Review
Medicine, General & Internal
Onika Banduni, Megha Saini, Neha Singh, Debasish Nath, S. Senthil Kumaran, Nand Kumar, M. V. Padma Srivastava, Amit Mehndiratta
Summary: Upper extremity motor impairment is common in stroke patients, and traditional rehabilitation methods have limitations. Virtual reality and rTMS provide technology-driven solutions for better post-stroke upper limb motor improvement. Interactive games in a VR environment can provide novel and motivating customized training, while rTMS can facilitate neuroplasticity and promote recovery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jiahao Meng, Zeya Yan, Feng Gu, Xinyu Tao, Tao Xue, Dan Liu, Zhong Wang
Summary: This study analyzed data from four randomized clinical trials and found that the combination of transcranial direct current stimulation (tDCS) with virtual reality (VR) did not significantly improve upper extremity rehabilitation in stroke patients compared to VR alone. However, tDCS combined with VR was shown to enhance Barthel Index scores, thereby improving the quality of daily living in stroke patients.
Article
Neurosciences
Tingting Zhang, Bingqi Guo, Zhentao Zuo, Xiaojing Long, Shimin Hu, Siran Li, Xin Su, Yuping Wang, Chunyan Liu
Summary: This study aimed to evaluate the modulatory effects of transcranial focus ultrasound stimulation (tFUS) on human motor cortex excitability and explore the mechanism of neurotransmitter-related intracortical circuitry and plasticity. The results showed that tFUS can significantly increase M1 excitability, decrease intracortical inhibition, and change the concentration of GABA and Glx in the brain. These findings provide new insights into how tFUS can modulate cortical excitability and plasticity.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Rehabilitation
Jie Hao, Haoyu Xie, Kimberly Harp, Zhen Chen, Ka-Chun Siu
Summary: This article systematically reviews and examines the effects of virtual reality (VR)-based rehabilitation on neural plasticity changes in survivors of stroke. The main neurophysiological changes observed after VR intervention include improved interhemispheric balance, enhanced cortical connectivity, increased cortical mapping of the affected limb muscles, increased activation of regions in the frontal cortex, and possible involvement of the mirror neuron system. This suggests that VR-based rehabilitation has a positive impact on neural plasticity changes in stroke survivors.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Multidisciplinary Sciences
Jin Seung Choung, Sohom Bhattacharjee, Jeong Pyo Son, Jong Moon Kim, Dong Sik Cho, Choon Sik Cho, MinYoung Kim
Summary: Repetitive transcranial magnetic stimulation (rTMS) is being explored as a new treatment technique for brain lesions, but the effects in animals cannot directly represent the effects in humans due to differences in size and mechanistic characteristics. This study aimed to develop a mouse rTMS device to simulate clinical application. The magnetic field intensity generated by the mouse coil was lower than that by the human coil, and the predicted simulation values matched the measured intensity in vivo. Further research using miniaturized rTMS devices for mice should be conducted to make the findings more relevant to humans.
SCIENTIFIC REPORTS
(2023)
Review
Engineering, Biomedical
Jamille A. Feitosa, Corina A. Fernandes, Raphael F. Casseb, Gabriela Castellano
Summary: Virtual reality (VR) rehabilitation has been shown to improve motor and cognitive abilities in different populations. This study systematically reviewed the effects of VR intervention on cortical reorganization and functional improvement. The results demonstrated changes in brain activation and reorganization patterns in stroke patients, older adults, and patients with other neurological conditions, which were associated with functional improvement after VR intervention.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Asher Geffen, Nicholas Bland, Martin V. Sale
Summary: The study investigated the effects of slow oscillatory (SO) tACS on motor cortical excitability and found that tACS had a facilitatory effect on motor cortical excitability that outlasted stimulation. However, there was no evidence supporting entrainment of endogenous oscillations as the underlying mechanism.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Maximilian Lenz, Amelie Eichler, Andreas Vlachos
Summary: Inflammation affects neuronal plasticity, and inflammation-induced alterations in synaptic plasticity are associated with the development of neuropsychiatric symptoms. Current diagnostic and intervention strategies are limited in restoring inflammation-induced deficits in synaptic plasticity.
Article
Cell Biology
Ya Zheng, Dan Zhao, Dong-Dong Xue, Ye-Ran Mao, Ling-Yun Cao, Ye Zhang, Guang-Yue Zhu, Qi Yang, Dong-Sheng Xu
Summary: This study found that nerve root magnetic stimulation can improve locomotor function, enhance nerve conduction in the injured spinal cord, and promote the recovery of synaptic ultrastructure in the sensorimotor cortex.
