Article
Geriatrics & Gerontology
Lea Chauveau, Elizabeth Kuhn, Cassandre Palix, Francesca Felisatti, Valentin Ourry, Vincent de La Sayette, Gael Chetelat, Robin de Flores
Summary: Studying the subregions of the medial temporal lobe is crucial for distinguishing age-related changes from Alzheimer's disease, with the findings highlighting the significant role of these subregions in cognitive functioning.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Anna-Maria Grob, Branka Milivojevic, Arjen Alink, Christian F. Doeller, Lars Schwabe
Summary: Memories are not stored in isolation. Insight into the relationship of initially unrelated events may trigger a flexible reconfiguration of the mnemonic representation of these events. However, stress impairs this process and leads to fragmented memories in PTSD. In this study, acute stress was found to reduce brain activity and disrupt the reconfiguration of memories, but interestingly, it enhanced long-term memory performance. These findings have implications for understanding memory distortions in stress-related mental disorders.
Article
Multidisciplinary Sciences
Wilma A. Bainbridge, Chris Baker
Summary: This study utilizes a large dataset from social media to investigate the neural substrates of autobiographical memories. The research finds tight interconnections among memory features and identifies a multidimensional topography in the medial parietal cortex that reflects memory content, age, and strength.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Jingyuan Ren, Furong Huang, Chuanji Gao, Jarrod Gott, Sarah F. Schoch, Shaozheng Qin, Martin Dresler, Jing Luo
Summary: This study investigated the impact of novel stimuli on the left and right medial temporal lobes, revealing different activations in response to novel designs of different usefulness. The findings suggest that the left medial temporal lobe is predominantly involved in usefulness processing, while the right medial temporal lobe is predominantly involved in novelty processing. Additionally, the left parahippocampal gyrus showed stronger connectivity with the anterior cingulate cortex when responding to novel useless designs, while the right parahippocampal gyrus showed stronger connectivity with the amygdala, midbrain, and hippocampus.
Article
Neuroimaging
Anna Doll, Martin Wegrzyn, Anissa Benzait, Markus Mertens, Friedrich G. Woermann, Kirsten Labudda, Christian G. Bien, Johanna Kissler
Summary: In patients with mesial temporal lobe epilepsy, there is minor extra-temporal plasticity, with the activation of contralateral mesial temporal lobe supporting intact memory performance.
NEUROIMAGE-CLINICAL
(2021)
Article
Multidisciplinary Sciences
Futing Zou, Guo Wanjia, Emily J. J. Allen, Yihan Wu, Ian Charest, Thomas Naselaris, Kendrick Kay, Brice A. A. Kuhl, J. Benjamin Hutchinson, Sarah DuBrow
Summary: Using 7T fMRI, the study found that hippocampal area CA1 and the entorhinal cortex predict temporal context memory for scene images by re-expressing activity patterns during subsequent encounters over a period of months. This suggests that CA1 and the entorhinal cortex play a crucial role in preserving temporal memories.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Yuchao Jiang, Wei Li, Yingjie Qin, Le Zhang, Xin Tong, Fenglai Xiao, Sisi Jiang, Yunfang Li, Qiyong Gong, Dong Zhou, Dongmei An, Dezhong Yao, Cheng Luo
Summary: This study used T1-weighted and T2-weighted MRI to investigate the myelination changes in temporal lobe epilepsy (TLE) patients. The mSCN analysis showed decreased myelination in frontotemporal regions, amygdala, and thalamus in both patient groups compared to healthy controls. Left TLE patients also had lower myelination in left medial temporal regions. The findings suggest that myelination alterations in TLE are related to epileptic seizures.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Melanie J. Sekeres, Morris Moscovitch, Gordon Winocur, Sara Pishdadian, Dan Nichol, Cheryl L. Grady
Summary: Reminders can effectively enhance memory by engaging prefrontal cortex and hippocampus, but do not improve the quality or details recalled. The results suggest that retrieval difficulties after a delay are primarily due to retrieval deficits rather than storage deficits.
Article
Neurosciences
Hye Bin Yoo, Gray Umbach, Bradley Lega
Summary: The construction of specific boundaries in space and time is necessary for the formation of episodic memories. Studies using rodent models and human microelectrode recordings have shown that the medial temporal lobe plays a role in representing boundary information. We identified episodic boundary neurons in human subjects, and found that their firing rates increased at the beginning and end of episodic episodes during a free recall task. These boundary neurons exhibited a U-shaped activity pattern and were organized by hippocampal theta oscillations.
Article
Clinical Neurology
Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi, Jafar Mehvari-Habibabadi, Roya Sharifpour, Bahram Mohajer, Neda Mohammadi-Mobarakeh, Seyed Sohrab Hashemi-Fesharaki, Kost Elisevich, Mohammad-Reza Nazem-Zadeh
Summary: The study demonstrates distinct patterns of hippocampal subfield atrophy in patients with left and right mesial temporal lobe epilepsy (mTLE), suggesting that the pathophysiology of epileptogenesis in left and right mTLE may be different.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Mieke Verfaellie, Renee Hunsberger, Margaret M. Keane
Summary: Studies on amnesic patients with medial temporal lobe (MTL) lesions have shown inconsistent results in moral decision-making, with personal framing not affecting the participants' moral judgments. Patients with MTL damage were less willing to endorse utilitarian options and rated actions as more emotionally intense compared to controls, suggesting the necessity of episodic processes in evaluating action-outcome contingencies.
