Review
Clinical Neurology
Dana Pourzinal, Jihyun Yang, Rachael A. Lawson, Katie L. McMahon, Gerard J. Byrne, Nadeeka N. Dissanayaka
Summary: This review evaluates the literature on data-driven subtypes of cognition in Parkinson's disease (PD), finding that there are subtype structures either showing a spectrum of severity or specific domains of impairment. Neuroimaging evidence provides insight into distinct patterns of brain alterations among subtypes. The clinical relevance of certain cognitive subtypes in PD is highlighted, but further research is needed to explore the underlying neural mechanisms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hai Lin, Zesi Liu, Wei Yan, Doudou Zhang, Jiali Liu, Bin Xu, Weiping Li, Qiusheng Zhang, Xiaodong Cai
Summary: This study investigated brain connectivity markers of MCI in PD patients using MRI techniques, identifying nine features significantly relevant to patient classification. These features, unique in PD patients, were successfully used to distinguish patients with and without MCI with an accuracy of 83.9% using a random forest model. The results suggest that structural and functional connectivity abnormalities may contribute to cognitive impairment in PD and facilitate predicting MCI diagnosis outcomes.
EUROPEAN RADIOLOGY
(2021)
Review
Clinical Neurology
Miles Berger, David Ryu, Melody Reese, Steven McGuigan, Lisbeth A. Evered, Catherine C. Price, David A. Scott, M. Brandon Westover, Roderic Eckenhoff, Laura Bonanni, Aoife Sweeney, Claudio Babiloni
Summary: As of 2022, older adults represent a significant proportion of the global population and surgical cases. Postoperative complications, particularly neurocognitive disorders like delirium, are common in older surgical patients and are associated with increased mortality, economic burden, and risk of long-term cognitive decline. Perioperative EEG monitoring has the potential to identify brain abnormalities and predict the development of delirium and cognitive decline, which could lead to targeted interventions and improved outcomes for older surgical patients.
Article
Biotechnology & Applied Microbiology
Riona Mc Ardle, Stephanie Pratt, Christopher Buckley, Silvia Del Din, Brook Galna, Alan Thomas, Lynn Rochester, Lisa Alcock
Summary: This study aimed to identify differences in balance impairments between different dementia disease subtypes, with the results showing that the Parkinson's disease dementia (PDD) group demonstrated significantly higher balance impairments compared to the Alzheimer's disease (AD) group. However, accelerometer-based balance during quiet standing was not accurate in differentiating dementia disease subtypes, suggesting the need for more challenging assessments to support differential diagnosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Medicine, General & Internal
Sebestina Anita Dsouza, Meena Ramachandran, Yuko Nishiura, Bhumika Tumkur Venkatesh, Lena Dahlberg
Summary: This study aims to investigate time perception and daily activity management in individuals with cognitive impairments through a systematic scoping review. The research will provide an assessment and description of time-related concepts, helping to understand the difficulties and needs of individuals with cognitive impairments in handling time.
Article
Neurosciences
Tian Sang, Jianzhong He, Jingqiang Wang, Chengzhe Zhang, Wenyang Zhou, Qingrun Zeng, Yuan Yuan, Lihua Yu, Yuanjing Feng
Summary: Cognitive impairment in Parkinson's disease leads to significant disability, with underlying neuroanatomic substrates not fully understood. White matter alterations and differences between cognitive stages in PD patients are complex and further research is needed to elucidate them.
