Article
Cardiac & Cardiovascular Systems
Xin-Ni Lv, Jing Cheng, Xue-Yun Liu, Jin-Cheng Liu, Lan Deng, Zuo-Qiao Li, Ming-Jun Pu, Chu Chen, Qi Li
Summary: This study found that ultraearly intraventricular hemorrhage growth is associated with early neurologic deterioration and poor functional outcomes in patients with intracerebral hemorrhage.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Medicine, General & Internal
Xin-Ni Lv, Zuo-Qiao Li, Qi Li
Summary: Intracerebral hemorrhage is a dangerous subtype of stroke with high rates of morbidity and mortality. Targeting prevention of hematoma growth and perihematomal edema expansion shows promise as a therapeutic approach. Blood-based biomarkers are being studied as potential diagnostic, predictive, and prognostic markers due to their accessibility and acceptance in clinical practice. Validation studies are needed to determine the usefulness of these biomarkers in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Junhong Li, Xiang Liao, Zhiyuan Yu, Hao Li, Jun Zheng
Summary: The study found that redefined hematoma expansion (rHE) was significantly associated with various clinical variables, and ultraearly hematoma growth (uHG) and computed tomography angiography (CTA) spot sign were identified as independent risk factors for predicting rHE. Both uHG and the spot sign were considered good predictors for rHE, with the spot sign showing better predictive accuracy.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Andreas Charidimou, Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein
Summary: The study found that hematoma expansion is common in patients with unclear symptom onset of intracerebral hemorrhage and independently associated with worse outcome. These findings suggest that patients with unclear symptom onset may benefit from clinical trials of medical treatments targeting hematoma expansion.
Article
Clinical Neurology
Vignan Yogendrakumar, Tim Ramsay, Bijoy K. Menon, Adnan Qureshi, Jeffrey L. Saver, Dar Dowlatshahi
Summary: This proof-of-concept study introduced an HE shift analysis model to enhance the evaluation of ICH therapies using data from the ATACH-2 trial. Results from analyzing 863 patients indicated that intensive blood pressure lowering treatment may reduce hematoma growth in high-risk patients, suggesting the potential benefits of the shift analysis model in assessing hemostatic agents for future studies.
Article
Critical Care Medicine
Wen-Song Yang, Yi-Qing Shen, Xiao-Dong Zhang, Li-Bo Zhao, Xiao Wei, Xin Xiong, Xiong-Fei Xie, Rui Li, Lan Deng, Xin-Hui Li, Xin-Ni Lv, Fa-Jin Lv, Qi Li, Peng Xie
Summary: The study suggests that hydrocephalus growth is strongly predictive of short- or long-term mortality and poor outcome at 90 days, showing higher accuracy in predicting outcomes compared to intraventricular hemorrhage growth or hematoma expansion.
NEUROCRITICAL CARE
(2021)
Article
Clinical Neurology
Wen-Juan Wang, Jing-Jing Lu, Li-Ping Liu, Jiao-Kun Jia, Xing-Quan Zhao
Summary: The study found that ultraearly hematoma growth speed is significantly associated with in-hospital mortality, 90-day, and 1-year poor outcomes after acute intracerebral hemorrhage.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Maximiliano A. Hawkes, Alejandro A. Rabinstein
Summary: The acute hypertensive response is common in patients with intracerebral hemorrhage and is associated with poor clinical outcomes. It is unclear whether high blood pressure is a cause of poor outcomes or simply a marker of severity. Intensive blood pressure treatment may be beneficial for some patients with intracerebral hemorrhage but harmful for others.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Cardiac & Cardiovascular Systems
Wen-Song Yang, Shu-Qiang Zhang, Yi-Qing Shen, Xiao Wei, Li-Bo Zhao, Xiong-Fei Xie, Lan Deng, Xin-Hui Li, Xin-Ni Lv, Fa-Jin Lv, Dar Dowlatshahi, Qi Li, Peng Xie
Summary: The study revealed that NCCT markers are independently associated with IVH growth and RHE, with the expansion-prone hematoma showing higher predictive accuracy. These findings can aid in risk stratification based on NCCT markers for predicting active bleeding.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Behavioral Sciences
Juexian Song, Yuting Nie, Pingping Wang, Huiqiang Lu, Li Gao
Summary: In acute SICH patients, Naoxueshu oral liquid can help reduce hematoma volume and cerebral edema, with the potential to improve short-term neurological function.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Abbas Jarrahi, Manan Shah, Meenakshi Ahluwalia, Hesam Khodadadi, Kumar Vaibhav, Askiel Bruno, Babak Baban, David C. Hess, Krishnan M. Dhandapani, John R. Vender
Summary: This study explores the role of remote ischemic conditioning (RIC) in promoting hematoma resolution and improving outcomes in patients with intracerebral hemorrhage (ICH). The study will conduct a pilot trial to evaluate the safety and efficacy of RIC compared to mock conditioning in ICH patients, and also include exploratory genomic analysis. The goal of this study is to establish a foundation for future larger, multi-center clinical trials.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Critical Care Medicine
Yong Soo Kim, Hee-Yun Chae, Han-Gil Jeong, Beom Joon Kim, Si-Un Lee, Jihoon Kang, Tackeun Kim, Jae Seung Bang, Hee-Joon Bae, Chang Wan Oh, Moon-Ku Han
Summary: The prevalence and association of NCCT markers with HE varied according to hematoma size. Quantitative hematoma density was associated with HE regardless of hematoma size.
