Article
Clinical Neurology
Stephen M. Wilson, Jillian L. Entrup, Sarah M. Schneck, Caitlin F. Onuscheck, Deborah F. Levy, Maysaa Rahman, Emma Willey, Marianne Casilio, Melodie Yen, Alexandra C. Brito, Wayneho Kam, L. Taylor Davis, Michael de Riesthal, Howard S. Kirshner
Summary: Most individuals with aphasia after stroke recover to some extent in the first year, and the recovery process is partially dependent on lesion location and extent. This study aims to provide a comprehensive description of patterns of recovery from aphasia in the first year after stroke. It found that lesion location and extent, as well as different language domains, have an impact on aphasia recovery.
Article
Clinical Neurology
James D. Stefaniak, Fatemeh Geranmayeh, Matthew A. Lambon Ralph
Summary: The recovery of language abilities in aphasia patients is heterogeneous and multidimensional, with different components of language showing distinct recovery trajectories. These components rely on different neural regions, suggesting that treatment strategies should be personalized based on individual language profiles to be effective.
Article
Rehabilitation
Julius Fridriksson, Alexandra Basilakos, Mary Boyle, Leora R. Cherney, Gayle DeDe, Jean K. Gordon, Stacy M. Harnish, Elizabeth L. Hoover, William D. Hula, Rebecca Hunting Pompon, Lorelei Phillip Johnson, Swathi Kiran, Laura L. Murray, Miranda L. Rose, Jessica Obermeyer, Christos Salis, Grant M. Walker, Nadine Martin
Summary: Behavioral communication treatment is supported as the standard of care for aphasia. The lack of a common framework to describe individual treatments hinders progress in the field. The Rehabilitation Treatment Specification System (RTSS) provides a systematic way to characterize aphasia treatment approaches, improving communication and facilitating comparisons.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Neurosciences
Max Wawrzyniak, Hans R. Schneider, Julian Klingbeil, Anika Stockert, Gesa Hartwigsen, Cornelius Weiller, Dorothee Saur
Summary: Diaschisis is a phenomenon observed in stroke patients, characterized by neuronal dysfunction in regions connected to the infarction site but spared by the lesion. This study found that the resolution of diaschisis contributes to the early recovery of language function in patients with post-stroke aphasia.
Article
Neurosciences
Janina Wilmskoetter, Xiaosong He, Lorenzo Caciagli, Jens H. Jensen, Barbara Marebwa, Kathryn A. Davis, Julius Fridriksson, Alexandra Basilakos, Lorelei P. Johnson, Chris Rorden, Danielle Bassett, Leonardo Bonilha
Summary: This study used network control theory to evaluate aphasia recovery after stroke. By reconstructing the whole-brain connectome, the researchers found that regional controllability measures were associated with treatment outcomes. The inferior frontal gyrus was the strongest predictor of recovery, outperforming traditional graph theory and demographic measures.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Aleksi J. Sihvonen, Veronika Vadinova, Kimberley L. Garden, Marcus Meinzer, Tracy Roxbury, Kate O'Brien, David Copland, Katie L. McMahon, Sonia L. E. Brownsett
Summary: Poststroke aphasia, caused by left-lateralized language network damage, is often accompanied by uncertainty in the contribution of the right hemisphere's homologues to aphasia recovery. In this study, the role of the right hemisphere's structural connectome in aphasia recovery was investigated. The results showed that certain pathways in the right hemisphere white matter made a maladaptive contribution to language recovery, while others supported the recovery of language comprehension abilities.
HUMAN BRAIN MAPPING
(2023)
Review
Clinical Neurology
Melissa D. Stockbridge, Lisa D. Bunker, Argye E. Hillis
Summary: This review discusses recent clinical investigations on rehabilitation in multiple functional domains, focusing on the needs and innovative research methods for stroke patients. Despite the attention on technological advancements such as virtual reality and robotics, consistent improvements have not been achieved.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Health Care Sciences & Services
Claire Cordella, Michael Munsell, Jason Godlove, Veera Anantha, Mahendra Advani, Swathi Kiran
Summary: This study investigates the effects of different dosage frequencies on the performance outcomes of individuals with poststroke speech, language, and cognitive deficits. The results demonstrate that higher dosage frequency is associated with greater therapy gains.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Clinical Neurology
Kathryn S. Hayward, Leonid Churilov, Emily J. Dalton, Amy Brodtmann, Bruce C. V. Campbell, David Copland, Numa Dancause, Erin Godecke, Tammy C. Hoffmann, Natasha A. Lannin, Matthew W. McDonald, Dale Corbett, Julie Bernhardt
Summary: The challenges of articulating dose in nonpharmacological stroke recovery research include the absence of specific internationally agreed dose reporting guidelines, inadequate conceptualization of dose, and unclear and inconsistent terminology. To address these challenges, a consistent approach to dose articulation is needed to stimulate critical thinking during intervention development and improve the accuracy of reported intervention doses.
