Article
Acoustics
Philipp Arens, Thomas Fischer, Steffen Dommerich, Heidi Olze, Markus Herbert Lerchbaumer
Summary: This study investigated the use of US-SWE to measure changes in tongue muscle stiffness during sHNS therapy in patients with OSAS, finding significant increases in SWV values on the side of stimulation during muscle contraction. The findings suggest that US-SWE is a reliable method for distinguishing and characterizing responders from non-responders in hypoglossal stimulation therapy, providing new possibilities for patient assessment and treatment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Otorhinolaryngology
Clara H. Lee, Everett G. Seay, James W. Reese, Xin Wu, Richard J. Schwab, Brendan Keenan, Raj C. Dedhia
Summary: Clinically acquired cephalometric measurements, specifically soft palate size, may help identify optimal candidates for hypoglossal nerve stimulation therapy outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Matthew D. Johnson, Yazan M. Dweiri, Jason Cornelius, Kingman P. Strohl, Armin Steffen, Maria Suurna, Ryan J. Soose, Michael Coleman, John Rondoni, Dominique M. Durand, Quan Ni
Summary: A detailed biophysical model was developed to predict the spatial recruitment of hypoglossal nerve fascicles and axons during stimulation through nerve cuff electrodes. Monopolar configurations required lower stimulation amplitudes than the guarded bipolar configuration to elicit action potentials within hypoglossal nerve axons, and the activated axons were more uniformly distributed for monopolar configurations.
Article
Biochemistry & Molecular Biology
Ralph Pries, Christian Lange, Nicole Behn, Karl-Ludwig Bruchhage, Armin Steffen
Summary: This study investigated the influence of hypoglossal nerve stimulation (HNS) on the distribution and differentiation of circulating monocyte subsets in patients with obstructive sleep apnea syndrome (OSAS). The results showed that HNS therapy significantly improved the apnea-hypopnea index (AHI) and Epworth Sleepiness Scale (ESS) scores in OSAS patients. HNS also had the potential to ensure normal distributions of blood monocyte subsets and even improve monocyte dynamics in selected patients. However, there were no significant correlations between HNS usage and daytime sleepiness.
Article
Medicine, Research & Experimental
Clara H. Lee, Graeme B. Mulholland, Raj C. Dedhia
Summary: This study aims to investigate the correlation between transoral and awake endoscopic examination in predicting outcomes of hypoglossal nerve stimulation. It was found that tongue motion has an impact on the success of HGNS, but the correlation with HGNS outcomes is relatively low.
Article
Pharmacology & Pharmacy
Maksim Korotun, Luis Quintero, Mark Shikowitz, Paul Mayo, Harly Greenberg
Summary: Ultrasound assessment of hyoid bone excursion during HGNS programming is a useful tool to optimize therapy.
AMERICAN JOURNAL OF THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Patrick Scheffler, Dana Eitan, Rupali Drewek, Sharon Gnagi
Summary: Hypoglossal nerve stimulation (HGNS) can be a safe and effective treatment modality for obstructive sleep apnea (OSA) in patients with cerebral palsy.
Article
Biology
Johannes Pordzik, Katharina Ludwig, Christopher Seifen, Tilman Huppertz, Katharina Bahr-Hamm, Christoph Matthias, Haralampos Gouveris
Summary: Obstructive sleep apnea (OSA) is often accompanied by insomnia and the prevalence rate of comorbid insomnia and sleep apnea (COMISA) is 30-50%. Positive airway pressure (PAP) therapy is the standard treatment, but insomnia may complicate the treatment and reduce adherence. Respiration-coupled hypoglossal nerve stimulation (HGNS) is a reliable alternative therapy, and this report provides evidence of its significant reduction in insomnia-related symptoms in OSA patients.
Review
Clinical Neurology
Pan Liu, Weiguo Kong, Caijing Fang, Kangxu Zhu, Xiaohua Dai, Xiangming Meng
Summary: This study evaluated the efficacy and adverse effects of hypoglossal nerve stimulation in adolescents with down syndrome and obstructive sleep apnea. The results showed that hypoglossal nerve stimulation significantly reduces apnea-hypopnea index and improves the quality of life.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Clemens Heiser, Armin Steffen, Benedikt Hofauer, Reena Mehra, Patrick J. Strollo, Olivier M. Vanderveken, Joachim T. Maurer
Summary: Therapeutic upper airway stimulation showed significant improvement in reducing the severity of obstructive sleep apnea, sleepiness symptoms, and enhancing quality of life compared to sham stimulation in participants with moderate-to-severe OSA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Ning Zhou, Jean-Pierre T. F. Ho, Rene Spijker, Ghizlane Aarab, Nico de Vries, Madeline J. L. Ravesloot, Jan de Lange
Summary: This systematic review compared the efficacy and safety of maxillomandibular advancement (MMA) and upper airway stimulation (UAS) in treating obstructive sleep apnea (OSA). The results showed that both MMA and UAS are effective and generally safe therapies for OSA, but there is currently no sufficient evidence to directly compare these two procedures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Michael D. Olson, Mithri R. Junna
Summary: Hypoglossal nerve stimulation therapy is a treatment option for obstructive sleep apnea patients intolerant to CPAP therapy, which reduces respiratory parameters and improves subjective sleep complaints through direct neurostimulation of the hypoglossal nerve.
