Article
Clinical Neurology
Bin Li, Lei-Lei Chang, Kang Xi
Summary: The central neurotensin system plays a vital role in regulating anxiety-related behaviors in rats, particularly in the prelimbic region of the medial prefrontal cortex. Activation or blockade of NTS1 in the PrL has different effects on anxiety, and downregulating NTS1 expression in the PrL also influences anxiety behaviors.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Yiwen Hou, Guichang Zou, Xianglian Wang, Hui Guo, Xiao Ma, Xingyu Cheng, Zhiyong Xie, Xin Zuo, Jing Xia, Huanhuan Mao, Man Yuan, Qi Chen, Peng Cao, Yupeng Yang, Li Zhang, Wei Xiong
Summary: Using a combination of chemo/optogenetic manipulation with calcium imaging and slice physiology, this study identifies neuronal ensembles in a hierarchically organized pathway essential for associative opioid analgesic tolerance. The signaling from the ventral hippocampus to dorsomedial prefrontal cortex cholecystokininergic neurons, and subsequently to baso-lateral amygdala glutamatergic neurons, relays the tolerance signal and leads to the loss of morphine analgesic efficacy.
Article
Clinical Neurology
Aline Fassini, America A. Scopinho, Eduardo A. T. Fortaleza, Leonardo B. M. Resstel, Fernando M. A. Correa
Summary: The study found that kappa-opioid receptors in the MeA modulate heart rate and corticosterone increases induced by acute restraint stress, reinforcing the idea of an inhibitory role exerted by MeA during aversive situations.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao-Yuan Jing, Yan Wang, Hua-Wei Zou, Zi-Lin Li, Ying-Juan Liu, Lai-Fu Li
Summary: The study assessed the functional roles of mGlu2/3 and mGlu5 within different subregions of the mPFC in modulating stress resilience and vulnerability, with results suggesting that mGlu2/3 in the PrL might play an important regulatory role in stress-related psychiatric disorders. Social avoidance symptoms in susceptible mice were rapidly relieved by intra-PrL administration of an mGluR2/3 antagonist, indicating a potential avenue for developing novel, personalized approaches to mitigate depression and promote stress resilience.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Saurabh S. Kokane, Robert D. Cole, Bogdan Bordieanu, Chevin M. Ray, Ishraq A. Haque, James M. Otis, Jacqueline F. McGinty
Summary: The dysregulation of prefrontal cortex (PFC) to nucleus accumbens (NAc) input is a significant factor in cue-induced opioid seeking. The physiological adaptations of different subtypes of PFC neurons after heroin abstinence and relapse were investigated. The activity of protein kinase A (PKA) in these neurons is crucial for both abstinence-induced physiological changes and cue-induced relapse to heroin seeking.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Reginald Cannady, Tiffany Nguyen, Audrey E. Padula, Jennifer A. Rinker, Marcelo F. Lopez, Howard C. Becker, John J. Woodward, Patrick J. Mulholland
Summary: The interaction between ethanol and stress may lead to increased alcohol consumption, cognitive deficits, and negative affective behaviors in mice. Ethanol exposure results in structural adaptations, while repeated stress exposure drives functional changes in prefrontal and infralimbic cortical neurons, suggesting distinct morphological and functional alterations may underlie excessive drinking and cognitive deficits associated with ethanol-stress interactions.
