Journal
NEURON
Volume 69, Issue 1, Pages 3-6Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2010.12.029
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Funding
- NINDS NIH HHS [R37 NS034179-11, R01 NS035806-13, R37 NS034179, R01 NS035806] Funding Source: Medline
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Activation of NMDA receptors during cerebral ischemia triggers signaling pathways that promote both neuronal death and survival. In this issue of Neuron, Sasaki et al. present evidence for a new endogenous survival pathway involving the kinase SIK2 and the CREB coactivator TORC1. The powerful neuroprotection conferred by this pathway has considerable translational potential for stroke therapy.
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