Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Review
Food Science & Technology
Laryssa Rosa de Sousa Franckilin, Anna Clara Paiva Menezes Dos Santos, Flavio Eduardo Dias Araujo Freitas, Isabela Garbazza Vieira, Carlos Eduardo de Freitas Jorge, Daniela Godoy Neri, Maria Vitoria Cota de Abreu, Janaina Koenen Fonseca, Renato Guimaraes Loffi, Giselle Foureaux
Summary: Gluten, the most common protein in wheat, is associated with celiac disease, wheat allergy, and non-celiac gluten sensitivity. These disorders have similar clinical manifestations but differ in development pathways and diagnostic criteria. A gluten-free diet is the most effective treatment for celiac disease and may also lead to improvements in neuropathologies and the gut microbiome.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Mauro Giuffre, Silvia Gazzin, Caterina Zoratti, John Paul Llido, Giuseppe Lanza, Claudio Tiribelli, Rita Moretti
Summary: Celiac disease is a complex multi-organ disease that can involve the neurological and psychiatric systems. Recent evidence suggests that the gut microbiota and the gut-liver-brain axis play important roles in the neurological manifestations of celiac disease. There is still debate on the use of serological and neurophysiological findings for the early diagnosis and monitoring of celiac disease-related neurological involvement, but most symptoms can be reversed with a strict gluten-free diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Review
Food Science & Technology
Xiaoxue Zhu, Xin-Huai Zhao, Qiang Zhang, Na Zhang, Olugbenga P. Soladoye, Rotimi E. Aluko, Yuhao Zhang, Yu Fu
Summary: This article reviews the latest research progress on the relationship between celiac disease (CD) and gluten. It emphasizes the structure and function of gluten peptides related to CD, gluten detection methods, the effects of processing on gluten, and gluten-free diets. The limitations in current CD research are also discussed. This study facilitates a comprehensive understanding of CD and gluten, providing a theoretical reference for future research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Benjamin Lebwohl, Alberto Rubio-Tapia
Summary: The incidence of celiac disease is increasing due to both improved recognition and a real increase of the disorder. The reasons for this true rise are unclear, but may be related to environmental factors. Early-life gluten exposure is a major focus of prevention efforts.
Review
Immunology
Renata Auricchio, Riccardo Troncone
Summary: Celiac disease is an autoimmune disorder triggered by gluten, with prevention strategies focusing on identifying at-risk individuals and eliminating risk factors. Research has shown that both genetic and environmental factors play a role in the development of the disease, suggesting that future interventions could involve protection from infections, manipulation of microbiota, and modulation of T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Michele J. Alkalay
Summary: Lactose malabsorption, celiac disease, non-celiac gluten sensitivity, and irritable bowel syndrome are conditions associated with food triggers and can cause nutritional detriments. This review provides an overview of the complex nutritional elements of these disorders, which is critical for medical providers to recognize.
Review
Medicine, General & Internal
Xingxing Wu, Lin Qian, Kexin Liu, Jing Wu, Zhaowei Shan
Summary: Coeliac disease is an autoimmune intestinal disease induced by gluten, and adherence to gluten-free diet is an effective treatment. The gut microbiota plays a crucial role in maintaining health, which is regulated by diet. There is a need for alternative treatments to GFD due to the increasing prevalence of coeliac disease.
ANNALS OF MEDICINE
(2021)
Article
Neurosciences
N. L. Taylor, A. D'Souza, B. R. Munn, J. Lv, L. Zaborszky, E. J. Muller, G. Wainstein, F. Calamante, J. M. Shine
Summary: Complex cognitive abilities are believed to come from the brain's ability to reconfigure its internal network structure in response to task demands. Recent research suggests that this flexibility is partly due to the widespread projections of the ascending arousal systems. This study found that the strength of structural connectivity between the noradrenergic and cholinergic arousal systems is related to the dynamic features of functional integration in the brain, indicating the crucial role of anatomical connections in mediating adaptive network dynamics.
Review
Biochemistry & Molecular Biology
Mariana Verdelho Machado
Summary: Celiac disease (CD) is a common autoimmune disease, affecting approximately 1% of the population. Regardless of symptoms, all CD patients must adhere to a lifelong gluten-free diet (GFD). However, this can be challenging due to a lack of gluten awareness in foods and the widespread use of gluten in processed foods. Research has been conducted to find pharmacological treatment for CD, but achieving full histological recovery on a GFD remains difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Veronica Segura, Angela Ruiz-Carnicer, Carolina Sousa, Maria de Lourdes Moreno
Summary: The only current treatment for celiac disease is a strict gluten-free diet, but there is a need for non-dietary alternatives to prevent damage from dietary transgressions. Recent therapies for CD focus on degrading gluten, regulating the immune response, and inducing immunological tolerance, with promising results seen in some phase III and II clinical trials.