Article
Behavioral Sciences
Masoomeh Dadkhah, Ali Rashidy-Pour, Abbas Ali Vafaei
Summary: This study identified the key role of the infralimbic (IL) region of the medial prefrontal cortex (mPFC) in regulating fear extinction. By infusing the D2 receptor antagonist sulpiride into the IL region, auditory fear extinction was enhanced in an inverted U-shape pattern, with moderate doses being most effective.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Psychiatry
Laura L. Huerta L. Sanchez, Mathangi Sankaran, Taylor L. L. Li, Hoa Doan, Alvin Chiu, Eleanora Shulman, Gabriella Shab, Tod E. Kippin, Karen K. Szumlinski
Summary: The study shows that regardless of the duration of drug self-administration, an increase in drug-seeking behavior is observed after 3 or 30 days of withdrawal. The increased expression of phospho-Akt1, phospho-CaMKII, and Homer2a/b in the prelimbic cortex may be responsible for incubated cocaine craving.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Aaron Katzman, Alireza Khodadadi-Jamayran, Dana Kapeller-Libermann, Xiaojing Ye, Aristotelis Tsirigos, Adriana Heguy, Cristina M. Alberini
Summary: The study found that in the dorsal hippocampus and prelimbic cortex of male rats, after inhibitory avoidance learning, transcriptomic profiles showed significant regional specificity and changes in transcription pathways. While there was some overlap in the transcriptome profiles of these two regions during learning, the main regulated biological pathways were significantly different.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Geoffrey W. Diehl, A. David Redish
Summary: Decision-making requires different aspects of information and involves multiple cognitive processes. The rodent medial prefrontal cortex (mPFC) is believed to play a central role in these abilities. Previous studies on mPFC function have yielded controversial results, but this study with rats performing an economic decision task revealed four distinct functional domains within mPFC, closely related to anatomical subregions. Dorsal mPFC regions were more involved in processing active decisions, while ventral regions were more engaged in motivational factors.
Article
Neurosciences
Tomasz Gorkiewicz, Konrad Danielewski, Karolina Andraka, Kacper Kondrakiewicz, Ksenia Meyza, Jan Kaminski, Ewelina Knapska
Summary: This study investigated the role of social support in fear extinction using a behavioral model and neuroscientific methods. The results showed that the presence of a partner during fear extinction training can inhibit fear response, but this effect is transient and differs from the mechanisms of individual extinction.
Article
Clinical Neurology
Bin Li, Leilei Chang, Qian-Xing Zhuang
Summary: The central histaminergic system plays an important role in regulating anxiety. Histaminergic neurons in the hypothalamus directly project to the bed nucleus of the stria terminalis (BNST), a brain region involved in anxiety and stress. The presence of histamine receptors in the BNST suggests their involvement in anxiety modulation. Blocking histamine receptors in the BNST ameliorated anxiety symptoms, suggesting a potential therapeutic strategy for anxiety disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Moises dos Santos Correa, Gabriel David Vieira Grisanti, Isabelle Anjos Fernandes Franciscatto, Tatiana Suemi Anglas Tarumoto, Paula Ayako Tiba, Tatiana Lima Ferreira, Raquel Vecchio Fornari
Summary: The ability to retrieve contextual fear memories relies on coordinated activation of brain circuitry. Training intensity and stress levels may influence the consolidation processes of emotional memories, leading to differential activation patterns and functional connectivity of key brain regions associated with fear conditioning retrieval.
NEUROBIOLOGY OF STRESS
(2022)
Article
Biochemistry & Molecular Biology
Daisuke Yamada, Junpei Takahashi, Keita Iio, Hiroshi Nagase, Akiyoshi Saitoh
Summary: The study showed that KNT-127 suppressed glutamate release from the presynaptic site in the PL-PFC, reducing neuronal excitability. This suggests that the inhibitory effects of KNT-127 on PL-PFC activity may contribute to its anxiolytic-like effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Elizabeth A. West, Mark Niedringhaus, Heather K. Ortega, Rachel M. Haake, Flavio Frohlich, Regina M. Carelli
Summary: The study establishes the importance of the PrL-NAc core circuit in behavioral flexibility and introduces a novel noninvasive brain stimulation method to rescue cocaine-induced frontal hypofunction and restore flexible behavior in rats.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Silvana Lopes-Azevedo, Eduardo Albino Trindade Fortaleza, Cristiane Busnardo, America Augusto Scopinho, Melina Matthiesen, Jose Antunes-Rodrigues, Fernando Morgan Aguiar Correa
