Article
Neurosciences
Eleonora Cocco, Paola Fadda
Summary: Multiple sclerosis is a complex disorder with a wide range of symptoms, categorized as visible and invisible. Fatigue is a common symptom in MS patients that significantly impacts daily living and quality of life, and it does not improve with rest.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Psychology, Clinical
Jonas O. Weinrich, Jochen Saliger, Mareike Eschweiler, Hans Karbe, Elke Kalbe, Joern Nielsen
Summary: This study examined the association between self-report measures of fatigue and tonic alertness in patients with multiple sclerosis (MS). The results showed that subjective fatigue is related to tonic alertness, but other variables also contribute to this association. Afternoon tonic alertness has the greatest potential for differentiation among performance groups. Further studies including relevant variables such as sleepiness are urgently needed.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Sport Sciences
Nicolas Royer, Callum G. Brownstein, Djahid Kennouche, Loic Espeit, Anthony Teston, Claire Boutet, Leonard Feasson, Jean-philippe Camdessanche, Guillaume Y. Millet
Summary: This study aimed to investigate the correlates of MS-related fatigue in patients with relapsing-remitting multiple sclerosis (MS), with a particular focus on fatigability. The results revealed that the high fatigue group exhibited greater performance fatigability and higher perceived exertion than the low fatigue group during a dynamic task.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Rehabilitation
Katie L. J. Cederberg, Brenda Jeng, Jeffer E. Sasaki, Robert W. Motl
Summary: This study examined the device-measured physical activity levels and sedentary behavior participation of adults with multiple sclerosis (MS) at different times of the day. The results showed that fatigued MS participants engaged in less moderate-to-vigorous physical activity, took fewer steps, and had more sedentary time compared to nonfatigued participants. Regardless of fatigue status, the highest levels of physical activity occurred in the morning and midday, while the highest levels of sedentary behavior were seen in the evening.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Clinical Neurology
Daniel Ontaneda, Tanuja Chitnis, Kottil Rammohan, Ahmed Z. Obeidat
Summary: Early treatment initiation in MS is crucial for preventing irreversible damage. Current assessment methods may not capture all early indicators of disease activity, highlighting the need for reassessment.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Christian Dettmers, Sina Marchione, Annette Weimer-Jaekel, Benjamin Godde, Michael Joebges
Summary: In patients with Multiple Sclerosis, employment status three months after discharge from the clinic can be more accurately predicted by cognitive fatigability (tonic alertness at 8 a.m. or increase of reaction time during the afternoon) than by the subjective sensation of fatigue as determined by the Fatigue Scale for Motor and Cognition.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Letter
Clinical Neurology
Steven Galetta, Aravind Ganesh, Ariane Lewis, James E. Siegler
Summary: The study suggests a link between central hypersomnia and fatigue and sleepiness in patients with multiple sclerosis (MS), while depression is more commonly associated with fatigue. It emphasizes the importance of monitoring and screening for sleep disorders in patients with demyelinating disease and suggests that restless leg syndrome may not play a prominent role in MS fatigue.
Review
Clinical Neurology
Joanna Tarasiuk, Katarzyna Kapica-Topczewska, Agata Czarnowska, Monika Chorazy, Jan Kochanowicz, Alina Kulakowska
Summary: Fatigue and depression are common symptoms in patients with multiple sclerosis (MS). Primary fatigue and depression in MS are caused by inflammatory, oxidative/nitrosative, and neurodegenerative processes. Secondary fatigue and depression may be caused by emotional factors, sleep disorders, pain, coexisting diseases, and medication use.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Multidisciplinary
Julia Schueler, Wanja Wolff, Julian Pfeifer, Romina Rihm, Jessica Reichel, Gerhard Rothacher, Christian Dettmers
Summary: The study found that patients with multiple sclerosis and chronic stroke complied with the World Health Organization's recommendations for health-promoting physical activity, but with differences in compliance levels. The difference in physical activity between patient groups was mainly attributed to the higher proportion of women in the multiple sclerosis sample, who engage more in household chores. For chronic stroke patients, sports activity levels were positively correlated with vitality, self-control, and self-efficacy.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oliver Neuhaus, Wolfgang Koehler, Florian Then Bergh, Wolfgang Kristoferitsch, Juergen Faiss, Thorsten Rosenkranz, Dirk Reske, Robert Patejdl, Hans-Peter Hartung, Uwe K. Zettl
Summary: This study aimed to investigate the correlation between clinical, neuropsychological, and immunological parameters in RRMS patients with fatigue before and during treatment with GA. After 12 months of treatment, 13 patients showed improvement in all three fatigue assessment scales, while 5 patients deteriorated and 7 patients showed inconsistent effects. Fatigue and overall quality of life improved, but no clear correlation between clinical and molecular effects of GA was found in RRMS patients with fatigue.
