Review
Health Care Sciences & Services
Giusy Guzzi, Attilio Della Torre, Domenico La Torre, Giorgio Volpentesta, Carmelino Angelo Stroscio, Angelo Lavano, Federico Longhini
Summary: Chronic low-back pain is a common disease with negative impacts on patients' quality of life and healthcare costs. When conventional treatments fail, patients may consider Spinal Cord Stimulation (SCS), which can effectively reduce symptoms in well-selected patients for up to eight years.
Article
Anesthesiology
Lisa Goudman, Ann De Smedt, Sam Eldabe, Philippe Rigoard, Bengt Linderoth, Mats De Jaeger, Maarten Moens
Summary: High-dose spinal cord stimulation (HD-SCS) has shown significant and sustained pain relief over a period of 12 months in patients with failed back surgery syndrome (FBSS). Additionally, HD-SCS resulted in improvement in sleep quality, functionality, and a decrease in pain medication usage.
Article
Clinical Neurology
Mette Nissen, Tiina-Mari Ikaheimo, Jukka Huttunen, Ville Leinonen, Henna-Kaisa Jyrkkanen, Mikael von Und Zu Fraunberg
Summary: The study showed that patients using gabapentinoids had lower rates of spinal cord stimulator explantation and were more likely to discontinue or reduce opioid use, indicating potential benefits of concomitant use of gabapentinoids in SCS patients.
Article
Anesthesiology
Courtney Chow, Richard Rosenquist
Summary: Chronic pain affects over 100 million Americans and has significant economic and quality of life impacts. Spinal cord stimulation (SCS) has proven effective in managing chronic pain, and as more physicians are trained in SCS placement, there have been significant changes in its utilization, cost, and service locations.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Engineering, Biomedical
Carmen Solanes, Jose L. Dura, M. Angeles Canos, Jose De Andres, Luis Marti-Bonmati, Javier Saiz
Summary: This study developed patient-specific 3D models from MRI images to optimize spinal cord stimulation therapy, showing that these models can help physicians choose the best stimulation parameters for improved neural activation and pain management.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Rehabilitation
Mehul J. Desai, Ryan Aschenbrener, Eduardo J. Carrera, Nirguna Thalla
Summary: The evolution of SCS in the past decades has been remarkable, providing novel abilities to alleviate pain signals. However, indications for specific disease states are limited and robust, non-industry-sponsored studies are relatively minimal. Balanced clinician-industry collaboration is crucial for the development of these therapies. Existing data support SCS for studied disease states and show promise for further indication expansion.
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
(2022)
Article
Engineering, Biomedical
Evan R. Rogers, Ehsan Mirzakhalili, Scott F. Lempka
Summary: This study investigated the neural response to different paresthesia-free spinal cord stimulation (SCS) waveforms using computational modeling. The results showed that the mechanisms of subthreshold SCS remain unclear, as none of the waveforms directly activate C-fibers and modulation of spike timing is unlikely at subthreshold amplitudes. The study suggested that potential subthreshold neuromodulatory effects of SCS on local cells are likely to be presynaptic in nature.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Ilknur Telkes, Amir Hadanny, Marisa DiMarzio, Girish Chitnis, Steven Paniccioli, Katherine O'Connor, Rachael Grey, Kevin McCarthy, Olga Khazen, Bryan McLaughlin, Julie G. Pilitsis
Summary: This study is the first to investigate the medio-lateral selectivity of a high-resolution spinal cord stimulation (HR-SCS) paddle in patients with chronic pain. The results suggest that HR-SCS may provide additional ipsilateral recruitment within the extremities, improving targeting of focal pain in the lower extremities. Additionally, this study supports the use of intraoperative neuromonitoring as a decision tool in thoracic SCS surgeries and provides a comprehensive methodological framework.
Article
Anesthesiology
Harsha Shanthanna, Sam Eldabe, David Anthony Provenzano, Benedicte Bouche, Eric Buchser, Raymond Chadwick, Tina L. Doshi, Rui Duarte, Christine Hunt, Frank J. P. M. Huygen, Judy Knight, Lynn Kohan, Richard North, Joshua Rosenow, Christopher J. Winfree, Samer Narouze
Summary: Spinal cord stimulation (SCS) has shown effectiveness for neuropathic pain, but some patients do not experience adequate long-term relief. Existing selection techniques, including SCS trials, have been questioned. A steering committee developed evidence-based guidelines for patient selection and the role of SCS trials, with 100% consensus from all members. These recommendations are intended to guide physicians and stakeholders, but individual patient considerations should still be taken into account.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Neurosciences
Mariana Pereira, Sofia Rita Fernandes, Pedro Cavaleiro Miranda, Mamede de Carvalho
Summary: The study aims to define the optimal tsDCS montage for maximizing the electric field in the lumbar spinal cord through computer modeling, and to measure its effect on LMN excitability and SSEPs.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Anesthesiology
Rui V. Duarte, Anthony Bentley, Nicole Soliday, Angela Leitner, Ashish Gulve, Peter S. Staats, Dawood Sayed, Steven M. Falowski, Corey W. Hunter, Rod S. Taylor
Summary: This study developed an economic model to evaluate the cost-effectiveness of Evoke closed-loop spinal cord stimulation (CL-SCS) compared to open-loop SCS (OL-SCS) for the management of chronic back and leg pain. The results showed that Evoke CL-SCS had strong cost-effectiveness at around 5 years postimplant, making it a viable treatment option for chronic back and leg pain.
CLINICAL JOURNAL OF PAIN
(2023)
Article
Medicine, Research & Experimental
Shashank Rajkumar, Lexie Zidanyue Yang, Vishal Venkatraman, Lefko Charalambous, Beth Parente, Hui-Jie Lee, Shivanand P. Lad
Summary: Chronic refractory low back pain (CRLBP) is a diagnosis characterized by chronic low back pain in patients who are poor candidates for surgery and fail conservative management. High-frequency spinal cord stimulation (HF-SCS) is a new advance in neuromodulation that may be effective in treating these patients. However, the cost burden of this therapy is yet undetermined.
Article
Clinical Neurology
Sally El Sammak, William Mualem, Giorgos D. Michalopoulos, Joshua M. Romero, Christopher T. Ha, Christine L. Hunt, Mohamad Bydon
Summary: This study systematically reviewed and evaluated the current literature on the use of novel waveform spinal cord stimulation for the management of failed back surgery syndrome refractory to conventional SCSs. The results showed that conversion to novel stimulation can significantly reduce back pain.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Review
Biochemistry & Molecular Biology
Vinicius Tieppo Francio, Keith F. Polston, Micheal T. Murphy, Jonathan M. Hagedorn, Dawood Sayed
Summary: Since 1967, spinal cord stimulation (SCS) technology has evolved significantly, with the introduction of the 10 kHz SCS system that selectively activates inhibitory interneurons in the dorsal horn. This high-frequency stimulation pattern has demonstrated significant pain control superiority in patients with chronic back pain and neuropathic pain.
Article
Medicine, Research & Experimental
Zahabiya Campwala, Pallavi Datta, Marisa DiMarzio, Vishad Sukul, Paul J. Feustel, Julie G. Pilitsis
Summary: The research indicates that spinal cord stimulation (SCS) can improve pain intensity, pain quality, functional disability, and depression severity in chronic low back pain (CLBP) patients, regardless of whether they have had previous spine surgery.