Article
Biochemistry & Molecular Biology
Takahiro Fujimoto, Takeshi Yaoi, Kenta Nakano, Tetsuya Arai, Tadashi Okamura, Kyoko Itoh
Summary: This study investigates the expression and function of Dp71 in the brain using a Dp71-specific transgenic mouse model. The results show that Dp71 is predominantly expressed at the inhibitory postsynapse and blood-brain barrier, and there is cell-type dependent expression of Dp71. Molecular analysis further reveals interactions between Dp71 and Dg, Dtna/Dtnb. This study provides valuable insights into the physiological expressions and functions of Dp71 and its interaction proteins in the brain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Analytical
Hua He, Lihua Liu, Xiaoliang Chen, Qian Wang, Xiaojuan Wang, Werner M. Nau, Fang Huang
Summary: This study developed a new technique for accurate single-molecule counting using spontaneous blinking of carbon dots, achieving high precision with a localization accuracy of 10 nm. The technique was successfully applied to study molecular interactions and distribution in subcellular fractions, as well as G-protein coupled receptors on cell membranes, providing insights into receptor oligomerization, clustering, and ligand-regulated distributions. The adaptation of nanoparticle self-blinking for molecular counting demonstrates the potential of carbon dots as reliable probes for deciphering sub-diffraction structures essential for biological functions.
ANALYTICAL CHEMISTRY
(2021)
Editorial Material
Chemistry, Physical
Vasily Bulatov, Wei Cai
Summary: The in situ electron microscopy study provides important insights into the enhanced dislocation mobility in iron and contributes to the ongoing debate on hydrogen embrittlement mechanisms.
Article
Chemistry, Applied
Ali Khodayari, Wim Thielemans, Ulrich Hirn, Aart W. Van Vuure, David Seveno
Summary: In this work, the interactions of five different hemicellulose models with cellulose nanocrystals were studied through molecular dynamics simulations. It was found that glucuronoarabinoxylan had the highest binding free energy, while xyloglucan showed the lowest interaction energies. The presence of water molecules was observed to weaken the interactions between hemicellulose and cellulose.
CARBOHYDRATE POLYMERS
(2021)
Editorial Material
Hematology
Helene Schoemans, Per Ljungman
Summary: The article investigates the antibody response in patients who received cellular therapy and COVID-19 vaccination.
Editorial Material
Nanoscience & Nanotechnology
Nadim Darwish
Summary: Transport measurements through a single molecule reveal the mechanism of the catalytic Suzuki-Miyaura cross-coupling reaction.
NATURE NANOTECHNOLOGY
(2021)
Editorial Material
Oncology
Ivan Ballesteros, Daniela Cerezo-Wallis, Andres Hidalgo
Summary: This article provides a comprehensive analysis of lung cancer patients at the single-cell level, revealing extreme immune diversity and defining neutrophil populations associated with treatment outcomes.
Editorial Material
Multidisciplinary Sciences
Amber Dance
Summary: Methods that combine imaging with sequencing are revealing the organizational principles of the genome and its impact on cell fates.
Editorial Material
Biochemistry & Molecular Biology
Aila Akosua Kattner
Summary: In this issue of Biomedical Journal, various advancements in medical research are covered, including COVID-19 prevention, HIV treatment, drug resistance in liver cancer, and therapeutic approaches for breast cancer. The journal showcases a wide range of cutting-edge achievements in the field of medicine.
BIOMEDICAL JOURNAL
(2021)
Editorial Material
Biochemistry & Molecular Biology
Folakemi T. T. Odedina, Rafaela Alves Pacheco, Marcia C. C. Castro
Summary: Tailored community engagement, led or co-led by the community, can establish trust and ensure health equity in underserved communities.
Article
Construction & Building Technology
Romain Dupuis, Roland J-M Pellenq
Summary: Understanding the formation and behavior of Alkali-silica reaction gel (ASR gel) in cement pore solutions is crucial in mitigating concrete strength retrogression. Advanced atomistic simulations demonstrate how ASR gel formation in cement pores can damage the paste structure, with drying or calcification affecting its strength. The attraction of alkali ions released during calcification by the gel alters its interaction with cement pore walls, potentially leading to concrete damage.
CEMENT AND CONCRETE RESEARCH
(2022)
Editorial Material
Biochemistry & Molecular Biology
Nicholas Rhind
Summary: In this paper, Claussin et al. present a novel approach that combines single-molecule resolution with genome-wide coverage to study the robust nature of DNA replication.
Article
Economics
M. A. Russo, L. Ruivo, D. Carvalho, N. Martins, A. Monteiro
Summary: The study explores different energy consumption patterns during the first year of the COVID-19 pandemic in Portugal, with a focus on the shift towards domestic sector consumption and the impact on energy supply and demand landscape. It suggests that actions targeting reduced mobility, such as home office practices and the decentralization of the workforce, could be relevant energy efficiency measures. The data show a 15.7% reduction in primary energy consumption compared to 2019 in Portugal, indicating the potential for new strategies to achieve EU 2050 Energy goals.
Editorial Material
Microbiology
Laurice Flowers, Amy Campbell, Aayushi Uberoi
Summary: The study reveals the coexistence of multiple C. acnes lineages on the skin surface, with individual pores being dominated by a specific lineage.
