Article
Pharmacology & Pharmacy
Mohammed H. Elkomy, Fatma I. Abo El-Ela, Randa Mohammed Zaki, Omar A. Alsaidan, Mohammed Elmowafy, Ameeduzzafar Zafar, Khaled Shalaby, Mohamed A. Abdelgawad, Hany A. Omar, Rania Salama, Hussein M. Eid
Summary: This study developed and optimized a drug-loaded thermosensitive gel for intranasal administration to combat depression. The results demonstrated that compared to other formulations, this thermosensitive gel significantly improved behavioral performance and alleviated neural tissue changes in depressed rats. Further research is needed to determine its effectiveness in humans.
Review
Pharmacology & Pharmacy
Emily R. Trunnell, Constanca Carvalho
Summary: Despite the prevalence of treatment-resistant depression, many pharmaceutical companies have abandoned the development of new antidepressants due to low quality preclinical tests, such as over-reliance on animal behavioral screens like the forced swim test (FST). A retrospective review found that out of 109 compounds tested in the FST, only 28% were explored for antidepressant effects in humans, and only three showed potential efficacy, but are not approved for treating depression. This suggests that the FST may not be a useful screening tool for identifying novel antidepressants.
DRUG DISCOVERY TODAY
(2021)
Article
Neurosciences
A. G. Sartim, J. Marques, K. M. Silveira, P. H. Gobira, F. S. Guimaraes, G. Wegener, S. R. Joca
Summary: The study found that CBD can exhibit antidepressant effects without causing hyperactivity, and it can also inhibit the psychostimulant effects induced by ketamine. The combined administration of CBD and ketamine may be a promising therapeutic strategy for achieving antidepressant effects while reducing unwanted side effects.
Article
Nutrition & Dietetics
Anna Rafalo-Ulinska, Bartlomiej Pochwat, Paulina Misztak, Ryszard Bugno, Agata Kryczyk-Poprawa, Wlodzimierz Opoka, Bozena Muszynska, Ewa Poleszak, Gabriel Nowak, Bernadeta Szewczyk
Summary: This study suggests that zinc deficiency may be an important risk factor for depression and can blunt the effectiveness of antidepressants. Using a rat model, the study found that zinc deficiency worsened depressive-like behaviors, while chronic treatment with antidepressants reduced these symptoms. Zinc deficiency decreased serum and brain zinc levels and affected the levels of zinc transporter proteins. Zinc supplementation may improve the effectiveness of antidepressants for specific depression symptoms.
Article
Behavioral Sciences
Kyle J. Brymer, Erin Y. Kulhaway, John G. Howland, Hector J. Caruncho, Lisa E. Kalynchuk
Summary: Repeated corticosterone injections in rats lead to cognitive deficits and depression-like behavior, highlighting the importance of considering cognitive impairments in assessing depression. Corticosterone significantly affects body weight, immobility in the forced swim test, startle amplitudes, and object recognition memory, suggesting a complex phenotype induced by chronic stress.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Plant Sciences
Taiwo G. Olubodun-Obadun, Ismail O. Ishola, Timisola P. Adesokan, Blessing O. Anih, Olufunmilayo O. Adeyemi
Summary: This study investigates the antidepressant and anxiolytic effects of ethanol seed extract of Cajanus cajan in mice. The extract shows potential in treating anxiety and other neurological disorders, possibly through the involvement of monoaminergic systems and GABA receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Wozniak, Barbara Budzynska
Summary: The study aimed to investigate the sex-dependent effects of imperatorin on antidepressant effects. The results showed that only males responded to imperatorin treatment and exhibited antidepressant effects, while serotonin levels in the prefrontal cortex of females decreased. This suggests that imperatorin may have antidepressant potential, but only in males.
Article
Neurosciences
Arnab Nandi, Garima Virmani, Aatmika Barve, Swananda Marathe
Summary: FST and TST are common behavioral tests for screening antidepressant drugs and assessing non-motor symptoms in movement disorder animal models. Manual analysis of these tests is time-consuming with large variability, but the open-source program DBscorer provides automated and unbiased analysis, allowing for a nuanced understanding of behavioral despair expression.
Article
Biochemistry & Molecular Biology
Liana Fattore, Petra Amchova, Paola Fadda, Jana Ruda-Kucerova
Summary: Depression leads to a decrease in reward sensitivity. In the olfactory bulbectomy (OBX) model of depression, rats showed increased drug-taking and seeking behaviors. Sex played a role in regulating these behaviors. Female rats responded more than males, but this effect was abolished by the OBX lesion. Strain-dependent effects were observed in the modulating role of sex and food restriction on operant responding and food intake.