Article
Psychology, Applied
Jussi Onninen, Mia Pylkkonen, Tarja Hakola, Sampsa Puttonen, Jussi Virkkala, Asko Tolvanen, Mikael Sallinen
Summary: This study investigated the causes of sleepiness among tram and long-haul truck drivers and found that the main reasons for sleepiness differ between the two groups. While drivers commonly reported sleep loss and insufficient rest breaks as causes of sleepiness, truck drivers primarily attributed their sleepiness to time of day and sleep loss.
TRANSPORTATION RESEARCH PART F-TRAFFIC PSYCHOLOGY AND BEHAVIOUR
(2021)
Article
Neurosciences
Justyna Redlicka, Ewa Zielinska-Nowak, Anna Lipert, Elzbieta Miller
Summary: The study demonstrated that moderate physical activity has a positive effect on cognitive functions, functional status, and postural stability in MS patients, with a more significant impact on emotional state among patients with high fatigue. Both groups benefited from the MPA program overall.
Article
Clinical Neurology
Marit L. Schlagheck, Sven T. Huebner, Niklas Joisten, David Walzik, Annette Rademacher, Florian Wolf, Jens Bansi, Clemens Warnke, Philipp Zimmer
Summary: Based on theoretical models, physical activity has been introduced as a promoting method to mitigate the disease severity, fatigue and relapse rate in multiple sclerosis. The primary objective of the study was to investigate the relation between self-reported physical activity level and disease severity, fatigue and relapse rate in persons with relapsing remitting multiple sclerosis (RRMS).
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Matthias Grothe, Stefan Gross, Marie Suesse, Sebastian Strauss, Iris Katharina Penner
Summary: Seasonal variations and outdoor temperature have an impact on fatigue severity in patients with multiple sclerosis. Fatigue is higher in summer compared to winter. This finding should be taken into account when clinically monitoring fatigue.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Nasim Rezaeimanesh, Pegah Rafiee, Roghayyeh Saeedi, Sharareh Eskandarieh, Mohammad Ali Sahraian, Pegah Khosravian, Maryam Abolhasani, Soodeh Razeghi Jahromi, Abdorreza Naser Moghadasi
Summary: This study investigated the role of physical activity level and body mass index in the comorbidities of depression, fatigue, and anxiety in multiple sclerosis (MS) patients. The results suggest that maintaining a physically active lifestyle and a normal weight category may lead to reduced symptoms of depression, fatigue, and anxiety in MS patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
I. J. Chou, C. F. Kuo, R. Tanasescu, C. R. Tench, C. G. Tiley, C. S. Constantinescu, W. P. Whitehouse
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Article
Health Care Sciences & Services
Nadina B. Lincoln, Lucy E. Bradshaw, Cris S. Constantinescu, Florence Day, Avril E. R. Drummond, Deborah Fitzsimmons, Shaun Harris, Alan A. Montgomery, Roshan das Nair, Miriam Morgan, Cris Constantinescu, Holly Chappell, Sara Clarke, Kara Crossley, Cara Knight, Kristy Martin, Perry Moore, Carolyn Young, Alexandra Cunliffe, Catherine Pollard, John Wilson, Basil Sharrack, Claire Isaac, David Griffiths, Emma Trigg, Serena Vanzan, Vera Fixter, Laura Hanley, Joanna Dalton, Stephanie Pegnall, Stephen Evans, Miranda Wheeler, Lena Palmer, Tracy Tyrell, Shannon Gaughan, Gemma Elliot, Sophie Keogh, Helen Oldknow, Catherine Edwards, Nigel Schofield, Hannah Carpenter, Heather Cogger, Rachel Harnell, Jacqueline Mhizha-Murira, Katie Powers, Luke Squires, Susan Evans, Olga Klein, Kirsty Sprange, Amy Evans, Jo Hobbs, Natalie Wakefield, Brian Barnes, Monica Crone, Matthew Foster, Chris Rumsey, Alexandra Erven, Rona Moss-Morris, Audrey Bowen, Rory O'Connor, Julia Scott, Shirlee McKeown, Jenny Freeman, Rod Taylor, Anita Rose
HEALTH TECHNOLOGY ASSESSMENT
(2020)
Article
Immunology
Peter A. C. Maple, Bruno Gran, Radu Tanasescu, David Pritchard, Cris S. Constantinescu
Review
Neurosciences
Abdulmajeed Alotaibi, Christopher Tench, Rebecca Stevenson, Ghadah Felmban, Amjad Altokhis, Ali Aldhebaib, Rob A. Dineen, Cris S. Constantinescu
Summary: Both type 1 and type 2 diabetes mellitus can impact the microstructural environment and cognitive functions of the brain. Diffusion Tensor Imaging (DTI) is a sensitive MRI-based technique that has been used to quantify brain microstructural abnormalities in patients with diabetes, demonstrating the potential affect on cognitive abilities.
