Article
Medicine, General & Internal
Adrienne E. Swanstrom, Robert J. Gorelick, Jorden L. Welker, Fabian Schmidt, Bing Lu, Kelly Wang, William Rowe, Matthew W. Breed, Kristin E. Killoran, Joshua A. Kramer, Duncan Donohue, James D. Roser, Paul D. Bieniasz, Theodora Hatziioannou, Cathi Pyle, James A. Thomas, Charles M. Trubey, Jim Zheng, Wade Blair, Stephen R. Yant, Jeffrey D. Lifson, Gregory Q. Del Prete
Summary: This study demonstrates that LEN has potent antiviral activity against stHIV-A19 and can prevent HIV-1 infection in a nonhuman primate model. The sustained plasma drug exposures of subcutaneous LEN support its potential as a long-acting PrEP for humans.
Article
Immunology
Xiang Liu, Xueling Zhu, Xiaorong Peng, Ran Tao, Zhikai Wan, Jiangjin Hui, Yongzheng Guo, Ying Hang, Biao Zhu
Summary: Lenalidomide may have an inhibitory effect on viral transcription of the HIV-1 reservoir and reduce HIV-related inflammation in patients with HIV-Associated cryptococcal meningitis (HIV-CM).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Geraldine Vilmen, Anna C. Smith, Hector Cervera Benet, Rajni Kant Shukla, Ross C. Larue, Alon Herschhorn, Amit Sharma
Summary: Infection of rhesus macaques with SHIVs encoding HIV-1 Envs is a common model for vaccine development, but the challenge lies in the fact that most circulating HIV-1 Envs do not efficiently use the rhesus CD4 receptor for viral entry. By altering the conformational state of HIV-1 Envs, open Env conformations can overcome this barrier and enhance SHIV replication in rhesus lymphocytes, indicating that the conformational state of the Env is crucial for SHIV replication and viral entry in rhesus macaques.
Article
Microbiology
Geraldine Vilmen, Anna C. Smith, Hector Cervera Benet, Rajni Kant Shukla, Ross C. Larue, Alon Herschhorn, Amit Sharma
Summary: Infection of rhesus macaques with simian-human immunodeficiency viruses (SHIVs) is a key model for vaccine development, but most circulating HIV-1 envelope glycoproteins cannot infect macaques. This study found that the conformational state of HIV-1 envelope glycoproteins is a major determinant for rhesus CD4 usage, viral-host membrane fusion, and SHIV replication.
Article
Microbiology
Jennillee Wallace, Hemil Gonzalez, Reshma Rajan, Srinivas D. Narasipura, Amber K. Virdi, Arnold Z. Olali, Ankur Naqib, Zarema Arbieva, Mark Maienschein-Cline, Lena Al-Harthi
Summary: Combination antiretroviral therapy (cART) has significantly improved the treatment of HIV/AIDS, but it may also affect cell dysregulation and increase susceptibility to comorbidities in persons living with HIV (PLWH).
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Immunology
Anna J. Jasinska, Ivona Pandrea, Cristian Apetrei
Summary: CCR5 is a chemokine receptor that plays a central role in immune responses and inflammation. It is involved in the pathogenesis of various health conditions, including HIV infection. Natural loss-of-function mutations of CCR5 can render individuals resistant to HIV. In addition, many African nonhuman primate species have developed strategies to minimize the effects of SIV infection by modulating CCR5 activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Alicia A. Annamalay, Salome Abbott, Siew-Kim Khoo, Julie Hibbert, Joelene Bizzintino, Guicheng Zhang, Ingrid Laing, Andrew Currie, Peter N. Le Souef, Robin J. Green
Summary: The study found that certain cytokines had higher concentrations in ALRI cases compared to non-respiratory controls, and that levels of certain cytokines were higher in ALRI cases with viruses. Additionally, HIV-infected cases had significantly lower levels of certain cytokines compared to HIV-uninfected cases, while levels of other cytokines were significantly higher in HIV-infected cases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Yao Li, Yanming Zeng, Yanqiu Lu, Xuejiao He, Yushan Wu, Wei Zhang, Yanqun Huang, Hui Chen, Yaokai Chen
Summary: This study compared the efficacy and safety of synergistic sulfonamides plus clindamycin with TMP-SMX plus azithromycin for the treatment of HIV-associated TE. The results showed that the regimen containing synergistic sulfonamides may have advantages in alleviating clinical symptoms, but there were no significant differences in radiological response, mortality events, and adverse events compared to the TMP-SMX plus azithromycin regimen.