Article
Nutrition & Dietetics
Aline Thomas, Cecile Proust-Lima, Marion Baillet, Catherine Helmer, Cecile Delcourt, Alexandra Foubert-Samier, Gwenaelle Catheline, Catherine Feart, Cecilia Samieri
Summary: This study found that an increase in plasma levels of total carotenoids and beta-carotene was associated with a smaller annual loss of medial temporal lobe volume, suggesting a potential beneficial role of carotenoids in preventing age-related neurodegeneration.
CLINICAL NUTRITION
(2021)
Review
Neurosciences
Cen Yang, He Chen, Yuji Naya
Summary: For living organisms, acquiring information about the external space is crucial for future actions. This review focuses on the brain mechanisms in nonhuman primates that link self-referenced and allocentric spatial representations. It proposes two types of neural substrates - view-center background signals and hippocampal neurons' dynamic activity - that facilitate the translation of stored location memory from an allocentric frame to a first-person perspective.
Article
Multidisciplinary Sciences
Larry R. Squire, Jennifer C. Frascino, Charlotte S. Rivera, Nadine C. Heyworth, Biyu J. He
Summary: One-trial, long-lasting perceptual learning relies on hippocampus-independent (nondeclarative) memory, independent of any requirement to consciously remember. Patients with hippocampal lesions or larger medial temporal lobe (MTL) lesions show intact perceptual learning but impaired memory for the images presented.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Behavioral Sciences
Hongkeun Kim
Summary: A network-level model was constructed to analyze the activities of different cognitive types in various brain regions, revealing a functional dissociation between different components. The validity of the model was evaluated through meta-analyses, which confirmed the predicted order of activities in different brain regions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Johannes S. Wrege, Anthony C. Ruocco, Dean Carcone, Undine E. Lang, Andy C. H. Lee, Marc Walter
Summary: In individuals with borderline personality disorder (BPD), heightened brain activation was observed in response to neutral faces compared to healthy controls (HC), while no significant differences were found in brain activation for different intensities of fearful expressions. The amygdala-hippocampal complex showed greater activation in BPD patients when processing neutral and moderate-intensity fearful faces, with self and interpersonal impairments being associated with specific brain regions during these tasks.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Anesthesiology
Lizbeth J. Ayoub, Mary Pat McAndrews, Alexander J. Barnett, Ka Chun Jeremy Ho, Iacopo Cioffi, Massieh Moayedi
Summary: Pain is a subjective experience with individual differences, and neural correlates play a role in determining the pain intensity. This study on an orthodontic procedure found that baseline neural architecture and connectivity were associated with subsequent peak pain ratings.
Article
Psychology, Clinical
J. S. Wrege, D. Carcone, A. C. H. Lee, C. Cane, U. E. Lang, S. Borgwardt, M. Walter, A. C. Ruocco
Summary: Patients with BPD show disruptions in frontoparietal regions related to a combination of response inhibition and attentional saliency or saliency processing alone. However, there are no specific neural activation differences related to response inhibition when attentional saliency is controlled. This suggests a neural dysfunction in BPD specifically underlying attention to salient or infrequent stimuli, supported by a negative correlation with self-rated impulsiveness.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology
Chi-Hsun Chang, Dan Nemrodov, Natalia Drobotenko, Maryam Sorkhou, Adrian Nestor, Andy C. H. Lee
Summary: Extensive research has shown that face recognition declines with age, but the impact of healthy aging on these abilities is still largely unknown. Older adults show compromised processing of facial shape and surface information, but age-related effects are less prominent compared to individual differences.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE
(2021)
Article
Biochemistry & Molecular Biology
Alexander J. Barnett, Walter Reilly, Halle R. Dimsdale-Zucker, Eda Mizrak, Zachariah Reagh, Charan Ranganath
Summary: Utilizing resting-state fMRI data analysis, this study identified networks that interact with the hippocampus and investigated the connectivity and functions of different subnetworks during memory-guided decision-making. A Neurosynth meta-analysis of fMRI studies proposed new hypotheses regarding the functions of the identified networks, providing a guide for future research on episodic memory neural architecture.
