Pharmacological Enhancement of Memory and Executive Functioning in Laboratory Animals

Selective lesions of the dorsomedial striatum impair serial spatial reversal learning in rats

(2010) Anna Castañé et al.   BEHAVIOURAL BRAIN RESEARCH

Working memory

(2010) Alan Baddeley   CURRENT BIOLOGY

Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade

(2010) Mark R. Stefani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models

(2010) Christopher J. O’Donnell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhancement of Spatial Reversal Learning by 5-HT2C Receptor Antagonism Is Neuroanatomically Specific

(2010) V. Boulougouris et al.   JOURNAL OF NEUROSCIENCE

Prefrontal and hippocampal contributions to encoding and retrieval of spatial memory

(2010) John C. Churchwell et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Enhancement of Attentional Performance by Selective Stimulation of α4β2* nAChRs: Underlying Cholinergic Mechanisms

(2010) William M Howe et al.   NEUROPSYCHOPHARMACOLOGY

ABT-594 improves performance in the 5-choice serial reaction time task under conditions of increased difficulty, sub-chronic dosing, and in poorly-performing subjects

(2010) Eric G. Mohler et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neurocognitive Mechanisms in Depression: Implications for Treatment

(2009) Luke Clark et al.   Annual Review of Neuroscience

Prefrontal cortex lesions and scopolamine impair attention performance of C57BL/6 mice in a novel 2-choice visual discrimination task

(2009) Gregory M. Dillon et al.   BEHAVIOURAL BRAIN RESEARCH

Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats

(2009) Trine Damgaard et al.   BEHAVIOURAL BRAIN RESEARCH

The AMPA modulator S 18986 improves declarative and working memory performances in aged mice

(2009) Aline Marighetto et al.   BEHAVIOURAL PHARMACOLOGY

Selective α7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes

(2009) Simon Sydserff et al.   BIOCHEMICAL PHARMACOLOGY

nAChR agonist-induced cognition enhancement: Integration of cognitive and neuronal mechanisms

(2009) Martin Sarter et al.   BIOCHEMICAL PHARMACOLOGY

TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

(2009) T.A. Hauser et al.   BIOCHEMICAL PHARMACOLOGY

On the role of dopamine replacement therapy in decision-making, working memory, and reward in Parkinson’s disease: Does the therapy-dose matter?

(2009) Diana Maria Elena Torta et al.   BRAIN AND COGNITION

Pharmacological or Genetic Inactivation of the Serotonin Transporter Improves Reversal Learning in Mice

(2009) J. L. Brigman et al.   CEREBRAL CORTEX

D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia

(2009) Samantha L. McLean et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Neural Suppression of Irrelevant Information Underlies Optimal Working Memory Performance

(2009) T. P. Zanto et al.   JOURNAL OF NEUROSCIENCE

Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil

(2009) D. Zolkowska et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regional Differential Effects of the Novel Histamine H3 Receptor Antagonist 6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on Histamine Release in the Central Nervous System of Freely Moving Rats

(2009) P. Giannoni et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Procognitive and Neuroprotective Activity of a Novel  7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders

(2009) R. Roncarati et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effect of acute and repeated treatment with desipramine or methylphenidate on serial reversal learning in rats

(2009) Emanuele Seu et al.   NEUROPHARMACOLOGY

AC-260584, an orally bioavailable M1 muscarinic receptor allosteric agonist, improves cognitive performance in an animal model

(2009) Stefania Risso Bradley et al.   NEUROPHARMACOLOGY

Ventral Striatal Dopamine Modulation of Different Forms of Behavioral Flexibility

(2009) Desirae M Haluk et al.   NEUROPSYCHOPHARMACOLOGY

Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition

(2009) Dawn M. Eagle et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Disruptions in spatial working memory, but not short-term memory, induced by repeated ketamine exposure

(2009) Takeshi Enomoto et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Source monitoring 15 years later: What have we learned from fMRI about the neural mechanisms of source memory?