Review
Otorhinolaryngology
Do Hyun Kim, Sung Won Kim, Jae Sang Han, Geun-Jeon Kim, Mohammed Abdullah Basurrah, Se Hwan Hwang
Summary: This study aimed to determine the efficacy of hypoglossal nerve stimulation (HGS) in the treatment of obstructive sleep apnea. Through reviewing relevant studies from multiple databases, it was found that HGS can improve sleep quality and quality of life, and the effects remained relatively stable between 12 and 36 months.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Clinical Neurology
Pien F. N. Bosschieter, Nico de Vries, Reena Mehra, Shalini Manchanda, Tapan A. Padhya, Olivier M. Vanderveken, M. J. L. Ravesloot
Summary: Based on data from the ADHERE Registry, this study found that upper airway stimulation (UAS) is an effective treatment for patients with obstructive sleep apnea (OSA) and an apnea-hypopnea index (AHI) of 15 events/h or higher. The study also concluded that there are no significant differences in self-reported outcomes and treatment success among different subgroups based on OSA severity.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Miuni Athauda Arachchige, Joerg Steier
Summary: Obstructive Sleep Apnoea (OSA) is a common condition that can have a significant impact on physical and mental health, including an increased risk of cardiovascular diseases. Continuous Positive Airway Pressure (CPAP) therapy is the recommended treatment for moderate to severe OSA, but long-term adherence remains a challenge. There are alternative non-CPAP treatments available, such as lifestyle changes, surgical options, and nerve stimulation. When choosing long-term therapies, symptom control, patient-related outcomes, and long-term cardiovascular health should be prioritized.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
R. Nisha Aurora, Nancy A. Collop, Ofer Jacobowitz, Sherene M. Thomas, Stuart F. Quan, Amy J. Aronsky
JOURNAL OF CLINICAL SLEEP MEDICINE
(2015)
Article
Medicine, Research & Experimental
Michael Friedman, Ofer Jacobowitz, Michelle S. Hwang, Wolfgang Bergler, Ingo Fietze, Philippe Rombaux, Gimbada B. Mwenge, Sreeya Yalamanchali, John Campana, Joachim T. Maurer
Article
Clinical Neurology
Ying-Shuo Hsu, Ofer Jacobowitz
JOURNAL OF CLINICAL SLEEP MEDICINE
(2017)
Meeting Abstract
Clinical Neurology
O. Jacobowitz, G. Bachar, V Certal, W. Hohenhorst, E. Thuler
Meeting Abstract
Clinical Neurology
O. Jacobowitz, G. Bachar, V Certal, W. Hohenhorst, E. Thuler
Letter
Medicine, General & Internal
Robson Capasso, Eric Kezirian, Ofer Jacobowitz, Edward M. Weaver
ANNALS OF INTERNAL MEDICINE
(2014)
Article
Otorhinolaryngology
Edward M. Weaver, Tucker Woodson, Bevan Yueh, Timothy Smith, Michael G. Stewart, Maureen Hannley, Kristine Schulz, Milesh M. Patel, David Witsell
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2011)
Letter
Clinical Neurology
Patrick J. Strollo, M. Safwan Badr, Michael P. Coppola, Samuel A. Fleishman, Ofer Jacobowitz, Clete A. Kushida
Article
Medicine, Research & Experimental
Katherine K. Green, David T. Kent, Mark A. D'Agostino, Paul T. Hoff, Ho-Sheng Lin, Ryan J. Soose, M. Boyd Gillespie, Kathleen L. Yaremchuk, Marina Carrasco-Llatas, B. Tucker Woodson, Ofer Jacobowitz, Erica R. Thaler, Jose E. Barrera, Robson Capasso, Stanley Yung Liu, Jennifer Hsia, Daljit Mann, Taha S. Meraj, Jonathan A. Waxman, Eric J. Kezirian
Article
Otorhinolaryngology
Moshe Ephrat, Ofer Jacobowitz, Mark Driver
Summary: The study showed that radiofrequency treatment of the nasal valve resulted in improvements in nasal obstruction symptoms and patients' quality of life that were sustained through 24 months, with stable and lasting effects.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Article
Clinical Neurology
Ofer Jacobowitz, Lamia Afifi, Thomas Penzel, Dalva Poyares, Marie Marklund, Clete Kushida
Summary: A task force evaluated the American Academy of Sleep Medicine's clinical practice guideline on the treatment of adult obstructive sleep apnea. The guideline was found to be relevant and applicable to the practice of sleep medicine in various regions of the world, with caveats for universal applicability.
Article
Clinical Neurology
Yu-Hsuan Kuo, Tien-Jen Liu, Feng-Hsiang Chiu, Yi Chang, Chia-Mo Lin, Ofer Jacobowitz, Ying-Shuo Hsu
Summary: The study found that iNAP therapy can alleviate velar, oropharyngeal, and tongue base obstruction in some patients when in supine position. Moreover, combining iNAP therapy with head rotation can also relieve velar, tongue base, and epiglottic obstruction in some patients. TCI-DISE can be used to screen possible responders for iNAP therapy as it is less time consuming than PSG.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Otorhinolaryngology
Ofer Jacobowitz, Mark Driver, Moshe Ephrat
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2019)
Meeting Abstract
Critical Care Medicine
T. Otvos, O. Jacobowitz, L. Pham, M. A. Guzman, H. Pho, P. J. C. Biselli, F. P. Sgambati, M. Sowho, E. M. Hawks, E. M. Wolfe, H. Schneider, J. P. Kirkness, P. L. Smith, A. R. Schwartz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2015)