Article
Integrative & Complementary Medicine
Sun Dan-chen, Wang Ran-ran, Xu Hao, Zhu Xue-hui, Sun Yan, Qiao Shi-qing, Qiao Wei
Summary: This study investigated the pharmacodynamic material basis, mechanism of actions, and targeted diseases of Salicornia europaea L. (SE) using the network pharmacology method. Pharmacological experiments verified the antidepressant-like effect of SE extract and suggested that it may regulate the Nrf2-ARE pathway and increase levels of dopamine and corticosterone in the hippocampus and cortex.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Christiane Brandwein, Cathalijn H. C. Leenaars, Laura Becker, Natascha Pfeiffer, Ana -Maria Iorgu, Melissa Hahn, Gaia A. Vairani, Lars Lewejohann, Andre Bleich, Anne S. Mallien, Peter Gass
Summary: This systematic mapping review provides a comprehensive overview of the evolution and commonly used set-ups of the Porsolt Forced Swim Test in rats. By offering detailed technical aspects and a list of existing publications, it enhances the reproducibility and comparability of this experiment, aiming to reduce animal usage and unnecessary replication.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Faizan Ul Haq, Mohammad Shoaib, Syed Wadood Ali Shah, Haya Hussain, Muhammad Zahoor, Riaz Ullah, Ahmed Bari, Amal Alotaibi, Muhammad Faisal Hayat
Summary: This study aimed to synthesize benzodiazepine derivatives and evaluate their antidepressant potentials. The results showed that compounds 2 and 5 exhibited significant antidepressant effects and increased GABA levels in the brain's hippocampus of experimental animals, indicating the possible involvement of the GABAergic mechanism.
Article
Medicine, Research & Experimental
Banu Cahide Tel, Gokcen Telli, Sevgen Onder, Emirhan Nemutlu, Turgut Emrah Bozkurt
Summary: The study examined the effect of montelukast on depression-like behavior in mice and found that chronic treatment with montelukast was not associated with depression, but there was a confirmed association between asthma and depression. Further research is needed to understand the neuropsychiatric side effects of montelukast.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Neurosciences
Kenneth M. McCullough, Galen Missig, Mykel A. Robble, Allison R. Foilb, Audrey M. Wells, Jakob Hartmann, Kasey J. Anderson, Rachael L. Neve, Eric J. Nestler, Kerry J. Ressler, William A. Carlezon
Summary: This study investigated the roles of two dopamine receptor neurons in the nucleus accumbens in sleep regulation using chemogenetics. The results showed that D1- and D2-MSNs play different roles in sleep regulation, affecting rapid eye movement sleep and slow wave sleep differently.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Behavioral Sciences
Elif Beyza Guven, Nicole Melisa Pranic, Gunes Unal
Summary: Environmental enrichment in rodents has various benefits on physiology, affect, and cognition. On the other hand, social isolation negatively affects neurobiological mechanisms and cognitive performance. This study showed that brief environmental enrichment following long-term social isolation had a significant anxiolytic effect but also increased behavioral despair in rats. Furthermore, the enriched rats exhibited better memory performance in the early stages of a water Y-maze test, indicating faster learning ability.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Manoj P. Dandekar, Dustin Luse, Carson Hoffmann, Patrick Cotton, Travis Peery, Christian Ruiz, Caroline Hussey, Vijayasree V. Giridharan, Jair C. Soares, Joao Quevedo, Albert J. Fenoy
JOURNAL OF AFFECTIVE DISORDERS
(2017)
Review
Biochemistry & Molecular Biology
Manoj P. Dandekar, Samira S. Valvassori, Gustavo C. Dal-Pont, Joao Quevedo
CURRENT DRUG METABOLISM
(2018)
Article
Biochemistry & Molecular Biology
M. P. Dandekar, A. J. Fenoy, A. F. Carvalho, J. C. Soares, J. Quevedo
MOLECULAR PSYCHIATRY
(2018)
Article
Clinical Neurology
Manoj P. Dandekar, Tao Peng, David D. McPherson, Joao Quevedo, Jair C. Soares, Shao-Ling Huang
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2018)
Article
Behavioral Sciences
Manoj P. Dandekar, Kartik T. Nakhate, Dadasaheb M. Kokare, Nishikant K. Subhedar
