Article
Clinical Neurology
Mette Nissen, Tiina-Mari Ikaheimo, Jukka Huttunen, Ville Leinonen, Henna-Kaisa Jyrkkanen, Mikael von Und Zu Fraunberg
Summary: The study showed that patients using gabapentinoids had lower rates of spinal cord stimulator explantation and were more likely to discontinue or reduce opioid use, indicating potential benefits of concomitant use of gabapentinoids in SCS patients.
Review
Public, Environmental & Occupational Health
Reza Alizadeh, Albert Thomas Anastasio, Ardalan Shariat, Mikhail Bethell, Gholamreza Hassanzadeh
Summary: Failed back surgery syndrome (FBSS) refers to persistent or new back pain after surgical intervention. This article discusses the need for less invasive treatments for FBSS, particularly tailored exercise training for geriatric patients. An internet-based platform called teleexercise is proposed as a practical and cost-effective method for exercise delivery, especially for geriatric patients with limited mobility and access to care.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Lisa Goudman, Julie Jansen, Nieke Vets, Ann De Smedt, Maarten Moens
Summary: This study evaluated whether an electronic nose could differentiate between chronic pain patients with Spinal Cord Stimulation (SCS) activated versus deactivated, finding that exhaled breath could not effectively distinguish between the two states in patients with Failed Back Surgery Syndrome (FBSS). The findings suggest that exhaled breath cannot be used as an additional marker of the effect of neuromodulation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Canan Bursali, Feyza Unlu Ozkan, Meryem Yilmaz Kaysin, Nimet Dortcan, Ilknur Aktas, Duygu Geler Kulcu
Summary: This study aimed to evaluate the effectiveness of r-TMS treatment in patients with FBSS, and results showed significant improvements in DN4, ODI, BDI, and PSQI scores in the r-TMS group compared to the sham group. Both groups experienced improvements in VAS scores, but the r-TMS group maintained these improvements at the third month follow-up. However, limitations included the small number of patients and short follow-up periods.
Article
Anesthesiology
Mohamed Amgad Elsayed Elkholy, Ahmed Nagaty, Ahmad Elsayed Abdelbar, Hisham Abdelsalam Mohamed Simry, Ahmed M. Raslan
Summary: This study aimed to evaluate the effects of neuromodulation procedures, specifically spinal cord stimulation, on pain scores, quality of life, and opioid medication intake in patients diagnosed with failed back surgery syndrome. The study found that spinal cord stimulation led to a significant reduction in pain scores, improvement in quality of life, and a decrease in opioid medication usage.
Review
Clinical Neurology
Giuseppe Francesco Papalia, Fabrizio Russo, Gianluca Vadala, Giuseppe Pascarella, Sergio De Salvatore, Luca Ambrosio, Sara Di Martino, Davide Sammartini, Emanuele Sammartini, Massimiliano Carassiti, Rocco Papalia, Vincenzo Denaro
Summary: This systematic review examines the efficacy of non-invasive procedures in relieving chronic pain caused by Failed Back Surgery Syndrome (FBSS). The findings indicate that conservative treatments, particularly high-frequency Spinal Cord Stimulation, demonstrate improvement in pain scores and reduced disability index. However, further research is needed to confirm the effectiveness of non-invasive interventions due to heterogeneity among trials and population characteristics.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Stefan Motov, Kaywan Aftahy, Ann-Kathrin Joerger, Arthur Wagner, Bernhard Meyer, Ehab Shiban
Summary: High-frequency spinal cord stimulation (HF10 SCS) demonstrates significant pain reduction in most patients with failed back surgery syndrome (FBSS) and predominant low back pain (LBP), potentially serving as an efficient alternative to revision surgery.
NEUROSURGICAL REVIEW
(2021)
Article
Rehabilitation
Mats De Jaeger, Lisa Goudman, Sam Eldabe, Robert Van Dongen, Ann De Smedt, Maarten Moens
Summary: This study aimed to investigate the relationship between pain intensity pre-treatment and disability, finding that pain reduction can help alleviate disability levels, but a low degree of disability does not always reflect low pain intensity.