Article
Behavioral Sciences
Marthe Mieling, Hannah Meier, Nico Bunzeck
Summary: This study examined the neuropathological changes in Alzheimer's disease and found that degenerations of the cholinergic Nucleus basalis of Meynert may precede medial temporal lobe alterations. The results also showed reduced gray matter in the amygdala and hippocampus in Alzheimer's disease and mild cognitive impairment, with potential more pronounced effects in Alzheimer's disease.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Food Science & Technology
Maria Purificacion Gonzalez, Catalina Ballestero-Fernandez, Violeta Fajardo, Maria Achon, Angela Garcia-Gonzalez, Elena Alonso-Aperte, Natalia Ubeda
Summary: The study assessed the contribution of GFP to the diets of children and adolescents with CD, finding that GFP accounted for a high percentage of total energy, carbohydrates, fiber, and salt intake, but a lower percentage of fat, sugar, and protein intake. It is important to reduce fat, saturated fat, and salt intake, and increase fiber content in processed GFP.
Article
Nutrition & Dietetics
Marios Hadjivassiliou, Panagiotis Zis, David S. Sanders, Nigel Hoggard, Ptolemaios G. Sarrigiannis
Summary: Stiff person syndrome is a rare autoimmune disease characterized by axial stiffness and episodic painful spasms, often associated with other autoimmune diseases and cerebellar ataxia. Most patients with SPS have gluten sensitivity or celiac disease. Gluten sensitivity plays an important role in the pathogenesis of SPS, and a gluten-free diet is an effective therapeutic intervention.
Article
Clinical Neurology
Yannick Braun, Katharina Filipski, Simon Bernatz, Peter Baumgarten, Bastian Roller, Jenny Zinke, Pia S. Zeiner, Elena Ilina, Christian Senft, Michael W. Ronellenfitsch, Karl H. Plate, Oliver Baehr, Elke Hattingen, Joachim P. Steinbach, Michel Mittelbronn, Patrick N. Harter
Summary: This study aims to characterize metabolic features in different molecular subgroups of gliomas, focusing on the impact of metabolic alterations on patient outcomes. Results showed that DNA methylation patterns of metabolic genes can distinguish between IDHmut and IDHwt gliomas, and mitochondrial DNA copy number and immune cell content analysis can predict patient survival under anti-angiogenic therapy. Genomic signatures related to metabolism could indicate specific tumor subgroups with metabolic vulnerabilities.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Christian Koelsche, Daniel Schrimpf, Damian Stichel, Martin Sill, Felix Sahm, David E. Reuss, Mirjam Blattner, Barbara Worst, Christoph E. Heilig, Katja Beck, Peter Horak, Simon Kreutzfeldt, Elke Paff, Sebastian Stark, Pascal Johann, Florian Selt, Jonas Ecker, Dominik Sturm, Kristian W. Pajtler, Annekathrin Reinhardt, Annika K. Wefers, Philipp Sievers, Azadeh Ebrahimi, Abigail Suwala, Francisco Fernandez-Klett, Belen Casalini, Andrey Korshunov, Volker Hovestadt, Felix K. F. Kommoss, Mark Kriegsmann, Matthias Schick, Melanie Bewerunge-Hudler, Till Milde, Olaf Witt, Andreas E. Kulozik, Marcel Kool, Laura Romero-Perez, Thomas G. P. Gruenewald, Thomas Kirchner, Wolfgang Wick, Michael Platten, Andreas Unterberg, Matthias Uhl, Amir Abdollahi, Juergen Debus, Burkhard Lehner, Christian Thomas, Martin Hasselblatt, Werner Paulus, Christian Hartmann, Ori Staszewski, Marco Prinz, Juergen Hench, Stephan Frank, Yvonne M. H. Versleijen-Jonkers, Marije E. Weidema, Thomas Mentzel, Klaus Griewank, Enrique de Alava, Juan Diaz Martin, Miguel A. Idoate Gastearena, Kenneth Tou-En Chang, Sharon Yin Yee Low, Adrian Cuevas-Bourdier, Michel Mittelbronn, Martin Mynarek, Stefan Rutkowski, Ulrich Schueller, Viktor F. Mautner, Jens Schittenhelm, Jonathan Serrano, Matija Snuderl, Reinhard Buettner, Thomas Klingebiel, Rolf Buslei, Manfred Gessler, Pieter Wesseling, Winand N. M. Dinjens, Sebastian Brandner, Zane Jaunmuktane, Iben Lyskjaer, Peter Schirmacher, Albrecht Stenzinger, Benedikt Brors, Hanno Glimm, Christoph Heining, Oscar M. Tirado, Miguel Sainz-Jaspeado, Jaume Mora, Javier Alonso, Xavier Garcia del Muro, Sebastian Moran, Manel Esteller, Jamal K. Benhamida, Marc Ladanyi, Eva Wardelmann, Cristina Antonescu, Adrienne Flanagan, Uta Dirksen, Peter Hohenberger, Daniel Baumhoer, Wolfgang Hartmann, Christian Vokuhl, Uta Flucke, Iver Petersen, Gunhild Mechtersheimer, David Capper, David T. W. Jones, Stefan Froehling, Stefan M. Pfister, Andreas von Deimling
