Article
Medicine, General & Internal
Anna Maria Czarnecka, Marta Obara-Michlewska, Dorota Wesol-Kucharska, Milena Greczan, Magdalena Kaczor, Janusz Ksiazyk, Dariusz Rokicki, Magdalena Zielinska
Summary: From the results, we found that the plasma level of S100B is positively correlated with ammonia level, while the plasma level of 3-NT does not correlate with ammonia concentration. This offers a unique perspective for future identification and monitoring of neurological deficits risk-linked with hyperammonemia episodes in patients with inherited hyperammonemias.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Debraj Ghorai, Kanak Kanti Das, Santanu Panda
Summary: In this study, a transition metal-free carbonyl-directed boron-Wittig reaction method was used to synthesize alkenyl oxindoles using alpha-bis(boryl)carbanions as substrates. The reaction showed high selectivity and allowed for specific substitution patterns. This method has significant research and application value.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Elise M. Van Fossen, Sonia Grutzius, Carl E. Ruby, Dan V. Mourich, Chris Cebra, Shay Bracha, P. Andrew Karplus, Richard B. Cooley, Ryan A. Mehl
Summary: In this study, we demonstrate the development of a selective nanobody using genetic code expansion technology, which provides a new tool for investigating oxidative stress-related pathologies.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Phillip Zhu, Kyle T. Nguyen, Aidan B. Estelle, Nikolai N. Sluchanko, Ryan A. Mehl, Richard B. Cooley
Summary: 14-3-3 proteins are key regulators of phosphorylated client proteins. Nitration of tyrosine residues in 14-3-3 alters its structure and function, affecting downstream signaling pathways.
Article
Medicine, General & Internal
Aleksander Nobis, Daniel Zalewski, Eliza Samaryn, Mateusz Maciejczyk, Anna Zalewska, Napoleon Waszkiewicz
Summary: Depression is a prevalent psychiatric disorder that significantly impacts individuals and public health worldwide. Recent research has focused on identifying biological markers to better understand the underlying mechanisms of depression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Dastgir Shakil Shaikh, Sangeeta Parmar, Dimpy Kalia
Summary: Oxidative stress is a characteristic feature of various diseases, and there is a need for sensitive and technically simple methods to measure blood plasma cysteine. In this study, researchers developed a series of fluorescence probes based on Michael addition-elimination-cyclization that can selectively detect cysteine and showed rapid kinetics and excellent sensitivity. One of the probes was able to detect a biomarker for cancer and liver cirrhosis, while another probe enabled live cell imaging to monitor oxidative stress in mammalian cells.
Article
Multidisciplinary Sciences
Justyna Piechocka, Monika Wyszczelska-Rokiel, Rafal Glowacki
Summary: This report presents a method for simultaneous determination of plasma HPPTCA and total low molecular-weight thiols content. The assay is based on HPLC-UV, involving disulfides reduction, derivatization, and sample deproteinization. The HPLC-UV assay provides a complementary tool for routine clinical analysis and facilitates further studies on the role of aminothiols and HPPTCA in living systems.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Organic
Tabassum Khan, Pallava Rajesh, Doma Arun, Srinivasarao Yaragorla
Summary: A new Ca-catalyzed reaction was developed to achieve tetrasubstituted alkenyl-sulfenylation using readily available aryl/alkyl thiols and easily prepared oxindole-derived propargyl alcohols under solvent-free conditions. The reaction proceeded with high diastereoselectivity, involving hydrogen bonding assisted regioselective alpha-thiolation and subsequent calcium catalyzed stereoselective alkenylation to yield E-alkenyl thioethers.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Physical
Francisxavier Paularokiadoss, Thiruthuvadevaraj Antony Sandosh, Alagan Sekar, Thayalaraj Christopher Jeyakumar
Summary: The reaction and electronic structural analysis of transition metal carbonyls and corresponding gallylene complexes were investigated theoretically. Orbital interactions between metal and gallium, as well as the formation order of bonds, were analyzed. The feasibility of complexes formation through a five-member coordinated transition state was confirmed.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Balasubramanian Sriram, Jeena N. Baby, Mary George, Yung-Fu Hsu, Sea-Fue Wang
Summary: This study develops a highly sensitive electrode material for the detection of NO2-Tyr by integrating the unique features of BiVO4 and MoS2. The MoS2@BiVO4 heterojunction exhibits excellent electrochemical behavior, allowing for the measurement of NO2-Tyr in biological media without time-consuming pretreatments. The synergistic interactions between BiVO4 and MoS2 contribute to low resistance charge transfer, a good response range, and a lower limit of detection for NO2-Tyr.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Barbora Katrencikova, Magdalena Vavakova, Zuzana Paduchova, Zuzana Nagyova, Iveta Garaiova, Jana Muchova, Zdenka Durackova, Jana Trebaticka
Summary: Oxidative stress is believed to be involved in the pathophysiology of depressive disorder, with markers of oxidative stress increased and antioxidant protection decreased in pediatric and adolescent patients with DD. Supplementation with omega-3 fatty acids has been shown to reduce oxidative stress in these patients, suggesting a potential therapeutic intervention.