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Christopher J. Love, Daniel Kirschenbaum, Magdy Selim, Eng H. Lo, Elisabeth Rushing, Myron Spector, Adriano Aguzzi
Summary: The study found that chronic hemorrhagic stroke lesions contain abundant collagenous material, primarily consisting of collagen 3. The collagenase rat model successfully reproduced the morphology and composition of chronic human hemorrhagic stroke lesions. By identifying new pathological features of hemorrhagic stroke lesions, these results are important for treatment and recovery strategies.
Article
Clinical Neurology
Juexian Song, Yuting Nie, Xinzuo Qin, Pingping Wang, Huiqiang Lu, Li Gao
Summary: This study found that oral Naoxueshu liquid can help reduce hematoma volume and cerebral edema, as well as improve neurological function in the treatment of acute SICH. Factors such as sex, cause of SICH, and timing of medication should be taken into consideration during treatment.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Lei Si, Xiaoying Chen, Menglu Ouyang, Xia Wang, Guofang Chen, Yong-jun Cao, Guojun Wu, Jinli Zhang, Jingfen Zhang, YuKai Liu, Shihong Zhang, Lili Song, Candice Delcourt, Hisatomi Arima, Lidan Wang, Thomas Lung, Mingsheng Chen, Craig S. Anderson, Stephen Jan
Summary: The cost-effectiveness analysis involved in the ENCHANTED study in China showed that low-dose alteplase in the treatment of acute ischemic stroke (AIS) did not save overall healthcare costs or improve quality-adjusted life-years (QALYs) compared to standard-dose alteplase. From an economic standpoint, there is no justification to shift from the standard-of-care thrombolysis in AIS to the use of low-dose alteplase.
CEREBROVASCULAR DISEASES
(2023)
Article
Peripheral Vascular Disease
Satoshi Hoshide, Koichi Yamamoto, Kenichi Katsurada, Yuichiro Yano, Akira Nishiyama, Ji-Guang Wang, S. N. Narasingan, Narsingh Verma, Erwinanto Erwinanto, Yuda Turana, Sang Hyun Ihm, Sungha Park, Nik Sherina Hanafi, Yook-Chin Chia, Tsolmon Unurjargal, Saulat Siddique, Deborah Ignacia D. Ona, Narayanaswamy Venketasubramanian, Boon Wee Teo, Godwin Constantine, Hsien-Li Kao, Chi-Sheng Hung, Apichard Sukonthasarn, Sirisawat Kunanon, Huynh Van Minh, Kazuomi Kario, Koichi Node, Hiroshi Itoh, Hiromi Rakugi
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Chen, Jin-Qiu Wei, Mo-Na Hong, Zhong Zhang, Han-Dan Zhou, Yuan-Yuan Lu, Jia Zhang, Yue-Tong Guo, Xin Chen, Ji-Guang Wang, Ping-Jin Gao, Xiao-Dong Li
Summary: This study reveals that different activation of MAPKs has different effects on the activation of adventitial fibroblasts, and participates in the process of neointima formation, possibly through the regulation of the GATA4/Cyclin D1 axis in cell cycle and inflammatory response.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Peripheral Vascular Disease
Xiao-Fei Ye, Qi-Fang Huang, Yan Li, Ji-Guang Wang
Summary: There is a seasonal variation in the antihypertensive treatment effect, with greater blood pressure reduction in patients who commenced treatment in the cold seasons.
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yi Chen, Wei Zhang, Chang-Sheng Sheng, Qi-Fang Huang, Yi-Bang Cheng, Qian-Hui Guo, Dong-Yan Zhang, Yan Li, Ben Freedman, Ji-Guang Wang
Summary: This study investigated the association between hypertension and atrial fibrillation (AF) in an elderly Chinese population. It found that only patients with stage 2 or 3 hypertension had a higher risk of AF.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Niki Chouliara, Trudi Cameron, Adrian Byrne, Sarah Lewis, Peter Langhorne, Thompson Robinson, Justin Waring, Marion Walker, Rebecca Fisher
Summary: This study aimed to understand how the adoption of core components of Early Supported Discharge (ESD) drives the delivery of responsive and intensive services in real-world settings. The findings showed that adhering to evidence-based selection criteria, promoting interdisciplinary skillsets, and supporting the role of rehabilitation assistants helped teams manage pressures and deliver services that met evidence-based standards. However, there are still variations in service provision in England and a more integrated and comprehensive stroke service provision is needed. Transferable lessons could be drawn to inform improvement interventions in different settings.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Orthopedics
Susil Pallikadavath, Caryl Richards, Vasiliki Bountziouka, Alastair J. Sandilands, Matthew P. M. Graham-Brown, Thompson Robinson, Anvesha Singh, Gerry P. McCann
Summary: This study investigated the risk of stroke in athletes with atrial fibrillation (AF) using an international online survey. The results indicate that there is a risk of stroke in athletes with AF, even in those considered to be at low risk according to the CHA(2)DS(2)-VASc score.