Summary: Sarcomas are malignant soft tissue and bone tumors that are morphologically heterogeneous, making classification challenging. Researchers developed a classifier using DNA methylation data, potentially improving classification for research and clinical purposes.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Tony Heurtaux, Melanie Kirchmeyer, Eric Koncina, Paul Felten, Lorraine Richart, Oihane Uriarte Huarte, Herve Schohn, Michel Mittelbronn
Summary: The study showed that the enantiomers of apomorphine can reduce A53T-induced microgliosis by activating the NRF2 signaling pathway, leading to a lower pro-inflammatory state and restoration of phagocytic activity.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Pia S. Zeiner, Leonhard Mann, Katharina Filipski, Tatjana Starzetz, Marie-Therese Forster, Michael W. Ronellenfitsch, Joachim P. Steinbach, Michel Mittelbronn, Marlies Wagner, Patrick N. Harter
Summary: This study retrospectively analyzed 15 patients with PML, finding that patients with MRI-defined iPML had a higher intensity of inflammation, while cPML patients also demonstrated inflammatory tissue alterations. Infiltration of CD163-positive microglia and macrophages correlated with PML lesion size.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Pierre Garcia, Wiebke Jurgens-Wemheuer, Oihane Uriarte Huarte, Alessandro Michelucci, Annette Masuch, Simone Brioschi, Andreas Weihofen, Eric Koncina, Djalil Coowar, Tony Heurtaux, Enrico Glaab, Rudi Balling, Carole Sousa, Tony Kaoma, Nathalie Nicot, Tatjana Pfander, Walter Schulz-Schaeffer, Ahmad Allouche, Nicolas Fischer, Knut Biber, Felix Kleine-Borgmann, Michel Mittelbronn, Marek Ostaszewski, Kristopher J. Schmit, Manuel Buttini
Summary: A key pathological process in Parkinson's disease is the transneuronal spreading of alpha-synuclein, but our study suggests that inclusion formation is not the major driver of neurodegeneration in the early stages. Instead, activated microglia, possibly through oligomeric alpha-syn, may play a key role in this process.
Article
Multidisciplinary Sciences
Elena I. Ilina, Camille Cialini, Dietlind L. Gerloff, Maitane Duarte Garcia-Escudero, Celine Jeanty, Marie-Laetitia Thezenas, Antoine Lesur, Vincent Puard, Francois Bernardin, Alina Moter, Anne Schuster, Monika Dieterle, Anna Golebiewska, Jean-Jacques Gerardy, Gunnar Dittmar, Simone P. Niclou, Tanja Mueller, Michel Mittelbronn
Summary: This study demonstrated that the expression of glycosyltransferase GLT8D1 is significantly higher in GBM patients compared to normal brain tissue, and it may be associated with decreased patient survival. In vitro experiments showed that increased GLT8D1 expression enhances GBM cell migration. Point mutation experiments revealed that the active site of GLT8D1 is essential for its glycosyltransferase activity and cell migration. Furthermore, the study identified potential interaction partners of GLT8D1 related to cytoskeleton and intracellular transport.
Article
Ecology
Anna Schleimer, Lorraine Richart, Frank Drygala, Francois Casabianca, Oscar Maestrini, Hannah Weigand, Chantal Schwartz, Michel Mittelbronn, Alain C. Frantz
Summary: Due to intensified domestification and hybridisation, the genetic distinctness of the Corsican wild boar has been found to be significantly different from domestic pigs. Molecular markers play a crucial role in assessing the impact of management practices on gene flow.
Article
Multidisciplinary Sciences
Davide G. Franchina, Henry Kurniawan, Melanie Grusdat, Carole Binsfeld, Luana Guerra, Lynn Bonetti, Leticia Soriano-Baguet, Anouk Ewen, Takumi Kobayashi, Sophie Farinelle, Anna Rita Minafra, Niels Vandamme, Anais Carpentier, Felix K. Borgmann, Christian Jager, Ying Chen, Markus Kleinewietfeld, Vasilis Vasiliou, Michel Mittelbronn, Karsten Hiller, Philipp A. Lang, Dirk Brenner
Summary: This study reveals that deficiency of glutamate cysteine ligase (Gclc), the enzyme for glutathione synthesis, has differential impacts on the homeostasis of follicular and marginal zone B cells (FoB and MZB), specifically impairing FoB activation and downstream antiviral immunity.
NATURE COMMUNICATIONS
(2022)
Review
Physiology
David S. Bouvier, Sonja Fixemer, Tony Heurtaux, Felicia Jeannelle, Katrin B. M. Frauenknecht, Michel Mittelbronn
Summary: Astrocytes play multiple roles in the central nervous system, but in age-related neurodegenerative diseases, they may exhibit neurotoxic phenotypes that contribute to disease progression. Chronic inflammation, oxidative stress, impaired phagocytosis, and altered physiological roles are the main manifestations of astrocytic toxicity. However, the involvement of astrocytes in brain deterioration in patients with neurodegenerative diseases is still controversial due to overlapping pathologies and technical challenges in studying human brain samples. This review provides an overview of astrocyte neurotoxicity from in vitro findings to animal models and patient-related research, and discusses the role of aging in astrocytes and potential therapeutic strategies.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Sonja Fixemer, Corrado Ameli, Gael Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gerardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S. Bouvier
Summary: Cellular alterations in the hippocampus lead to memory decline, a shared symptom in AD and DLB patients. The subregional deterioration patterns differ between AD and DLB, with CA1 being more severely affected in AD. Microglial activation may play a role in selective volume loss in the hippocampus.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Bob Biewer, Felix Kleine-Borgmann, Gael P. Hammer, Eric H. Rompen, Michel Mittelbronn, Pascale Quatresooz
Summary: This study evaluated the influence of Low-Intensity Pulsed Ultrasound (LIPUS) on bone regeneration in irradiated and non-irradiated rabbit tibias with non-critical-size defects. The results showed that LIPUS treatment significantly improved bone formation in non-irradiated bones, while its effects on irradiated bones were less clear. Further studies are needed to refine the understanding of these results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biodiversity Conservation
Anna C. Schleimer, Alain Frantz, Lorraine Richart, Joerg Mehnert, Gono Semiadi, Michel Wirdateti, Johanna Rode-Margono, Michel Mittelbronn, Stuart Young, Frank Drygala
Summary: This study demonstrates how biogeographic processes and human activities can significantly impact species conservation. The Bawean pig was found to have diverged at least 166 k years ago and is currently facing a small population size. Additionally, the Javan pig showed evidence of secondary contact with another pig species. Immediate action should be taken to protect both species.
DIVERSITY AND DISTRIBUTIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Bob Biewer, Eric Rompen, Michel Mittelbronn, Gael P. Hammer, Pascale Quatresooz, Felix Kleine Borgmann
Summary: This in vivo study examined the effect of minocycline-HCl administration and calvaria perforation on extra-skeletal bone generation. The results showed a continuous increase in tissue fill over time in all groups. The combination of minocycline-HCl administration and calvaria perforation resulted in the strongest tissue augmentation and the most mineralized tissue, indicating an enhancing effect on vertical bone augmentation.
Article
Oncology
Ernesto Gargiulo, Elodie Viry, Pablo Elias Morande, Anne Largeot, Susanne Gonder, Feng Xian, Nikolaos Ioannou, Mohaned Benzarti, Felix Bruno Kleine Borgmann, Michel Mittelbronn, Gunnar Dittmar, Petr Nazarov, Johannes Meiser, Basile Stamatopoulos, Alan G. Ramsay, Etienne Moussay, Jerome Paggetti
Summary: This study investigated the interactions between cancer cells and the microenvironment using mouse models of chronic lymphocytic leukemia (CLL). It found that small extracellular vesicles (sEVs) derived from CLL tissue contain specific miRNA and immune-checkpoint ligands, which alter the function and exhaustion of CD8+ T cells. Blocking sEV biogenesis delayed CLL pathogenesis and high expression of sEV-related genes correlated with poor outcomes in CLL patients.
BLOOD CANCER DISCOVERY
(2023)
Article
Clinical Neurology
Alberto Vogrig, Sarah Pericart, Anne-Laurie Pinto, Veronique Rogemond, Sergio Muniz-Castrillo, Geraldine Picard, Marion Selton, Michel Mittelbronn, Helene-Marie Lanoiselee, Patrick Michenet, Marie Benaiteau, Jeremie Pariente, Helene Zephir, Caroline Giordana, Solveig Montaut, Hayet Salhi, Panagiotis Bachoumas, Alexis Montcuquet, Igor Letovanec, Emmanuelle Uro-Coste, Jerome Honnorat
Summary: The study reports clinical features of Kelch-like protein 11 antibody-associated paraneoplastic neurological syndrome, introduces a new clinical score (MATCH score) for patient identification, and examines the immune response in brain and tumor samples for better understanding of the immunopathogenesis.
BRAIN COMMUNICATIONS
(2021)
