Article
Fisheries
Kifayatullah Mengal, Golara Kor, Pavel Kozak, Hamid Niksirat
Summary: Heat shock proteins (HSPs) are essential for proper protein folding and protect aquatic organisms against environmental stressors. They not only serve as molecular chaperones but also activate innate immune responses. Utilizing non-lethal heat shock and exogenous HSP-inducing compounds can enhance protective immunity and reduce stressful conditions in farmed decapod crustaceans.
AQUACULTURE REPORTS
(2023)
Review
Fisheries
Wisarut Junprung, Premruethai Supungul, Anchalee Tassanakajon
Summary: This review focuses on the structural and functional roles of crustacean HSPs in the innate immune response, highlighting their importance in disease resistance and their potential immunomodulatory role.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meric A. Altinoz, Sinan Guloksuz, Aysel Ozpinar
Summary: Noscapine is a versatile alkaloid with various pharmacological effects that can be used to treat neurodegenerative and psychiatric diseases such as multiple sclerosis, Parkinson's Disease, Amyotrophic Lateral Sclerosis, stroke, anxiety, depression, and Alzheimer's Disease.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Physiology
Sebastian Koetter, Martina Krueger
Summary: This review explores the composition of the sarcomere, the smallest molecular unit of muscle contraction and relaxation, and focuses on the role of the sarcomere protein titin and its relationship with protein quality control. It summarizes the current state of research on titin turnover and discusses the involvement of various intracellular degradation mechanisms. Additionally, it examines how perturbations in protein quality control can affect sarcomeric proteins, particularly titin, in different disease states.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Miriana Scordino, Monica Frinchi, Giulia Urone, Domenico Nuzzo, Giuseppa Mudo, Valentina Di Liberto
Summary: The differentiation of neural progenitors involves complex regulatory mechanisms that can be modulated by signals such as HSP70 and SOD1. These regulatory mechanisms are crucial for understanding stem cell and cancer research and therapy. In this study, the expression of HSP70 and SOD1 was found to play a role in promoting cell survival and protecting against oxidative stress-induced damage during the differentiation process of SH-SY5Y cells.
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Review
Genetics & Heredity
Timothy F. Spracklen, Graham Chakafana, Peter J. Schwartz, Maria-Christina Kotta, Gasnat Shaboodien, Ntobeko A. B. Ntusi, Karen Sliwa
Summary: Peripartum cardiomyopathy (PPCM) is a condition characterized by heart failure and systolic dysfunction occurring late in pregnancy or within months following delivery. Approximately 20% of PPCM patients screened for cardiomyopathy genes have an identified pathogenic mutation, with TTN truncations being most commonly implicated. Molecular chaperones such as heat shock proteins may play a role in modulating PPCM pathogenesis.
Article
Plant Sciences
Anthony Guihur, Bruno Fauvet, Andrija Finka, Manfredo Quadroni, Pierre Goloubinoff
Summary: In the scorching summer dawn, land plants establish molecular defenses to prepare for extreme midday temperatures, inducing heat-shock proteins for acquired thermotolerance. Despite high protein crowding, heat priming did not accumulate HSP chaperones in chloroplasts, while HSP20s accumulated in the cytosol, suggesting their role in preventing heat-labile protein aggregation.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Immunology
Stefan Tukaj, Jagoda Mantej, Michal Sobala, Katarzyna Potrykus, Zbigniew Tukaj, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz
Summary: The study found that Hsp70 immunization and anti-Hsp70 antibody treatment can decrease disease severity in a psoriasis-like skin inflammation mouse model by affecting T cell populations. This suggests that Hsp70 may be a promising therapeutic target for psoriasis and other autoimmune dermatoses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ahmed Barakat, Even Birkeland, Melissa D. Jorstad, Magalie El Hajj, Msafiri Marijani, Anne Doskeland, Olav Mjaavatten, Frode S. Berven, Tehmina Mustafa
Summary: This study investigated the proteomic profile of PBMCs in pulmonary tuberculosis (PTB) patients to predict treatment response. Blood samples were collected from 8 adult PTB patients in Tanzania at baseline, 2 months of treatment, and treatment completion. Proteins extracted from PBMCs were quantified and analyzed using LC-MS/MS. The results identified differentially expressed proteins involved in cellular processes, metabolic processes, binding, and catalytic activity, suggesting that proteome analysis of PBMCs can be used as a novel technique to monitor anti-tuberculosis treatment response and gain insights into PTB.
Article
Biology
Danuta Piotrzkowska, Elzbieta Miller, Ewa Kucharska, Marta Niwald, Ireneusz Majsterek
Summary: The study focused on the impact of microRNAs on the expression of neuroprotective proteins in peripheral blood mononuclear cells in multiple sclerosis patients. The results suggest dysregulation of gene expression in immune cells, potentially inhibiting neuroprotective functions and contributing to inflammation in multiple sclerosis development.
Article
Plant Sciences
Tung-Yi Lin, Wei-Jyun Hua, Hsin Yeh, Ai-Jung Tseng
Summary: The study demonstrates that FIPs LZ-8 and GMI induce changes in the proteomic profile of tumor lesions in LLC1 cell-bearing mouse, potentially regulating heat shock proteins (HSPs)-related cell viability and inhibiting cell migration and inducing apoptosis. Inhibition of HSPs may contribute to the anti-lung cancer activity of FIPs.
Article
Biochemistry & Molecular Biology
Fatemeh Habibpourmehraban, Yunqi Wu, Jemma X. Wu, Sara Hamzelou, Farhad Masoomi-Aladizgeh, Karthik Shantharam Kamath, Ardeshir Amirkhani, Brian J. Atwell, Paul A. Haynes
Summary: Rice crops are affected by multiple abiotic stresses, with different genotypes exhibiting varied physiological and proteomic responses. Under combined drought, salt, and extreme temperature stress, rice stomata close, ABA levels increase, and proteins like heat shock proteins show consistent responsiveness in two rice genotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Roland Toth, Nikolett Tokodyne Szabadi, Bence Lazar, Kitti Buda, Barbara Vegi, Judit Barna, Eszter Patakine Varkonyi, Krisztina Liptoi, Bertrand Pain, Elen Gocza
Summary: Heat stress from high environmental temperatures can negatively affect animal productivity, with studies showing a significant increase in the expression levels of HSP90 and HSF4 in heat-treated female chicken gonads.