CELL HOST & MICROBE
(2022)
Article
Multidisciplinary Sciences
A. Guthrie, S. Kafanov, M. T. Noble, Yu A. Pashkin, G. R. Pickett, V Tsepelin, A. A. Dorofeev, V. A. Krupenin, D. E. Presnov
Summary: Researchers have successfully demonstrated real-time detection of single quantum vortices in superfluid He-4 at 10 millikelvin using nanoscale resonant beams. By controlling the vortex density in the environment, they observed the processes of vortex capture and release.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Alessandra Folci, Angela Steinberger, Boram Lee, Ruslan Stanika, Susanne Scheruebel, Marta Campiglio, Claudia Ramprecht, Brigitte Pelzmann, Johannes W. Hell, Gerald J. Obermair, Martin Heine, Valentina Di Biase
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Neurosciences
Mael Dumenieu, Oleg Senkov, Andrey Mironov, Emmanuel Bourinet, Michael R. Kreutz, Alexander Dityatev, Martin Heine, Arthur Bikbaev, Jeffrey Lopez-Rojas
Article
Neurosciences
Johannes Brockhaus, Miriam Schreitmueller, Daniele Repetto, Oliver Klatt, Carsten Reissner, Keith Elmslie, Martin Heine, Markus Missler
JOURNAL OF NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Barbara Schweitzer, Jeet Singh, Anna Fejtova, Laurent Groc, Martin Heine, Renato Frischknecht
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Nikhil J. Pandya, Christian Seeger, Norbert Babai, Miguel A. Gonzalez-Lozano, Volker Mack, Johannes C. Lodder, Yvonne Gouwenberg, Huibert D. Mansvelder, U. Helena Danielson, Ka Wan Li, Martin Heine, Sabine Spijker, Renato Frischknecht, August B. Smit
Article
Neurosciences
Karen M. J. van Loo, Christine K. Rummel, Julika Pitsch, Johannes Alexander Mueller, Arthur F. Bikbaev, Erick Martinez-Chavez, Sandra Blaess, Dirk Dietrich, Martin Heine, Albert J. Becker, Susanne Schoch
JOURNAL OF NEUROSCIENCE
(2019)
Review
Neurosciences
Martin Heine, Jennifer Heck, Anna Ciuraszkiewicz, Arthur Bikbaev
Article
Neurosciences
Jennifer Heck, Pierre Parutto, Anna Ciuraszkiewicz, Arthur Bikbaev, Romy Freund, Jessica Mitloehner, Maria Andres-Alonso, Anna Fejtova, David Holcman, Martin Heine
Article
Cell Biology
Steffen Fricke, Kristin Metzdorf, Melanie Ohm, Stefan Haak, Martin Heine, Martin Korte, Marta Zagrebelsky
Review
Neurosciences
Martin Heine, David Holcman
TRENDS IN NEUROSCIENCES
(2020)
Article
Neurosciences
Arthur Bikbaev, Anna Ciuraszkiewicz-Wojciech, Jennifer Heck, Oliver Klatt, Romy Freund, Jessica Mitloehner, Sara Enrile Lacalle, Miao Sun, Daniele Repetto, Renato Frischknecht, Cornelia Ablinger, Astrid Rohlmann, Markus Missler, Gerald J. Obermair, Valentina Di Biase, Martin Heine
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Niklas Krick, Stefanie Ryglewski, Aylin Pichler, Arthur Bikbaev, Torsten Goetz, Oliver Kobler, Martin Heine, Ulrich Thomas, Carsten Duch
Summary: The study reveals the presence of two different voltage-gated calcium channels at the presynaptic terminals of glutamatergic neuromuscular synapses in fruit flies, showing spatial and functional separation in regulating neurotransmitter release and recycling. The Cav2 channel is required for neurotransmitter release, while the Cav1 channel mainly contributes to calcium influx and fine-tuning short-term plasticity. The findings suggest a conserved functional triad of Cav2, Cav1, and PMCA for separate control of synaptic vesicle release and recycling rates in presynaptic terminals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Tina Ghelani, Marc Escher, Ulrich Thomas, Klara Esch, Janine Luetzkendorf, Harald Depner, Marta Maglione, Pierre Parutto, Scott Gratz, Tanja Matkovic-Rachid, Stefanie Ryglewski, Alexander M. Walter, David Holcman, Kate O'Connor Giles, Martin Heine, Stephan J. Sigrist
Summary: In this study, dynamic intravital single-molecule imaging was used to investigate the interaction between scaffold proteins and voltage-gated calcium channels (VGCCs) during presynaptic homeostatic potentiation in Drosophila AZs. It was found that the interaction between the intracellular carboxyl terminus of the Cac channel and the amino-terminal region of the ELKS-family protein Bruchpilot played a crucial role in the sustained potentiation of AZs.
Review
Biochemistry & Molecular Biology
Jennifer Heck, Ana Carolina Palmeira Do Amaral, Stephan Weissbach, Abderazzaq El Khallouqi, Arthur Bikbaev, Martin Heine
Summary: Voltage-gated calcium channels (VGCCs) play a crucial role in regulating calcium influx in excitable cells, triggering signaling cascades and neurotransmitter release. Recent studies have expanded the understanding of VGCCs beyond being mere calcium-permeable channels, revealing their involvement in various cellular functions such as voltage sensing, complex formation with other proteins, and direct participation in gene regulation.
Article
Multidisciplinary Sciences
Ruth D. Taylor, Martin Heine, Nigel J. Emptage, Laura C. Andreae
