Journal
NEUROPSYCHOLOGIA
Volume 46, Issue 12, Pages 2888-2895Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2008.05.027
Keywords
cognitive decline; neural inefficiency; relapsing remitting multiple sclerosis; brain; cortical reorganization; individual differences; focused attention; inhibition
Funding
- National Institute on Aging [RO1 AG25667, RO1 AG25032]
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Recent studies with multiple sclerosis (MS) participants have provided evidence for cortical reorganization. Greater recruitment of task-related areas and additional brain regions are thought to play an adaptive role in the performance of cognitive tasks. In this study, we compared cortical circuitry recruited by MS patients and controls during a selective attention task that requires both focusing attention on task-relevant information and ignoring or inhibiting task-irrelevant information. Despite comparable behavioral performance, MS patients demonstrated increased neural recruitment of task-related areas along with additional activation of the prefrontal cortices. However, this additional activation was associated with poor behavioral performance, thereby providing evidence against compensatory brain reorganization. Future studies specifically investigating the nature of additional activation seen in MS patients in a wider variety of cognitive tasks would provide insight into the specific cognitive decline in Ms. Published by Elsevier Ltd.
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