Article
Chemistry, Applied
Meijuan Liao, Ruyi Zhang, Yi Zhou, Duoxia Xu, Yahong Han, Fuguo Liu, Jiaqi Su, Shuai Chen
Summary: The aim of this study was to develop particle-filled microgels based on zein and rc-carrageenan for efficient delivery of CoQ10. The optimized formulation showed an average particle diameter of 807.4 nm and a zeta-potential of -28.4 mV. It effectively reduced the chemical degradation of CoQ10 and controlled its release during simulated gastrointestinal digestion, leading to improved oral bioavailability.
FOOD HYDROCOLLOIDS
(2023)
Article
Cardiac & Cardiovascular Systems
Albert E. Raizner, Miguel A. Quinones
Summary: Coenzyme Q(10) is a naturally occurring compound in animals and humans, playing a fundamental role in cellular energy production. Deficiency of CoQ(10) may be related to symptoms like statin-associated muscle symptoms (SAMS) and features observed in heart failure (HF) patients. While conflicting results have been seen in clinical trials of CoQ(10) in SAMS, meta-analyses support its use. Additional research is needed to explore the potential benefits of exogenous CoQ(10) in patients with HF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Trine Baur Opstad, Jan Alexander, Jan Aaseth, Anders Larsson, Ingebjorg Seljeflot, Urban Alehagen
Summary: This study aimed to investigate the influence of a SeQ(10) intervention on SIRT1 concentration and its potential interactions with microRNAs. The results showed that the SeQ(10) intervention increased SIRT1 concentration, which was associated with reduced cardiovascular mortality, partly mediated via miR-130a-3p.
Article
Biochemistry & Molecular Biology
Zuzana Sumbalova, Jarmila Kucharska, Zuzana Rausova, Anna Gvozdjakova, Maria Szantova, Branislav Kura, Viliam Mojto, Jan Slezak
Summary: This study investigated the effects of hydrogen-rich water on coenzyme Q10 content and platelet mitochondrial bioenergetics in patients with non-alcoholic fatty liver disease (NAFLD). The results showed that drinking hydrogen-rich water can increase coenzyme Q10 concentration, reduce oxidative stress levels, and improve mitochondrial function, suggesting a potential therapeutic effect on NAFLD patients' recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jacob Alex, Elise Landa, Arjun Trivedi, Leo M. Parsons, Nabeel Shabo
Summary: Coxsackie B infections can cause necrotizing myopathy and extremely high levels of creatine phosphokinase, and it is associated with high mortality. This case highlights the importance of Coxsackie B4 as a potential pathogen.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Malarkodi Suppamutharwyam, Tunku Muzafar Shah
Summary: Statins are widely used in clinical practice, but statin-associated autoimmune myopathy is an exceptionally rare and severe complication. This case study presents a challenging case of statin-associated autoimmune myopathy that developed after long-term use of atorvastatin, resulting in debilitating weakness. Recognizing such cases and implementing statin discontinuation and aggressive immunosuppressive therapy can reduce morbidity and mortality.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Ilenia Cirilli, Elisabetta Damiani, Phiwayinkosi Vusi Dludla, Iain Hargreaves, Fabio Marcheggiani, Lauren Elizabeth Millichap, Patrick Orlando, Sonia Silvestri, Luca Tiano
Summary: Coenzyme Q(10) plays a significant role in health and disease through its classical antioxidant and bioenergetic functions, as well as novel mechanisms involving redox-regulated activation of molecular pathways. While cardiovascular research and fertility are major fields of application for Coenzyme Q(10), there is growing interest in new applications, particularly in relation to topical use. Bioavailability is a major challenge, and innovation in formulation aspects is becoming increasingly important in this regard.
Review
Medical Laboratory Technology
Federico V. Pallardo, Giovanni Pagano, Laura R. Rodriguez, Pilar Gonzalez-Cabo, Alex Lyakhovich, Marco Trifuoggi
Summary: Friedreich's Ataxia is an autosomal recessive genetic disease caused by frataxin deficiency, and research suggests that a combination strategy involving iron chelators, antioxidants, and mitochondrial cofactors may help mitigate the disease progression.
TRANSLATIONAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Carolyn B. Sue-Ling, Willie M. Abel, Keith Sue-Ling
Summary: Coenzyme Q(10) (CoQ(10)) supplementation added to conventional therapy is safe and beneficial in predominantly older adult males with cardiovascular disease (CVD) or hypertension (HTN) at both clinical and cellular levels. However, caution should be exercised when interpreting the results of the trials, and further research is needed before recommending widespread usage of CoQ(10) in all older adults.
JOURNAL OF NUTRITION
(2022)
Article
Medicine, General & Internal
Mariana Rios-Gomez, Arturo Villanueva-Salinas, Sarahi Arias-Martinez, Juan Andres Pimentel-Esparza, Alejandra Aguirre-Sanchez, Javier Delgado-Villafana, Martha Elia Perez-Santana, Juan E. Montes-Ramirez
Summary: Inflammatory myopathies are a group of diseases characterized by immune-mediated muscle damage, one of which is polymyositis. The definition of polymyositis is controversial, with arguments for both immunohistochemical and histopathological findings in muscle biopsies, as well as clinical manifestations and histopathological findings. Polymyositis is a rare disease characterized by progressive symmetrical muscle weakness, especially in the proximal muscles. Diagnostic methods include elevated levels of sarcoplasmic enzymes in laboratory studies, nerve conduction tests, and muscle biopsy, which is considered the gold standard for diagnosing inflammatory myopathy and distinguishing subclasses. This article reports a case of a 61-year-old male patient with generalized symmetrical weakness, mainly in the upper extremities, and dysphagia, whose laboratory studies, autoantibodies, and muscle biopsy confirmed the diagnosis of polymyositis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ahlam M. Alhusaini, Rahaf Alsoghayer, Lina Alhushan, Abeer M. Alanazi, Iman H. Hasan
Summary: The study aimed to examine the hepatoprotective effects of acetyl-L-carnitine (A-CAR) and liposomal-coenzyme Q(10) (L-CoQ(10)) against propionic acid (PRA)-induced liver injury. The results showed that A-CAR and/or L-CoQ(10) reduced oxidative stress, inflammatory response, apoptosis, and fibrosis in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Michaela B. Polmann, Richard I. Suarez, Ali Saad, Kebir H. Bedran
Summary: The author discussed a serious side effect - he found that his patient, although no longer taking the statin medication that was harmful to his muscles, still exhibited symptoms of necrotizing autoimmune myositis with positive antibodies. It is important to be vigilant for adverse reactions that may occur with therapeutic medications when assessing patients with this condition.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Leander Cornelis, Julien Duyck, Franciska Dedeurwaerdere, Gert De Schoenmakere, Thomas Malfait
Summary: Statins are effective in treating hypercholesterolemia, but can sometimes cause muscle-related side effects. Recently, there have been reports of statin-induced necrotizing autoimmune myopathy (SINAM) which can be life-threatening. We present a case of a female patient who experienced persistent symptoms after discontinuing statin therapy and was diagnosed with SINAM, leading to treatment with immunosuppressants.
ACTA CLINICA BELGICA
(2023)
Article
Biochemistry & Molecular Biology
Alenka Nemec Svete, Tomaz Vovk, Mojca Bohar Topolovec, Peter Kruljc
Summary: The study found that vitamin E alone or in combination with Coenzyme Q(10) can prevent lipid peroxidation in untrained leisure horses subjected to acute moderate exercise. The supplemented antioxidants did not affect the concentrations of vitamin E and CoQ(10), oxidative stress parameters, or serum muscle enzymes.
Article
Clinical Neurology
Sarah A. Friedman, Zeinab Charmchi, Michael Silver, Nuri Jacoby, Jonathan Perk, Yaacov Anziska
Summary: This study found that elevated creatine kinase (CK) levels in COVID-19 patients are associated with the severity of the disease, suggesting that CK can be used as an additional data point for predicting disease progression.