DISABILITY AND REHABILITATION
(2021)
Review
Anesthesiology
Nick Christelis, Brian Simpson, Marc Russo, Michael Stanton-Hicks, Giancarlo Barolat, Simon Thomson, Stephan Schug, Ralf Baron, Eric Buchser, Daniel B. Carr, Timothy R. Deer, Ivano Dones, Sam Eldabe, Rollin Gallagher, Frank Huygen, David Kloth, Robert Levy, Richard North, Christophe Perruchoud, Erika Petersen, Philippe Rigoard, Konstantin Slavin, Dennis Turk, Todd Wetzel, John Loeser
Summary: The term "Failed back surgery syndrome (FBSS)" is considered inadequate and misleading for describing patients with persistent pain following spine surgery. The International Association for the Study of Pain (IASP) proposed "Chronic pain after spinal surgery (CPSS)" as a replacement term, which is now accepted by the World Health Organization (WHO). Through a structured workshop and Delphi process, "Persistent spinal pain syndrome" was selected as a preferred option and suggested for adoption to strengthen the new ICD-11 classification.
Article
Clinical Neurology
Ralf Weigel, Hans-Holger Capelle, Shadi Al-Afif, Joachim K. Krauss
Summary: This study aimed to describe specific symptoms and investigate the primary and secondary underlying causes of failed back surgery syndrome (FBSS) in patients who had lumbar spinal surgery. The results showed that most patients complained of low back pain, pseudoradicular pain, and neuropathic pain, and specific treatment strategies were determined based on symptomatic, morphological, and functional dimensions.
ACTA NEUROCHIRURGICA
(2021)
Article
Anesthesiology
Concepcion Perez, Elena Rojo, Cesar Margarit, Noelia Sanchez, Tania Blanco, Manuel Munoz, Carlos Crespo, Dolores Ochoa
Summary: This study compared the effectiveness of CMM and SCS for managing FBSS, finding that SCS may improve HRQoL and functionality in the long term. However, there were also limitations in the study design and sample size.
Review
Medicine, General & Internal
Grzegorz Miekisiak
Summary: The introduction of Persistent Spinal Pain Syndrome (PSPS-T1/2) as a replacement for Failed Back Surgery Syndrome (FBSS) has significantly impacted the diagnosis and treatment of post-surgical spinal pain. This comprehensive review discusses the effect of this change on patient care. The management of PSPS-T1/2 involves both causative treatments and symptomatic treatments, with emphasis on a multidisciplinary and holistic approach.
MEDICINA-LITHUANIA
(2023)
Article
Clinical Neurology
Richard L. Witkam, Elisabeth A. M. Kragt, Inge J. J. Arnts, Ewald M. Bronkhorst, Robert van Dongen, Erkan Kurt, Monique A. H. Steegers, Frank G. A. M. van Haren, Natasja J. G. Maandag, Cees Gort, Dylan J. H. A. Henssen, Jessica T. Wegener, Kris C. P. Vissers
Summary: Spinal cord stimulation (SCS) is recommended for treating failed back surgery syndrome (FBSS). The study compared the long-term clinical outcomes and safety of trialed and nontrialed implantation strategies, finding a statistically significant but not clinically significant difference in pain intensity between the two groups.
Article
Anesthesiology
Valerie Dauriac-Le Masson, Marie-Therese Gatt, Corinne Chekroun, Baris Turak, Marie Christine Djian
Summary: The study found that spinal cord stimulation (SCS) is an effective treatment for patients with failed back surgery syndrome (FBSS), resulting in a high return to work (RTW) rate. Factors positively associated with RTW include functional improvement and shorter unemployment duration, while longer unemployment duration has a negative impact on RTW.
Article
Clinical Neurology
Sally El Sammak, William Mualem, Giorgos D. Michalopoulos, Joshua M. Romero, Christopher T. Ha, Christine L. Hunt, Mohamad Bydon
Summary: This study systematically reviewed and evaluated the current literature on the use of novel waveform spinal cord stimulation for the management of failed back surgery syndrome refractory to conventional SCSs. The results showed that conversion to novel stimulation can significantly reduce back pain.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Article
Clinical Neurology
Bjoern Carsten Schultheis, Christian Wille, Nikolas Eugenio Ross-Steinhagen, Dirk De Ridder, Tim Vancamp, Patrick A. Weidle
Summary: Alternative neurostimulation implantation techniques can be used when the traditional percutaneous placement of dorsal root ganglion electrodes is not eligible for patients. These techniques, performed by experienced doctors, can achieve stable pain suppression similar to the common percutaneous technique.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Clinical Neurology
Alison M. M. Luckey, S. Lauren McLeod, S. Anusha Mohan, Sven Vanneste
Summary: This study compares the effects of transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) on associative memory performance. The results show that 40 Hz tACS enhances attention during memory encoding and significantly improves the number of words learned on Day 1, while active tDCS results in a significant increase in the number of words recalled on Day 7.