CHINESE MEDICAL JOURNAL
(2022)
Article
Microbiology
Mingyu Han, Vincent Cantaloube-Ferrieu, Maorong Xie, Marie Armani-Tourret, Marie R. Woottum, Jean-Christophe Pages, Philippe R. Colin, Bernard Lagane, Serge R. Benichou
Summary: The study shows that HIV-1 can effectively infect macrophages through cell-to-cell transfer, even with virus isolates initially defined as non-macrophage tropic in cell-free infection. This intercellular viral transfer is facilitated by enhanced interactions between the HIV-1 envelope glycoproteins and cellular entry receptors.
Review
Multidisciplinary Sciences
Erica A. Mendes, Yuyang Tang, Guochun Jiang
Summary: HIV infection is a chronic disease that can be effectively suppressed by antiretroviral therapy (ART), but stable viral reservoirs cannot be eradicated by ART alone. Mammalian cells have an integrated stress response (ISR) mechanism to detect and respond to stresses such as nutrient fluctuation, unfolded protein accumulation, and viral infection. Understanding how ISR responds to the off-target effects of ART and persistent HIV infection may help us better understand stable HIV reservoirs and HIV-associated neurocognitive disorders.
Article
Cell Biology
Nongthombam Boby, Alyssa Ransom, Barcley T. Pace, Kelsey M. Williams, Christopher Mabee, Arpita Das, Sudesh K. Srivastav, Edith Porter, Bapi Pahar
Summary: Increased production of TGF-beta was observed in intestinal CD3(-)CD20(-)CD68(+) cells from SIV-infected rhesus macaques, which negatively correlated with the frequency of jejunum CD4(+) T cells. Disruption of a negative feedback loop mediated by SMAD7 may enhance TGF-beta production and SMAD-dependent signaling in SIV infection.
Article
Biochemistry & Molecular Biology
Ayan Roy, Surajit Basak
Summary: The study reveals distinct features of envelope genes in different categories of HIV-1 disease progression in human beings, indicating that slow progressors and long-term non-progressors exhibit more severe selection constraints from both human and chimpanzee hosts. This contrasts with the more relaxed selection pressures observed in rapid progressors. Evolutionary forces of selection appear to be comparatively more stringent on slow progressors, long-term non-progressors and SIVcpz types.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Multidisciplinary Sciences
Massimiliano Bissa, Sohyoung Kim, Veronica Galli, Slim Fourati, Sarkis Sarkis, Anush Arakelyan, Isabela Silva de Castro, Mohammad Arif Rahman, Saori Fujiwara, Monica Vaccari, Jeffrey A. Tomalka, James D. Stamos, Luca Schifanella, Giacomo Gorini, Ramona Moles, Anna Gutowska, Guido Ferrari, Alexei Lobanov, David C. Montefiori, George W. Nelson, Margaret C. Cam, Marita Chakhtoura, Elias K. Haddad, Melvin N. Doster, Katherine McKinnon, Sophia Brown, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Kristin E. Killoran, Joshua Kramer, Leonid Margolis, Rafick P. Sekaly, Gordon L. Hager, Genoveffa Franchini
Summary: This study reports the efficacy of a vaccine based on specific antibodies mediating apoptosis of infected cells and efferocytosis. The findings suggest that efferocytosis plays a role in reducing inflammation and maintaining tissue homeostasis, thereby contributing to the efficacy of the vaccine.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sonnieliz Cotto Rios, Jose O. Colon Saez, Orestes Quesada, Katherine Quiroz Figueroa, Jose A. Lasalde Dominicci
Summary: This study investigated the effects of HIV soluble component gp120 on the cholinergic anti-inflammatory response (CAR) by focusing on the role of alpha7-nAChR. The results showed that gp120 disrupted CAR functioning in macrophages, leading to increased inflammation. Further research on medications targeting alpha7-nAChR is needed to reactivate CAR and ameliorate inflammation in HIV-infected individuals.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Virology