BEHAVIOURAL BRAIN RESEARCH
(2011)
Article
Medicine, Research & Experimental
Amita A. Bhorkar, Manoj P. Dandekar, Kartik T. Nakhate, Nishikant K. Subhedar, Dadasaheb M. . Kokare
Article
Biochemistry & Molecular Biology
Manoj A. Upadhya, Manoj P. Dandekar, Dadasaheb M. Kokare, Praful S. Singru, Nishikant K. Subhedar
Article
Psychology, Biological
Manoj P. Dandekar, Kartik T. Nakhate, Dadasaheb M. Kokare, Nishikant K. Subhedar
PHYSIOLOGY & BEHAVIOR
(2012)
Article
Neurosciences
Manoj P. Dandekar, Ashwini Saxena, Giselli Scaini, Joo Hyun Shin, Agata Migut, Vijayasree Vayalanellore Giridharan, Yuzhi Zhou, Tatiana Barichello, Jair C. Soares, Joao Quevedo, Albert J. Fenoy
MOLECULAR NEUROBIOLOGY
(2019)
Article
Neurosciences
Manoj P. Dandekar, Ashish P. Bharne, Pradip D. Borkar, Nishikant K. Subhedar, Dadasaheb M. Kokare
Article
Chemistry, Medicinal
Neelima Sinha, Navnath P. Karche, Mahip Kalyan Verma, Sameer S. Walunj, Prashant B. Nigade, Gourhari Jana, Sanjay P. Kurhade, Anil K. Hajare, Ajay R. Tilekar, Ganesh R. Jadhav, Baban R. Thube, Javed S. Shaikh, Sudhakar Balgude, Lairikyengbam Bikramjit Singh, Vijaya Mahimane, Shridhar K. Adurkar, Girish Hatnapure, Firoj Raje, Yogesh Bhosale, Dnyaneshwar Bhanage, Sachchidanand Sachchidanand, Ruchi Dixit, Rajesh Gupta, Anand M. Bokare, Manoj Dandekar, Ashish Bharne, Manavi Chatterjee, Sagar Desai, Sarita Koul, Dipak Modi, Maneesh Mehta, Vinod Patil, Minakshi Singh, Jayasagar Gundu, Rajan N. Goel, Chirag Shah, Sharad Sharma, Dhananjay Bakhle, Rajender Kumar Kamboj, Venkata P. Palle
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Mahip K. Verma, Rajan N. Goel, Anand M. Bokare, Manoj P. Dandekar, Sarita Koul, Sagar Desai, Santoshkumar Tota, Nilendra Singh, Prashant B. Nigade, Vinod B. Patil, Dipak Modi, Maneesh Mehta, Jayasagar Gundu, Sameer S. Walunj, Navnath P. Karche, Neelima Sinha, Rajender K. Kamboj, Venkata P. Palle
Summary: The study introduces a novel alpha 7 nAChR positive allosteric modulator (PAM), LL-00066471, which shows excellent oral bioavailability and potential in symptomatically alleviating cognitive deficits and sensorimotor gating deficits.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Manojkumar R. Shukla, Sukanya Patra, Mahip Verma, Gayathri Sadasivam, Nirmal Jana, Sachin J. Mahangare, Prashant Vidhate, Dipak Lagad, Anand Tarage, Murthy Cheemala, Chaitanya Kulkarni, Shankar Bhagwat, Vinod D. Chaudhari, Majid Sayyed, Vipul Pachpute, Ramesh Phadtare, Gopal Gole, Samiron Phukan, Brahmam Sunkara, Charudatt Samant, Manisha Shingare, Aditya Naik, Sneha Trivedi, Ajit Kumar Marisetti, Madhusudhan Reddy, Milind Gholve, Nilesh Mahajan, Sudeep Sabde, Vinod Patil, Dipak Modi, Maneesh Mehta, Prashant Nigade, Kaustubh Tamane, Swati Tota, Hemant Goyal, Harish Volam, Shashikant Pawar, Prajakta Ahirrao, Lal Dinchhana, Sadanand Mallurwar, Atul Akarte, Anand Bokare, Rupesh Kanhere, Neetinkumar Reddy, Sarita Koul, Manoj Dandekar, Minakshi Singh, Peter R. Bernstein, Lakshmi Narasimham, Mandar Bhonde, Jayasagar Gundu, Rajan Goel, Sanjeev Kulkarni, Sharad Sharma, Rajender Kumar Kamboj, Venkata P. Palle
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Immunology
Ziaur Rahman, Manoj P. Dandekar
Summary: This article discusses the connection between gut microbiota and the host immune system, and how changes in their interaction can affect the incidence of stroke and post-injury neurological issues. The activation of inflammatory cells can lead to systemic inflammation, blood brain barrier disruption, and aggravation of ischemic brain injury. Fine-tuning gut microbiota may help regulate the activation of resident cells in the central nervous system.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Rishabh A. Babel, Manoj P. Dandekar
Summary: Modern lifestyle, changing eating habits, and reduced physical work are known to contribute to the global pandemic of diabetes. Hyperglycemia in diabetes leads to both microvascular and macrovascular complications, with oxidative stress and production of reactive oxygen species playing a central role in the development of these complications.
CURRENT DIABETES REVIEWS
(2021)