☆ 4.7 Article

Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration

NEUROPHARMACOLOGY (2014)

Journal

NEUROPHARMACOLOGY

Volume 82, Issue -, Pages 1-10

Publisher

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.neuropharm.2014.02.021

Keywords

Voltammetry; Self-administration; Cocaine; Methylphenidate; Amphetamine; Rat

Funding

NIH [R01 DA021325, R01 DA030161, R01 DA014030, T32 DA007246, F31 DA031533]

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Long-access methylphenidate (MPH) self-administration has been shown to produce enhanced amphetamine potency at the dopamine transporter and concomitant changes in reinforcing efficacy, suggesting that MPH abuse may change the dopamine system in a way that promotes future drug abuse. While long-access self-administration paradigms have translational validity for cocaine, it may not be as relevant a model of MPH abuse, as it has been suggested that people often take MPH intermittently. Although previous work outlined the neurochemical and behavioral consequences of long-access MPH self-administration, it was not clear whether intermittent access (6 h session; 5 min access/30 min) would result in similar changes. For cocaine, long-access self-administration resulted in tolerance to cocaine's effects on dopamine and behavior while intermittent-access resulted in sensitization. Here we assessed the neurochemical consequences of intermittent-access MPH self-administration on dopamine terminal function. We found increased maximal rates of uptake, increased stimulated release, and subsensitive D2-like autoreceptors. Consistent with previous work using extended-access MPH paradigms, the potencies of amphetamine and MPH, but not cocaine, were increased, demonstrating that unlike cocaine, MPH effects were not altered by the pattern of intake. Although the potency results suggest that MPH may share properties with releasers, dopamine release was increased following acute application of MPH, similar to cocaine, and in contrast to the release decreasing effects of amphetamine. Taken together, these data demonstrate that MPH exhibits properties of both blockers and releasers, and that the compensatory changes produced by MPH self-administration may increase the abuse liability of amphetamines, independent of the pattern of administration. (C) 2014 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

Significance

Scientific rigor

Rate this paper

The impact of psychostimulants on central and peripheral neuro-immune regulation: a scoping review of cytokine profiles and their implications for addiction

Joana Bravo, Catarina Magalhaes, Elva B. B. Andrade, Ana Magalhaes, Teresa Summavielle

Summary: It has been established that psychostimulants induce neuroinflammation by acting on glial cells, which increases their neurotoxic effects. Neuroinflammation is characterized by an inflammatory response mediated by various cytokines, reactive oxygen species, chemokines, and other inflammatory markers within the central nervous system. Several studies have shown that psychostimulants affect the production and release of cytokines, both centrally and peripherally, although the results are often contradictory. This scoping review examines the impact of different psychostimulants on cytokine profiles, grouping publications by substance addressed, type of exposure, and period of evaluation.

FRONTIERS IN CELLULAR NEUROSCIENCE (2023)