Article
Chemistry, Analytical
Lina Mikaliunaite, David B. Green
Summary: The ion-pair HPLC method coupled with indirect fluorescence detection has reduced sample preparation time and increased sample throughput compared to traditional HPLC methods, with no significant statistical differences observed in the determination of HCy, Cys, or Cys-Gly in plasma samples between the two methods.
ANALYTICAL METHODS
(2021)
Article
Agriculture, Dairy & Animal Science
D. Barcarolo, E. Angeli, L. E. Ribas, S. M. Addona, H. H. Ortega, G. J. Hein
Summary: In dairy cows, oxidative stress during the transition period can be influenced by environmental conditions such as heat stress. A study developed and validated a method for accurate determination of 3-NT in blood, urine, and liver samples in dairy cows using LC-MS/MS. Results showed higher 3-NT concentrations in cows that gave birth during spring, along with higher BHBA and lower glucose concentrations. Liver TAG content and aspartate transaminase activity were also higher in cows that gave birth during spring.
Article
Clinical Neurology
Gayatri Maria Schur, Julia Dunn, Sara Nguyen, Anna Dedio, Kristin Wade, Jaclyn Tamaroff, Nithya Mitta, Neil Wilson, Ravinder Reddy, David R. Lynch, Shana E. McCormack
Summary: In adults with Friedreich's ataxia, decreased OXPHOS capacity was reflected by a slower decline in post-exercise Creatine Exchange Saturation Transfer (CrCEST). These individuals also showed differences in muscle group engagement during exercise, possibly indicating decreased coordination. Additionally, higher adiposity and lower physical activity levels were associated with smaller changes in creatine levels following exercise.
JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
I Sogut, A. Senat, E. Kabadayi-Sahin, T. Duymaz, O. Erel
Summary: Individuals with alcohol use disorder (AUD) showed signs of oxidative stress in both mental and biochemical tests, including abnormal levels of thiol-disulfide compounds and biochemical markers. Increased intra- and extracellular GSSG/GSH % may serve as an indicator of developing oxidative stress in individuals with AUD.
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Food Science & Technology
Bernadetta Lis, Joanna Rywaniak, Dariusz Jedrejek, Aleksandra Szustka, Anna Stochmal, Beata Olas
Summary: Numerous studies have shown that natural compounds in dandelion may modulate blood platelets' function. Testing four fractions from different parts of dandelion revealed that the leaf fraction can reduce thrombus formation and platelet activation in whole blood. This suggests a potential avenue for research in antiplatelet supplementation for cardiovascular diseases.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Microbiology
Magdalena Ulanowska, Beata Olas
Summary: COVID-19, caused by SARS-CoV-2 virus, affects respiratory function and disrupts the coagulation system, leading to clotting and thrombotic events. Inflammation and cytokine storms are major causes of hemostasis disorders, with the use of anticoagulants such as heparin recommended to prevent and treat thrombosis. The relationship between blood platelets and COVID-19, as well as the potential use of antiplatelet drugs in COVID-19 cases, are also areas of focus in research.
Article
Medicine, Research & Experimental
Bartosz Skalski, Sylwia Pawelec, Dariusz Jedrejek, Agata Rolnik, Rostyslav Pietukhov, Renata Piwowarczyk, Anna Stochmal, Beata Olas
Summary: The phenylpropanoid glycosides in European broomrapes have antioxidant and anticoagulant properties, indicating potential for treating cardiovascular diseases. The structure of the compounds, particularly the presence of acyl and catechol moieties, is closely related to their bioactivity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Justyna Piechocka, Natalia Litwicka, Rafal Glowacki
Summary: This study provides evidence for the formation of the adduct 1,3-thiazinane-4-carboxylic acid (TCA) in humans through the reaction of homocysteine/thiolactone (Hcy/HTL) and formaldehyde (FA). A GC-MS method has been developed and successfully applied for the quantification of TCA in human urine samples. This method may serve as a new analytical tool for the investigation of TCA's role in living systems in routine clinical analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Beata Olas
Summary: Apitherapy, a form of alternative therapy that uses bee products, shows potential in preventing and treating cardiovascular diseases. Bee pollen, royal jelly, bee venom, propolis, and bee bread have been found to possess new bioactivities, making them interesting natural products for the prevention and treatment of common cardiovascular diseases.
