Article
Biochemistry & Molecular Biology
Lijuan Yin, Jingjing Li, Jing Wang, Tianjie Pu, Jing Wei, Qinlong Li, Boyang Jason Wu
Summary: Perineural invasion (PNI) is an important indicator of cancer progression and poor prognosis, especially in prostate cancer. The study revealed that MAOA plays a crucial role in promoting PNI in PC, and inhibition of MAOA can reduce PNI and potentially serve as a targeted treatment strategy for PC in the future.
Article
Multidisciplinary Sciences
Maria Raquel Santos Carvalho, Andre Henrique Barbosa de Carvalho, Giulia Moreira Paiva, Carolina de Castro Andrade Jorge, Fernanda Caroline dos Santos, Gabriella Koltermann, Jerusa Fumagalli de Salles, Korbinian Moeller, Guilherme Maia de Oliveira Wood, Vitor Geraldi Haase
Summary: Math anxiety is influenced by genetic vulnerability and negative experiences in learning mathematics, and is usually higher in girls. This study explores the role of the monoamine oxidase A gene (MAOA) in math anxiety and its sex differences. The results suggest that girls with the MAOA-L genotype exhibit higher levels of math anxiety.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Oncology
Jing Wei, Lijuan Yin, Jingjing Li, Jing Wang, Tianjie Pu, Peng Duan, Tzu-Ping Lin, Allen C. Gao, Boyang Jason Wu
Summary: The study reveals a reciprocal regulatory circuit between MAOA and AR in prostate cancer, with implications for cancer development and growth, particularly CRPC. Targeting MAOA may enhance the efficacy of AR-targeted therapies.
Review
Cell Biology
Ana Beatriz Castro Goncalves, Caroline Ferreira Fratelli, Jhon Willatan Saraiva Siqueira, Ligia Canongia de Abreu Cardoso Duarte, Aline Ribeiro Barros, Isabella Possatti, Mauricio Lima dos Santos, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da Silva
Summary: This systematic review investigates the influence of MAOA uVNTR polymorphism on MDD and reveals differences in genotypic frequencies between healthy control and MDD groups in different populations, showing consistency across the analyzed articles.
Article
Clinical Neurology
Margus Kanarik, Katre Sakala, Denis Matrov, Tanel Kaart, Arunima Roy, Georg C. Ziegler, Toomas Veidebaum, Klaus-Peter Lesch, Jaanus Harro
Summary: Congenital absence of monoamine oxidase A (MAO-A) activity increases the likelihood of antisocial impulsive behavior, and the MAOA uVNTR low-expressing genotype (MAOA-L) combined with childhood maltreatment is associated with similar phenotypes in males. Family environment may contribute to this behavior through DNA methylation. In a study of 121 males, it was found that methylation levels at CpG3 site of MAOA were significantly lower in individuals with antisocial behavior involving police contact. At age 25, CpG3 methylation was lower in individuals with alcohol use disorder, but only in MAOA-H genotype. The study also found correlations between MAOA CpG3 methylation and adaptive impulsivity in different age groups. CpG3 methylation was associated with dietary intake of several micronutrients, such as zinc and calcium. This study highlights the importance of MAOA CpG3 methylation in understanding impulsive and antisocial behavior, and its potential role as a marker for neuroplasticity.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Psychiatry
Mimi Qiu, Chenchen Zhang, Yu Dai, Lingrui Zhang, Yang Wang, Wei Peng, Yalin Chen, Chao Wen, Hui Li, Tianmin Zhu
Summary: This study identified significantly upregulated expression of MAOA mRNA in peripheral blood mononuclear cells (PBMCs) of patients with PIU, and a significant positive correlation between the relative expression of MAOA mRNA and scores on the Young's Internet Addiction Test and Self-Rating Depression Scale.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Patricia A. Handschuh, Matej Murgas, Chrysoula Vraka, Lukas Nics, Annette M. Hartmann, Edda Winkler-Pjrek, Pia Baldinger-Melich, Wolfgang Wadsak, Dietmar Winkler, Marcus Hacker, Dan Rujescu, Katharina Domschke, Rupert Lanzenberger, Marie Spies
Summary: This study assessed the influence of MAOA promoter/exon I/intron I region DNA methylation on global MAO-A distribution volume using positron emission tomography. No significant influence of MAOA DNA methylation on global MAO-A distribution volume was found. However, season affected average methylation levels in women, with higher levels in spring and summer.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Tuana Kant, Emiko Koyama, Clement C. Zai, Joseph H. Beitchman, James L. Kennedy
