Article
Neurosciences
Thomas Schueller, Sina Kohl, Till Dembek, Marc Tittgemeyer, Daniel Huys, Veerle Visser-Vandewalle, Ningfei Li, Laura Wehmeyer, Michael Barbe, Jens Kuhn, Juan Carlos Baldermann
Summary: Deep brain stimulation can effectively treat obsessive-compulsive disorder, but it may also increase impulsive behavior. This study investigated the effects of stimulation on impulsive decision making and found that it increased impulsivity. The effects were dependent on the location of the stimulation and the associated fiber bundles.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Neuroimaging
Thomas Schueller, Theo O. J. Gruendler, Ezra E. Smith, Juan Carlos Baldermann, Sina Kohl, Adrian G. Fischer, Veerle Visser-Vandewalle, Markus Ullsperger, Jens Kuhn, Daniel Huys
Summary: The study observed increased electromagnetic activity in the medial frontal cortex and striatum during negative performance feedback in patients with OCD, while decreased connectivity in the right lateral side was associated with symptom severity. Following DBS, electromagnetic activity in the medial frontal cortex significantly decreased.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Cristina Torres Diaz, Svenja Treu, Bryan Strange, Monica Lara, Marta Navas, Elena Ezquiaga, Elisa Seijo Zazo, Juncal Sevilla Vicente, Isabel Muniz, Fernando Seijo Fernandez
Summary: This study demonstrated that deep brain stimulation targeting the nucleus accumbens, internal capsule, and ventral striatum significantly improved symptoms in patients with medication-resistant obsessive-compulsive disorder. Adjustment of the stimulation site based on individual response may optimize treatment outcomes.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Botao Xiong, Bin Li, Rong Wen, Yuan Gao, Feilong Gong, Denghui Li, Yangyang Xu, Hao Deng, Linglong Xiao, Senlin Yin, Wei Zhang, Andres M. Lozano, Wei Wang
Summary: This study investigates the effects of differential stimulation on the efficacy of DBS for OCD. By implanting a novel designed electrode and IPG that allows independent programming of different contacts, the study found that differential stimulation can significantly improve the outcomes of DBS for OCD.
JOURNAL OF NEUROSURGERY
(2023)
Review
Psychiatry
Michal Sobstyl, Marek Prokopienko, Tadeusz Pietras
Summary: Deep brain stimulation is an experimental treatment for psychiatric disorders. Stimulating structures in the brain's reward circuit, such as the ventral striatum, may have antidepressant effects. Current studies suggest that the ventral striatum and visual cortex are promising targets for deep brain stimulation.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Joan A. Camprodon, Tina Chou, Abigail A. Testo, Thilo Deckersbach, Jeremiah M. Scharf, Darin D. Dougherty
Summary: Deep Brain Stimulation (DBS) is an invasive neuromodulation technique approved for the treatment of movement disorders and obsessive-compulsive disorder. A patient with Major Depressive Disorder (MDD) who received DBS therapy developed voltage-dependent Tourette-like symptoms, leading to the diagnosis of iatrogenic voltage-dependent activation of cortico-subcortical circuits.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Thilo Rusche, Joern Kaufmann, Juergen Voges
Summary: This study aimed to visualize the afferent and efferent connections of the nucleus accumbens (NAc) and validate the methodology for clinical applications. The results show good concordance with existing data, suggesting potential for selective electrical stimulation of NAc projections using deep brain stimulation with directional lead technology.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Tingting Xu, Yuan Gao, Bin Li, Jiaxin Jiang, Huirong Guo, Xianzhi Liu, Hongxing Huang, Yuqi Cheng, Hualin Yu, Jie Hu, Xi Wu, Wei Wang, Zhen Wang
Summary: This study aims to evaluate the efficacy and safety of combined ALIC- and NAcc-DBS for treatment-refractory OCD. A total of 64 patients will be recruited and randomly allocated to active and sham-stimulation groups. Primary outcome measures include treatment response rate and adverse events, while secondary outcome measures include changes in multiple scale scores.
Article
Neurosciences
Gizem Temiz, Cyril Atkinson-Clement, Brian Lau, Virginie Czernecki, Eric Bardinet, Chantal Francois, Yulia Worbe, Carine Karachi
Summary: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and vocal tics, often accompanied by psychiatric comorbidities. This study used tractography to investigate the connectivity of different brain regions in TS patients and found increased limbic cortical connectivity in the subthalamic area, particularly with the insular cortex, which may contribute to higher levels of impulsivity and anxiety observed in TS.