NEURAL REGENERATION RESEARCH
(2022)
Article
Clinical Neurology
Lipeng Ning, Yogesh Rathi, Tracy Barbour, Nikos Makris, Joan A. Camprodon
Summary: This study utilized novel dMRI analysis to investigate microstructural changes related to rTMS treatment response in 21 MDD patients, finding that rTMS significantly affected the white matter microstructure in the anterior-medial prefrontal fiber bundles, while changes in lateral prefrontal tracts were correlated with treatment response. Further research with larger datasets is needed to fully understand the impact of rTMS on structural connectivity in MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
P. O. Boucher, R. A. Ozdemir, D. Momi, M. J. Burke, A. Jannati, P. J. Fried, A. Pascual-Leone, M. M. Shafi, Emiliano Santarnecchi
Summary: In this study, the effects of continuous TBS and intermittent TBS protocols on corticospinal excitability were compared over time, with results showing varying effects on motor evoked potentials. However, these effects were generally diminished in repeat visits. The findings challenge the efficacy and reliability of TBS protocols, highlighting the need to consider sham effects when evaluating TBS outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Adriano H. Moffa, Tjeerd W. Boonstra, Ashley Wang, Donel Martin, Colleen Loo, Stevan Nikolin
Summary: Theta burst stimulation (TBS) is a new form of non-invasive transcranial magnetic stimulation (TMS) that can modulate cortical excitability. This study investigated the neuromodulatory effects of TBS on the dorsolateral prefrontal cortex (DLPFC) using EEG, ECG, and MRI recordings. The findings provide foundational knowledge for future research on the application of TBS.
Review
Clinical Neurology
Gesa Hartwigsen, Juha Silvanto
Summary: This review examines the application of noninvasive brain stimulation techniques in the study and rehabilitation of cognitive functions. It challenges the incomplete and simplistic conceptualizations of the mechanisms of action and proposes an interactive model to explain the effects.
Article
Clinical Neurology
Mohd Faizal Mohd Zulkifly, Ornela Merkohitaj, Juergen Brockmoeller, Walter Paulus
Summary: The study investigated the impact of caffeine on brain plasticity and found that it increased motor cortex excitability in caffeine-naive subjects, enhanced PAS 25 effects, and affected alertness and motor evoked potentials under light deprivation. Time of day had no effect on tACS-induced plasticity in caffeine consumers.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Jodi D. Edwards, Adan Ulises Dominguez-Vargas, Charlotte Rosso, Meret Branscheidt, Lisa Sheehy, Fanny Quandt, Simon A. Zamora, Melanie K. Fleming, Valentina Azzollini, Ronan A. Mooney, Charlotte J. Stagg, Chiristian Gerloff, Simone Rossi, Leonardo G. Cohen, Pablo Celnik, Michael A. Nitsche, Cathrin M. Buetefisch, Numa Dancause
Summary: The purpose of this study was to address the translation barriers in stroke rehabilitation research using non-invasive brain stimulation techniques, and to provide consensus recommendations to overcome these barriers. The study identified five key barriers and formulated five core consensus recommendations, including increased understanding of NIBS mechanisms, improved methodological rigor, standardization of outcome measures, increased clinical relevance in preclinical animal models, and optimization and individualization of NIBS protocols.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Neurosciences
Luis F. Schettino, Sergei V. Adamovich, Hamid Bagce, Mathew Yarossi, Eugene Tunik
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Mathew Yarossi, Thushini Manuweera, Sergei V. Adamovich, Eugene Tunik
FRONTIERS IN HUMAN NEUROSCIENCE
(2017)
Article
Engineering, Biomedical
Howard Poizner, Jack Lancaster, Eugene Tunik, Shalini Narayana, Crystal Franklin, William Rogers, Xiaoyan Li, Peter T. Fox, Donald A. Robin
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2012)
Article
Engineering, Biomedical
Eugene Tunik, Soha Saleh, Sergei V. Adamovich
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2013)
Article
Neurosciences
Hamid F. Bagce, Soha Saleh, Sergei V. Adamovich, John W. Krakauer, Eugene Tunik
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Neurosciences
J. R. Lukos, J. Snider, M. E. Hernandez, E. Tunik, S. Hillyard, H. Poizner
Article
Engineering, Biomedical
Mariusz P. Furmanek, Luis F. Schettino, Mathew Yarossi, Sofia Kirkman, Sergei V. Adamovich, Eugene Tunik
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2019)
Article
Clinical Neurology
Soha Saleh, Sergei V. Adamovich, Eugene Tunik
NEUROREHABILITATION AND NEURAL REPAIR
(2014)
Proceedings Paper
Engineering, Biomedical
Soha Saleh, Sergei V. Adamovich, Eugene Tunik
2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2012)
Proceedings Paper
Engineering, Biomedical
S. Saleh, H. Bagce, Q. Qiu, G. Fluet, A. Merians, S. Adamovich, E. Tunik
2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2011)
Proceedings Paper
Engineering, Biomedical
Hamid F. Bagce, Soha Saleh, Sergei V. Adamovich, Eugene Tunik
2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2011)