Article
Multidisciplinary Sciences
Anne Kathrin Loesslein, Florens Lohrmann, Lisa Scheuermann, Kourosh Gharun, Jana Neuber, Julia Kolter, Aaron James Forde, Christian Kleimeyer, Ying Yee Poh, Matthias Mack, Antigoni Triantafyllopoulou, Micah D. Dunlap, Shabaana A. Khader, Maximilian Seidl, Alexandra Hoelscher, Christoph Hoelscher, Xue Li Guan, Anca Dorhoi, Philipp Henneke
Summary: The study identifies monocyte progenitors with high giant cell-forming potential and the ability to accumulate cholesterol and lipids as key players in the immune response to mycobacteria. These monocyte progenitors may be exploited by mycobacteria to create a favorable niche for growth.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Narumi Otsuka-Kamakura, Yoshiya Sugiura, Toshiki Yamazaki, Naomi Shimizu, Nobuyuki Hiruta
Summary: This article reports a case of plasmablastic neoplasm with multinucleated giant cells, contributing to the knowledge of cancer stem cell biology.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Shreyasee Hazra, Suman Kalyan Dinda, Naba Kumar Mondal, Sk Rajjack Hossain, Pratyay Datta, Afsana Yasmin Mondal, Pushkar Malakar, Dipak Manna
Summary: This article explores the formation of Multinucleated Giant Cells (MGCs) in the protozoan parasite Entamoeba. The formation of MGCs is a unique phenomenon in Entamoeba and is thought to be a survival strategy to cope with adverse environmental conditions. MGCs have increased resistance to stress and may play a role in the virulence of Entamoeba. The study of MGCs in Entamoeba provides valuable insights into the biology of this organism and opens up avenues for potential therapeutic interventions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jihye Yoo, Jiyoung Park, Darong Kim, Yeonjoo Huh, Hea-Young Park Choo, Hyun Ae Woo
Summary: By synthesizing 12 novel compounds and evaluating their biological activities, it was found that 4 compounds exhibited strong inhibitory activities on IL-1 beta and IL-6 mRNA expression. Further in vivo activity evaluation indicated that 2 compounds significantly decreased mRNA levels of IL-1 beta, IL-6, and TNF-alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Tiago C. Luis, Nikolaos Barkas, Joana Carrelha, Alice Giustacchini, Stefania Mazzi, Ruggiero Norfo, Bishan Wu, Affaf Aliouat, Jose A. Guerrero, Alba Rodriguez-Meira, Tiphaine Bouriez-Jones, Iain C. Macaulay, Maria Jasztal, Guangheng Zhu, Heyu Ni, Matthew J. Robson, Randy D. Blakely, Adam J. Mead, Claus Nerlov, Cedric Ghevaert, Sten Eirik W. Jacobsen
Summary: In this study, the researchers uncover a feedback mechanism in which IL-1 secreted by activated platelets signals through niche Lepr+ cells to activate HSCs and restore platelet homeostasis.
NATURE COMMUNICATIONS
(2023)
Review
Biology
Malgorzata Kloc, Ahmed Uosef, Arijita Subuddhi, Jacek Z. Kubiak, Rafal P. Piprek, Rafik M. Ghobrial
Summary: This article introduces the formation of senescent multinucleated giant cells and their role in aging and age-related diseases. It explains the molecular and cellular features of senescence and aging, as well as the role of multinucleated giant cells in cancer development and progression. The article also discusses the reversibility of senescence and its impact on cancer initiation and metastasis.
Article
Medicine, General & Internal
Peng Deng, Nana Tang, Lin Li, Guohui Zou, Yang Xu, Zhongyong Liu
Summary: The combined detection of IL-1 beta, IL-6, and TNF-alpha shows better diagnostic value for sepsis-induced cardiomyopathy (SIC) and is closely related to the prognoses of patients.
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Article
Immunology
Yusha Wang, Jun Wang, Wenjie Zheng, Jiahui Zhang, Jinbo Wang, Taijie Jin, Panfeng Tao, Yibo Wang, Chenlu Liu, Jiqian Huang, Pui Y. Lee, Xiaomin Yu, Qing Zhou
Summary: A novel missense variant in IL-1R1 was identified in a patient with CRMO, leading to unopposed IL-1 signaling. Researchers designed an IL-1 therapeutic that effectively targets IL-1-driven diseases.