NEUROSCIENCE LETTERS
(2022)
Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Laura M. Wright, Paul C. Donaghy, David J. Burn, John -Paul Taylor, John T. O'Brien, Alison J. Yarnall, Fiona E. Matthews, Michael J. Firbank, Alan J. Thomas, Rachael A. Lawson
Summary: There is a limited longitudinal relationship between neuropsychiatric symptoms (NPS) and cognitive decline in prodromal Lewy body dementias (LBD). Core neuropsychiatric symptoms are not strongly associated with cognition, suggesting different underlying neuropathological mechanisms.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Jacob D. Jones, Rhiannon Rivas, Kenya Luna, Cameron A. Ryczek, Kelsey R. Thomas
Summary: According to the MDS, subjective cognitive complaints (SCC) are a diagnostic criterion for PD-MCI, but they are often not considered in classification. This study aimed to investigate the impact of inclusion/exclusion of SCC on the occurrence of PD-MCI and its association with cognitive decline and CSF markers. Results showed that including SCC decreased the rates of PD-MCI and that PD-MCI + SCC group had greater cognitive decline and higher levels of tau/ab and p-tau/ab.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Vaitsa Giannouli, Magda Tsolaki
Summary: The study found that both PD and FTD patients' general cognitive functioning and financial capacity performance are negatively influenced by apathy rather than depression. This suggests that apathy should not be overlooked in clinical assessments, and further research is needed to explore the impact of mood factors on financial capacity impairment in larger populations with PD and FTD.
Article
Neurosciences
Tara C. Carlisle, Luis D. Medina, Samantha K. Holden
Summary: In this study, three tools were used to calculate the personalized risk of cognitive decline in Parkinson's disease (PD), and it was found that these tools can predict changes in baseline and 5-year follow-up cognitive scores. MoPaRDS is a PD-specific tool, but it does not focus on modifiable risk factors. LIBRA focuses on these factors, while pPREDICT may demonstrate improved performance in calculating the risk of cognitive decline in PD patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Catarina Severiano e Sousa, Margherita Fabbri, Catarina Godinho, Rita Simoes, Ines Chendo, Miguel Coelho, Isabel Pavao Martins, Joaquim J. Ferreira
Summary: This study aimed to evaluate the frequency of dementia in late-stage Parkinson's disease patients and assess the impact of using different diagnostic criteria. The results showed a high discrepancy in the frequency of dementia depending on the criteria applied, with major depression playing a significant role in determining dementia frequency.
FRONTIERS IN NEUROLOGY
(2021)
Letter
Clinical Neurology
Syed Ijlal Ahmed, Farhan Khalid, Syeda Beenish Bareeqa, Syeda Sana Samar
Summary: RBD is associated with Parkinson's disease and Lewy body dementia, and it is crucial to consider and exclude RBD when studying CSF markers in order to improve the specificity of test results.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Seong Ho Jeong, Hyun-Jae Jeong, Mun Kyung Sunwoo, Sung Soo Ahn, Seung-Koo Lee, Phil Hyu Lee, Yun Joong Kim, Young H. Sohn, Chae Jung Park, Seok Jong Chung
Summary: The volume of the choroid plexus (CP) is associated with cognitive decline and dementia conversion risk in patients with Parkinson disease (PD). A larger CP volume is correlated with lower baseline frontal/executive function scores and higher risk of dementia conversion. The effect of CP volume on dementia conversion is completely mediated by frontal/executive function.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Katerina Touliou, Nicos Maglaveras, Evangelos Bekiaris
Summary: The necessity for reliable, standardized and validated fitness to drive assessment tools for older drivers have been highlighted and discussed for over three decades. Existing neuropsychological tests of driving performance are focusing mostly on visuo-spatial attention and executive functioning rather than other senses. The findings revealed that olfactory deficits are important for predicting driving ability.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Charlotte van't Westende, Sylke J. Steggerda, Lisette Jansen, Annette A. van den Berg-huysmans, Laura A. van de Pol, Francisca T. Wiggers-de Bruine, Cornelis J. Stam, Cacha M. P. C. D. Peeters-Scholte
Summary: This study investigates the relationship between motor outcome and advanced MRI and EEG measures in preterm born children at school age. The results show that ventricular volume and relative upper alpha power on EEG are independently associated with motor outcome, indicating a lasting interplay between brain structure and function underlying adverse motor outcome.
