Review
Medicine, General & Internal
Joht Singh Chandan, Kirsty Brown, Nikita Simms-Williams, Jenny Camaradou, Nasir Bashir, Dominic Heining, Olalekan Lee Aiyegbusi, Grace Turner, Samantha Cruz Rivera, Richard Hotham, Krishnarajah Nirantharakumar, Manoj Sivan, Kamlesh Khunti, Devan Raindi, Steven Marwaha, Sarah E. Hughes, Christel McMullan, Melanie Calvert, Shamil Haroon
Summary: This article discusses postviral syndromes (PVS), specifically the non-pharmacological treatments for long COVID, and summarizes the symptoms and health impacts associated with PVS. The research methods include literature searches and data extraction, with effect estimates being pooled through meta-analysis. The findings of this study will be published in peer-reviewed journals and shared with clinical and patient groups.
Review
Clinical Neurology
Lauren S. Krivitzky, Robyn Westmacott, Richard Boada, Leigh Sepeta, Lauren Reppert, Christine Mrakotsky
Summary: Significant progress has been made in the treatment of acute and chronic medical consequences of stroke in childhood. This article provides a review of the current literature on neuropsychological outcomes in pediatric stroke and discusses recent developments in functional neuroimaging and rehabilitation intervention models. Future directions for clinical practice and research in pediatric stroke are also discussed.
Review
Clinical Neurology
Kah Hui Yap, Shahrul Azmin, Jemaima Che Hamzah, Norfazilah Ahmad, Bart van de Warrenburg, Norlinah Mohamed Ibrahim
Summary: Spinocerebellar ataxias are a rare genetic subgroup within degenerative ataxias, lacking an evidence-based review on management. Pharmacological and non-pharmacological management of SCA present challenges and require further investigation.
JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Yu Shi, Wen Wu
Summary: This review explores the mechanisms and clinical potential of non-invasive non-pharmacological therapies (NINPT) for chronic pain populations. NINPT utilizes peripheral, spinal, and supraspinal mechanisms to restore normal pain processing and limit central sensitization. However, further research is needed to optimize treatment protocols and individual responses through precision medicine approaches.
Article
Biochemistry & Molecular Biology
Samo Ribaric
Summary: This narrative review summarizes the evidence supporting physical exercise as a non-pharmacological intervention for delaying cognitive decline in patients with Alzheimer's disease. It suggests that physical exercise can improve cardiovascular fitness and attenuate neuroinflammation, thus potentially mitigating the symptoms and progression of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Laura H. H. Malinin, Meara Faw, Deana Davalos
Summary: Participation in psychosocial enrichment activities, such as music and arts programming, can delay or reduce functional decline in individuals with dementia. This community case study describes a performing-arts program that engaged people with dementia and their informal care partner in existing performing-arts programs, providing social hours and season tickets. The program evaluation suggests strategies and benefits of designing performing-arts programs as psychosocial interventions in other communities.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Clinical Neurology
Ping Lin, Junyu Sun, Qi Cheng, Yue Yang, Dennis Cordato, Jianqun Gao
Summary: Alzheimer's disease is a progressive neurodegenerative disorder without a cure. There is a growing need for more promising therapies due to the increasing elderly population worldwide. Recent efforts in clinical trials have focused on disease modification and symptomatic treatment, with varying results reported. The outcome of these trials and mechanisms of therapeutic agents are critical for guiding future drug development strategies.
NEUROLOGY AND THERAPY
(2021)
Review
Medicine, General & Internal
Guanyu Hu, Hongshi Zhang, Yufeng Wang, Deyu Cong
Summary: This study aims to assess the relative efficacy and safety of different non-pharmacological interventions for PSS rehabilitation, providing evidence to support the optimization of rehabilitation programs.
Article
Biochemistry & Molecular Biology
Aleksandra N. Mladenovic Djordjevic, Marianna Kapetanou, Natasa Loncarevic-Vasiljkovic, Smilja Todorovic, Sofia Athanasopoulou, Milena Jovic, Milica Prvulovic, Era Taoufik, Rebecca Matsas, Selma Kanazir, Efstathios S. Gonos
Summary: This study demonstrated the potential therapeutic effect of proteasome activation in alleviating Alzheimer's disease pathology in a transgenic mouse model. Activation of proteasome led to reduced amyloid-beta load, improved motor functions, reduced anxiety, and reduced frailty level, opening up new directions for future therapeutic interventions targeting proteasome-mediated proteolysis enhancement.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Alina Renner, Sharon Jean Baetge, Melanie Filser, Stephanie Lau, Jana Poettgen, Iris-Katharina Penner
Summary: This study aimed to investigate the efficacy of two non-pharmacological interventions in individuals with progressive multiple sclerosis (PMS). The results showed that computerized cognitive training improved immediate and delayed verbal memory, recognition, verbal working memory, and perceived cognitive deficits, but also led to increased anxiety. Participants who received cognitive-behavioral therapy reported high program satisfaction and less cognitive difficulties. The combination of both interventions yielded better performance in immediate and delayed verbal memory, and information processing speed, and also had positive effects on anxiety and depression.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Respiratory System
Sandhya Matthes, Johannes Holl, Johannes Randerath, Marcel Treml, Michael Bockover, Simon Herkenrath, Lars Hagmeyer, Johannes Knoch, Ulrike Oesterlee, Georgios Sofianos, Winfried Randerath
Summary: A retrospective observational study was conducted on consecutive COVID-19 hospital admissions in a university-affiliated pulmonary centre in Germany. The study found that most patients could be treated with the maximum required therapy according to disease severity following the national guidelines, and the escalation of therapy modality was associated with disease severity and mortality.
