Prins, James L. McGaugh, Erno J. Hermans, Patrizia Campolongo, Nael Nadif Kasri, Benno Roozendaal
Summary: Noradrenergic activation of the basolateral amygdala influences recognition memory by suppressing activity in the anterior insular cortex. This finding sheds light on the broader dynamics of the brain network involved in emotional regulation of memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Sha-Sha Yang, Nancy R. Mack, Yousheng Shu, Wen-Jun Gao
Summary: Prefrontal cortical GABAergic interneurons play a crucial role in executing complex behaviors, with long-range afferents from subcortical structures activating parvalbumin-expressing and somatostatin expressing interneurons to regulate specific PFC-dependent behaviors.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Review
Biochemistry & Molecular Biology
Maria F. M. Braga, Jenifer Juranek, Lee E. Eiden, Zheng Li, Taiza H. Figueiredo, Marcio de Araujo Furtado, Ann M. Marini
Summary: Traumatic brain injury (TBI) is a global epidemic and a major public health concern in the United States. Anxiety is the second most common neuropsychiatric disorder that develops in those with persistent symptoms after TBI, with abnormalities or atrophy in the temporal lobe being observed in most cases. This review compares human and animal studies to explore the relationship between post-traumatic anxiety and structural/functional changes in the amygdala, leading to both preliminary insights and potential directions for rational and more effective treatments.
Article
Immunology
Xiao Zhuang, Bing Zhan, Yufeng Jia, Chaoze Li, Nan Wu, Ming Zhao, Nuo Chen, Yaxin Guo, Yingxin Du, Yi Zhang, Baihui Cao, Yan Li, Faliang Zhu, Chun Guo, Qun Wang, Yuan Li, Lining Zhang
Summary: Hyper-inflammatory reaction can activate anxiety circuits by suppressing BDNF and GABAergic neurons transmission.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Medicine, Research & Experimental
Zu-Cheng Shen, Jian-Min Liu, Jie-Yan Zheng, Meng-Die Li, Dan Tian, Yue Pan, Wu-Cheng Tao, Shuang-Qi Gao, Zhi-Xuan Xia
Summary: Protein palmitoylation/nitrosylation crosstalk plays a critical role in regulating anxiety behavior and may serve as a potential target for anxiolytic intervention.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Vivien Miczan, Krisztina Kelemen, Judit R. Glavinics, Zsofia Laszlo, Benjamin Barti, Kata Kenesei, Mate Kisfali, Istvan Katona
Summary: The molecular repertoire of calcium-binding proteins in Ca2+ signaling pathways plays a crucial role in meeting the specific kinetic requirements of Ca2+-dependent processes in different types of neurons. By investigating CB1/CCK-positive interneurons, it was revealed that NECAB1 and NECAB2 are predominant calcium-binding proteins in this cell type, showing functional differences at the subcellular nanoscale level.
Article
Neurosciences
Jun Liu, Longnian Lin, Dong Wang
Summary: Specific BLA neurons exhibit increased firing rates, accompanied by increased heart rate and freezing, in response to height threats. These neurons are only activated under height threats, not other conditions, and develop conditioned responses to the context after fear conditioning, indicating a convergence in processing of dangerous/risky contextual information.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Qi Zhang, Shun-Heng Gao, Zhong-Shan Shen, Yun Wang, Su-Wan Hu, Guang-Bing Duan, Ye Liu, Dan-Ya Zhong, Jing Liu, Meng-Han Sun, Xin Zhang, Tian-Yu Cao, Jun-Li Cao, Qiong-Yao Tang, Zhe Zhang
Summary: Anxiety disorders are mental disorders characterized by anxiety and fear, and their molecular basis is still unclear. The study reveals the role of Slack channels in controlling anxious behaviors by decreasing the excitability of BLA-vHPC glutamatergic projections. This provides a potential target for anxiolytic therapies.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yann S. Mineur, Tenna N. Mose, Kathrine Lefoli Maibom, Steven T. Pittenger, Alexa R. Soares, Hao Wu, Seth R. Taylor, Yaqing Huang, Marina R. Picciotto
