Article
Multidisciplinary Sciences
Emi Hasegawa, Ai Miyasaka, Katsuyasu Sakurai, Yoan Cherasse, Yulong Li, Takeshi Sakurai
Summary: The sleep cycle involves alternating non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. A transient increase of dopamine in the basolateral amygdala terminates NREM sleep and initiates REM sleep, playing a critical role in sleep cycle generation. This mechanism is also implicated in cataplectic attacks in narcoleptics.
Article
Multidisciplinary Sciences
Kuldeep Singh, Cathleen S. Cornell, Robert Jackson, Mostafa Kabiri, Michael Phipps, Mitul Desai, Robert Fogle, Xiaoyou Ying, Gulbenk Anarat-Cappillino, Sarah Geller, Jennifer Johnson, Errin Roberts, Katie Malley, Tim Devlin, Matthew DeRiso, Patricia Berthelette, Yao Zhang, Susan Ryan, Srinivas Rao, Beth L. Thurberg, Dinesh S. Bangari, Sirkka Kyostio-Moore
Summary: The study successfully created a homozygous Pah knock-out mouse model using CRISPR/Cas9 technology, exhibiting biochemical, behavioral, and pathologic features similar to PKU patients. This novel mouse model can serve as a valuable translational tool for PKU preclinical research and drug development.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Francisco Figueiredo, Zsuzsa Sarkany, Alexandra Silva, Daniela Vilasboas-Campos, Patricia Maciel, Andreia Teixeira-Castro, Pedro M. Martins, Sandra Macedo-Ribeiro
Summary: The accumulation of mutant Atx3 in neuronal nuclear inclusions is a pathological hallmark of MJD, and inhibiting Atx3 aggregation can be a potential disease-modifying strategy. Dopamine and other catecholamines have shown to be potent inhibitors of Atx3 aggregation in vitro. Although dopamine itself cannot cross the blood-brain barrier, drugs that increase dopamine levels in the brain, such as levodopa, may have potential applications in reducing Atx3 accumulation in the brains of MJD patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Sara Alvente, Chiara Berteotti, Stefano Bastianini, Viviana Lo Martire, Gabriele Matteoli, Alessandro Silvani, Giovanna Zoccoli
Summary: The study found that in orexin-deficient mouse models, higher arterial pressure during sleep and smaller differences in arterial pressure between sleep and wakefulness are mediated by alterations in cardiovascular sympathetic control.
Article
Biochemistry & Molecular Biology
Vladimir M. Pogorelov, Michael L. Martini, Jian Jin, William C. Wetsel, Marc G. Caron
Summary: L-DOPA is the main treatment for Parkinson's disease, but it can lead to dyskinesia over time. In this study, dopamine-depleted dopamine-transporter KO (DDD) mice were used as an acute PD model to screen novel compounds for anti-parkinsonian and L-DOPA-induced dyskinesia. The researchers found that oral stereotypies could be used as an index for LID in DDD mice.
Article
Neurosciences
Edenia C. Menezes, Relish Shah, Lindsay Laughlin, K. Yaragudri Vinod, John F. Smiley, Catarina Cunha, Andrea Balla, Henry Sershen, Francisco X. Castellanos, Andre Corvelo, Catia M. Teixeira
Summary: Early life is a critical period where enhanced neural plasticity allows the developing brain to adapt to its environment. Exposure to fluoxetine in early postnatal period can lead to reduced effort-related motivation and blunted dopaminergic activation in reward tasks in adulthood. Administering bupropion in adulthood can rescue the reduction in motivation, highlighting the involvement of the dopaminergic system in this process.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Margherita Tassan Mazzocco, Fabrizia Claudia Guarnieri, Elena Monzani, Fabio Benfenati, Flavia Valtorta, Stefano Comai
Summary: Deletion of Syns in mice results in behavioral abnormalities and neurobiological changes, including hyperactivity, social impairment, anxiety-like behavior, reduced firing activity of DRN 5-HT neurons, enhanced responsiveness of DRN 5-HT-1A autoreceptors, and lower hippocampal 5-HT levels.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Maria Arnoriaga-Rodriguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodriguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnes, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos, Salvador Pedraza, Ramon Brugada, Joan C. Vilanova, Joaquin Serena, Jordi Barretina, Jordi Gich, Vicente Perez-Brocal, Andres Moya, Xavier Fernandez-Real, Lluis Ramio-Torrenta, Reinald Pamplona, Joaquim Sol, Mariona Jove, Wifredo Ricart, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernandez-Real
Summary: The study revealed the relationship between inhibitory control and obesity, as well as the interactions between gut microbiota, metabolomics, and brain structure. Metabolic pathway alterations associated with obesity were found to be linked to inhibitory control, and results were validated in mice through fecal microbiota transplantation.
