Article
Pharmacology & Pharmacy
Aitziber Mendiguren, Erik Aostri, Irati Rodilla, Iker Pujana, Ekaterina Noskova, Joseba Pineda
Summary: The pharmacological profile of cannabigerol (CBG), particularly its effect on alpha(2)-adrenoceptor and 5-HT1A receptor, is poorly understood. In this study, male Sprague-Dawley rat brain slices were used to investigate the impact of CBG on firing rate of LC NA cells and DRN 5-HT cells, as well as its interaction with alpha(2)-adrenergic and 5-HT1A autoreceptors. CBG was also evaluated for its anxiolytic-like effects using behavior tests. The findings indicate that CBG inhibits the suppressive effects of alpha(2)-adrenoceptor and 5-HT1A receptor agonists on NA-LC and 5-HT-DRN neurons, and produces anxiolytic-like effects through the 5-HT1A receptor.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Fang-Chia Chang
Summary: The neuropeptide Hypocretin is released in response to stress and plays a role in regulating arousal and energy balance. In a study, researchers found that footshock stimulation led to an increase in Hypocretin release and suppressed REM sleep in rodents. The study also showed that the elevated levels of Hypocretin disrupted both REM sleep and slow wave activity during NREM sleep. Furthermore, the footshock stimulation also caused an increase in innate anxiety.
Article
Behavioral Sciences
Jennyfer M. Payet, Kira-Elise Wilson, Adrian M. Russo, Anthony Angiolino, William Kavanagh-Ryan, Stephen Kent, Christopher A. Lowry, Matthew W. Hale
Summary: This study examined the involvement of serotonergic systems in social behavior and response to SSRI treatment in peri-adolescent female BALB/c mice. The results showed that chronic fluoxetine treatment led to social approach behavior comparable to controls, while acute fluoxetine treatment increased avoidance behavior. Activation of serotonergic neurons in the dorsal raphe nucleus correlated with social approach behavior. More research is needed to understand the effects and mechanisms of chronic SSRI treatment in females.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Anesthesiology
Carmen Camarena-Delgado, Meritxell Llorca-Torralba, Irene Suarez-Pereira, Lidia Bravo, Carolina Lopez-Martin, Jose A. Garcia-Partida, Juan A. Mico, Esther Berrocoso
Summary: The transition from acute to chronic pain leads to maladaptive brain remodeling and sensory hypersensitivity. This study found time-dependent plasticity of locus coeruleus (LC) neurons related to the site of injury and discovered the involvement of the LC -> dorsal reticular nucleus (DRt) pathway in chronic pain. Lidocaine blockade of LC ipsilateral to the lesion increased cold allodynia and reversed pain-induced depression. Inactivation of the LCcontra -> DRt(contra) pathway produced consistent analgesia in chronic pain and induced depressive-like behavior in naive animals.
Article
Neurosciences
Behrus Puladi, Maja Dinekov, Thomas Arzberger, Max Taubert, Christoph Kohler
Summary: Tau pathology and granulovacuolar degeneration (GVD) were found together in neurons to varying degrees in different brain regions. Factors such as age, percentage of neurons with pretangles in a region, and neuronal metabolism may influence the prevalence of neurons containing GVBs.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Cell Biology
Carolyn W. Harley, Susan G. Walling, Qi Yuan, Gerard M. Martin
Summary: Braak describes the onset of Alzheimer's Disease in the locus coeruleus, focusing on the pretangle stages and their connection to tau biology. Pretangle tau in locus coeruleus is believed to be influenced by the operational characteristics of the area. Understanding the timeline of pretangle and tangle formation in locus coeruleus is important for preventing cognitive decline and dementia. Promoting the health of locus coeruleus neurons can have positive effects on normal aging and cognitive function.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sen Li, Ikuo Otsuka, Takaki Tanifuji, Satoshi Okazaki, Tadasu Horai, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Akitoyo Hishimoto
Summary: Previous evidence has shown increased ribosomal DNA (rDNA) content in the blood of patients with schizophrenia (SCZ) among European populations. This study investigated rDNA copy number (rDNAcn) of SCZ in East Asian populations, as well as in blood and brain tissues. The results showed that patients with SCZ had significantly increased rDNAcn in both blood and brain tissues compared to controls. These findings replicate previous observations in Europeans and provide new insights into the molecular mechanisms underlying SCZ pathophysiology.
