Article
Clinical Neurology
Xingming Wang, Akifumi Eguchi, Yuko Fujita, Xiayun Wan, Lijia Chang, Yong Yang, Jiajing Shan, Youge Qu, Li Ma, Yukihiko Shirayama, Chisato Mori, Jianjun Yang, Kenji Hashimoto
Summary: This study found that gut microbiota and microbiome-derived metabolites play important roles in susceptibility versus resilience in rats exposed to inescapable electric stress. The relative abundances of Asaccharobacter, Eisenbergiella, and Klebsiella in the gut microbiota of susceptible rats were significantly higher than that of resilient rats. Additionally, several microbiome and metabolites were found to be significantly altered between susceptible and resilient rats.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Stevenson Desmercieres, Virginie Lardeux, Jean-Emmanuel Longueville, Myriam Hanna, Leigh Panlilio, Nathalie Thiriet, Marcello Solinas
Summary: The newly developed PSS procedure provides a quantifiable breakpoint to measure animals' propensity to continue working for a reward despite progressively increasing electric shock intensity. The break point is sensitive to hunger and changes in the qualitative incentive value of the reward, and it shows differences compared to the traditional PR procedure.
Article
Biochemistry & Molecular Biology
Michelle Ren, Shahrdad Lotfipour
Summary: Communication between the brain and gut bacteria affects drug and addiction behaviors. Researchers investigated the impact of gut microbiota on fentanyl reinforcement and reward by depleting gut bacteria in adult male and female rats using antibiotics and allowing them to self-administer fentanyl. The results showed that antibiotic treatment increased fentanyl self-administration in males, but not females, at the lowest reinforcement schedule. Both males and females treated with antibiotics self-administered higher amounts of fentanyl at higher reinforcement schedules. Replenishing microbial metabolites restored normal fentanyl self-administration levels, indicating a significant relationship between gut microbiome and opioid use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
David De Sa Nogueira, Romain Bourdy, Rafael Alcala-Vida, Dominique Filliol, Virginie Andry, Yannick Goumon, Jean Zwiller, Pascal Romieu, Karine Merienne, Mary C. Olmstead, Katia Befort
Summary: This study investigated the long-term adaptations induced by cocaine self-administration, including transcriptional modifications and associated epigenetic processes. The results suggest that the endogenous cannabinoid system may play a role in this process, and highlight the key role of the hippocampus in cocaine-induced plasticity.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dmitrii S. Traktirov, Ilya R. Nazarov, Valeria S. Artemova, Raul R. Gainetdinov, Nina S. Pestereva, Marina N. Karpenko
Summary: This article explores the roles of dopamine and serotonin in the central nervous system and the impact of knockout of the DAT gene on neurotransmission. The study reveals that excessive dopamine leads to dysregulation of neurotransmission in multiple brain regions and significant effects on the serotonin system. These findings highlight the importance of considering these factors in drug therapies.
Article
Behavioral Sciences
John T. Madden, Nicole C. Reyna, Emerald Goranson, Tiffany A. Gonzalez, Arturo R. Zavala, Nathan S. Pentkowski
Summary: Research has shown that pretreatment with the selective 5-HT2A receptor antagonist M100907 dose-dependently attenuated the acquisition of methamphetamine-induced CPP in adult female rats, indicating the involvement of the 5-HT2A receptor subtype in the behavioral effects of methamphetamine.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychology, Biological
John M. Holden
Summary: This study examined the effectiveness of serotonergic anti-depressants in reducing sign-tracking behavior and preventing cue-triggered relapse. The results showed that these drugs were able to reduce sign-tracking behavior, although their effects on goal-tracking varied.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Panayotis K. Thanos, Madison McCarthy, Daniela Senior, Samantha Watts, Carly Connor, Nikki Hammond, Kenneth Blum, Michael Hadjiargyrou, David Komatsu, Heinz Steiner
Summary: This study found that chronic co-administration of methylphenidate (MP) and fluoxetine (FLX) can significantly reduce depressive and anxiety-like behaviors, as well as increase overall activity levels. These results provide important insights into the potential neurobiological and neurochemical effects of simultaneously using these two drugs.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Business
Andy Luse, Jim Burkman
Summary: Research shows that attribution theory has untapped potential in studying issues in management and social science, yet lacks a concise measurement tool; limitations of previous measures, such as psychometric issues, may hinder its application in the business domain; developing a new set of scales has resulted in a stable, parsimonious instrument for measuring attribution style.