Article
Multidisciplinary Sciences
Wen-Hsuan W. Lin, Annie J. Tsay, Erin N. Lalime, Andrew Pekosz, Diane E. Griffin
Summary: Research suggests that measles virus infection may be initiated through apical infection of respiratory epithelial cells, followed by infection of lymphoid tissue and systemic spread. Infection from the apical surface leads to the production of multinucleated giant cells and the maintenance of cell-cell electrical resistance, while infection from the basolateral surface results in epithelial damage and clustering of MeV-positive cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Kourosh Ahmadzadeh, Margot Vanoppen, Carlos D. Rose, Patrick Matthys, Carine Helena Wouters
Summary: Monocytes and macrophages can fuse to form multinucleated giant cells, with different types and functions. Osteoclasts participate in bone remodeling under normal conditions but contribute to bone destruction and loss under pathological conditions. Foreign body giant cells are involved in immune reactions against foreign material, while Langhans giant cells are associated with granulomas in infectious and non-infectious diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Paul Humbert, Meadhbh A. Brennan, Julien De Lima, Regis Brion, Annie Adrait, Celine Charrier, Benedicte Brulin, Valerie Trichet, Yohann Coute, Frederic Blanchard, Pierre Layrolle
Summary: Osteoclasts play a key role in bone regeneration, and apoptosis is found to be important for the effectiveness of MSCs. Experimental results show that apoptotic secretion of MSCs can inhibit the development of inflammatory multinucleated giant cells.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Chunyun Fang, Lixia Wang, Jingting Qiao, Lina Chang, Qing He, Xiaona Zhang, Ming Liu
Summary: This study investigated the mechanism of impaired immune response in diabetic patients. By studying the production of cytokines in macrophages induced by LPS, it was found that pretreatment with palmitic acid (PA) can differentially regulate the production of TNF-alpha and IL-1 beta, and this effect is associated with the cellular metabolism of PA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Editorial Material
Developmental Biology
K. Grace Foley, Michele T. Pritchard, Francesca E. Duncan
Summary: Inflammaging is a chronic, low-grade inflammation associated with aging that contributes to age-related diseases. Recent studies have shown an age-associated increase in inflammation in the mammalian ovary, accompanied by a shift in the immune cell profile. Macrophage-derived multinucleated giant cells found in reproductively old mouse ovaries are considered potential markers or functional drivers of inflammation in ovarian aging.
Review
Biochemistry & Molecular Biology
Katrin Witte, Robert Sabat, Ellen Witte-Haendel, Kamran Ghoreschi, Kerstin Wolk
Summary: Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease characterized by painful skin lesions in various areas of the body. It affects about 1% of the population and is associated with comorbidities such as metabolic syndrome. Current therapeutic options for HS are limited, and novel treatment options are needed. Recent research suggests that immune mediators IL-1 beta, IL-17A, and G-CSF play a key role in the development of HS. Phytomedical drugs, which have potent immunoregulatory properties, have not been considered as a treatment for HS. This review explores the potential of targeting the IL-1/IL-17/G-CSF axis for an integrated phytomedical treatment of HS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Ellen Gelpi, Jasmin Rahimi, Sigrid Klotz, Susanne Schmid, Gerda Ricken, Sara Forcen-Vega, Herbert Budka, Gabor G. Kovacs
Review
Neurosciences
Satoshi Nozuma, Ryuji Kubota, Steven Jacobson
JOURNAL OF NEUROVIROLOGY
(2020)
Article
Infectious Diseases
Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Kimiko Izumo, Nobuaki Nakano, Eiji Matsuura, Mineki Saito, Masahiro Nagai, Masahisa Horiuchi, Atae Utsunomiya, Hiroshi Takashima, Ryuji Kubota, Shuji Izumo
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Clinical Neurology