CLINICAL JOURNAL OF SPORT MEDICINE
(2023)
Article
Peripheral Vascular Disease
Jin Zhang, Wei Zhang, Jie Yan, Qian Ge, Xiao-Hong Lu, Shao-Xing Chen, Wen-Jie Xu, Ying Li, Jin-Feng Li, Shi-Ying He, Ji-Guang Wang
Summary: This phase 2 study showed that sacubitril/allisartan is effective and well tolerated for treating hypertension in Chinese patients with mild to moderate hypertension.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Yuanyuan Kang, Qihong Wu, Jianzhong Xu, Mona Hong, Yu Ma, Xiaofeng Tang, Limin Zhu, Pingjin Gao, Jiguang Wang
Summary: To date, the exact role and utility of intravascular ultrasound (IVUS) in the diagnosis and treatment of renal artery fibromuscular dysplasia (FMD) have not been clearly defined. Our study investigated the use of IVUS in hypertensive patients with focal renal artery FMD and found that patients with IMT subtype were more likely to achieve hypertension cure.
HYPERTENSION RESEARCH
(2023)
Article
Clinical Neurology
Yuesong Pan, Xia Meng, Baoshi Yuan, S. Claiborne Johnston, Hao Li, Philip M. Bath, Qiang Dong, Anding Xu, Jing Jing, Jinxi Lin, Yong Jiang, Xuewei Xie, Aoming Jin, Yue Suo, Hongqin Yang, Yefang Feng, Yanhua Zhou, Qing Liu, Xueli Li, Bin Liu, Hui Zhu, Jinguo Zhao, Xuerong Huang, Haitao Li, Yunyun Xiong, Zixiao Li, Yilong Wang, Xingquan Zhao, Liping Liu, Yongjun Wang
Summary: This study compared indobufen with aspirin in reducing the risk of recurrent stroke in patients with moderate-to-severe ischemic stroke. The results showed that indobufen was not non-inferior to aspirin in reducing the risk of recurrent stroke at 90 days. Additionally, there was no significant difference in the risk of moderate or severe bleeding between the two drugs. Therefore, the findings do not support the use of indobufen for secondary stroke prevention in patients with moderate-to-severe ischemic stroke.
Review
Anesthesiology
Jessica X. L. Li, Xia Wang, Amanda Henry, Craig S. Anderson, Naomi Hammond, Katie Harris, Hueiming Liu, Kelly Loffler, John Myburgh, Jeyaraj Pandian, Brendan Smyth, Balasubramanian Venkatesh, Cheryl Carcel, Mark Woodward
Summary: This study aimed to determine sex differences in pain prevalence and intensity reported by participants with diverse disease states. The study found that females were more likely to report pain and experienced higher levels of pain compared to males. This study reinforces the importance of reporting sex-disaggregated analysis to identify similarities and differences between females and males that may affect disease profiles and management.
Article
Medicine, General & Internal
Chen Chen, Menglu Ouyang, Sheila Ong, Luyun Zhang, Guobin Zhang, Candice Delcourt, Grant Mair, Leibo Liu, Laurent Billot, Qiang Li, Xiaoying Chen, Mark Parsons, Joseph P. Broderick, Andrew M. Demchuk, Philip M. Bath, Geoffrey A. Donnan, Christopher Levi, John Chalmers, Richard I. Lindley, Sheila O. Martins, Octavio M. Pontes-Neto, Paula Munoz Venturelli, Veronica Olavarria, Pablo Lavados, Thompson G. Robinson, Joanna M. Wardlaw, Gang Li, Xia Wang, Lili Song, Craig S. Anderson
Summary: This study aimed to investigate the effect of intensive blood pressure lowering on the size of cerebral infarction in patients with acute ischemic stroke after thrombolysis. The results showed that intensive blood pressure lowering to a systolic target of 130-140 mm Hg within 24-36 hours did not increase the size of cerebral infarction.
Meeting Abstract
Peripheral Vascular Disease
Xiaofei Ye, Qifang Huang, Yan Li, Jiguang Wang
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Wei Zhang, Yi Chen, Leixiao Hu, Jiahui Xia, Xiaofei Ye, Yibang Cheng, Ying Wang, Qianhui Guo, Yan Li, Nicole Lowres, Ben Freedman, Jiguang Wang
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Jianfeng Huang, Dongyan Zhang, Dewei An, Mingxuan Li, Xin Chen, Yingqing Feng, Qidong Zheng, Yan Li, Jiguang Wang
JOURNAL OF HYPERTENSION
(2023)