Article
Behavioral Sciences
Tomohisa Mori, Naoki Uzawa, Daiki Masukawa, Shigeto Hirayama, Yoshiyuki Iwase, Mayuna Hokazono, Yuya Udagawa, Tsutomu Suzuki
Summary: Orexinergic system is involved in regulating the rewarding effects of psychostimulants, but there is a risk of establishing these effects even under orexin deficiency. Conversely, deficiencies in orexin may enhance the abuse liability of MDMA by changing a postsynaptic signal transduction accompanied by changes in discriminative stimulus effects themselves.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Oncology
Maria P. Mogavero, Alessandro Silvani, Lourdes M. DelRosso, Michele Salemi, Raffaele Ferri
Summary: This narrative review discusses the complex interrelationship between cancer and neurodegeneration, exploring potential mechanisms underlying their inverse relationship. Research shows a lower prevalence of cancer in individuals with neurodegenerative diseases, suggesting a propensity towards one type of disease may decrease the risk of the other. Genetic, protein, and pathway dysregulation in cancer and neurodegenerative diseases often show opposite patterns, indicating a complex biological interconnection between the two.
Article
Biochemistry & Molecular Biology
Zachary Yu, Ya-Tin Lin, Jin-Chung Chen
Summary: The study suggests that NPFFR2 modulates LPS-induced depressive-like behavioral phenotypes by downregulating 5HT1AR in the ventral hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Baiba Svalbe, Baiba Zvejniece, Gundega Stelfa, Karlis Vilks, Edijs Vavers, Jose Miguel Vela, Maija Dambrova, Liga Zvejniece
Summary: This study found that the absence of Sig1R significantly influenced metabolic pathways such as amino acids, sphingolipids, and serotonin. Sig1R KO mice had higher levels of serotonin and histamine in their blood and brain tissues, which were correlated with behavioral changes.
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Article
Biology
Susan M. Tyree, Kimberly J. Jennings, Oscar C. Gonzalez, Shi-bin Li, Janet R. Nicholson, Moritz von Heimendahl, Luis de Lecea
Summary: Neurons expressing Hypocretin in the lateral hypothalamus are crucial for regulating arousal stability. This study investigates the dynamics of Hypocretin neuronal circuit during stop action impulsivity in mice performing a Go/NoGo task. The findings suggest that Hypocretin neurons play a key role in integrating salient stimuli to produce appropriate responses to rewarding and aversive cues.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Yuki Kambe, Junichi Sakaguchi, Honami Setoyama, Akihiro Yamanaka, Tomoyuki Kuwaki
Article
Multidisciplinary Sciences
Jingyang Su, Zhi Li, Akira Yamashita, Ikue Kusumoto-Yoshida, Takuto Isomichi, Liying Hao, Tomoyuki Kuwaki
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Honami Setoyama, Yunsu Hwang, Akihiro Yamanaka, Tomoyuki Kuwaki
Article
Biochemistry & Molecular Biology
Shuichi Matsuda, Jun-Dal Kim, Fumihiro Sugiyama, Yuji Matsuo, Junji Ishida, Kazuya Murata, Kanako Nakamura, Kana Namiki, Tatsuhiko Sudo, Tomoyuki Kuwaki, Masahiko Hatano, Koichiro Tatsumi, Akiyoshi Fukamizu, Yoshitoshi Kasuya
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Physiology
Sichong Chen, Nobuaki Takahashi, Changping Chen, Jordan L. Pauli, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Biology
Tomoyuki Kuwaki, Kouta Kanno
Summary: The study examined courtship behavior in orexin neuron-ablated mice (ORX-AB), a model of narcolepsy/cataplexy, and found that these mice displayed cataplexy-like behavior in response to female encounter, with a predominant presence during dark periods when exposed to chocolate. Studying cataplexy-like behavior in narcoleptic mice is useful for understanding mechanisms behind positive emotions, such as those associated with chocolate and courtship.