Article
Neurosciences
Connor J. McNulty, Isabella P. Fallon, Jose Amat, Rory J. Sanchez, Nathan R. Leslie, David H. Root, Steven F. Maier, Michael V. Baratta
Summary: Stress-linked disorders are more common in women and have different clinical presentations. Investigating sex differences in factors that determine susceptibility or resilience to stress outcomes and the circuit elements that mediate these effects is important. This study found that in male rats, instrumental control over stressors prevented the negative effects of stress exposure, but this protective effect was not observed in females. Interestingly, the researchers found that the dorsolateral striatum supported the controlling response in females instead of the dorsomedial striatum observed in males.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Yijuan Du, Sanghoon Choi, Alexander Pilski, Steven M. Graves
Summary: The study found that methamphetamine increases MAO-dependent mitochondrial stress in LC and DR neurons, resulting in degeneration of LC neurons while DR neurons are resistant. The differential vulnerability between LC and DR neurons may be attributed to the presence of L-type Ca2+ channel-dependent mitochondrial stress.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Ross A. McDevitt, Rosa Anna M. Marino, Hugo A. Tejeda, Antonello Bonci
Summary: Serotonin plays a crucial role in cue-reward learning in mice, as serotonin reuptake inhibitors can reduce lever pressing behavior, and alterations in serotonin levels in different brain regions can impact behavioral responses.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Daniil Grinchii, Lubica Lacinova, Eliyahu Dremencov
Summary: The acute effects of DOR agonist SNC80 and antagonist naltrindole on the firing activity of hippocampal glutamate and brainstem monoamine neurons were investigated. SNC80 dose-dependently inhibited the activity of glutamate, 5-HT, and dopamine neurons, while naltrindole dose-dependently stimulated 5-HT neurons. The co-administration of SNC80 and naltrindole inhibited noradrenaline neurons. These findings suggest that DOR ligands can modulate the firing activity of hippocampal glutamate and brainstem monoamine neurons in vivo conditions.
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Joseph A. Stucynski, Amanda L. Schott, Justin Baik, Shinjae Chung, Franz Weber
Summary: This study demonstrates the role of GABAergic neurons in the dorsomedial medulla in promoting and maintaining REM sleep in mice and suggests that their slow activity fluctuations may coordinate the timing of REM sleep episodes with infraslow brain rhythms.
Article
Biochemistry & Molecular Biology
Teodora Z. Markova, Claire J. Ciampa, Jourdan H. Parent, Molly R. LaPoint, Mark D'Esposito, William J. Jagust, Anne S. Berry
Summary: The study used [F-18]Fluoro-m-tyrosine ([F-18]FMT) PET imaging to measure serotonin synthesis capacity in the brains of healthy adults, and found that serotonin synthesis capacity increases with age. This is associated with longitudinal changes in cortical thickness, self-reported depression symptoms, AD-related tau and β-amyloid pathology, and sex differences.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Nima Khalighinejad, Sanjay Manohar, Masud Husain, Matthew F. S. Rushworth
Summary: Decision-making involves choosing actions, as well as determining when and whether to initiate them. Different brain regions, such as DRN, BF, and ACC, contribute to different stages of decision-making, with 5-HT and ACh playing complementary roles.