JOURNAL OF BUSINESS RESEARCH
(2022)
Article
Sport Sciences
Yu Zhou, Graham Finlayson, Xudong Liu, Qichen Zhou, Tianze Liu, Chenglin Zhou
Summary: The study examined the effects of acute moderate-intensity dance and aerobic exercise on drug craving, appetite, prefrontal neural activation to food cues, and food reward in women with methamphetamine dependence. Results showed that both interventions reduced subjective craving for drugs and increased implicit wanting and relative preferences for high-calorie savory foods. The findings suggest that moderate-intensity exercise can be used as a therapeutic intervention to restore the balance between drug and nondrug rewards.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Neurosciences
Gaelle Augier, Veronika Schwabl, Asmae Lguensat, Mihai Atudorei, Osamudiamen Consoler Iyere, Sandra Eriksson Solander, Eric Augier
Summary: Animal models of substance use disorders have limited translation, and the availability of non-drug rewards as an alternative has been overlooked. Previous studies showed that rats prefer alcohol over a sweet reward, but it is unknown if this preference extends to social rewards. In this study, we found that rats consistently chose alcohol over social interaction, regardless of the social partner or housing conditions. These results suggest that the social choice model may not apply to alcohol, highlighting the potential role of specific interactions between alcohol and social reward.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Diana M. Cortes-Patino, Valentyna Martin Neira, Hans Ballesteros-Acosta, Angie Bustos-Rangel, Marisol R. Lamprea
Summary: Adolescents are highly sensitive to both nicotine and social interaction, and when presented together, they enhance the incentive value of the context. This study aimed to examine the interaction between nicotine and social reward in group-reared male adolescent rats using a conditioned place preference model (CPP). The results showed that the joint presentation of nicotine and social reward induced CPP, and this coincided with an increase in TH levels in socially conditioned rats.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Environmental Studies
Tianyu Ying, Jingyi Tang, Jun Wen, Shun Ye, Yaqing Zhou, Fangxuan (Sam) Li
Summary: This study investigates how constraints influence pet owners' travel intentions and how these barriers can be overcome using a two-step, mixed-methods approach. Perceived constraints can inhibit traveling with pets through increased learned helplessness, however, negotiation can reduce helplessness and encourage pet owners' tourism participation. Implications and limitations are discussed.
TOURISM MANAGEMENT
(2021)
Review
Pharmacology & Pharmacy
Xiaohang Che, Jialing Cai, Yueyang Liu, Tianyu Xu, Jingyu Yang, Chunfu Wu
Summary: This article discusses the role of oxytocin in treating drug addiction, including its effects on drug reward, stress responses, and social impairments. Studies have shown that oxytocin administration can alleviate drug-induced neurobehavioral changes and be beneficial in reducing substance use disorders of various drugs.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Clinical Neurology
Anthony Yuan, Catherine Claussen, Zachary Jones, Bin Tang, Nachum Dafny
Summary: Methylphenidate increases dopamine, norepinephrine, and serotonin levels in the brain, affecting neurocognitive function. This study recorded neuronal activity in different brain regions of rats and found that chronic methylphenidate administration led to either behavioral sensitization or tolerance. The dorsal raphe nucleus showed the most significant response to methylphenidate compared to other brain areas.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Biochemistry & Molecular Biology
Jacob T. Beckley, Patrick K. Randall, Rachel J. Smith, Benjamin A. Hughes, Peter W. Kalivas, John J. Woodward
Article
Neurosciences
Jacob T. Beckley, Sophie Laguesse, Khanhky Phamluong, Nadege Morisot, Scott A. Wegner, Dorit Ron
JOURNAL OF NEUROSCIENCE
(2016)
Article
Behavioral Sciences
Jazmin Fontenot, Esteban C. Loetz, Matthew Ishiki, Sondra T. Bland
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Chemistry, Medicinal
John V. Mulcahy, Hassan Pajouhesh, Jacob T. Beckley, Anton Delwig, J. Du Bois, John C. Hunter
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Developmental Biology
Lamya'a M. Dawud, Esteban C. Loetz, Brian Lloyd, Rachel Beam, Simon Tran, Kim Cowie, Kim Browne, Tassawwar Khan, Richard Montoya, Benjamin N. Greenwood, Sondra T. Bland
Summary: This study explored the impact of post-weaning social isolation (PSI) on conditioned social fear development, finding that PSI rats displayed a unique circling behavior that was enhanced after paired treatment. Furthermore, social behaviors were altered by both PSI and the paired footshock and social CS, with differences observed in the mTOR pathway between male and female rats.
