Review: Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience-dependent plasticity

Effects of Environmental Enrichment on Repetitive Behaviors in the BTBR T+tf/J Mouse Model of Autism

(2013) Stacey Reynolds et al.   Autism Research

Towards Environmental Construct Validity in Animal Models of CNS Disorders: Optimizing Translation of Preclinical Studies

(2013) Emma Burrows et al.   CNS & Neurological Disorders-Drug Targets

Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model

(2013) David J. Harrison et al.   EXPERIMENTAL NEUROLOGY

Stem cells and the treatment of Parkinson's disease

(2013) Fahad Ali et al.   EXPERIMENTAL NEUROLOGY

Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis

(2013) C. Y. Daniel Lee et al.   FEBS Journal

Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis

(2013) Arnaud Tanti et al.   HIPPOCAMPUS

Genetics of dementia

(2013) Clement T Loy et al.   LANCET

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

Environmental Novelty Activates β2-Adrenergic Signaling to Prevent the Impairment of Hippocampal LTP by Aβ Oligomers

(2013) Shaomin Li et al.   NEURON

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

(2013) Yuan-Shih Hu et al.   PLoS One

Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain

(2013) Roger A. Barker et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

Bridging animal and human models of exercise-induced brain plasticity

(2013) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

A Tale of Two Maladies? Pathogenesis of Depression with and without the Huntington’s Disease Gene Mutation

(2013) Xin Du et al.   Frontiers in Neurology

Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner

(2012) Philipp Klaissle et al.   BMC NEUROSCIENCE

Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy

(2012) Kiren Ubhi et al.   EXPERIMENTAL NEUROLOGY

The search for genetic mouse models of prodromal Parkinson's disease

(2012) Gaynor A. Smith et al.   EXPERIMENTAL NEUROLOGY

Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease

(2012) Juan Beauquis et al.   EXPERIMENTAL NEUROLOGY

Environmental Enrichment Increases the GFAP+ Stem Cell Pool and Reverses Hypoxia-Induced Cognitive Deficits in Juvenile Mice

(2012) N. Salmaso et al.   JOURNAL OF NEUROSCIENCE

Differential effects of early environmental enrichment on emotionality related behaviours in Huntington's disease transgenic mice

(2012) Thibault Renoir et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cognitive reserve in ageing and Alzheimer's disease

(2012) Yaakov Stern   LANCET NEUROLOGY

Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice

(2012) Laure Verret et al.   NEUROBIOLOGY OF AGING

Effects of environmental manipulations in genetically targeted animal models of affective disorders

(2012) Thibault Renoir et al.   NEUROBIOLOGY OF DISEASE

Environmental and pharmacological modulations of cellular plasticity: Role in the pathophysiology and treatment of depression

(2012) Kristie T. Ota et al.   NEUROBIOLOGY OF DISEASE

Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models

(2012) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

(2012) Karlie A. Intlekofer et al.   NEUROBIOLOGY OF DISEASE

Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity

(2012) Terence Y.C. Pang et al.   NEUROPHARMACOLOGY

Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL/6J mice

(2012) M.L. Mustroph et al.   NEUROSCIENCE

Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington’s disease

(2012) J. Nithianantharajah et al.   NEUROSCIENCE

Short-Term Enrichment Makes Male Rats More Attractive, More Defensive and Alters Hypothalamic Neurons

(2012) Rupshi Mitra et al.   PLoS One

Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms

(2012) Inês Marques-Aleixo et al.   PROGRESS IN NEUROBIOLOGY

Environmental enrichment influences brain cytokine variations elicited by social defeat in mice

(2012) Robyn J. McQuaid et al.   PSYCHONEUROENDOCRINOLOGY

Brief environmental enrichment elicits metaplasticity of hippocampal synaptic potentiation in vivo

(2012) Arne Buschler et al.   Frontiers in Behavioral Neuroscience

Environmental enrichment rescues female-specific hyperactivity of the hypothalamic-pituitary-adrenal axis in a model of Huntington's disease

(2012) X Du et al.   Translational Psychiatry

The impact of environmental enrichment in laboratory rats—Behavioural and neurochemical aspects

(2011) Joy Simpson et al.   BEHAVIOURAL BRAIN RESEARCH

Environmental enrichment improves recent but not remote memory in association with a modified brain metabolic activation profile in adult mice

(2011) Marianne Leger et al.   BEHAVIOURAL BRAIN RESEARCH

Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise

(2011) Thibault Renoir et al.   BRITISH JOURNAL OF PHARMACOLOGY

Moderate Environmental Enrichment Mitigates Tauopathy in a Neurofibrillary Tangle Mouse Model

(2011) Inbal Lahiani-Cohen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Running is the neurogenic and neurotrophic stimulus in environmental enrichment

(2011) T. Kobilo et al.   LEARNING & MEMORY

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Preventive and therapeutic types of environmental enrichment counteract beta amyloid pathology by different molecular mechanisms