Article
Physiology
Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J. Homma, Shinji Yamaguchi
Summary: Serotonin is a neurotransmitter that plays an important role in regulating mental states and processing emotions in mammals. This study conducted a molecular dissection of serotonergic neurons in the brainstem of birds and found heterogeneity among these neurons. These findings contribute to a better understanding of the correspondence between bird and mammalian serotonergic neurons.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Alejandra Delgado-Sequera, Maria Hidalgo-Figueroa, Marta Barrera-Conde, Ma Carmen Duran-Ruiz, Carmen Castro, Cristina Fernandez-Aviles, Rafael de la Torre, Ismael Sanchez-Gomar, Victor Perez, Noelia Geribaldi-Doldan, Patricia Robledo, Esther Berrocoso
Summary: This study investigated the effects of chronic cannabis use on olfactory neuroepithelium cells, revealing alterations in cell processes and changes in functional proteomic pathways. Cannabis users showed changes in protein expression related to cytoskeleton, cell proliferation, and cell death, as well as implications in cancer, gastrointestinal, and neurodevelopmental pathologies. The findings suggest that cannabis may impact key processes in the developing brain, resembling characteristics seen in mental disorders such as DiGeorge syndrome, schizophrenia, and bipolar disorder.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Meritxell Llorca-Torralba, Carmen Camarena-Delgado, Irene Suarez-Pereira, Lidia Bravo, Patricia Mariscal, Jose Antonio Garcia-Partida, Carolina Lopez-Martin, Hong Wei, Antti Pertovaara, Juan Antonio Mico, Esther Berrocoso
Summary: There is a strong comorbidity between chronic pain and depression. The activation of noradrenergic locus coeruleus neurons is closely related to pain and depression. The time of injury also affects the symptoms, with early injury causing sensory hypersensitivity and long-term pain leading to depressive-like behavior.
Article
Anesthesiology
Carmen Camarena-Delgado, Meritxell Llorca-Torralba, Irene Suarez-Pereira, Lidia Bravo, Carolina Lopez-Martin, Jose A. Garcia-Partida, Juan A. Mico, Esther Berrocoso
Summary: The transition from acute to chronic pain leads to maladaptive brain remodeling and sensory hypersensitivity. This study found time-dependent plasticity of locus coeruleus (LC) neurons related to the site of injury and discovered the involvement of the LC -> dorsal reticular nucleus (DRt) pathway in chronic pain. Lidocaine blockade of LC ipsilateral to the lesion increased cold allodynia and reversed pain-induced depression. Inactivation of the LCcontra -> DRt(contra) pathway produced consistent analgesia in chronic pain and induced depressive-like behavior in naive animals.
Review
Neurosciences
Esther Berrocoso, Irene Suarez-Pereira, Meritxell Llorca-Torralba, Lidia Bravo, Carmen Camarena-Delgado, Carles Soriano-Mas
Summary: The locus coeruleus-noradrenergic system plays a crucial role in modulating pain and its comorbidity with anxiety and depressive disorders. However, the mechanisms underlying these effects are not fully understood. Novel research tools have helped redefine the locus coeruleus system and have shown its functional heterogeneity. This review summarizes the available data on the efferent activity of the locus coeruleus-noradrenergic system in relation to pain and its comorbidity with anxiodepressive disorders.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
L. Perez-Caballero, M. L. Soto-Montenegro, M. Desco, J. A. Mico, E. Berrocoso