Letter
Clinical Neurology
Hsueh-Sheng Chiang, Scott Shakal, Jeremy F. Strain, Kyle Womack, Michael Kraut, Sven Vanneste, John Hart
Article
Clinical Neurology
Vincent Raymaekers, Sven Bamps, Wim Duyvendak, Eric Put, Gert Roosen, Steven Vanvolsem, Maarten Wissels, Sven Vanneste, Dirk De Ridder, Mark Plazier
Summary: The aim of this study was to identify and describe clusters of patients with sciatica caused by lumbar disc herniation. Three significant clusters were identified, each with different characteristics. Patients in cluster 1 had the most severe pain, highest disability, and underwent more surgeries. Cluster 2 had lower pain and disability but higher quality of life, while cluster 3 had high pain awareness and catastrophizing but limited disability and maintained quality of life.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Neurosciences
Anusha Mohan, Alison Luckey, Nathan Weisz, Sven Vanneste
Summary: Tinnitus may result from predictive coding issues, with patients potentially being more sensitive to auditory stimuli unrelated to tinnitus characteristics. In individuals with minimal or no hearing loss, a more top-down subtype of tinnitus driven by maladaptive changes in the auditory predictive coding network may exist. Empirical evidence suggests the presence of maladaptive changes in hierarchical predictive coding network in a subgroup of tinnitus patients with minimal to no hearing loss.
Article
Behavioral Sciences
Anusha Mohan, Sook Ling Leong, Dirk De Ridder, Sven Vanneste
Summary: Tinnitus is a heterogeneous disorder that is difficult to classify based on clinical profiles. This article proposes a framework that views tinnitus as a dimensional disorder and explores the interactions between different dimensions to determine the characteristics of tinnitus. This perspective can enhance our understanding of tinnitus and improve treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Clinical Neurology
Dirk De Ridder, Sven Vanneste, Mark Smith, Divya Adhia
Summary: Acute pain is a physiological response to tissue injury, while chronic pain can lead to suffering and functional impairment. The triple network model offers a framework to understand neuropsychiatric illnesses. Personalized treatment methods should be developed for pain management.
FRONTIERS IN NEUROLOGY
(2022)
Review
Otorhinolaryngology
Dirk De Ridder, Sven Vanneste, Jae-Jin Song, Divya Adhia
Summary: Tinnitus is the conscious awareness of a sound without an identifiable external sound source. It can lead to suffering and negative cognitive, emotional, and autonomic responses. The triple network model proposes that abnormal interactions among three cardinal networks underlie brain disorders, including tinnitus. Chronic tinnitus can be explained by the interaction of the sound pathway, the suffering pathway, and the noise-canceling pathway. This model paves the way for individualized treatment modalities.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2022)
Article
Multidisciplinary Sciences
Brendan Conlon, Caroline Hamilton, Emma Meade, Sook Ling Leong, Ciara O. Connor, Berthold Langguth, Sven Vanneste, Deborah A. Hall, Stephen Hughes, Hubert H. Lim
Summary: A new study finds that bimodal neuromodulation combining sound and tongue stimulation can significantly reduce tinnitus symptoms and this therapeutic effect can last for up to 12 months after treatment.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Divya Bharatkumar Adhia, Ramakrishnan Mani, John N. J. Reynolds, Sven Vanneste, Dirk De Ridder
Summary: This pilot study aims to evaluate the feasibility, safety, and acceptability of a novel neuromodulation technique, high-definition transcranial infraslow pink noise stimulation (HD-tIPNS), in people with chronic low back pain (CLBP), and explore the trend of its effect on pain and function. The study will collect clinical and physiological data through a randomized controlled trial and analyze them descriptively and qualitatively. The findings will contribute to the development of more valuable experimental designs and treatment approaches in the future.