Review
Medicine, General & Internal
Amjad I. AlTokhis, Abdulmajeed M. AlOtaibi, Ghadah A. Felmban, Cris S. Constantinescu, Nikos Evangelou
Article
Pharmacology & Pharmacy
Wanshan Feng, Chaolong Qin, Elena Cipolla, Jong Bong Lee, Atheer Zgair, Yenju Chu, Catherine A. Ortori, Michael J. Stocks, Cris S. Constantinescu, David A. Barrett, Peter M. Fischer, Pavel Gershkovich
Summary: Oral sesame oil-based formulation helps deliver CBD to the lymphatic system and blood circulation, but also leads to variability in absorption. Adding MCT to the formulation increases CBD distribution into the micellar phase, while surfactants do not further enhance this distribution. MCT improves emulsification and micellar solubilization of CBD, reducing variability in concentrations in vivo.
Review
Neurosciences
Abdulmajeed Alotaibi, Anna Podlasek, Amjad AlTokhis, Ali Aldhebaib, Rob A. Dineen, Cris S. Constantinescu
Summary: The study investigated brain microstructural changes and neuroaxonal pathology in white matter lesions of patients with multiple sclerosis using NODDI metrics. The results showed a significant reduction in Neurite Density Index (NDI) in MS lesions and normal-appearing white matter (NAWM) compared to healthy participants, indicating potential damage or loss of neurites in MS.
Article
Environmental Sciences
Holly Oliver-Hall, Elena Ratschen, Christopher R. Tench, Helen Brooks, Cris S. Constantinescu, Laura Edwards
Summary: This study investigated pet ownership rates and attachment levels among people with and without MS, as well as the impact of pet ownership on quality of life, satisfaction with social roles, and self-efficacy. Results showed a small decrease in satisfaction with social roles associated with pet ownership, but most participants perceived positive roles of pets during the pandemic.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Amjad Altokhis, Aimee M. Hibbert, Christopher M. Allen, Olivier Mougin, Abdulmajeed Alotaibi, Su-Yin Lim, Cris S. Constantinescu, Rasha Abdel-Fahim, Nikos Evangelou
Summary: This study found that the presence and number of iron rims surrounding lesions in patients with clinically isolated syndrome and multiple sclerosis are associated with long-term disability.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Lauren Astbury, Seema Kalra, Radu Tanasescu, Cris S. Constantinescu
Summary: In this study, the impact of CSF pleocytosis at diagnosis on long-term disease progression in multiple sclerosis patients was investigated. The results showed that CSF pleocytosis was not associated with higher long-term disability and had no long-term prognostic value in routine clinical circumstances.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Mohammed Alrouji, Ali Manouchehrinia, Jehan Aram, Abdulmajeed Alotaibi, Sharif Alhajlah, Yasir Almuhanna, Othman Alomeir, Anas Shamsi, Bruno Gran, Cris S. Constantinescu
Summary: This study quantitatively examines the effect of cigarette smoking on serum uric acid levels in people with multiple sclerosis (pwMS) before and after smoking cessation. It also investigates the possible correlation between uric acid levels and disability progression and disease severity. The results show that smokers with pwMS have significantly lower serum uric acid levels compared to non-smokers, which can be restored after smoking cessation. However, there is no correlation between serum uric acid levels and disability or disease severity in current smokers with pwMS.
Article
Neurosciences
Radu Tanasescu, Olivier Mougin, I-Jun Chou, Ali Al-Radaideh, Oltita P. Jerca, Su-Yin Lim, Penny Gowland, Cris S. Constantinescu
Summary: Natalizumab can prevent the progression of microstructural tissue damage in patients with multiple sclerosis, as shown by high-field MRI.
Article
Clinical Neurology
Radu Tanasescu, Nanci Frakich, I. -Jun Chou, Perla Filippini, Giulio Podda, Gao Xin, Ranjithmenon Muraleedharan, Oltita Jerca, David Onion, Cris S. Constantinescu
Summary: Natalizumab (NTZ) is a monoclonal antibody that blocks the interaction between activated T cells and B cells with endothelial cells of the central nervous system (CNS), effectively preventing new lesion formation and relapses in multiple sclerosis (MS). This study investigated the effects of NTZ treatment on regulatory T cells (Treg) and other lymphocyte populations in MS patients. The results suggest that NTZ does not have a sustained effect on Treg cells, but it may affect the expression of molecules involved in MS pathogenesis differently from interferon-beta-1a (IFN-β1a).
NEUROLOGY AND THERAPY
(2023)
Article
Neurosciences
Sonika Singh, Christopher R. Tench, Radu Tanasescu, Cris S. Constantinescu
Article
Clinical Neurology
Srishti Gupta, Mohnish Suri, Cris S. Constantinescu
NEUROLOGY AND THERAPY
(2020)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.