Emma Jones, Holger Hummerich, Emmanuelle Vir, James Uphill, Athanasios Dimitriadis, Helen Speedy, Tracy Campbell, Penny Norsworthy, Liam Quinn, Jerome Whitfield, Jacqueline Linehan, Zane Jaunmuktane, Sebastian Brandner, Parmjit Jat, Akin Nihat, Tze How Mok, Parvin Ahmed, Steven Collins, Christiane Stehmann, Shannon Sarros, Gabor G. Kovacs, Michael D. Geschwind, Aili Golubjatnikov, Karl Frontzek, Herbert Budka, Adriano Aguzzi, Hata Karamujic-Comic, Sven J. van der Lee, Carla A. Ibrahim-Verbaas, Cornelia M. van Duijn, Beata Sikorska, Ewa Golanska, Pawel P. Liberski, Miguel Calero, Olga Calero, Pascual Sanchez-Juan, Antonio Salas, Federico Martinon-Torres, Elodie Bouaziz-Amar, Stephane Haik, Jean-Louis Laplanche, Jean-Phillipe Brandel, Phillipe Amouyel, Jean-Charles Lambert, Piero Parchi, Anna Bartoletti-Stella, Sabina Capellari, Anna Poleggi, Anna Ladogana, Maurizio Pocchiari, Serena Aneli, Giuseppe Matullo, Richard Knight, Saima Zafar, Inga Zerr, Stephanie Booth, Michael B. Coulthart, Gerard H. Jansen, Katie Glisic, Janis Blevins, Pierluigi Gambetti, Jiri Safar, Brian Appleby, John Collinge, Simon Mead
Article
Clinical Neurology
Sigrid Klotz, Theresa Konig, Marcus Erdler, Andreas Ulram, Anita Nguyen, Thomas Strobel, Alexander Zimprich, Elisabeth Stogmann, Gunther Regelsberger, Romana Hoftberger, Herbert Budka, Gabor G. Kovacs, Ellen Gelpi
Summary: This study presents a rare case of a patient with both C9orf72 expansion mutation-related frontotemporal lobe degeneration and sporadic Creutzfeldt-Jakob disease. The neuropathology exhibited multiple protein aggregates along with a high degree of Alzheimer-related pathology. Further studies are needed to investigate a potential link between these two neurodegenerative pathologies.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Microbiology
Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Satoshi Nozuma, Eiji Matsuura, Hiroshi Takashima, Shuji Izumo, Ryuji Kubota
Summary: The study compared the performance of different detection methods in the CSF of HAM/TSP patients and HTLV-1 carriers, demonstrating that CLIA was closer to PA in performance, while CLEIA had lower sensitivity.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Virology
Ellen Gelpi, Sigrid Klotz, Nuria Vidal-Robau, Gerda Ricken, Gunther Regelsberger, Thomas Strobel, Ognian Kalev, Marlene Leoni, Herbert Budka, Gabor G. Kovacs
Summary: The study found that in sporadic Creutzfeldt-Jakob disease, the MM2C subtype is more likely to accumulate PrPd in white matter oligodendrocytes, and this pathology is more prominent in patients with a longer disease duration.
Article
Immunology
Yuichi Tashiro, Eiji Matsuura, Yasuko Sagara, Satoshi Nozuma, Daisuke Kodama, Masakazu Tanaka, Chihaya Koriyama, Ryuji Kubota, Hiroshi Takashima
Summary: Japan is a highly endemic area for HTLV-1, and the infection rate increases with age. This study estimated the number and rate of HTLV-1 infection in Kagoshima using preoperative screening data. The results showed a high infection rate among the elderly, suggesting that the infection risk may have been present since infancy.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2022)
Article
Neurosciences
Ellen Gelpi, Simone Baiardi, Carlos Nos, Sofia Dellavalle, Iban Aldecoa, Raquel Ruiz-Garcia, Lourdes Ispierto, Domingo Escudero, Virgina Casado, Elena Barranco, Anuncia Boltes, Laura Molina-Porcel, Nuria Bargallo, Marcello Rossi, Angela Mammana, Dorina Tiple, Luana Vaianella, Elisabeth Stoegmann, Ingrid Simonitsch-Klupp, Gregor Kasprian, Sigrid Klotz, Romana Hoeftberger, Herbert Budka, Gabor G. Kovacs, Isidre Ferrer, Sabina Capellari, Raquel Sanchez-Valle, Piero Parchi
Summary: This study identified a new subtype of sCJD with clinicopathological features significantly overlapping with those of the VV1 subtype, possibly representing the missing evidence of V1 sCJD strain propagation in the 129MV host genotype.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Clinical Neurology
Satoshi Nozuma, Eiji Matsuura, Yuichi Tashiro, Ryusei Nagata, Masahiro Ando, Yu Hiramatsu, Yujiro Higuchi, Yusuke Sakiyama, Akihiro Hashiguchi, Kumiko Michizono, Keiko Higashi, Toshio Matsuzaki, Daisuke Kodama, Masakazu Tanaka, Yoshihisa Yamano, Takashi Moritoyo, Ryuji Kubota, Hiroshi Takashima
Summary: This study evaluated the efficacy and safety of l-arginine in patients with HAM/TSP. The results showed that l-arginine therapy improved motor function and reduced inflammatory markers in the cerebrospinal fluid. Therefore, l-arginine may be a promising therapeutic option for patients with HAM/TSP.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Orthopedics