Article
Clinical Neurology
Fernando Caravaggio, Alexander J. Barnett, Shinichiro Nakajima, Yusuke Iwata, Julia Kim, Carol Borlido, Wanna Mar, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrero
Summary: This study investigated the effects of AMPT-induced dopamine depletion on resting-state functional connectivity of the basal ganglia and canonical resting-state networks in healthy individuals. The results showed reduced connectivity between the caudate and the medial prefrontal cortex, as well as decreased connectivity between several brain regions and the occipital cortex, while increased connectivity was observed between the dorsal caudate and the sensorimotor network. AMPT also significantly decreased self-reported motivation and increased fatigue. Moreover, greater fatigue was associated with reduced connectivity between the substantia nigra and the medial prefrontal cortex, and decreased motivation was correlated with decreased connectivity between the ventral tegmental area and the left sensorimotor cortex.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Dylan C. M. Yeates, Dallas Leavitt, Sajeevan Sujanthan, Nisma Khan, Denada Alushaj, Andy C. H. Lee, Rutsuko Ito
Summary: The ventral hippocampal CA3 and CA1 subfields regulate adaptive behavior by projecting to the lateral septum in a subfield-specific manner. Inhibition of the vCA3-LS caudodorsal pathway enhances approach behavior towards conflict-inducing stimuli, while inhibition of the vCA1-LS rostroventral pathway enhances approach behavior non-specifically. Furthermore, animals with inhibited vCA3-LS caudodorsal pathway are less hesitant to explore food under environmental uncertainty, while animals with inhibited vCA1-LS rostroventral pathway take longer to initiate food exploration.
NATURE COMMUNICATIONS
(2022)
Article
Psychiatry
Dean Carcone, Katherine Gardhouse, Vina M. Goghari, Andy C. H. Lee, Anthony C. Ruocco
Summary: Stress has a negative impact on memory, the hippocampus, and psychological health. This study explores the relationship between cumulative stress, episodic memory, and the hippocampus, as well as the mediating role of stress in the relationship between personality psychopathology and hippocampal size and activation.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Developmental
Sathesan Thavabalasingam, Supreet Aashat, Daniela J. Palombo, Mieke Verfaellie, Andy C. H. Lee
Summary: Temporal information is crucial for event sequence memory, and aging has a negative impact on memory for temporal order and duration. Older adults perform worse than younger adults in making temporal order match-mismatch judgments and duration match-mismatch judgments.
AGING NEUROPSYCHOLOGY AND COGNITION
(2022)
Article
Multidisciplinary Sciences
Cody Cane, Dean C. Carcone, Katherine Gardhouse, Andy C. H. Lee, Anthony Ruocco
Summary: Cognitive control is associated with impulsive and harmful behaviors, as well as major depressive disorder (MDD) and borderline personality disorder (BPD). The neural basis of response inhibition in MDD and BPD is not fully understood and could differentiate between the disorders and underlie individual differences in cross-cutting pathological traits. However, the associations between neural activation and pathological personality traits may be small in magnitude.
Article
Psychology, Developmental
Nichole R. Bouffard, Celia Fidalgo, Iva K. Brunec, Andy C. H. Lee, Morgan D. Barense
Summary: Associative memory deficits in aging are characterized by false recognition, especially when stimuli are similar. Introducing distinctive stimuli can help differentiate items in memory and understand age-related brain changes. How older adults use distinctive information to distinguish overlapping memories is still unknown.
AGING NEUROPSYCHOLOGY AND COGNITION
(2023)
Article
Neurosciences
Sonja Chu, Cendri Hutcherson, Rutsuko Ito, Andy C. H. Lee
Summary: The prefrontal cortex (PFC) and medial temporal lobe (MTL) contribute differently to resolving conflict information and uncertainty during approach-avoidance decisions. The PFC may adjust response caution and evidence strength towards each choice, involving the anterior cingulate cortex and dorsolateral prefrontal cortex, while the MTL contributes to evidence generation, particularly through the hippocampus. These findings suggest unique contributions of MTL and PFC regions in arbitrating approach-avoidance conflict.
Article
Biology
Sandeep S. Dhawan, Carl Pinter, Andy C. H. Lee, Rutsuko Ito
Summary: Traditional neural models have suggested that the hippocampus plays a crucial role in approaching or avoiding conflicts, but recent research challenges this perspective and suggests that the perirhinal cortex is also critically involved in object-related conflicts. Moreover, the ventral hippocampus appears to be more involved in context-related conflicts. These findings indicate that the type of stimulus can impact the involvement of the medial temporal lobe during approaching or avoiding conflicts, and a nuanced understanding of its contributions to impaired behavior is necessary.
Article
Psychology, Biological
James W. Antony, Jacob Van Dam, Jarett R. Massey, Alexander J. Barnett, Kelly A. Bennion
Summary: Antony et al. investigate the connection between long-term surprises across multiple events and memory formation. Their analysis of basketball fan questionnaires and NBA data shows that surprising events are associated with better memory recall across different timescales. This study expands our understanding of surprise in learning models and highlights its importance in real-world contexts.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Behavioral Sciences
Chi-Hsun Chang, Sukhan Zehra, Adrian Nestor, Andy C. H. Lee
Summary: This study used a behavioral-based image reconstruction approach to reveal the pictorial representations of face perception in two amnesic patients and demonstrated the applicability of this method to individuals with brain damage. The face oddity judgment task showed impaired performance in face discrimination for one patient (BL), while the other patient (DA) had intact performance accuracy. Although atypical face representations were observed in BL, the recovered pictorial content of faces was comparable between both patients and controls.