Article
Biochemistry & Molecular Biology
Stefan Schwerin, Catharina Westphal, Claudia Klug, Gerhard Schneider, Matthias Kreuzer, Rainer Haseneder, Stephan Kratzer
Summary: Recent evidence suggests that dexmedetomidine might directly inhibit HCN channels, but the effects are modest at clinically relevant concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Kevin Jehasse, Laurent Massotte, Sebastian Hartmann, Romain Vitello, Sofian Ringlet, Marie Vitello, Han Chow Chua, Stephan A. Pless, Dominique Engel, Jean-Francois Liegeois, Bernard Lakaye, Jochen Roeper, Vincent Seutin
Summary: The research showed that the compound XG selectively inhibits the pacemaking of dopamine neurons without affecting their bursting behavior. It demonstrated specificity in its effects on different types of neurons and seemed to target a small subthreshold XG-sensitive current carried by Na+ and Cl- ions. The molecular target of XG and its precise mechanism of action remain to be elucidated, but these findings represent a significant step towards understanding pacemaking in dopamine neurons.
Article
Multidisciplinary Sciences
Zeinab Jahed, Yang Yang, Ching-Ting Tsai, Ethan P. Foster, Allister F. McGuire, Huaxiao Yang, Aofei Liu, Csaba Forro, Zen Yan, Xin Jiang, Ming-Tao Zhao, Wei Zhang, Xiao Li, Thomas Li, Annalisa Pawlosky, Joseph C. Wu, Bianxiao Cui
Summary: This study develops mechanically robust nanocrown electrodes with high success rates achieved through electroporation, and validates their accurate recording of intracellular action potentials through simultaneous patch clamp recording. The study also demonstrates the ability of nanocrown electrodes to enable prolonged recording of the same cells after sequential addition of drugs. This technological advancement is significant for establishing a screening assay for preclinical evaluation of drug-induced arrhythmogenicity.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Julia Bukanova, Elena Solntseva, Rodion Kondratenko, Eva Kudova
Summary: Epi is a positive modulator of GABA-induced chloride current (I-GABA) with an EC50 of 5.7 μM in Purkinje cells and 9.3 μM in hippocampal neurons. The potentiation of I-GABA by Epi is more pronounced at low GABA concentrations.
Article
Chemistry, Analytical
Ke Li, Huiying Gong, Jinyu Qiu, Ruimin Li, Qili Zhao, Xin Zhao, Mingzhu Sun
Summary: This study proposes a method for pipette tip-cell contact in automated patch-clamp systems and designs corresponding algorithms and network models. Experimental results show that this method can improve the success rate in patch-clamp experiments.
Article
Biochemistry & Molecular Biology
Victoria L. Luck, David P. Richards, Ashif Y. Shaikh, Henrik Franzyk, Ian R. Mellor
Summary: Alterations in the polyamine and tyrosine moieties of philanthotoxin-343 were investigated for their effects on locust nAChRs antagonism. The analogues showed different potencies in inhibiting ACh-induced inward currents, with a combination of alterations generating the most potent analogue. Modulation by different analogues indicated the presence of two pharmacologically distinct nAChR groups in the locust mushroom body.
Article
Biochemistry & Molecular Biology
Dieter Janzen, Benedikt Slavik, Markus Zehe, Christoph Sotriffer, Helene M. Loos, Andrea Buettner, Carmen Villmann
Summary: This study analyzed the modulatory potential of 11 SQTs at GABA(A) receptors to characterize their potential neurotropic activity. The research found differences in receptor modulation by SQTs in HEK293 cells and neurons, with the presence of gamma(2) and delta subunits being important for SQT modulation. Additionally, the study provided insight into how nutritional digestion can affect the neurotropic potential of natural compounds.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Noemi Binini, Francesca Talpo, Paolo Spaiardi, Claudia Maniezzi, Matteo Pedrazzoli, Francesca Raffin, Niccolo Mattiello, Antonio N. Castagno, Sergio Masetto, Yuchio Yanagawa, Clayton T. Dickson, Stefano Ramat, Mauro Toselli, Gerardo Rosario Biella
Summary: The perirhinal cortex (PRC) acts as a gateway between cortical areas and hippocampus, with its neurons being able to amplify output signals and coordinate network activity in the brain through resonance. This resonance ability is crucial for information transmission and memory enhancement between neocortex and hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Anesthesiology
Jie Li, Elizabeth K. Serafin, Mark L. Baccei
Summary: This study investigated the intrinsic and synaptic properties of lamina I spino-PAG neurons and their modulation by neonatal injury. The results showed that the firing of spino-PAG neurons is mainly governed by their intrinsic membrane properties and is resistant to the influence of neonatal tissue damage.
Article
Biochemistry & Molecular Biology
Julia V. Bukanova, Rodion V. Kondratenko, Elena I. Solntseva
Summary: This study investigates the interaction between positive allosteric modulators (PAMs) and competitive antagonists of GABA(A)Rs, demonstrating unblocking effects and revealing an allosteric relationship between these two types of compounds.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel Leon-Aparicio, Jorge Arreola, Patricia Perez-Cornejo, Alfredo Sanchez-Solano
Summary: The study shows that oleic acid irreversibly blocks the TMEM16A chloride channel in a dose- and voltage-dependent manner, possibly through an allosteric mechanism. This blockage is intensified by increasing the extracellular anion concentration and is independent of voltage for certain pore mutants.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Neurosciences
Wissam B. Nassrallah, Daniel Ramandi, Judy Cheng, Jean Oh, James Mackay, Marja D. Sepers, David Lau, Hilmar Bading, Lynn A. Raymond
Summary: Cortical-striatal synaptic dysfunction is an important feature before Huntington's disease, and Activin A can improve this dysfunction by inhibiting extrasynaptic N-methyl-D-aspartate receptor (eNMDARs) signaling.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Anesthesiology
Misa Oyama, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe
Summary: Increasing the levels of inhibitory neurotransmitters by blocking their reuptake is a promising therapeutic strategy for relieving chronic pain. In this study, the effects of GABA transporter inhibitors on synaptic transmission in the spinal dorsal horn were investigated. The results showed that GAT1 and GAT3 inhibitors exert distinct GABA(B) receptor-mediated inhibitory effects on excitatory synaptic transmission, contributing to their analgesic effects.
Article
Dentistry, Oral Surgery & Medicine
Saori Yamada, Susumu Tanaka, Soju Seki, Mikihiko Kogo
Summary: Zinc deprivation affected the membrane properties and spike-discharge features of MTNs, with an increase in Ca2+-dependent K+ conductance observed in zinc-deficient MTNs. Other action potential properties were not significantly altered by zinc deprivation.
JOURNAL OF ORAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Junli Jiang, Yingfu Jiao, Po Gao, Wen Yin, Wei Zhou, Yunchun Zhang, Yanjun Liu, Daxiang Wen, Yuan Wang, Liang Zhou, Tian Yu, Weifeng Yu
Summary: Propofol, the most commonly used intravenous anesthetic worldwide, exerts its suppressive effects on consciousness and respiration by targeting GABAergic neurons in different nuclei. The study demonstrated distinct pharmacodynamic effects of propofol on various nuclei, shedding light on its mechanism of action during anesthesia.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