PEDIATRIC RESEARCH
(2022)
Article
Neurosciences
Linda Douw, Ida A. Nissen, Sophie M. D. D. Fitzsimmons, Fernando A. N. Santos, Arjan Hillebrand, Elisabeth C. W. van Straaten, Cornelis J. Stam, Philip C. De Witt Hamer, Johannes C. Baayen, Martin Klein, Jaap C. Reijneveld, Djai B. Heyer, Matthijs B. Verhoog, Rene Wilbers, Sarah Hunt, Huibert D. Mansvelder, Jeroen J. G. Geurts, Christiaan P. J. de Kock, Natalia A. Goriounova
Summary: This study investigates the cellular substrates of functional network integration in patients with temporal lobe epilepsy (TLE). The findings show that functional network centrality is related to memory performance and cellular integrative properties. These findings provide insights into the focal pathology and network disturbances in TLE.
Review
Clinical Neurology
Charlotte Van 't Westende, Victor J. Geraedts, Tino Van Ramesdonk, Jeroen Dudink, Linda J. Schoonmade, Marjo S. Van der Knaap, Cornelis J. Stam, Laura A. Van de Pol
Summary: This study evaluated quantitative EEG measures as predictors of long-term neurodevelopmental outcomes in infants, finding that several studies showed associations between absolute power in different frequency bands of conventional EEG and favorable long-term outcomes. Additionally, a lower presence of discontinuous background patterns was also linked to positive outcomes. However, interpretation of results is limited by study design and population heterogeneity.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Neurosciences
Dareia S. Roos, Martin Klein, Dorly J. H. Deeg, Richard L. Doty, Henk W. Berendse
Summary: This study aimed to determine the prevalence of known non-motor symptoms associated with an increased risk of Parkinson's disease (PD) in a late middle-aged population, as well as their association with motor function. The results showed that approximately 11% of the late middle-aged population had two or more known PD risk factors, and these subjects had significantly worse motor function.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neuroimaging
Tim D. van Balkom, Odile A. van den Heuvel, Henk W. Berendse, Ysbrand D. van der Werf, Chris Vriend
Summary: This study investigated the effects of cognitive training on brain network connectivity and topology in Parkinson's disease. The results showed that eight weeks of computerized cognitive training did not have significant effects on the overall brain network, but there were localized connectivity changes in key regions involved in cognitive function.
NEUROIMAGE-CLINICAL
(2022)
Article
Neuroimaging
Rosanne Govaarts, Emma Beeldman, Matteo Fraschini, Alessandra Griffa, Marjolein M. A. Engels, Michael A. van Es, Jan H. Veldink, Leonard H. van den Berg, Anneke J. van der Kooi, Yolande A. L. Pijnenburg, Marianne de Visser, Cornelis J. Stam, Joost Raaphorst, Arjan Hillebrand
Summary: This study aimed to investigate if there are similarities in resting-state brain activity and functional connectivity between patients with early symptomatic amyotrophic lateral sclerosis (ALS) and behavioral variant frontotemporal dementia (bvFTD). The findings showed differences in brain activity and connectivity between ALS and bvFTD patients, contributing to our understanding of these diseases.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Shanna D. Kulik, Ilse M. Nauta, Prejaas Tewarie, Ismail Koubiyr, Edwin van Dellen, Aurelie Ruet, Kim A. Meijer, Brigit A. de Jong, Cornelis J. Stam, Arjan Hillebrand, Jeroen J. G. Geurts, Linda Douw, Menno M. Schoonheim
Summary: Cognitive impairment in multiple sclerosis (MS) is related to structural and functional connectivity, but it is still unclear whether the interplay between these two types of connectivity can serve as a biomarker for MS-related cognitive impairment. Further research is needed to explore the potential of this measure as a biomarker.
NETWORK NEUROSCIENCE
(2022)
Review
Dentistry, Oral Surgery & Medicine
Merel C. Verhoeff, Michail Koutris, Ralph de Vries, Henk W. Berendse, Karin D. van Dijk, Frank Lobbezoo
Summary: This article provides an overview of objective assessments and subjective experiences of salivary problems in patients with Parkinson's disease. It found that these patients have a lower salivary flow rate and a higher prevalence of xerostomia and drooling compared to controls. A multidisciplinary approach is necessary to avoid conflicting treatments from different healthcare professionals.