Summary: Psychopathic traits may be associated with the gene monoamine oxidase A (MAOA), and developmental factors may play a crucial role in the relationship between MAOA polymorphism and psychopathic traits in males.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Biology
Roger Marcelo Martinez, Tsai-Tsen Liao, Yang-Teng Fan, Yu-Chun Chen, Chenyi Chen
Summary: Martinez, Liao, and colleagues investigate the interaction between variations in genes linked to serotonergic brain function and the processing of fearful stimuli. They find that certain genetic variations are associated with larger fearful MMN amplitudes in males, indicating an impact on threat processing and social cognition.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Rana Ghamari, Fatemeh Yazarlou, Zahra Khosravizadeh, Atefeh Moradkhani, Elaheh Abdollahi, Fatemeh Alizadeh
Summary: Functional polymorphisms in MAOA and SLC6A4 are associated with the occurrence of schizophrenia. The carriers of 5-HTTLPR S allele and STin2.12 repeat are more frequent in schizophrenia patients, and being a carrier of STin2.12 repeat significantly increases the risk of schizophrenia.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Katre Sakala, Urmeli Katus, Evelyn Kiive, Toomas Veidebaum, Jaanus Harro
Summary: Lower platelet monoamine oxidase (MAO) activity has been associated with problem behaviors, including criminal behavior. This longitudinal birth cohort study examined platelet MAO activity and antisocial behavior involving police contact. The findings showed that males with a record of antisocial behavior had lower platelet MAO activity, and this association was independent of smoking. Moreover, females with past antisocial behavior also exhibited lower platelet MAO activity.
Article
Biochemistry & Molecular Biology
Benoit Labonte, Khaled Abdallah, Gilles Maussion, Volodymyr Yerko, Jennie Yang, Thibault Bittar, Francis Quessy, Sam A. Golden, Luis Navarro, Dave Checknita, Carolina Gigek, Juan Pablo Lopez, Rachael L. Neve, Scott J. Russo, Richard E. Tremblay, Gilles Cote, Michael J. Meaney, Naguib Mechawar, Eric J. Nestler, Gustavo Turecki
Summary: High levels of impulsivity and aggressiveness are associated with poor behavioral control, and the molecular mechanisms underlying these traits are not well understood. A newly identified long noncoding RNA, named MAOA-associated lncRNA (MAALIN), has been found to regulate the expression of the MAOA gene in the brain, impacting impulsive and aggressive behaviors through epigenetic mechanisms such as DNA methylation. This study suggests that DNA methylation variations play a role in regulating the expression of MAALIN, affecting MAOA expression and impulsive-aggressive behaviors.
MOLECULAR PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Gabriel Moura Alves Seixas, Renata de Souza Freitas, Caroline Ferreira Fratelli, Calliandra Maria de Souza Silva, Luciano Ramos de Lima, Marina Morato Stival, Silvana Schwerz Funghetto, Izabel Cristina Rodrigues da Silva
Summary: This study analyzed the frequency of the MAOA uVNTR polymorphism genotype in an older adult population diagnosed with diabetes mellitus/arterial hypertension, and associated this frequency with clinical characteristics impacting daily life. The results showed that patients with genotypes solely containing the 3R allele had smoking and alcoholism, and only those with the 3R genotypes (female 3R/3R homozygote or male 3R* hemizygote) were significant. Although not statistically significant, only patients with 3R and 3R/4R genotypes presented cases of severe depression per the revised BDI interpretations.
JOURNAL OF AGING RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Hasan Kaya, Ozlem Bolat Kaya, Asli Enez Darcin, Raziye Sercin Yalcin Cavus, Aybeniz Civan Kahve, Nesrin Dilbaz
Summary: This study investigated the relationship between the MAOA gene polymorphism, temperament characteristics, impulsivity, and alcohol use disorder. The results suggest that novelty seeking and motor impulsivity may be important predictors of alcohol use disorder. The MAOA gene may play an indirect role in the etiology of alcohol use disorders and serve as a partial marker for impulsivity.
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
(2021)
Review
Neurosciences
Sofi da Cunha-Bang, Gitte Moos Knudsen
Summary: The review presents the progress made in understanding the potential link between chronically low brain serotonin levels and impulsive aggression, as well as the effects of serotonin alterations on brain activity in regions involved in impulsive aggression.