Article
Neurosciences
Rebecca Roth, Natalie Busby, Janina Wilmskoetter, Deena Schwen Blackett, Ezequiel Gleichgerrcht, Lisa Johnson, Chris Rorden, Roger Newman-Norlund, Argye E. Hillis, Dirk B. den Ouden, Julius Fridriksson, Leonardo Bonilha
Summary: In post-stroke aphasia, language improvements following speech therapy are variable and can only be partially explained by the lesion. Brain tissue integrity beyond the lesion (brain health) may influence language recovery and can be impacted by cardiovascular risk factors, notably diabetes. We examined the impact of diabetes on structural network integrity and language recovery.
Article
Neurosciences
Michele Masson-Trottier, Tanya Dash, Pierre Berroir, Ana Ines Ansaldo
Summary: Studies have shown that bilingual individuals have an advantage in cognitive control tasks and in recovery from aphasia. The structural changes in the right hemisphere gray matter and improved performance in picture-naming tasks and narrative discourse suggest a bilingual advantage, potentially due to enhanced cognitive control abilities supported by right hemisphere neural reserve.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Yuying Zhou, Xiaoxia Du, Jun Xiao, Yunpeng Cao, Qihao Guo, Aihong Zhou, Jiong Zhou, Nan Li, Yinhua Wang, Lifei Jiao
Summary: The survey revealed knowledge gaps among physicians in China regarding the assessment and management of poststroke aphasia, with most physicians using a combination of drug and non-drug treatments. There is a pressing need for clinical guidelines and standardization of treatment for poststroke aphasia in China.
Article
Audiology & Speech-Language Pathology
Durjoy Lahiri, Alfredo Ardila, Souvik Dubey, Alok Mukherjee, Kingshuk Chatterjee, Biman Kanti Ray
Summary: Bilingual patients showed better recovery in post-stroke aphasia compared to monolingual patients, across different variables such as stroke location, gender, and age groups. They had higher recovery probability, better improvement in severity assessment, and higher AQ improvement than monolinguals. This study is the first to report differences in aphasia recovery between bilingual and monolingual individuals.
Article
Clinical Neurology
Bing-Fong Lin, Shih-Ching Yeh, Yu-Chieh Jill Kao, Chia-Feng Lu, Po-Yi Tsai
Summary: This study evaluated the effects of low-frequency rTMS on chronic poststroke aphasia and found that it can improve language abilities through functional remodeling.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Julius Fridriksson, Argye Elizabeth Hillis
Summary: Aphasia, a common and devastating condition after stroke, is primarily treated with behavioral speech and language therapy. Recent studies suggest that aphasia therapy can improve language processing for many patients, although responses vary among patients with different severity levels.
Article
Neurosciences
Marcelo L. Berthier, Guadalupe Davila, Maria Jose Torres-Prioris, Ignacio Moreno-Torres, Jordi Clarimon, Oriol Dols-Icardo, Maria J. Postigo, Victoria Fernandez, Lisa Edelkraut, Lorena Moreno-Campos, Diana Molina-Sanchez, Paloma Solo de Zaldivar, Diana Lopez-Barroso
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Neurosciences
Marcelo L. Berthier, Lisa Edelkraut, Bettina Mohr, Friedemann Pulvermueller, Sergio E. Starkstein, Cristina Green-Heredia, Guadalupe Davila
Summary: This study evaluated the effects of Intensive Language-Action Therapy (ILAT) on language and mood outcomes in individuals with fluent post-stroke aphasia. The results showed that participants receiving ILAT had significant improvements in depression and aphasia severity scores, while no significant changes were found in the control group.
NEUROPSYCHOLOGICAL REHABILITATION
(2022)
Article
Geriatrics & Gerontology
Marcelo L. Berthier, Florencia Hoet, Alvaro Beltran-Corbellini, Daniel Santana-Moreno, Lisa Edelkraut, Guadalupe Davila
Summary: The study reported findings from two elderly patients with PSP who presented with dynamic aphasia and irrepressible echolalia. Despite markedly impoverished verbal production, their performance in other tasks and auditory comprehension were preserved or only mildly impaired. Experimental tests revealed impaired word and sentence generation in response to verbal and non-verbal stimuli.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Audiology & Speech-Language Pathology
Marcelo L. Berthier, Daniel Santana-Moreno, Alvaro Beltran-Corbellini, Juan C. Criado-Alamo, Lisa Edelkraut, Diana Lopez-Barroso, Guadalupe Davila, Maria Jose Torres-Prioris
Summary: This pilot study aimed to evaluate the effectiveness of a cholinergic enhancing drug combined with speech language therapy in reducing SPs and other non-perseverative semantic errors in a person with chronic post-stroke aphasia. The results showed that the combined therapy significantly reduced SPs and improved everyday communication with low doses of donepezil.