Article
Clinical Neurology
Andre R. Brunoni, Hamed Ekhtiari, Andrea Antal, Paradee Auvichayapat, Chris Baeken, Isabela M. Bensenor, Marom Bikson, Paulo Boggio, Barbara Borroni, Filippo Brighina, Jerome Brunelin, Sandra Carvalho, Wolnei Caumo, Patrick Ciechanski, Leigh Charvet, Vincent P. Clark, Roi Cohen Kadosh, Maria Cotelli, Abhishek Datta, Zhi-De Deng, Rudi De Raedt, Dirk De Ridder, Paul B. Fitzgerald, Agnes Floel, Flavio Frohlich, Mark S. George, Peyman Ghobadi-Azbari, Stephan Goerigk, Roy H. Hamilton, Shapour J. Jaberzadeh, Kate Hoy, Dawson J. Kidgell, Arash Khojasteh Zonoozi, Adam Kirton, Steven Laureys, Michal Lavidor, Kiwon Lee, Jorge Leite, Sarah H. Lisanby, Colleen Loo, Donel M. Martin, Carlo Miniussi, Marine Mondino, Katia Monte-Silva, Leon Morales-Quezada, Michael A. Nitsche, Alexandre H. Okano, Claudia S. Oliveira, Balder Onarheim, Kevin Pacheco-Barrios, Frank Padberg, Ester M. Nakamura-Palacios, Ulrich Palm, Walter Paulus, Christian Plewnia, Alberto Priori, Tarek K. Rajji, Lais B. Razza, Erik M. Rehn, Giulio Ruffini, Klaus Schellhorn, Mehran Zare-Bidoky, Marcel Simis, Pawel Skorupinski, Paulo Suen, Aurore Thibaut, Leandro C. L. Valiengo, Marie-Anne Vanderhasselt, Sven Vanneste, Ganesan Venkatasubramanian, Ines R. Violante, Anna Wexler, Adam J. Woods, Felipe Fregni
Summary: This study discusses the implementation of transcranial electric stimulation (tES) digital trials and evaluates the methodological aspects of tES trial designs. The findings highlight the advantages of tES, such as its non-pharmacological nature, safety, affordability, and potential scalability. However, insufficient supervision and unclear regulatory status are identified as weaknesses. The study proposes a conceptual framework for digitizing tES trials and emphasizes the potential of leveraging mobile-Health technologies in the digital trials process.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Hsueh-Sheng Chiang, Michael Motes, Michael Kraut, Sven Vanneste, John Hart
Summary: This study found that High Definition transcranial Direct Current Stimulation (HD-tDCS) can improve cognitive performance in individuals with chronic traumatic brain injury (TBI) and observed changes in brain oscillations through electroencephalography (EEG). These findings have significance in guiding future research and selecting patients who may respond optimally to treatment.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Divya Bharatkumar Adhia, Ramakrishnan Mani, John N. J. Reynolds, Matthew Hall, Sven Vanneste, Dirk De Ridder
Summary: A novel technique called HD-tIPNS was developed to modulate key hubs of the pain pathways. The study demonstrated that HD-tIPNS can safely alter the functional and effective connectivity between pain-related brain regions, but did not lead to changes in clinical pain measures.
Article
Medicine, Research & Experimental
Katherine S. Adcock, Brian Lawlor, Ian H. Robertson, Sven Vanneste
Summary: This study aims to investigate the effect of transcutaneous electrical stimulation on improving episodic memory in individuals with Mild Cognitive Impairment, using a double-blind, placebo-controlled study design. The primary outcome will be determined by a word association task, while neurophysiological changes will be assessed using resting state EEG.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
Article
Biology
Alison M. Luckey, Lauren S. McLeod, Yuefeng Huang, Anusha Mohan, Sven Vanneste
Summary: Non-invasive transcutaneous electrical stimulation of the greater occipital nerve (NITESGON) during learning elicited a long-term memory effect by enhancing memory consolidation via modulation of dopaminergic input. This finding may have significant implications for neurocognitive disorders that inhibit memory consolidation such as Alzheimer's disease.