DEVELOPMENTAL PSYCHOBIOLOGY
(2021)
Article
Psychology, Biological
Richard J. Johnson, William L. Wilson, Sondra T. Bland, Miguel A. Lanaspa
Summary: This study suggests a link between fructose intake and behavioral disorders, proposing that high sugar and HFCS intake may cause hyperactive foraging responses that increase the risk for ADHD, bipolar disease, and aggressive behavior. Chronic stimulation of the pathway driven by high glycemic carbohydrates and sugars could lead to desensitization of hedonic responses and induce depression.
EVOLUTION AND HUMAN BEHAVIOR
(2021)
Article
Behavioral Sciences
Nicolette A. Moya, Margaret K. Tanner, Abigail M. Smith, Aleezah Balolia, Jazmyne K. P. Davis, Kelsey Bonar, Jennifer Jaime, Troy Hubert, Jorge Silva, William Whitworth, Esteban C. Loetz, Sondra T. Bland, Benjamin N. Greenwood
NEUROBIOLOGY OF LEARNING AND MEMORY
(2020)
Article
Anesthesiology
Jacob T. Beckley, Hassan Pajouhesh, George Luu, Sheri Klas, Anton Delwig, Dennis Monteleone, Xiang Zhou, Denise Giuvelis, Ian D. Meng, David C. Yeomans, John C. Hunter, John Mulcahy
Summary: The voltage-gated sodium channel Na(v)1.7 plays a crucial role in pain signal transmission, making it a promising target for analgesic therapy. The small molecule Na(v)1.7 inhibitor ST-2530 demonstrated high selectivity for human Na(v)1.7 and exhibited potent analgesic effects in various mouse pain models, without affecting motor function.
Article
Multidisciplinary Sciences
H. Pajouhesh, J. T. Beckley, A. Delwig, H. S. Hajare, G. Luu, D. Monteleone, X. Zhou, J. Ligutti, S. Amagasu, B. D. Moyer, D. C. Yeomans, J. Du Bois, J. V. Mulcahy
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Medicinal
Matthew D. Hill, Maria-Jesus Blanco, Francesco G. Salituro, Zhu Bai, Jacob T. Beckley, Michael A. Ackley, Jing Dai, James J. Doherty, Boyd L. Harrison, Ethan C. Hoffmann, Tatiana M. Kazdoba, David Lanzetta, Michael Lewis, Michael C. Quirk, Albert J. Robichaud
Summary: NMDAR PAMs have emerged as a powerful mechanism for treating CNS disorders. The discovery of the endogenous neuroactive steroid 24(S)-hydroxycholesterol as an NMDAR PAM has led to the development of the oral drug candidate SAGE-718. This compound has shown promising results in phase 1 and is currently undergoing phase 2 clinical trials for the treatment of cognitive impairment in Huntington's disease.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Hassan Pajouhesh, Anton Delwig, Jacob T. Beckley, Sheri Klas, Dennis Monteleone, Xiang Zhou, George Luu, J. Du Bois, John C. Hunter, John V. Mulcahy
Summary: The voltage-gated sodium channel isoform Na(V)1.7 has been identified as a potential target for pain treatment, but selectivity over other related proteins has been a challenge. By utilizing a unique sequence variation in primate Na(V)1.7, a series of inhibitors have been discovered, with compound 25 exhibiting high selectivity and efficacy in a preclinical pain model.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Weiting Tang, Jacob T. Beckley, Jin Zhang, Rui Song, Yuchen Xu, Sukhan Kim, Michael C. Quirk, Albert J. Robichaud, Eva Sarai Diaz, Scott J. Myers, James J. Doherty, Michael A. Ackley, Stephen F. Traynelis, Hongjie Yuan
Summary: N-methyl-D-aspartate receptors (NMDARs) are crucial for brain functions and neuropathological conditions. Endogenous neuroactive steroids and synthetic analogs derived from them enhance NMDAR function. This study explores their mechanism of action and their potential for treating NMDAR-related neuropsychiatric disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jacob T. Beckley, Teresa K. Aman, Michael A. Ackley, Tatiana M. Kazdoba, Michael C. Lewis, Anne C. Smith, Brandon J. Farley, Jing Dai, Wayne Deats, Ethan Hoffmann, Albert J. Robichaud, James J. Doherty, Michael C. Quirk
Summary: This study identified a neuroactive steroid NMDA receptor PAM called SAGE-718, which improves conditions associated with NMDA receptor hypofunction by increasing channel open probability.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Brian A. Lloyd, Holly S. Hake, Takayuki Ishiwata, Caroline E. Farmer, Esteban C. Loetz, Monika Fleshner, Sondra T. Bland, Benjamin N. Greenwood
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Behavioral Sciences
Dayton J. Goodell, Megan A. Ahern, Jessica Baynard, Vanessa L. Wall, Sondra T. Bland
BEHAVIOURAL BRAIN RESEARCH
(2017)