(2009) Karen J. Mitchell et al.   PSYCHOLOGICAL BULLETIN

Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting

(2009) Brian Villumsen Broberg et al.   PSYCHOPHARMACOLOGY

Activation of 5-HT6 receptors facilitates attentional set shifting

(2009) Katherine E. Burnham et al.   PSYCHOPHARMACOLOGY

Blockade of serotonin 2A receptors prevents PCP-induced attentional performance deficit and CREB phosphorylation in the dorsal striatum of DBA/2 mice

(2009) Laura Pozzi et al.   PSYCHOPHARMACOLOGY

Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT6 and 5-HT2A receptor mechanisms

(2009) Nagi Idris et al.   PSYCHOPHARMACOLOGY

Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat

(2009) Samantha L. McLean et al.   PSYCHOPHARMACOLOGY

Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats

(2009) Andrea Bari et al.   PSYCHOPHARMACOLOGY

Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models

(2009) Hiroyo Koseki et al.   SYNAPSE

The amygdala and emotional modulation of competition between cognitive and habit memory

(2008) Jeffrey C. Wingard et al.   BEHAVIOURAL BRAIN RESEARCH

A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats

(2008) Samantha L. McLean et al.   BEHAVIOURAL BRAIN RESEARCH

Neural circuits subserving behavioral flexibility and their relevance to schizophrenia

(2008) Stan B. Floresco et al.   BEHAVIOURAL BRAIN RESEARCH

Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat

(2008) Marie L. Woolley et al.   BEHAVIOURAL PHARMACOLOGY

Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

(2008) Karin R. Tietje et al.   CNS Neuroscience & Therapeutics

Noradrenergic Signaling in Infralimbic Cortex Increases Cell Excitability and Strengthens Memory for Fear Extinction

(2008) D. Mueller et al.   JOURNAL OF NEUROSCIENCE

ADX47273 [S-(4-Fluoro-phenyl)- -methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities

(2008) F. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Behavioral and Neurochemical Effects of a Novel D-Amino Acid Oxidase Inhibitor Compound 8 [4H-Thieno [3,2-b]pyrrole-5-carboxylic Acid] and D-Serine

(2008) S. M. Smith et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness

(2008) A. B. Hains et al.   LEARNING & MEMORY

Noradrenergic activation of the basolateral amygdala modulates consolidation of object recognition memory☆

(2008) Benno Roozendaal et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats

(2008) Fabrício A. Pamplona et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function

(2008) Kevin C.F. Fone   NEUROPHARMACOLOGY

Looking for episodic memory in animals and young children: Prospects for a new minimalism

(2008) Nicola S. Clayton et al.   NEUROPSYCHOLOGIA

Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval

(2008) Boyer D. Winters et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia☆

(2008) D BOULAY et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: Interactions with clozapine actions and attentional performance in rats

(2008) Amir H. Rezvani et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effect of R3487/MEM3454, a novel nicotinic α7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats

(2008) Amir H. Rezvani et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat

(2008) M. L. Woolley et al.   PSYCHOPHARMACOLOGY

Asenapine restores cognitive flexibility in rats with medial prefrontal cortex lesions

(2008) David S. Tait et al.   PSYCHOPHARMACOLOGY

Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats

(2008) J. David Jentsch et al.   PSYCHOPHARMACOLOGY

Drug enhancement of memory consolidation: historical perspective and neurobiological implications

(2008) James L. McGaugh et al.   PSYCHOPHARMACOLOGY

Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice

(2008) A. Marighetto et al.   PSYCHOPHARMACOLOGY

Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice

(2008) Suzanne C. Wood et al.   PSYCHOPHARMACOLOGY

Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040

(2008) Eric Southam et al.   PSYCHOPHARMACOLOGY

Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat—a back translational study

(2008) Pascal Goetghebeur et al.   PSYCHOPHARMACOLOGY

Protracted cognitive effects produced by clonidine in Macaca nemestrina performing a delayed matching task

(2008) Jerry J. Buccafusco et al.   PSYCHOPHARMACOLOGY

Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behavior

(2008) Vasileios Boulougouris et al.   PSYCHOPHARMACOLOGY

Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration

(2008) Nurith Amitai et al.   PSYCHOPHARMACOLOGY

Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys

(2008) Emanuele Seu et al.   PSYCHOPHARMACOLOGY

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

(2008) Dawn M. Eagle et al.   PSYCHOPHARMACOLOGY

Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats

(2008) M. Danet S. Lapiz-Bluhm et al.   PSYCHOPHARMACOLOGY

Atomoxetine reverses attentional deficits produced by noradrenergic deafferentation of medial prefrontal cortex

(2008) Lori A. Newman et al.   PSYCHOPHARMACOLOGY

The 5-HT2C receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test

(2007) R NAVARRA   BEHAVIOURAL BRAIN RESEARCH

Phencyclidine-Induced Cognitive Deficits in Mice Are Improved by Subsequent Subchronic Administration of the Novel Selective α7 Nicotinic Receptor Agonist SSR180711

(2007) Kenji Hashimoto et al.   BIOLOGICAL PSYCHIATRY

Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning

(2007) Sarvin Ghods-Sharifi et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test

(2007) Rachel Navarra et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY