Article
Neurosciences
Qianqian Si, Caiting Gan, Heng Zhang, Xingyue Cao, Huimin Sun, Min Wang, Lina Wang, Yongsheng Yuan, Kezhong Zhang
Summary: This study used dynamic functional network connectivity analysis to investigate the neural activity of levodopa-induced dyskinesia in Parkinson's disease. The results suggest that dyskinesia is associated with the dysfunctional inhibition of cognitive executive network on motor loops and excessive excitation of visual network and sensorimotor network.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Naomi Hannaway, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Andreas-Antonios Roussakis, Jonathan Howard, Matthew B. Wall, Clare Loane, Roger A. Barker, Paola Piccini
Summary: The study found that there are changes over time in the blood-oxygen-level dependent response of Parkinson's disease patients undertaking a simple motor task. These changes primarily occur in the ipsilateral cerebellum and may be compensatory in nature.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Multidisciplinary Sciences
Lewis A. Ingram, Vincent K. Carroll, Annie A. Butler, Matthew A. Brodie, Simon C. Gandevia, Stephen R. Lord
Summary: The study evaluated the validity of the upper limb Physiological Profile Assessment (PPA) in people with Parkinson's disease (PD) and found that the PPA can effectively differentiate PD patients from healthy controls and detect differences in upper limb test domains between different medication states. Six key tests, including handgrip strength, finger-press reaction time, 9-hole peg test, bimanual pole test, arm stability, and shirt buttoning, were identified for assessing upper limb function in PD patients. These findings suggest that clinical assessments in PD patients should prioritize tests of muscle strength, unilateral movement and dexterity, bimanual coordination, arm stability and functional tasks.
Article
Biochemistry & Molecular Biology
Ana Gabrielle Bispo, Caio S. Silva, Camille Sena-dos-Santos, Dafne Dalledone Moura, Brenda Hanae Bentes Koshimoto, Bruno Lopes Santos-Lobato, Andrea Ribeiro-dos-Santos, Giovanna C. Cavalcante
Summary: Mitophagy dysfunction caused by gene mutations is associated with the development of Parkinson's Disease (PD). However, the association between the variants of mitophagy-related genes and the treatment with levodopa (LD) in PD patients has not been well explored. This study investigated the association of 14 variants of the PRKN gene with LD treatment in PD patients. The results suggest that while age at onset of symptoms, duration of PD, and LD treatment and dosage can influence the occurrence of dyskinesia, the investigated PRKN variants did not show a significant association.
Article
Clinical Neurology
Martina Mrackova, Radek Marecek, Jiri Mekyska, Milena Kostalova, Irena Rektorova
Summary: This study aimed to explore the neural mechanisms by which levodopa affects articulation and prosody in patients with Parkinson's disease (PD). The results showed that levodopa did not have a significant impact on acoustic parameters, but it may induce neural changes within the basal ganglia circuitries that are related to changes in speech prosody and articulation.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Pharmacology & Pharmacy
Peter Kempster, Andrew Ma
Summary: A large proportion of drugs for neurological disorders are derived from naturally occurring compounds, especially plant alkaloids. The treatment of Parkinson's disease has strong botanical origins, with plant-derived substances playing a significant role. The interaction between plant compounds and animal dopaminergic systems has deep evolutionary roots.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ritam Bandopadhyay, Nainshi Mishra, Ruhi Rana, Gagandeep Kaur, Mohammed M. Ghoneim, Sultan Alshehri, Gulam Mustafa, Javed Ahmad, Nabil. A. Alhakamy, Awanish Mishra
Summary: This study focuses on the recent updates in molecular mechanisms and therapeutic approaches for the effective management of levodopa-induced dyskinesia (LID) in Parkinson's disease patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Piniel Alphayo Kambey, Wen Ya Liu, Jiao Wu, Chuanxi Tang, Wokuheleza Buberwa, Adonira Saro, Alphonce M. K. Nyalali, Dianshuai Gao
Summary: This study revealed the crucial role of Amphiregulin (Areg) gene in levodopa-induced dyskinesia in Parkinson's disease. Inhibition of Areg was found to alleviate dyskinetic movements and decrease the expression of related proteins. Therefore, Areg may serve as a potential target for therapy development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Eva Schaeffer, Thomas Vaterrodt, Laura Zaunbrecher, Inga Liepelt-Scarfone, Kirsten Emmert, Benjamin Roeben, Morad Elshehabi, Clint Hansen, Sara Becker, Susanne Nussbaum, Jan-Hinrich Busch, Matthis Synofzik, Daniela Berg, Walter Maetzler
Summary: Our independent analysis of three PD cohorts consisting of a total of 1124 PD patients found that patients taking Levodopa CR reported a significantly higher burden of nocturnal akinesia. Higher Levodopa intake and MDS-UPDRS part IV scores predicted worse quality of sleep and higher subjective nocturnal immobility scores, while disease duration and severity were not predictive. Levodopa intake was not associated with objectively changed mobility during sleep.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Yu-tong Zhao, Li Liu, Yong Zhao, Zong-yi Xie
Summary: The study found that levodopa alone therapy may be superior in motor symptom relief for early Parkinson's disease patients compared to levodopa-sparing therapy, and the motor advantage of levodopa alone may increase over time. Levodopa alone therapy may increase the risk of wearing-off and dyskinesia, but the events between the two groups may not be different in the long term.
JOURNAL OF NEUROLOGY
(2022)
Review
Health Care Sciences & Services
Daniel van Poppelen, Annelie N. M. Tromp, Rob M. A. de Bie, Joke M. Dijk
Summary: Based on a retrospective case series and literature review, it was found that patients with Parkinson's disease who have persisting medication related motor response fluctuations despite DBS or CLI treatment may benefit from an additional or alternative treatment with either CLI or DBS.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Annalisa Gessani, Francesco Cavallieri, Valentina Fioravanti, Isabella Campanini, Andrea Merlo, Giulia Di Rauso, Benedetta Damiano, Sara Scaltriti, Elisa Bardi, Maria Giulia Corni, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Alessandro Fraternali, Annibale Versari, Giuseppe Biagini, Valerie Fraix, Serge Pinto, Elena Moro, Carla Budriesi, Franco Valzania
Summary: This study aimed to evaluate the long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on speech in advanced Parkinson's Disease (PD) patients. The results showed that speech intelligibility stayed at the same level as preoperative values in the long-term follow-up. However, there was a significant acute improvement of speech intelligibility in the postoperative assessment.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Bruno L. Santos-Lobato, Luiz Gustavo Gardinassi, Mariza Bortolanza, Ana Paula Ferranti Peti, Angela V. Pimentel, Lucia Helena Faccioli, Elaine A. Del-Bel, Vitor Tumas
Summary: Metabolomic analysis revealed a distinct metabolic profile associated with levodopa-induced dyskinesia (LID) in Parkinson's disease (PD), particularly characterized by dysregulation of the glycosphingolipid metabolic pathway and bile acid biosynthesis metabolites in plasma and CSF. These findings suggest a potential link between lipid metabolism dysregulation and LID in PD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Miranda J. Munoz, James L. Reilly, Gian D. Pal, Leo Verhagen Metman, Yessenia M. Rivera, Quentin H. Drane, Daniel M. Corcos, Fabian J. David, Lisa C. Goelz
Summary: This study examined the effect of anti-Parkinsonian medication on visually-guided saccades (VGS) and found inconsistent findings in previous research. The use of different paradigms or target eccentricities may have contributed to these inconsistencies. Medication had adverse effects on saccade latency, gain, and peak velocity, and did not provide therapeutic benefits.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Thiago Kenzo Fujioka Shida, Claudia Eunice Neves de Oliveira, Debora da Silva Fragoso de Campos, Emanuele Los Angeles, Claudionor Bernardo, Luana dos Santos de Oliveira, Layla Cupertino Salloum e Silva, Thayna Magalhaes Novaes, Solaiman Shokur, Mohamed Bouri, Daniel Boari Coelho
Summary: This study evaluated the effects of medication and freezing of gait (FoG) on the kinematic and kinetic parameters of gait in people with Parkinson's disease. The results showed that FoG mainly affects distal joints, such as the ankle and knee. Parkinson's disease patients exhibited changes in joint range of motion and lower ground reaction force compared to healthy individuals.
NEUROSCIENCE LETTERS
(2023)