NEUROENDOCRINOLOGY
(2020)
Article
Behavioral Sciences
Eduardo Albino Trindade Fortaleza, Cristiane Busnardo, Aline Fassini, Ivaldo Jesus Almeida Belem-Filho, Gislaine Almeida-Pereira, Jose Antunes-Rodrigues, Fernando Morgan Aguiar Correa
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2020)
Article
Clinical Neurology
Melina Matthiesen, Leonardo D. Mendes, Aitton Spiacci Jr, Eduardo A. T. Fortaleza, Fernando M. A. Correa, Helio Zangrossi Jr
JOURNAL OF PSYCHOPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Taiz F. S. Brasil, Silvana Lopes-Azevedo, Ivaldo J. A. Belem-Filho, Eduardo A. T. Fortaleza, Jose Antunes-Rodrigues, Fernando M. A. Correa
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Clinical Neurology
Aline Fassini, America A. Scopinho, Eduardo A. T. Fortaleza, Leonardo B. M. Resstel, Fernando M. A. Correa
Summary: The study found that kappa-opioid receptors in the MeA modulate heart rate and corticosterone increases induced by acute restraint stress, reinforcing the idea of an inhibitory role exerted by MeA during aversive situations.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Cell Biology
Taiz F. S. Brasil, Ivaldo J. A. Belem-Filho, Eduardo A. T. Fortaleza, Jose Antunes-Rodrigues, Fernando M. A. Correa
Summary: The renin-angiotensin system (RAS) is involved in cardiovascular and hydroelectrolytic control, being associated with the development of hypertension. The restraint stress (RS) model induces an increase in angiotensin-II contents in the circulation and CNS, as well as an increased expression of AT-1 receptors in CNS structures related to stress, facilitating the cardiovascular response caused by stress. The modulation of autonomic, neuroendocrine, and functional RS-caused alterations by RAS via the AT-1 receptor may be a potential pharmacological strategy to treat cardiovascular consequences of stress.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ivaldo Jesus Almeida Bel, Taiz Francine Silva Brasil, Eduardo Albino Trindade Fortaleza, Jose Antunes-Rodrigues, Fernando Morgan Aguiar Correa
Summary: The study found that increased secretion of oxytocin during restraint stress can attenuate tachycardic responses by increasing parasympathetic activity, promoting cardioprotection.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Cristiane Busnardo, Aline Fassini, Bruno Rodrigues, Jose Antunes-Rodrigues, Carlos C. Crestani, Fernando M. A. Correa
Summary: The study demonstrates the involvement of the NMDA glutamate receptor in cardiovascular and circulating vasopressin responses to hemorrhagic stimuli, as well as in the control of hemorrhagic shock. Treatment with the NMDA receptor antagonist MK801 delayed and decreased hemorrhage-induced hypotension, while also increasing vasopressin levels during both the hemorrhage and post-bleeding periods. Additionally, NMDA receptor antagonism did not impact the decrease in NO synthesis in specific brain regions following hemorrhage.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Physiology
Davi C. Lagatta, Aline Fassini, Ana L. Terzian, Fernando M. A. Correa, Leonardo B. M. Resstel
Summary: The cardiac baroreflex is a neural mechanism that modulates the cardiovascular system, primarily controlled by medullary nuclei in the brain stem. However, the ventral portion of medial prefrontal cortex (vMPFC) is also involved, with the glutamatergic NMDA/NO pathway and cannabinoid receptors playing a role in baroreflex bradycardic and tachycardic responses. The vMPFC is associated with cardiovascular responses during stress and may be affected in mental and neurodegenerative disorders, leading to baroreflex impairment and cardiovascular risk.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Clinical Neurology
Melissa T. Goulart, Cristiane Busnardo, Ivaldo J. A. Belem-Filho, Ricardo Benini, Aline Fassini, Carlos C. Crestani, Ana C. Godoy, Fernando M. A. Correa, Fernando H. F. Alves
Summary: The involvement of glutamatergic neurotransmission within the insular cortex (IC) in cardiovascular, autonomic, and neuroendocrine responses to restraint stress was investigated in this study. The researchers found that the antagonism of NMDA receptors in the IC enhanced the cardiovascular responses to stress, while the blockade of non-NMDA receptors did not affect these responses. Additionally, the study showed that IC glutamatergic neurotransmission, acting via local NMDA receptors, plays a prominent role in the control of autonomic and cardiovascular responses to restraint stress, but without affecting neuroendocrine adjustments.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Nilson C. Ferreira-Junior, Carlos C. Crestani, Davi C. Lagatta, Leonardo B. M. Resstel, Fernando M. A. Correa, Fernando H. F. Alves
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.