Evidence from in vivo molecular neuroimaging suggests associations between impulsive aggression and serotonin receptor binding, transporter levels, and monoamine oxidase A levels, indicating that low brain serotonin levels may be a neurobiological risk factor for impulsive aggressive behavior.
Future studies should focus on assessing unique clinical features of impulsive aggression and investigating knowledge gaps to confirm, refute, or modify proposed models of impulsive aggression.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Haeme R. P. Park, Miranda R. Chilver, Arthur Montalto, Javad Jamshidi, Peter R. Schofield, Leanne M. Williams, Justine M. Gatt
Summary: Higher levels of mental wellbeing are associated with increased neural activity in the brain region involved in processing positive emotions. This association is influenced by unique environmental factors, not genetics.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Fiona Kumfor, Cheng Tao Liang, Jessica L. Hazelton, Cristian E. Leyton, Cassandra Kaizik, Emma Devenney, Emily Connaughton, Robyn Langdon, Eneida Mioshi, John B. Kwok, Carol Dobson-Stone, Glenda M. Halliday, Olivier Piguet, John R. Hodges, Ramon Landin-Romero
Summary: This study explores the presence, severity, content and neural correlates of delusions in a large cohort of dementia patients. The findings reveal that delusions are relatively common in dementia and are associated with unique cognitive and neural characteristics. The results highlight the importance of identifying individuals at risk of neuropsychiatric features in dementia for targeted symptom management.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychiatry
Miranda R. Chilver, Haeme R. P. Park, Peter R. Schofield, C. Richard Clark, Leanne M. Williams, Justine M. Gatt
Summary: Depression and anxiety symptoms are strongly associated with differences in processing fearful and happy facial expressions, as reflected by emotional event-related potentials (ERPs), particularly the N170. However, these alterations are not related to mental wellbeing, indicating that emotional ERPs may be more indicative of mental health issues rather than overall wellbeing, especially in subconscious processing pathways.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Clinical
Arthur Montalto, Haeme R. P. Park, Leanne M. Williams, Mayuresh S. Korgaonkar, Miranda R. Chilver, Javad Jamshidi, Peter R. Schofield, Justine M. Gatt
Summary: The study found that greater resilience to trauma is associated with less activation of the anterior insula during a condition requiring sustained attention. This possibly suggests a pattern of 'neural efficiency' in people who may be more resilient to trauma.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
John C. Morris, Michael Weiner, Chengjie Xiong, Laurel Beckett, Dean Coble, Naomi Saito, Paul S. Aisen, Ricardo Allegri, Tammie L. S. Benzinger, Sarah B. Berman, Nigel J. Cairns, Maria C. Carrillo, Helena C. Chui, Jasmeer P. Chhatwal, Carlos Cruchaga, Anne M. Fagan, Martin Farlow, Nick C. Fox, Bernardino Ghetti, Alison M. Goate, Brian A. Gordon, Neill Graff-Radford, Gregory S. Day, Jason Hassenstab, Takeshi Ikeuchi, Clifford R. Jack, William J. Jagust, Mathias Jucker, Johannes Levin, Parinaz Massoumzadeh, Colin L. Masters, Ralph Martins, Eric McDade, Hiroshi Mori, James M. Noble, Ronald C. Petersen, John M. Ringman, Stephen Salloway, Andrew J. Saykin, Peter R. Schofield, Leslie M. Shaw, Arthur W. Toga, John Q. Trojanowski, Jonathan Voeglein, Stacie Weninger, Randall J. Bateman, Virginia D. Buckles
Summary: This study compared biomarker changes in individuals with autosomal dominant Alzheimer's disease and late onset Alzheimer's disease and found similarities in their pathophysiology, suggesting a shared pathobiological construct.
Article
Behavioral Sciences
Yu Chen, Ramon Landin-Romero, Fiona Kumfor, Muireann Irish, Carol Dobson-Stone, John B. Kwok, Glenda M. Halliday, John R. Hodges, Olivier Piguet
Summary: This study clarifies the impact of C9orf72 repeat expansion on cerebellar integrity in FTD and reveals overlapping patterns of cerebellar atrophy in C9orf72 positive and negative groups. The associations with cognitive functions suggest that the type of pathology linked with cerebellar atrophy is an important variable to consider in future studies.