Article
Clinical Neurology
Deborah N. Schoonhoven, Casper T. Briels, Arjan Hillebrand, Philip Scheltens, Cornelis J. Stam, Alida A. Gouw
Summary: This study assessed the sensitivity and reproducibility of two metrics of functional connectivity, corrected amplitude envelope correlation (AEC-c) and phase lag index (PLI), in patients with Alzheimer's disease (AD) and healthy elderly controls. The results showed that these metrics were able to distinguish functional connectivity differences between AD patients and controls, and their sensitivity varied across different frequency bands.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Hisse Arnts, Prejaas Tewarie, Willemijn S. van Erp, Berno U. Overbeek, Cornelis J. Stam, Jan C. M. Lavrijsen, Jan Booij, William P. Vandertop, Rick Schuurman, Arjan Hillebrand, Pepijn van den Munckhof
Summary: This study investigated the effects of DBS on oscillatory activity and functional connectivity in a patient with prolonged minimally conscious state. The results showed that a lower frequency and larger volume of tissue activation in DBS were associated with increased functional connectivity and neural variability throughout the brain. However, the patient's neurophysiological markers and objective measures of consciousness remained lower than in healthy controls.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Rajanikant Panda, Aurore Thibaut, Ane Lopez-Gonzalez, Anira Escrichs, Mohamed Ali Bahri, Arjan Hillebrand, Gustavo Deco, Steven Laureys, Olivia Gosseries, Jitka Annen, Prejaas Tewarie, Muireann Irish
Summary: Understanding the recovery of consciousness and its underlying mechanisms is of crucial importance in basic neuroscience and medicine. This study used a time-resolved functional connectivity framework to explore the repertoire of functional network states as potential markers of consciousness, comparing patients with unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). The findings suggest a reduction in functional network repertoire and metastability in UWS patients, supporting the role of time-resolved thalamo-cortical connections and metastability in the recovery of consciousness.
Article
Neurosciences
Eva M. M. Strijbis, Yannick S. S. Timar, Deborah N. Schoonhoven, Ilse M. Nauta, Shanna D. Kulik, Lodewijk R. J. de Ruiter, Menno M. Schoonheim, Arjan Hillebrand, Cornelis J. Stam
Summary: This study systematically investigated the presence of drowsiness during resting-state MEG recordings and how it affects neurophysiological measurements. The findings showed that drowsiness is present in the majority of epochs, which significantly impacts spectral properties but has minimal effects on functional connectivity and network topology.
FRONTIERS IN NEUROSCIENCE
(2022)
Correction
Clinical Neurology
Lennard I. iii Boon, Wouter V. Potters, Thomas J. C. Zoon, Odile A. van den Heuvel, Naomi Prent, Rob M. A. de Bie, Maarten Bot, P. Richard Schuurman, Pepijn Van den Munckhof, Cornelis J. Stam, Arjan Hillebrand, Gert J. Geurtsen, Anne-Fleur van Rootselaar, Henk W. Berendse
Article
Neuroimaging
Marike R. R. van Lingen, Lucas C. C. Breedt, Jeroen J. G. Geurts, Arjan Hillebrand, Martin Klein, Mathilde C. M. Kouwenhoven, Shanna D. D. Kulik, Jaap C. C. Reijneveld, Cornelis J. J. Stam, Philip C. C. De Witt Hamer, Mona L. M. Zimmermann, Fernando A. N. Santos, Linda Douw
Summary: This study found that frontoparietal network centrality of multilayer networks is related to and predicts executive functioning in glioma patients, but it does not predict postoperative changes in executive functioning.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Clinical Neurology
Shira Simon, Ilse M. Nauta, Arjan Hillebrand, Menno M. Schoonheim, Bernard M. J. Uitdehaag, Maureen van Dam, Hanneke E. Hulst, Martin Klein, Cornelis J. Stam, Brigit A. de Jong, Eva M. M. Strijbis
Summary: This study investigates neurophysiological markers of cognitive impairment in MS, while explicitly addressing performance validity. The results suggest that neuronal slowing and altered resting-state functional connectivity can be considered cognitive markers in MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