(2011) Arne Herring et al.   NEUROBIOLOGY OF DISEASE

“Brain training” improves cognitive performance and survival in a transgenic mouse model of Huntington's disease

(2011) Nigel I. Wood et al.   NEUROBIOLOGY OF DISEASE

Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

(2011) Natalie R.S. Goldberg et al.   NEUROBIOLOGY OF DISEASE

Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation

(2011) Young C. Chung et al.   NEUROPHARMACOLOGY

Synapse formation in adult barrel cortex following naturalistic environmental enrichment

(2011) M.S. Landers et al.   NEUROSCIENCE

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

(2011) L.A. Raymond et al.   NEUROSCIENCE

Short-Term Environmental Enrichment Rescues Adult Neurogenesis and Memory Deficits in APPSw,Ind Transgenic Mice

(2011) Jorge Valero et al.   PLoS One

Cognitive and behavioural effects of physical exercise in psychiatric patients

(2011) Christian Knöchel et al.   PROGRESS IN NEUROBIOLOGY

Spines, Plasticity, and Cognition in Alzheimer's Model Mice

(2011) Tara Spires-Jones et al.   NEURAL PLASTICITY

Environmental Enrichment Reduces Neuronal Intranuclear Inclusion Load But Has No Effect on Messenger RNA Expression in a Mouse Model of Huntington Disease

(2010) Caroline L. Benn et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1

(2010) Y Sztainberg et al.   MOLECULAR PSYCHIATRY

A retrospective study of the impact of lifestyle on age at onset of Huntington disease

(2010) M. Kaye Trembath et al.   MOVEMENT DISORDERS

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Enriched environment promotes similar neuronal and behavioral recovery in a young and aged mouse model of Parkinson's disease

(2010) N.R.S. Goldberg et al.   NEUROSCIENCE

Gene–environment interactions and construct validity in preclinical models of psychiatric disorders

(2010) Emma L. Burrows et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Mechanisms mediating brain and cognitive reserve: Experience-dependent neuroprotection and functional compensation in animal models of neurodegenerative diseases

(2010) Jess Nithianantharajah et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Prevention and treatment of drug addiction by environmental enrichment

(2010) Marcello Solinas et al.   PROGRESS IN NEUROBIOLOGY

Modeling Brain Reserve: Experience-Dependent Neuronal Plasticity in Healthy and Huntington's Disease Transgenic Mice

(2009) Jess Nithianantharajah et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration

(2009) Konstantinos Pothakos et al.   BMC NEUROSCIENCE

Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease

(2009) Sebastian Mirochnic et al.   HIPPOCAMPUS

A single exposure to an enriched environment stimulates the activation of discrete neuronal populations in the brain of the fos-tau-lacZ mouse

(2009) Ata E.A. Ali et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Enrichment from Birth Accelerates the Functional and Cellular Development of a Motor Control Area in the Mouse

(2009) Teresa Simonetti et al.   PLoS One

The neurobiology of brain and cognitive reserve: Mental and physical activity as modulators of brain disorders

(2009) Jess Nithianantharajah et al.   PROGRESS IN NEUROBIOLOGY

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

(2009) C. D. Clelland et al.   SCIENCE

Enrich the environment to empower the brain

(2009) Alessandro Sale et al.   TRENDS IN NEUROSCIENCES

Wheel-running in a transgenic mouse model of Alzheimer's disease: Protection or symptom?

(2008) Helene Richter et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice

(2008) Nicole Görtz et al.   BEHAVIOURAL BRAIN RESEARCH

A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats

(2008) J BRENES et al.   BEHAVIOURAL BRAIN RESEARCH

Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease

(2008) Anton van Dellen et al.   BMC NEUROSCIENCE

The R6 lines of transgenic mice: A model for screening new therapies for Huntington's disease

(2008) Joana M. Gil et al.   BRAIN RESEARCH REVIEWS

Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis

(2008) Nathan C. Stam et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndromeMecp2gene dosage effects and BDNF expression

(2008) Mari Kondo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Environmental enrichment enhances cellular plasticity in transgenic mice with Alzheimer-like pathology

(2008) Arne Herring et al.   EXPERIMENTAL NEUROLOGY

Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease

(2008) Terence Y.C. Pang et al.   HUMAN MOLECULAR GENETICS

Enhanced Plasticity in Zincergic, Cortical Circuits after Exposure to Enriched Environments

(2008) A. S. Nakashima et al.   JOURNAL OF NEUROSCIENCE

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

(2008) Giovanni Laviola et al.   NEUROBIOLOGY OF DISEASE

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

(2008) A. Parachikova et al.   NEUROBIOLOGY OF DISEASE

Long-term exposure to environmental enrichment since youth prevents recognition memory decline and increases synaptic plasticity markers in aging

(2008) Perla Leal-Galicia et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Reversal of cocaine addiction by environmental enrichment

(2008) M. Solinas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY

Gene–environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington’s disease transgenic mice

(2007) Jess Nithianantharajah et al.   NEUROBIOLOGY OF DISEASE