Summary: This study identified the effects of escitalopram on metabolic activity in various brain areas, showing increased activity in certain regions and decreased activity in others. These changes are closely related to the serotonergic system and are similar to those observed after treatment with other fast-acting antidepressant approaches.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Albert Martinez-Pinteno, Gisela Mezquida, Miquel Bioque, Jose M. Lopez-Ilundain, Alvaro Andreu-Bernabeu, Inaki Zorrilla, Anna Mane, Roberto Rodriguez-Jimenez, Iluminada Corripio, Salvador Sarro, Angela Ibanez, Judith Usall, Olga Rivero, Patricia Gasso, Juan Carlos Leza, Manuel J. Cuesta, Mara Parellada, Ana Gonzalez-Pinto, Esther Berrocoso, Sergi Mas, Miguel Bernardo, S. Amoretti, C. Moren, E. Urbiola, J. Gonzalez-Penas, A. Roldan, A. Catalan, I Gonzalez-Ortega, A. Toll, T. Legido, L. Sanchez-Pastor, M. Dompablo, E. Pomarol-Clotet, R. Landin-Romero, A. Butjosa, E. Rubio, M. Ribeiro, I Lopez-Torres, L. Leon-Quismondo, J. Nacher, F. Contretas, A. Lobo, M. Gutierrez-Fraile, Pa Saiz
Summary: This study examined the relationship between plasma levels of BDNF/NGF and symptom severity in first-episode schizophrenia patients in remission. The results showed significant correlations between BDNF/NGF levels and symptom severity, but they were not predictive of relapse. These findings suggest that BDNF and NGF may serve as potential biomarkers for long-term severity in schizophrenia.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Maria Hidalgo-Figueroa, Alejandro Salazar, Cristina Romero-Lopez-Alberca, Karina S. MacDowell, Borja Garcia-Bueno, Miquel Bioque, Miquel Bernardo, Mara Parellada, Ana Gonzalez-Pinto, Maria Paz Garcia Portilla, Antonio Lobo, Roberto Rodriguez-Jimenez, Esther Berrocoso, Juan C. Leza
Summary: This study analyzed the plasma oxytocin and prolactin levels in FEP patients and found that low oxytocin, high prolactin, poor premorbid IQ, and sustained attention deficits are associated with FEP, indicating potential therapeutic targets. Further research in these biological and cognitive domains could lead to improved outcomes for FEP patients, possibly with gender-specific strategies.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lucia Beltran-Camacho, Sara Eslava-Alcon, Marta Rojas-Torres, Daniel Sanchez-Morillo, Ma Pilar Martinez-Nicolas, Victoria Martin-Bermejo, Ines Garcia de la Torre, Esther Berrocoso, Juan Antonio Moreno, Rafael Moreno-Luna, Ma Carmen Duran-Ruiz
Summary: This study evaluated the impact of serum from asymptomatic COVID-19 individuals on circulating angiogenic cells (CACs) using a proteomics-based quantitative approach. The results confirmed that SARS-CoV-2 infection in asymptomatic individuals caused protein level changes related to coagulation and inflammatory processes. Additionally, certain proteins were up-regulated only in CACs treated with serum from asymptomatic patients during the highest peak of infection. These findings provide insight into the effects of SARS-CoV-2 infection and the development of potential treatment methods.
MOLECULAR MEDICINE
(2022)
Article
Psychiatry
Natalia Rodriguez, Patricia Gasso, Albert Martinez-Pinteno, Alex-Gonzalez Segura, Gisela Mezquida, Lucia Moreno-Izco, Javier Gonzalez-Penas, Inaki Zorrilla, Marta Martin, Roberto Rodriguez-Jimenez, Iluminada Corripio, Salvador Sarro, Angela Ibanez, Anna Butjosa, Fernando Contreras, Miquel Bioque, Manuel-Jesus Cuesta, Mara Parellada, Ana Gonzalez-Pinto, Esther Berrocoso, Miquel Bernardo, Sergi Mas, S. Silvia Amoretti, Constanza Moren, Carol Stella, Xaquin Gurriaran, Anna Alonso-Solis, Eva Grasa, Jessica Fernandez, Itxaso Gonzalez-Ortega, Francesc Casanovas, Antoni Bulbuena, Agatha Nunez-Doyle, Olga Jimenez-Rodriguez, Edith Pomarol-Clotet, Isabel Feria-Raposo, Judith Usall, Daniel Munoz-Samons, Jose L. Ilundain, Ana Maria Sanchez-Torres, Jeronimo Saiz-Ruiz, Isabel Lopez-Torres, Juan Nacher, Concepcion De-la-Camara, Miguel Gutierrez, Pilar Alejandra Saiz
Summary: By analyzing the association between blood co-expression modules and clinical data, we found that certain modules were correlated with clinical manifestations of schizophrenia, showing overlap with gene expression analysis in brain tissues. The hub genes in these modules were involved in multiple signaling pathways related to schizophrenia, suggesting their significant role in the development of the disease. These genes could potentially serve as targets for the development of peripheral biomarkers for schizophrenia.