Article
Clinical Neurology
Thomas Kannampallil, Ruixuan Dai, Nan Lv, Lan Xiao, Chenyang Lu, Olusola A. Ajilore, Mark B. Snowden, Elizabeth M. Venditti, Leanne M. Williams, Emily A. Kringle, Jun Ma
Summary: Using machine learning algorithms, it is possible to predict depression remission for patients undergoing PST treatment, with key predictors including sex, sleep disturbance, sleep-related impairment, and negative problem orientation. The models showed accuracy significantly greater than chance in predicting remission at baseline and 2-months, offering opportunities for personalized early treatment optimization.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Bridget L. Kajs, Peter J. van Roessel, Gwynne L. Davis, Leanne M. Williams, Carolyn I. Rodriguez, Lisa A. Gunaydin
Summary: This study found abnormalities in valence processing in a preclinical rodent model of compulsive behavior similar to those observed in OCD patients. The findings suggest that targeting valence processing alterations could be a novel therapeutic approach for OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Yi-Jun Ge, Ya-Nan Ou, Yue-Ting Deng, Bang-Sheng Wu, Liu Yang, Ya-Ru Zhang, Shi-Dong Chen, Yu-Yuan Huang, Qiang Dong, Lan Tan, Jin-Tai Yu
Summary: In this study, genetic and proteomic data were integrated to prioritize drug targets for neurodegenerative diseases. The analysis identified several proteins as potential targets for different diseases, such as BIN1, GRN, RET, CD38, DGKQ, GPNMB, FCRL3, LMAN2, MAPK3, DHRS11, FAM120B, SHMT1, PSMB3, SARM1, and SCFD1.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Lyndal Henden, Liam G. Fearnley, Natalie Grima, Emily P. McCann, Carol Dobson-Stone, Lauren Fitzpatrick, Kathryn Friend, Lynne Hobson, Sandrine Chan Moi Fat, Dominic B. Rowe, Susan D'Silva, John B. Kwok, Glenda M. Halliday, Matthew C. Kiernan, Srestha Mazumder, Hannah C. Timmins, Margaret Zoing, Roger Pamphlett, Lorel Adams, Melanie Bahlo, Ian P. Blair, Kelly L. Williams
Summary: In this study, we analyzed whole-genome sequencing data from 608 patients with sporadic ALS, 68 patients with sporadic FTD, and 4703 matched controls using three tools. We found that 17.6% of clinically diagnosed ALS and FTD cases had expanded STR alleles reported to be pathogenic or intermediate for other neurodegenerative diseases, providing evidence for their contribution to the development of these diseases. We also identified multiple disease-relevant STR expansions associated with neurodegenerative diseases, highlighting the clinical and pathological pleiotropy of neurodegenerative disease genes and their importance in ALS and FTD.
Review
Cell Biology
Jose L. Marin-Rubio, Ishier Raote, Joseph Inns, Carol Dobson-Stone, Neil Rajan
DISEASE MODELS & MECHANISMS
(2023)
Article
Sport Sciences
Katherine A. A. Collins, Kim M. M. Huffman, Ruth Q. Q. Wolever, Patrick J. J. Smith, Ilene C. C. Siegler, Leanna M. M. Ross, John M. M. Jakicic, Paul T. T. Costa, William E. E. Kraus
Summary: This study aimed to determine if there are race and sex differences in determinants and timing of dropout among individuals enrolled in an exercise and/or caloric restriction intervention. The findings show that regardless of race and sex, most participants dropped out during the ramp period of the exercise intervention.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2023)
Article
Sport Sciences
Katherine A. Collins, Kim M. Huffman, Ruth Q. Wolever, Patrick J. Smith, Leanna M. Ross, Ilene C. Siegler, John M. Jakicic, Paul T. Costa, William E. Kraus
Summary: The purpose of this study was to identify predictors of exercise intervention adherence based on baseline demographic, clinical, and psychosocial factors. 947 adults with dyslipidemia or prediabetes were enrolled in either a control group or one of 10 exercise interventions. The results showed that baseline demographic, clinical, and psychosocial variables explain approximately 22% of the variance in exercise adherence, suggesting the need for further research to identify additional measures to improve adherence.
TRANSLATIONAL JOURNAL OF THE AMERICAN COLLEGE OF SPORTS MEDICINE
(2023)