Article
Endocrinology & Metabolism
Matteo Ponzano, N. Tibert, S. Brien, L. Funnell, J. C. Gibbs, H. Keller, J. Laprade, S. N. Morin, A. Papaioannou, Z. Weston, T. H. Wideman, L. M. Giangregorio
Summary: We found a knowledge gap in the management of osteoporotic vertebral fractures without drugs and surgery. This international consensus process has established multidisciplinary biopsychosocial recommendations for pain, nutrition, safe movement, and exercise in individuals with acute and chronic vertebral fractures. These recommendations will guide clinical practice and inform future research.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Verity Longley, Christine Hazelton, Calvin Heal, Alex Pollock, Kate Woodward-Nutt, Claire Mitchell, Gorana Pobric, Andy Vail, Audrey Bowen
Summary: The effects of non-pharmacological interventions for spatial neglect in patients following stroke remain unclear. There is insufficient evidence to support or refute any specific rehabilitation approach based on current randomized controlled trials. Future research should focus on high-quality methodological design and outcomes that are important to patients, as well as involve patient and public participation to improve the quality of research.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Clinical Neurology
Elena Gambella, Arianna Margaritini, Marco Benadduci, Lorena Rossi, Paola D'Ascoli, Giovanni R. R. Riccardi, Sara Pasquini, Patrizia Civerchia, Giuseppe Pelliccioni, Roberta Bevilacqua, Elvira Maranesi
Summary: This study aims to evaluate the effectiveness of a treatment approach that combines cognitive training and physical exercise with virtual reality and reminiscence elements for patients with mild Alzheimer's disease. The study recruited 78 patients and conducted treatment sessions and evaluations. The ultimate goal is to improve the patients' cognitive status and quality of life.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Xinlu Wang, Ning Ding, Yuanjie Sun, Yu Chen, Hangyu Shi, Lili Zhu, Shuai Gao, Zhishun Liu
Summary: This study reviews the literature on non-pharmacologic therapies for chronic pelvic pain (CPP) in adult women, and summarizes the most commonly used non-pharmacologic treatments. By evaluating the effectiveness and safety of each therapy, the study concludes that non-pharmacologic therapies should be included in the initial treatment plan due to their high degree of safety and low rate of side effects. The study provides evidence to fill the lack of data on non-pharmacologic therapies for CPP.
Article
Geriatrics & Gerontology
Dario Moreno-Agostino, Alejandro de la Torre-Luque, Leandro da Silva-Sauer, Bruce W. Smith, Bernardino Fernandez-Calvo
Summary: The research found that both individual and social resilience resources are negatively related to depressive and anxiety symptoms in adults regardless of age, with direct and indirect effects on emotional symptoms. This pattern of relationships was found to be invariant across age groups.
AGING & MENTAL HEALTH
(2022)
Article
Audiology & Speech-Language Pathology
Mariana L. Martins, Melyssa K. C. Galdino, Bernardino Fernandez-Calvo, Fatima C. A. Branco-Barreiro, Thiago P. Fernandes, Marine R. D. da Rosa
Summary: The study aimed to investigate the direct and indirect effects of resilience, personality traits, and psychiatric symptoms on tinnitus perception. The results showed that resilience and psychiatric symptoms did not have a direct or indirect influence on tinnitus annoyance, severity, or loudness. However, there was a direct association of resilience with annoyance and neuroticism trait with tinnitus severity and annoyance.
JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY
(2022)
Article
Clinical Neurology
Leandro da Silva-Sauer, Ricardo Basso Garcia, Alan Ehrich de Moura, Bernardino Fernandez-Calvo
Summary: The study aimed to verify whether working memory can be measured by the d2 Test of Attention, and the results suggest that working memory may be a secondary construct assessed by this instrument.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Neurosciences
Israel Contador, Patricia Alzola, Felix Bermejo-Pareja, Teodoro del Ser, Sara Llamas-Velasco, Bernardino Fernandez-Calvo, Julian Benito-Leon
Summary: This study investigates the impact of education and literacy on dementia incidence in stroke and TIA patients. The results show that low education and literacy are significantly associated with a higher risk of dementia. Furthermore, low/null literacy has a different effect on dementia risk compared to education.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Suellen Marinho Andrade, Daniel Gomes da Silva Machado, Leandro da Silva-Sauerc, Claudio Teixeira Regis, Cristina Katya Torres Teixeira Mendes, Juliana Sousa Soares de Araujo, Kleyber Dantas Torres de Araujo, Larissa Pereira Costa, Maria Eduarda Bezerra Sales Queiroz, Marcio Martins Leitao, Bernardino Fernandez-Calvo
Summary: The study found that multisite anodal transcranial direct current stimulation combined with cognitive stimulation can improve cognitive function and brain activity in patients with Alzheimer's disease, and the changes in cognitive performance are associated with changes in brain activity.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Renata Emanuela Lyra de Brito Aranha, Nelson Torro-Alves, Suellen Marinho Andrade, Eliane Araujo de Oliveira, Bruna Nadiely Victor da Silva, Egina Karoline Goncalves da Fonseca, Gabriela Emilio Lima dos Santos, Natalia Monteiro Guedes, Tatyanne dos Santos Falcao Silva, Bernardino Fernandez-Calvo
Summary: This study compared the effects of different frequencies of transcranial direct current stimulation on chronic migraine patients and found that a once-daily session can significantly decrease migraine-related disability, while a twice-daily session did not show better results.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Cell Biology
Israel Contador, Patricia Alzola, Yaakov Stern, Alejandro de la Torre-Luque, Felix Bermejo-Pareja, Bernardino Fernandez-Calvo
Summary: This study conducted a systematic review and meta-analyses to examine the effect of socio-behavioral cognitive reserve proxies on cognitive decline after stroke. The findings showed that high education is associated with a decreased rate of post-stroke dementia, and other CR proxies demonstrate a protective effect against non-dementia cognitive decline after stroke. The results suggest that CR may prevent cognitive decline after stroke, but this effect can be influenced by different factors such as the CR proxy and individual characteristics.
AGEING RESEARCH REVIEWS
(2023)
Article
Environmental Sciences
Ruben Juy, Ana Nieto, Israel Contador, Francisco Ramos, Bernardino Fernandez-Calvo
Summary: This study investigated the prevalence of burnout syndrome (BS) and its associated psychosocial factors in Spanish occupational therapists (OTs), as well as its relationship with health. Results showed that emotional exhaustion was the most common symptom, and emotional management and social support were protective factors. This highlights the importance of raising awareness and promoting well-being and health among OTs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Joenilton Saturnino Caze da Silva, Fabiola da Silva Albuquerque, Flavio Freitas Barbosa, Leandro Da Silva-Sauer, Bernardino Fernandez-Calvo
Summary: This study examined the performance of young and older adults on memory questions and found that older adults only used memory strategy for solving questions based on the temporal element, while young adults used both memory and non-memory strategies. This suggests that aging leads to a reduction in memory strategies.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Neurosciences
Suellen Marinho Andrade, Leandro da Silva-Sauer, Carolina Dias de Carvalho, Elidianne Layanne Medeiros de Araujo, Eloise de Oliveira Lima, Fernanda Maria Lima Fernandes, Karen Lucia de Araujo Freitas Moreira, Maria Eduarda Camilo, Lisieux Marie Marinho dos Santos Andrade, Daniel Tezoni Borges, Edson Meneses da Silva Filho, Ana Raquel Lindquist, Rodrigo Pegado, Edgard Morya, Seidi Yonamine Yamauti, Nelson Torro Alves, Bernardino Fernandez-Calvo, Jose Mauricio Ramos de Souza Neto
Summary: This study aims to investigate the impact of acetylcholinesterase inhibitors treatment on cognitive function in Alzheimer's Disease (AD). Through EEG observations on 70 AD patients, a machine learning algorithm was used to identify four brain regions that are associated with the treatment response of tDCS plus cognitive intervention.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Fatima Cuadrado, Adoracion Antoli, Bernardino Fernandez-Calvo, Julia Vacas
Summary: This article investigates how different framings of Alzheimer's disease (AD) impact attitudes and emotions towards the disease. Two studies were conducted, one focusing on the individual with AD and the other on the relationship between the individual with AD and their family. The results show that positive framings lead to more positive attitudes and emotions, while negative framings trigger negative emotions. Reframing AD is crucial for changing attitudes and reducing stigma associated with the disease.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Geriatrics & Gerontology
Leandro da Silva-Sauer, Ricardo Basso Garcia, Egina Karoline Goncalves Fonseca, Bernardino Fernandez-Calvo
Summary: This study reveals that regular physical activity can help alleviate the adverse effects of caregiver burden on somatic health among caregivers of people with dementia. Encouraging and endorsing physical activity interventions for caregivers may provide significant benefits for their health and overall well-being.
Article
Geriatrics & Gerontology
Sayonara P. da Silva, Carla C. M. de Castro, Livia N. Rabelo, Rovena C. Engelberth, Bernardino Fernandez-Calvo, Felipe P. Fiuza
Summary: This study explores the regional differences in A beta deposition in the brains of Alzheimer's disease (AD) patients and finds associations with age, gender, and education. Additionally, the study reveals correlations between A beta burden and inflammatory proteins.