Eiji Matsuura, Satoshi Nozuma, Ayano Shigehisa, Mika Dozono, Tomonori Nakamura, Masakazu Tanaka, Ryuji Kubota, Akihiro Hashiguchi, Hiroshi Takashima
Summary: This case report describes a rare association between HTLV-1 infection and sporadic late onset nemaline myopathy (SLONM). Further studies are needed to understand the relationship between retroviruses and muscle diseases.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Virology
Ellen Gelpi, Sigrid Klotz, Miriam Beyerle, Sven Wischnewski, Verena Harter, Harald Kirschner, Katharina Stolz, Christoph Reisinger, Elisabeth Lindeck-Pozza, Alexander Zoufaly, Marlene Leoni, Gregor Gorkiewicz, Martin Zacharias, Christine Haberler, Johannes Hainfellner, Adelheid Woehrer, Simon Hametner, Thomas Roetzer, Till Voigtlaender, Gerda Ricken, Verena Endmayr, Carmen Haider, Judith Ludwig, Andrea Polt, Gloria Wilk, Susanne Schmid, Irene Erben, Anita Nguyen, Susanna Lang, Ingrid Simonitsch-Klupp, Christoph Kornauth, Maja Nackenhorst, Johannes Klaeger, Renate Kain, Andreas Chott, Richard Wasicky, Robert Krause, Guenter Weiss, Judith Loeffler-Rag, Thomas Berger, Patrizia Moser, Afshin Soleiman, Martin Asslaber, Roland Sedivy, Nikolaus Klupp, Martin Klimpfinger, Daniele Risser, Herbert Budka, Lucas Schirmer, Anne-Katrin Probstel, Romana Hoeftberger
Summary: We conducted a neuropathological analysis on 32 patients who died from COVID-19 in Austria between 2020 and 2021. The results showed diffuse white matter damage and microglial activation in all cases, indicating indirect brain damage rather than direct virus-specific damage. Inflammatory changes and vascular pathologies were also observed, along with silent neurodegenerative pathologies in elderly patients. These findings align with experimental data on SARS-CoV-2-related brain damage and provide a better understanding of the mechanisms underlying neurological symptoms after COVID-19.
Article
Clinical Neurology
Ryusei Nagata, Eiji Matsuura, Satoshi Nozuma, Mika Dozono, Yutaka Noguchi, Masahiro Ando, Yu Hiramatsu, Daisuke Kodama, Masakazu Tanaka, Ryuji Kubota, Munekazu Yamakuchi, Yujiro Higuchi, Yusuke Sakiyama, Hitoshi Arata, Keiko Higashi, Teruto Hashiguchi, Shunya Nakane, Hiroshi Takashima
Summary: This study investigated the correlation between the presence of serum anti-ganglionic acetylcholine receptor (gAChR) antibodies and autonomic symptoms in patients with functional neurological symptom disorder/conversion disorder (FNSD/CD). The results showed that among the 59 FNSD/CD patients, 88.1% exhibited autonomic disturbances and 27.1% were positive for serum anti-gAChR antibodies. Patients positive for anti-gAChR antibodies had a higher prevalence of cardiovascular autonomic dysfunction but a lower prevalence of involuntary movements compared to antibody-negative patients. The findings suggest that an autoimmune mechanism mediated by anti-gAChR antibodies may be involved in the etiology of FNSD/CD in a subgroup of patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Satoshi Nozuma, Eiji Matsuura, Masakazu Tanaka, Daisuke Kodama, Toshio Matsuzaki, Akiko Yoshimura, Yusuke Sakiyama, Shingo Nakahata, Kazuhiro Morishita, Yoshimi Enose-Akahata, Steven Jacoboson, Ryuji Kubota, Hiroshi Takashima
Summary: This study demonstrates that analyzing TCR repertoires of HTLV-1-infected cells can provide insights into the clonal dynamics and potential pathogenic clones expanded in the CNS of HAM/TSP patients. The TCR beta repertoire analysis reveals a higher clonal expansion in HTLV-1-infected cells compared to noninfected cells, and the TCR sequences of infected cells remain stable over time. Furthermore, highly expanded infected clones are found in the cerebrospinal fluid of HAM/TSP patients.
Article
Microbiology
Eiji Matsuura, Satoshi Nozuma, Mika Dozono, Daisuke Kodama, Masakazu Tanaka, Ryuji Kubota, Hiroshi Takashima
Summary: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressive neurological disease caused by HTLV-1 infection. The most common clinical manifestations of HAM/TSP include weakness of the proximal muscles of the lower extremities and atrophy of the paraspinal muscles, with the upper extremities being mostly unaffected. This study aimed to identify the muscle involvement pattern in HAM/TSP to aid diagnosis, rehabilitation and understanding of its pathogenesis.