Summary: The balance between excitatory and inhibitory signaling in the brain is crucial for maintaining homeostatic function. Acetylcholine (ACh) signaling in the basolateral amygdala (BLA) has been found to influence stress-sensitive behaviors by altering the balance of activity among different types of neurons. These findings suggest that ACh modulates the GABAergic signaling network in the BLA, leading to changes in coping strategies during stress.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
J. T. Yorgason, J. H. Rose, J. M. Mcintosh, M. J. Ferris, S. R. Jones
Article
Neurosciences
Ja Wook Koo, Benoit Labonte, Olivia Engmann, Erin S. Calipari, Barbara Juarez, Zachary Lorsch, Jessica J. Walsh, Allyson K. Friedman, Jordan T. Yorgason, Ming-Hu Han, Eric J. Nestler
BIOLOGICAL PSYCHIATRY
(2016)
Article
Substance Abuse
Cody A. Siciliano, Erin S. Calipari, Jordan T. Yorgason, Yolanda Mateo, Christa M. Helms, David M. Lovinger, Kathleen A. Grant, Sara R. Jones
DRUG AND ALCOHOL DEPENDENCE
(2016)
Article
Neurosciences
Jordan T. Yorgason, Erin S. Calipari, Mark J. Ferris, Anushree N. Karkhanis, Steven C. Fordahl, Jeffrey L. Weiner, Sara R. Jones
Article
Multidisciplinary Sciences
Erin S. Calipari, Rosemary C. Bagot, Immanuel Purushothaman, Thomas J. Davidson, Jordan T. Yorgason, Catherine J. Pena, Deena M. Walker, Stephen T. Pirpinias, Kevin G. Guise, Charu Ramakrishnan, Karl Deisseroth, Eric J. Nestler
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Neurosciences
Cody A. Siciliano, Erin S. Calipari, Jordan T. Yorgason, David M. Lovinger, Yolanda Mateo, Vanessa A. Jimenez, Christa M. Helms, Kathleen A. Grant, Sara R. Jones
PSYCHOPHARMACOLOGY
(2016)
Article
Neurosciences
Christopher E. Vaaga, Jordan T. Yorgason, John T. Williams, Gary L. Westbrook
JOURNAL OF NEUROPHYSIOLOGY
(2017)
Article
Neurosciences
Jordan T. Yorgason, Douglas M. Zeppenfeld, john T. Williams
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
David M. Hedges, J. Daniel Obray, Jordan T. Yorgason, Eun Young Jang, Vajira K. Weerasekara, Joachim D. Uys, Frederick P. Bellinger, Scott C. Steffensen
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Courtney D. Prince, Andrew R. Rau, Jordan T. Yorgason, Rodrigo A. Espana
ACS CHEMICAL NEUROSCIENCE
(2015)
Article
Substance Abuse
Jordan T. Yorgason, Mark J. Ferris, Scott C. Steffensen, Sara R. Jones
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2014)
Article
Neurosciences
Jordan T. Yorgason, Rodrigo A. Espana, Joanne K. Konstantopoulos, Jeffrey L. Weiner, Sara R. Jones
EUROPEAN JOURNAL OF NEUROSCIENCE
(2013)
Article
Biochemistry & Molecular Biology
David M. Hedges, Jordan T. Yorgason, Andrew W. Perez, Nathan D. Schilaty, Benjamin M. Williams, Richard K. Watt, Scott C. Steffensen
Article
Biochemistry & Molecular Biology
James N. Brundage, Colin P. Mason, Hillary A. Wadsworth, Chris S. Finuf, Josh J. Nelson, P. Joakim W. Ronstrom, Sara R. Jones, Cody A. Siciliano, Scott C. Steffensen, Jordan T. Yorgason
Summary: Striatal dopamine release dynamics differ across sexes, with female mice showing less regional differences in dopamine release compared to male mice. Blocking voltage-gated K+ channels with 4-aminopyridine had the greatest effects in ventral regions of female mice, indicating regional differences in Kv channel expression. The dopamine transporter blocker cocaine enhanced detection across subregions in both sexes, with females showing greater overall increased release than males.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Nathan D. Schilaty, David M. Hedges, Eun Young Jang, Ryan J. Folsom, Jordan T. Yorgason, J. Michael McIntosh, Scott C. Steffensen
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2014)