COMMUNICATIONS BIOLOGY
(2021)
Article
Behavioral Sciences
Hideki Kashiwadani, Yurina Higa, Mitsutaka Sugimura, Tomoyuki Kuwaki
Summary: The study found that linalool odor exposure still triggered analgesic effects even in TRPA1-deficient mice, and intranasal application of TRPA1 selective antagonist did not alter the analgesic effects of linalool odor, indicating that linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.
BEHAVIORAL AND BRAIN FUNCTIONS
(2021)
Article
Biochemistry & Molecular Biology
Tomoyuki Kuwaki
Summary: This article summarizes the recent research findings of the author's research group on the role of orexin in the state-dependent adjustment of central autonomic regulation, as well as new discoveries using optogenetic manipulation of the orexin system. The study suggests that the orexin system may play a crucial role in coordinating circuits controlling autonomic functions and behaviors.
Article
Multidisciplinary Sciences
Yurina Higa, Hideki Kashiwadani, Mitsutaka Sugimura, Tomoyuki Kuwaki
Summary: The exposure to Linalool odor induces analgesic effects in mice, which are triggered by olfactory input and involve hypothalamic orexinergic neurons. Specifically, the activation of the orexinergic descending pathway by Linalool odor exposure suppresses neuronal activity in the spinal cord, leading to reduced nociceptive information flow and pain relief.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Akira Yamashita, Shunpei Moriya, Ryusei Nishi, Jun Kaminosono, Akihiro Yamanaka, Tomoyuki Kuwaki
Summary: Orexin neurons in the perifornical area of the hypothalamus play a critical role in the defense response, as shown by rapid increase in neuronal activity just prior to changes in heart rate. The memory of aversive stimulus can activate orexin neurons and increase heart rate. Targeting orexin neurons may enable treatment of psychiatric disorders associated with chronic stress and traumatic memories.
Article
Cell Biology
Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Junichi Sakaguchi, Yoko Ikoma, Yoshimune Sameshima, Yuki Kambe, Akihiro Yamanaka, Tomoyuki Kuwaki
Summary: The study reveals that acute nociceptive stimuli rapidly increase the activities of AS/A7 NA or B2 5-HT neurons in awake mice, while non-noxious stimuli do not have this effect. This suggests that AS/A7 NA or B2 5-HT neurons play important roles in nociceptive processing in the central nervous system.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Shi Zhou, Akira Yamashita, Jingyang Su, Yang Zhang, Wuyang Wang, Liying Hao, Akihiro Yamanaka, Tomoyuki Kuwaki
Summary: The study found that the activity of orexin-deficient mice's neurons increased before the onset of cataplexy-like behavior but decreased during the episode. This suggests that orexin neurons are moderately inhibited during cataplexy, providing insights for better understanding and treatment of cataplexy in narcolepsy patients.
Article
Physiology
Tatsuroh Kaneko, Tomoyuki Kuwaki, Hideki Kashiwadani
Summary: The study reveals that orexin neurons in the lateral hypothalamus modulate pain and itch in an opposite way, with pain relief and itch exacerbation. Most of these neurons respond to both pain and itch input.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Mayuko Yoshida, Koki Yamamoto, Tomoyuki Kuwaki
Summary: This study investigated the relationship between cataplexy and positive emotions in narcolepsy mice. The researchers found that narcolepsy mice could remember the chocolate-associated chamber and exhibited more cataplexy-like behaviors in that chamber. The activation patterns of the nucleus accumbens during spontaneous and chocolate-induced cataplexy were similar. These findings support the hypothesis that some spontaneous cataplexy in narcolepsy mice might indicate the remembering of happy moments.
Review
Neurosciences
Tomoyuki Kuwaki, Nobuaki Takahashi
Summary: TRPA1 is a member of the TRP superfamily of cation channels and is widely expressed in sensory neural pathways. It detects irritant chemicals, hypoxia, and hyperoxia. Its role in respiratory and behavioral modulation has been studied using Trpa1 knockout mice. The results show that TRPA1 is necessary for protective responses in respiration and behavior, suggesting that TRPA1 channels in the airway may play a sentinel role for environmental threats.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.