Article
Audiology & Speech-Language Pathology
M. Ali, A. Lifshitz Ben Basat, M. Berthier, M. Blom Johansson, C. Breitenstein, D. A. Cadilhac, F. Constantinidou, M. Cruice, G. Davila, M. Gandolfi, M. Gil, R. Grima, E. Godecke, L. Jesus, L. Martinez Jiminez, M. Kambanaros, T. Kukkonen, A. Laska, I Mavis, R. Mc Menamin, C. Mendez-Orellana, H. Obrig, P. Ostberg, H. Robson, K. Sage, M. Van De Sandt-koenderman, K. Sprecht, E. Visch-Brink, E. Wehling, S. Wielaert, S. J. Wallace, L. J. Williams, M. C. Brady
Summary: This study aims to document and inform international delivery of post-stroke aphasia treatment to optimize recovery and reintegration of people with aphasia. It is a prospective, multi-center open study focusing on participants with post-stroke aphasia, assessing outcomes at baseline, discharge, 6 months, and 12 months post-stroke. The research will explore associations between demographics, therapy, medication use, and outcomes to identify cost-effective approaches for optimizing rehabilitation and benefiting people with aphasia.
Review
Neurosciences
Friedemann Pulvermueller, Rosario Tomasello, Malte R. Henningsen-Schomers, Thomas Wennekers
Summary: Neural network models have the potential to improve our understanding of brain functions, but they need to be more neurobiologically realistic. Although these models have advanced significantly, there are still imperfections in their similarity to aspects of brain anatomy and physiology.
NATURE REVIEWS NEUROSCIENCE
(2021)
Article
Neurosciences
Rosario Tomasello, Luigi Grisoni, Isabella Boux, Daniela Sammler, Friedemann Pulvermueller
Summary: Speech prosody provides important clues about the speaker's communicative intentions. This study used high-density electroencephalography (EEG) to investigate the neurophysiological basis of intonation and speech act understanding, finding that prosodic features are reflected at the neurophysiological level. The results demonstrate that humans can rapidly detect and understand speaker intentions in linguistic interactions through neurophysiological indexes when pragmatic and lexico-semantic information are fully expressed.
Editorial Material
Neurosciences
Guadalupe Davila, Heidi M. Feldman, Diana Lopez-Barroso
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Correction
Psychology, Experimental
Malte R. Henningsen-Schomers, Friedemann Pulvermueller
PSYCHOLOGICAL RESEARCH-PSYCHOLOGISCHE FORSCHUNG
(2022)
Article
Psychology, Experimental
Malte R. Henningsen-Schomers, Friedemann Pulvermuller
Summary: A neurobiologically constrained deep neural network was used to investigate the formation of conceptual categories and semantic feature extraction. The study found that concrete concepts have complete feature sharing among instances, while abstract concepts have less feature overlap between instances, which may explain the difficulty children face when learning abstract words.
PSYCHOLOGICAL RESEARCH-PSYCHOLOGISCHE FORSCHUNG
(2022)
Article
Psychiatry
Lisa Edelkraut, Diana Lopez-Barroso, Maria Jose Torres-Prioris, Sergio E. Starkstein, Ricardo E. Jorge, Jessica Aloisi, Marcelo L. Berthier, Guadalupe Davila
Summary: The study consists of a literature review and an observational study on neuropsychiatric symptoms (NPS) in post-stroke aphasia patients. The literature review reveals a wide range of NPS in this population, highlighting the need for improved assessment and treatment approaches. The observational study shows that the majority of participants experienced depressive symptoms, followed by agitation/aggression and irritability.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Article
Behavioral Sciences
Luigi Grisoni, Friedemann Pulvermueller
Summary: The recent finding of predictive brain signals preceding anticipated perceptual and linguistic stimuli raises new questions for experimental research. This study investigates the neural basis of phonological predictions and their relationship to phonological priming. The results show that expected stimuli induce a slow anticipatory activity, while incongruent pairings elicit weaker post-stimulus responses.
Article
Audiology & Speech-Language Pathology
Isabella P. Boux, Konstantina Margiotoudi, Felix R. Dreyer, Rosario Tomasello, Friedemann Pulvermueller
Summary: The study found that indirect replies were less certain, less predictable, less coherent with and less semantically similar to their context question compared to direct replies. These effects were smaller when direct and indirect replies were matched for the type of speech acts for which they were used. All measured cognitive dimensions were strongly associated with each other.
LANGUAGE COGNITION AND NEUROSCIENCE
(2023)
Article
Biology
Malte R. Henningsen-Schomers, Max Garagnani, Friedemann Pulvermueller
Summary: A neurobiologically constrained model was used to simulate the acquisition of concrete and abstract concepts in the human brain. The study found that the presence of verbal labels improved the learning of categories, especially for abstract concepts.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Lea Doppelbauer, Bettina Mohr, Felix R. Dreyer, Benjamin Stahl, Verena Buescher, Friedemann Pulvermueller
Summary: The study demonstrates that intensive language-action therapy can sustainably improve language functions in patients with chronic aphasia for up to 2.5 years. Younger patients may retain these improvement effects better. However, the long-term stability of communicative efficacy remains uncertain.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)