Isabelle M. Castro, Michael J. Ricciardi, Lucas Gonzalez-Nieto, Eva G. Rakasz, Jeffrey D. Lifson, Ronald C. Desrosiers, David Watkins, Mauricio A. Martins
Summary: This study tracks the long-term effects of an AIDS vaccine on rhesus macaques, showing sustained anti-SIV immune responses and successful protection against a second round of rectal SIV exposure. These findings are relevant for the development of HIV vaccines.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Chie Sugimoto, Atsuhiko Hasegawa, Yohei Saito, Yayoi Fukuyo, Kevin B. Chiu, Yanhui Cai, Matthew W. Breed, Kazuyasu Mori, Chad J. Roy, Andrew A. Lackner, Woong-Ki Kim, Elizabeth S. Didier, Marcelo J. Kuroda
JOURNAL OF IMMUNOLOGY
(2015)
Article
Clinical Neurology
Hui Qin Xing, Yu Zhang, Kimiko Izumo, Shiho Arishima, Ryuji Kubota, Xiang Ye, Qiping Xu, Kazuyasu Mori, Shuji Izumo
Article
Virology
Chie Sugimoto, Kristen M. Merino, Atsuhiko Hasegawa, Xiaolei Wang, Xavier A. Alvarez, Hiroshi Wakao, Kazuyasu Mori, Woong-Ki Kim, Ronald S. Veazey, Elizabeth S. Didier, Marcelo J. Kuroda
JOURNAL OF VIROLOGY
(2017)
Article
Virology
Masayuki Fujino, Hirotaka Sato, Tomotaka Okamura, Akihiko Uda, Satoshi Takeda, Nursarat Ahmed, Shigeyuki Shichino, Teiichiro Shiino, Yohei Saito, Satoru Watanabe, Chie Sugimoto, Marcelo J. Kuroda, Manabu Ato, Yoshiyuki Nagai, Shuji Izumo, Kouji Matsushima, Masaaki Miyazawa, Aftab A. Ansari, Francois Villinger, Kazuyasu Mori
JOURNAL OF VIROLOGY
(2017)
Correction
Virology
Chie Sugimoto, Kristen M. Merino, Atsuhiko Hasegawa, Xiaolei Wang, Xavier A. Alvarez, Hiroshi Wakao, Kazuyasu Mori, Woong-Ki Kim, Ronald S. Veazey, Elizabeth S. Didier, Marcelo J. Kuroda
JOURNAL OF VIROLOGY
(2017)
Article
Oncology
Jun Wang, Yu Zhang, Qiping Xu, Jinhua Qiu, Honghua Zheng, Xiang Ye, Yuhua Xue, Yongmei Yin, Zhou Zhang, Ying Liu, Yanling Hao, Qiang Wei, Wei Wang, Kazuyasu Mori, Shuji Izumo, Ryuji Kubota, Yiming Shao, Hui Qin Xing
Article
Cell Biology
L. E. Pereira, N. Onlamoon, X. Wang, R. Wang, J. Li, K. A. Reimann, F. Villinger, K. Pattanapanyasat, K. Mori, A. A. Ansari
CELLULAR IMMUNOLOGY
(2009)
Article
Genetics & Heredity
Taeko K. Naruse, Zhiyong Chen, Risa Yanagida, Tomoko Yamashita, Yusuke Saito, Kazuyasu Mori, Hirofumi Akari, Yasuhiro Yasutomi, Masaaki Miyazawa, Tetsuro Matano, Akinori Kimura
Article
Genetics & Heredity
Taeko K. Naruse, Yukiko Okuda, Kazuyasu Mori, Hirofumi Akari, Tetsuro Matano, Akinori Kimura
Article
Immunology
Nattawat Onlamoon, Kenneth Rogers, Ann E. Mayne, Kovit Pattanapanyasat, Kazuyasu Mori, Francois Villinger, Aftab A. Ansari
Article
Biotechnology & Applied Microbiology
Chie Sugimoto, Emi E. Nakayama, Tatsuo Shioda, Francois Villinger, Aftab A. Ansari, Naoki Yamamoto, Yasuo Suzuki, Yoshiyuki Nagai, Kazuyasu Mori
JOURNAL OF GENERAL VIROLOGY
(2008)
Article
Virology
Chie Sugimoto, Shinichiro Nakamura, Shoko I. Hagen, Yasuko Tsunetsugu-Yokota, Francois Villinger, Aftab A. Ansari, Yasuo Suzuki, Naoki Yamamoto, Yoshiyuki Nagai, Louis J. Picker, Kazuyasu Mori
JOURNAL OF VIROLOGY
(2012)
Article
Virology
Kaoru Takeuchi, Noriyo Nagata, Sei-ich Kato, Yasushi Ami, Yuriko Suzaki, Tadaki Suzuki, Yuko Sato, Yasuko Tsunetsugu-Yokota, Kazuyasu Mori, Nguyen Van Nguyen, Hideki Kimura, Kyosuke Nagata
JOURNAL OF VIROLOGY
(2012)
Article
Multidisciplinary Sciences
Chie Sugimoto, Satoru Watanabe, Taeko Naruse, Eiji Kajiwara, Teiichiro Shiino, Natsuko Umano, Kayoko Ueda, Hirotaka Sato, Shinji Ohgimoto, Vanessa Hirsch, Francois Villinger, Aftab A. Ansari, Akinori Kimura, Masaaki Miyazawa, Yasuo Suzuki, Naoki Yamamoto, Yoshiyuki Nagai, Kazuyasu Mori