Article
Multidisciplinary Sciences
Hemmings Wu, Bina Kakusa, Sophie Neuner, Daniel J. Christoffel, Boris D. Heifets, Robert C. Malenka, Casey H. Halpern
Summary: This study used in vivo imaging to examine the activity of D1 and D2 neurons in the nucleus accumbens during hedonic feeding and investigated the effects of continuous DBS and responsive DBS. The results suggest that D1 neuron activity is increased prior to high-fat food approach and responsive DBS can durably reduce high-fat intake, while continuous DBS does not have the same effect.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Allen L. Ho, Austin Y. Feng, Daniel A. N. Barbosa, Hemmings Wu, Monique L. Smith, Robert C. Malenka, Peter A. Tass, Casey H. Halpern
Summary: The study found that CRS stimulation can reduce binge-like alcohol drinking behavior effectively, with CRS targeting NAc significantly decreasing binge drinking without interfering with social and locomotor activities.
Article
Biochemistry & Molecular Biology
Cyril Atkinson-Clement, Camille-Albane Porte, Astrid de Liege, Yanica Klein, Cecile Delorme, Benoit Beranger, Romain Valabregue, Cecile Gallea, Trevor W. Robbins, Andreas Hartmann, Yulia Worbe
Summary: Tourette disorder (TD) is not generally considered a product of impulsivity, but unmedicated TD patients show increased waiting impulsivity compared to controls, which correlates with tic severity. Waiting impulsivity is related to functional connectivity of orbito-frontal cortex with caudate nucleus and structural changes within limbic areas in TD patients. The study suggests that waiting impulsivity in TD is specifically related to tic severity and certain brain structures.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yi-Fan Luo, Lu Lu, Heng-Yi Song, Han Xu, Zhi-Wei Zheng, Zhou-Yue Wu, Chen-Chen Jiang, Chu Tong, Hao-Yang Yuan, Xiu-Xiu Liu, Xiang Chen, Mei-ling Sun, Ya-Min Tang, Heng-Yu Fan, Feng Han, Ying-Mei Lu
Summary: The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry is poorly understood. In this study, the researchers investigated the role of pyramidal neurons (PNs) in the prelimbic cortex (PL) and found that alterations in the PL projections to fast-spiking interneurons (FSIs) in the dorsal striatum (dSTR) and PNs of the basolateral amygdaloid nucleus (BLA) mediated the hyperexcitability of FSIs and PNs, which contributed to autism- and anxiety-like behaviors, respectively. These findings provide insights into the neural circuitry underlying the comorbidity of autism and anxiety and may lead to the development of new therapeutics.
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Jason Yuen, Abhinav Goyal, Aaron E. Rusheen, Abbas Z. Kouzani, Michael Berk, Jee Hyun Kim, Susannah J. Tye, Osama A. Abulseoud, Tyler S. Oesterle, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Yoonbae Oh, Hojin Shin
Summary: Opioids are the leading cause of overdose death in the United States, with nearly 70,000 deaths in 2020. Deep brain stimulation (DBS) is a promising treatment for substance use disorders. This study investigated the modulation of dopaminergic and respiratory effects of oxycodone by DBS of the ventral segmental area (VTA) in rodents. The results demonstrated that DBS reduced baseline dopamine levels and alleviated the increase in dopamine levels and respiratory depression induced by oxycodone.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Ssu-Ju Li, Yu-Chun Lo, Hsin-Yi Tseng, Sheng-Huang Lin, Chao-Hung Kuo, Ting-Chieh Chen, Ching-Wen Chang, Yao-Wen Liang, Yi-Chen Lin, Chih-Yu Wang, Tsai-Yu Cho, Mu-Hua Wang, Ching-Te Chen, You-Yin Chen
Summary: Through experiments on mice models, it was found that NAc-DBS can restore emotional deficits in CSDS-subjected mice, alter functional connectivity and metabolic profile in the dopaminergic pathway, providing a potential strategy for ameliorating emotional processes in individuals with MDD.
NEUROBIOLOGY OF STRESS
(2023)