Article
Neurosciences
Lidia Bravo, Patricia Mariscal, Meritxell Llorca-Torralba, Jose Maria Lopez-Cepero, Juan Nacher, Esther Berrocoso
Summary: This study examined the effects of neuropathic pain on noradrenergic neurons in the locus coeruleus (LC) and found that neuropathic pain leads to an increase in excitatory synapse markers and a decrease in mitochondrial and lysosomal densities. Long-term pain also activates apoptosis.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jose Antonio Garcia-Partida, Sonia Torres-Sanchez, Karina MacDowell, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Maria Luisa Soto-Montenegro, Diego Romero-Miguel, Nicolas Lamanna-Rama, Juan Carlos Leza, Manuel Desco, Esther Berrocoso
Summary: Mango leaf extract may serve as an alternative therapeutic or preventive add-on strategy for schizophrenia, improving clinical expression and modifying the course of the disease at earlier stages.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Manuel J. Cuesta, Alejandro Ballesteros, Ana M. Sanchez-Torres, Silvia Amoretti, Jose M. Lopez-Ilundain, Jessica Merchan-Naranjo, Itxaso Gonzalez-Ortega, Purificacion Salgado, Roberto Rodriguez-Jimenez, Alexandra Roldan-Bejarano, Salvador Sarro, Angela Ibanez, Judith Usall, M. Jose Escarti, Lucia Moreno-Izco, Gisela Mezquida, Mara Parellada, Ana Gonzalez-Pinto, Esther Berrocoso, Miguel Bernardo
Summary: This study found that cognitive functioning improved in processing speed and social cognition in FES patients during follow-up. Social cognition showed a significant interaction with relapse in this sample.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Clinical Neurology
Ana M. Sanchez-Torres, Silvia Amoretti, Monica Enguita-German, Gisela Mezquida, Lucia Moreno-Izco, Rocio Panadero-Gomez, Lide Rementeria, Alba Toll, Roberto Rodriguez-Jimenez, Alexandra Roldan, Edith Pomarol-Clotet, Angela Ibanez, Judith Usall, Fernando Contreras, Eduard Vieta, Jose M. Lopez-Ilundain, Jessica Merchan-Naranjo, Ana Gonzalez-Pinto, Esther Berrocoso, Miguel Bernardo, Manuel J. Cuesta
Summary: This study aimed to investigate the relationship between relapse, cognitive function, and cognitive reserve in schizophrenia patients. The results showed that higher personal cognitive reserve mitigated the negative effects of relapse on attention performance, while higher cognitive reserve (both personal and familial) improved processing speed and visual memory in patients who did not relapse. These findings provide evidence for the protective effect of cognitive reserve over the course of the illness.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Celtia Dominguez-Fernandez, June Egiguren-Ortiz, Jone Razquin, Margarita Gomez-Galan, Laura De las Heras-Garcia, Elena Paredes-Rodriguez, Egoitz Astigarraga, Cristina Miguelez, Gabriel Barreda-Gomez
Summary: Neurodegenerative disorders are characterized by progressive neuron loss in specific brain areas. Current clinical tests have limited capability in diagnosing similar disorders and detecting early stages of the disease. New diagnostic methods, such as neuroimaging techniques and biomarker discovery, along with artificial intelligence, can significantly improve early diagnosis and patient outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Alex-Gonzalez Segura, Llucia Prohens, Gisela Mezquida, Silvia Amoretti, Miquel Bioque, Maria Ribeiro, Xaquin Gurriaran-Bas, Lide Rementeria, Daniel Berge, Roberto Rodriguez-Jimenez, Alexandra Roldan, Edith Pomarol-Clotet, Angela Ibanez, Judith Usall, Maria Paz Garcia-Portilla, Manuel J. Cuesta, Mara Parellada, Ana Gonzalez-Pinto, Esther Berrocoso, Miquel Bernardo, Sergi Mas
Summary: The present study found that epigenetic age acceleration may be associated with relapse in schizophrenia patients, and shorter telomere length is related to cognitive performance.
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.