Review
Nutrition & Dietetics
Beata Olas
Summary: Cardiovascular diseases (CVDs) are a leading cause of death, and traditional treatments often have side effects. The European Society of Cardiology recommends a preventative strategy based on a varied diet. Dandelion, a medicinal plant rich in secondary metabolites, has multidirectional health-promoting effects and potential to protect the heart. This review summarizes the effects of dandelion on the cardiovascular system and CVDs and highlights its cardioprotective potential.
Article
Nutrition & Dietetics
Beata Olas
Summary: Patients with COVID-19 often experience various hemostasis dysfunctions, including coagulation dysfunction and changes in blood platelet function, which are a major cause of death. Recent research suggests that dietary phenolic compounds may play an important role in the treatment of COVID-19, but recommendations regarding their use to prevent or reduce the risk of cardiovascular diseases during COVID-19 infection remain uncertain.
Article
Nutrition & Dietetics
Beata Olas, Bartosz Skalski
Summary: Sea buckthorn is a plant rich in vitamins, phenolic compounds, amino acids, fatty acids, and micro- and macro-elements. Numerous studies have found that preparations from various organs of sea buckthorn have anti-cancer, anti-ulcer, and hepatoprotective properties, as well as antibacterial and antiviral activities. This paper reviews the positive role of sea buckthorn preparations in the treatment and prevention of cardiovascular diseases, focusing on their effect on hemostasis.
Article
Biochemistry & Molecular Biology
Dominika Szczerbiec, Justyna Piechocka, Rafal Glowacki, Agnieszka Torzewska
Summary: This study investigates the antibacterial effect of organic acids secreted by Lactobacillus strains on urinary tract infections caused by P. mirabilis. The results show that these acids have a high inhibitory effect on the growth and biofilm formation of P. mirabilis and could be used as novel agents for the treatment of urinary tract infections.
Review
Nutrition & Dietetics
Beata Olas
Summary: The caper, derived from the Latin word capra meaning goat, refers to the salt-fermented floral buds of the perennial shrubs from the Capparis genus. C. spinosa is one of the most popular species, and its aromatic floral buds are collected before blooming, dried, and pickled. Capers are commonly marinated and enjoyed in vinegar, brine, or oil. They have potential as dietary supplements due to their low calorie content and abundance of bioactive phytochemicals. Research has shown that C. spinosa possesses various nutritional and biological properties, including antioxidant activity from its phenolic compounds. This paper reviews the biological properties, including toxicity, of the fruits, buds, seeds, roots, and leaves of C. spinosa.
Article
Nutrition & Dietetics
Natalia Slawinska, Jerzy Zuchowski, Anna Stochmal, Beata Olas
Summary: Sea buckthorn, a small tree, has been valued for its medicinal properties. Its berries and leaves are known to contain phytochemicals and have been used in folk medicine for the treatment of various conditions. This study examined the phytochemical content and biological activity of sea buckthorn seeds. The results showed that sea buckthorn seeds contain various flavonoids and have antioxidant and anticoagulant potential. However, further research is needed to identify the specific compounds responsible for these effects, especially in vivo models.
Review
Nutrition & Dietetics
Natalia Slawinska, Beata Olas
Summary: Seeds contain various phytochemicals with diverse biological activities. This review summarizes the chemical content and biological activity of seeds from eight plant species. Studies have shown that these seeds have health-promoting effects and could be used in drug development and functional food preparation. However, further animal studies and clinical trials are needed to determine their potential application in disease prevention and treatment.
Review
Nutrition & Dietetics
Beata Olas
Summary: Schisandra chinensis berries are valuable agents in modern phototherapy with anti-cancer, hepatoprotective, anti-inflammatory, and antioxidant properties. The unique chemical composition of these berries, particularly their lignan content, contributes to their therapeutic potential. The selected lignans, including schisandrin, schisandrin B, schisantherin A, schisantherin B, schisanhenol, deoxyschisandrin, and gomisin A, possess cardioprotective properties.
Review
Biochemistry & Molecular Biology
Magdalena Brys, Karina Urbanska, Beata Olas
Summary: Genipin, an important compound isolated from Gardenia jasminoides and Genipa americana fruits, has various potential therapeutic properties and industrial applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Anna Dietrich-Muszalska, Joanna Kolodziejczyk-Czepas, Pawel Nowak
Summary: The study shows that patients with schizophrenia have higher levels of oxidative stress compared to healthy subjects, but a 4-week treatment with atypical antipsychotics can reduce lipid peroxidation and increase total plasma antioxidant activity.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
